S-192 Prevalence and predictors of mortality with Stress induced Cardiomyopathy in critically ill patients

( Myungjin Song ),( Jisoo Choi ),( Bora Yoon ),( Ah Young Leem ),( Joo Han Song ),( Song Yee Kim ),( Eun Young Kim ),( Ji Ye Jung ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ),( Moo Suk Park ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Purpose:?The aims of this study were to assess frequency of stress induced cardiomyopathy (SCMP) and predictors for incidence of SCMP in patients who admitted to medical ICU. We also explored the predictors of in-hospital mortality in patients with SCMP.?Method:?It is a retrospective cohort study. A total of 338 patients admitted to medical ICU and underwent transthoracic echocardiography (TTE) between January 2015 and December 2015 were enrolled. Definition of SCMP was defines as follows: 1) transient hypokinesis, akinesis of the left ventricular mid segments with or without apical involvement or the regional wall motion abnormalities extend beyond a single epicardial vascular distribution; 2) absence of obstructive coronary disease; 3) new EKG abnormalities or modest elevation in cardiac troponin; 4) absence of pheochromocytoma, myocarditis. Logistic regression model was used to analysis predictors for incidence of SCMP and predictors of in-hospital mortality in SCMP respectively. Cox regression model was used to analysis the influence of SCMP to mortality.?Results:?Of the 338 patients, SCMP was observed in 42 patients (12.4%). Compared to 296 patients without SCMP, patients with SCMP had lower frequency of DM (19% vs 29.2%, p=0.01), COPD (4.8% vs 16.9%, p=0.04) and higher prevalence of using mechanical ventilator (MV, 90.5% vs 71.9%, p=0.03), and lower ejection fraction (EF, 38.0±15.6 vs 61.7±11.8, p<0.001). In multivariate analysis, lower BMI (odd ratio, 0.88; 95% CI, 0.78 to 0.99; p=0.04) and lower EF (odd ratio, 0.90; 95% CI, 0.87 to 0.92; p<0.01) were associated with development of SCMP. In a Cox regression model adjusted with several confounders (age, DM, malignancy, liver cirrhosis, shock, acute kidney injury, use of MV) SCMP showed trend to increase of 60-day mortality (p=0.052). Among 42 patients with SCMP, acute kidney injury(AKI) was the only risk factor for predicting in-hospital mortality (odd ratio, 8.19; 95% CI, 1.35 to 47.75; p=0.02).?Conclusions:?Our study showed that prevalence of SCMP was 12.4% and trend to increase of 60-day mortality of critically ill patients. In patients with SCMP, AKI was the only risk factor for predicting in-hospital mortality.

Development of artificial skin which extracellular matrix includes subcutaneous angiogenesis activity

Sokho Kim,Jinhyoung Kim,Myungjin Kim,Hyunkyu Go,Dohyeong Kim 한국실험동물학회 2018 한국실험동물학회 학술발표대회 논문집 Vol.2018 No.7

휴머노이드 로봇의 실시간 드로잉을 위한 윤곽선의 궤적 좌표 집합 추출 알고리즘

김바울(Paul Kim),송명진(Myungjin Song),이근주(Geunju Lee),김용덕(Yongdeok Kim),김상욱(Sangwook Kim),김경덕(Kyungdeok Kim) 한국정보과학회 2011 한국정보과학회 학술발표논문집 Vol.38 No.1C

휴머노이드 로봇이 인간처럼 그림을 그리기 위해서는 순서를 가지는 드로잉 좌표 집합이 필요하다. 하지만 기존 영상 처리를 통한 윤곽선에서의 좌표 집합은 순서가 없고 로봇 암을 들어 올리는 좌표가 없다. 또한 불필요한 좌표가 다수 포함되어 있어서 효율적인 드로잉을 하기가 어려워 드로잉하는데 시간이 많이 걸린다. 따라서 본 논문에서는 3축으로 구성된 휴머노이드 로봇 암이 드로잉하기 위한 좌표 집합을 추출하는 알고리즘을 개발한다. 이를 구현하기 위해서는 로봇이 드로잉하기 위한 윤곽선 추출 알고리즘과 추출한 드로잉 좌표 집합에서 드로잉 순서와 로봇 암을 들어 올리는 점을 전체 좌표 리스트에 포함해야 한다. 제안하는 알고리즘이 추출하는 좌표 집합은 캠 영상으로부터 입력되는 컬러 이미지에서 이미지 프로세싱을 거친 윤곽선을 입력으로 하며, 추출한 좌표들의 순서와 로봇 암의 드로잉 시작점을 삽입함으로서 빠르고 효율적인 로봇 드로잉 좌표 집합 추출 알고리즘을 구현한다. 또한 제안하는 추출 알고리즘을 휴머노이드 로봇에 적용하여 실험하였으며, 좌표 추출 알고리즘의 정확성과 효율성을 비교하였다.

