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Xiao, Ailan,Wu, Chuncao,Kuang, Lei,Lu, Weizhong,Zhao, Xin,Kuang, Zhiping,Hao, Na The Korean Pain Society 2020 The Korean Journal of Pain Vol.33 No.4
Background: Zhongyi paste is a traditional Chinese medicine herbal paste that is externally applied to reduce inflammation and relieve pain. Methods: An acute foot swelling inflammation model in C57BL/6J mice was established by carrageenan-induced pathogenesis. Zhongyi paste raised the pain threshold and also reduced the degree of swelling in mice with carrageenan-induced foot swelling. Results: Analysis indicated that serum tumor necrosis factor-alpha, interleukin-1 beta, and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) cytokine levels and PGE<sub>2</sub> levels in the paw tissue of the mice were decreased by Zhongyi paste treatment. The quantitative polymerase chain reaction and western blot results showed that Zhongyi paste downregulated the mRNA and protein expression of extracellular signal-regulated kinase 1/2 (ERK1/2), and cyclooxygenase-2 (COX-2), and also downregulated the mRNA expression of PGE<sub>2</sub>. At the same time, the Zhongyi paste exerted a stronger effect as an external drug than that of indomethacin, which is an oral drug, and voltaren, which is an externally applied drug. Conclusions: Our results indicated that Zhongyi paste is a very effective drug to reduce inflammatory swelling of the foot, and its mechanism of action is related to regulation of the ERK1/2-COX-2-PGE<sub>2</sub> pathway.
Donghua Zheng,Dawei Liu,Na Liu,Yukun Kuang,Qiang Tai 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.8
Astragalin, a bioactive component of medicinalplants such as Rosa agrestis, has anti-inflammatory andantioxidant features. Induction of heme oxygenase (HO)-1is an effective strategy to reduce excessive generated oxidantsduring the pathogenesis of acute lung injury (ALI). The aim of the present study is to investigate that whetherthe anti-inflammatory and antioxidant features of astragalinis HO-1 dependent in lipopolysaccharide (LPS)-inducedALI. Sprague–Dawley rats were used in animal study. Intratracheal LPS was performed to induce experimentalALI model. Astragalin was administrated 1 h after LPSchallenge. Human lung epithelial cells were used in cellstudy. Samples from rats were harvested at 24 h post LPSchallenge. Astragalin treatment inhibited LPS-inducedinflammatory cells infiltration in the lung and pulmonaryedema. Astragalin treatment markedly enhanced theactivity of HO-1 compared with vehicle-treated group at24 h post LPS challenge. Levels of lipid hydroperoxide, amarker for oxidative stress, were decreased in astragalintreatedanimals compared with vehicle-treated group. However, the protective effect of astragalin on LPS-inducedALI was abolished in an inhibitor of HO-1-treatedanimals. Moreover, the astragalin-induced the upregulationof HO-1 in human lung epithelial cells was inhibited whennuclear factor erythroid-2-related factor 2 (Nrf2) wassilenced by small interfering RNA. Astragalin reducesLPS-induced ALI via activation of Nrf2/HO-1 pathway.
Qiu-Hua Wang,Na Kuang,Wen-yue Hu,Dan Yin,Ying-Yi Wei,Ting-Jun Hu 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.4
Background: Panax notoginseng saponins (PNS) are bioactive substances extracted from P. notoginseng that are widely used to treat cardiovascular and cerebrovascular diseases and interstitial diseases. PNS have the functions of scavenging free radicals, anti-inflammation, improving blood supply for tissue and so on. Objectives: The aim of this study was to investigate the effects of PNS on the oxidative stress of immune cells induced by porcine circovirus 2 (PCV2) infection in vitro and in vivo. Methods: Using an oxidative stress model of PCV2 infection in a porcine lung cell line (3D4/2 cells) and mice, the levels of nitric oxide (NO), reactive oxygen species (ROS), total glutathione (T-GSH), reduced glutathione (GSH), and oxidized glutathione (GSSG) and the activities of xanthine oxidase (XOD), myeloperoxidase (MPO) and inducible nitric oxide synthetase (iNOS) were determined to evaluate the regulatory effects of PNS on oxidative stress. Results: PNS treatment significantly reduced the levels of NO and ROS, the content of GSSG and the activities of XOD, MPO, and iNOS (p < 0.05), while significantly increasing GSH and the ratio of GSH/GSSG in infected 3D4/2 cells (p < 0.05).Similarly, in the in vivo study, PNS treatment significantly decreased the level of ROS in spleen lymphocytes of infected mice (p < 0.05), increased the levels of GSH and T-GSH (p < 0.05), significantly decreased the GSSG level (p < 0.05), and decreased the activities of XOD, MPO, and iNOS. Conclusions: PNS could regulate the oxidative stress of immune cells induced by PCV2 infection in vitro and in vivo.