Rapid drug susceptibility test of Mycobacterium tuberculosis using microscopic time-lapse imaging in an agarose matrix

Choi, Jungil,Yoo, Jungheon,Kim, Ki-jung,Kim, Eun-Geun,Park, Kyung Ock,Kim, Hyejin,Kim, Haeun,Jung, Hyunju,Kim, Taeyoung,Choi, Myungjin,Kim, Hee Chan,Ryoo, Sungweon,Jung, Yong-Gyun,Kwon, Sunghoon Springer-Verlag 2016 Applied microbiology and biotechnology Vol.100 No.5

<P>Tuberculosis (TB) is a major global health problem, and multi-drug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) are spreading throughout the world. However, conventional drug susceptibility test (DST) methods, which rely on the detection of the colony formation on a solid medium, require 1-2 months to the result. A rapid and accurate DST is necessary to identify patients with drug-resistant TB and treat them with appropriate drugs. Here, we used microscopic imaging of Mycobacterium tuberculosis (MTB) immobilized in an agarose matrix for a rapid DST. The agarose matrix, which was molded in a microfluidic chip, was inoculated with MTB, and TB drugs in liquid culture medium diffused throughout the agarose to reach the MTB immobilized in the agarose matrix. After the responses of MTB to drugs were tracked with an automated microscopic system, an image-processing program automatically determined the susceptibility and resistance of MTB to specific doses of TB drugs. The automatic DST system was able to assess the drug susceptibility of various drug-resistant clinical TB strains within 9 days with an accuracy comparable to that of conventional method. Our rapid DST method based on microscopic time-lapse imaging greatly reduces the time required for a DST and can be used to rapidly and accurately treat TB patients.</P>

Annealing Effects after Nitrogen Ion Casting on Monolayer and Multilayer Graphene

Kim, Ki-jeong,Yang, Sena,Park, Youngchan,Lee, Myungjin,Kim, BongSoo,Lee, Hangil American Chemical Society 2013 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.117 No.5

<P>The modification of the electronic properties of a coverage-dependent graphene layer by nitrogen ions irradiation was investigated using core-level photoemission spectroscopy (CLPES). Here we describe preparation of monolayer and multilayer epitaxial graphene (EG) functionalized by nitrogen ions irradiation with 100 eV to minimize the damage of graphene layer as we annealed up to 1300 K to track the surface property changes using CLPES. As a result, on the monolayer EG, we found that pyridinic nitrogen mainly existed on the surface. On the multilayer EG, we observed the formation of graphitic nitrogen remaining as a major species confirmed using N 1s core-level spectra. Through a work function change (ΔΦ) measurement, both systems indicated p-type doping properties with 4.71 (monolayer EG) and 4.87 eV (multilayer EG) of work function values after N<SUB>2</SUB> ion irradiation. Interestingly, we observed that monolayer EG maintained its p-type doping character, whereas multilayer EG changed the doping character from p-type to n-type as we annealed both systems up to 1300 K due to the discrepancy of the electron charge transfer. We will systematically demonstrate these variations of electronic properties for both monolayer and multilayer EG.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2013/jpccck.2013.117.issue-5/jp309964m/production/images/medium/jp-2012-09964m_0006.gif'></P>

Taiwan’s Concepts of Military Strategy and Military Power Construction in Response to Chinese Threats

( Myungjin Kim ),( Kwanhaeng Cho ) 한국국방연구원 2022 The Korean Journal of Defense Analysis Vol.34 No.4

The Taiwan Strait poses a risk of war at any time due to a combination of international political factors such as China’s national strength, willingness to unify, Taiwan’s independence, and the U.S.-China leadership competition. In this situation, this paper analyzed the scenario of China’s invasion of Taiwan, and considered the comparison of military power on both sides and the direction of Taiwan’s military power construction. In conclusion, the war in the Taiwan Strait is likely to trigger geopolitical conflicts between the United States and North Korea on the Korean Peninsula, and the ROK will have to respond to diplomatic and security challenges simultaneously. Therefore, we must face up to the fact that tensions and crises between the two sides in the Taiwan Strait are directly linked to the security crisis on the Korean Peninsula. It is necessary to closely monitor the conflict between the two sides and preemptively prepare diplomatic and security response strategies for each situation.

Dialogue in the Self

Kim, Myungjin 서울대학교 영문화권연구소 1999 영문화권연구 Vol.1999 No.7

Fabrication of a Submicron-Sized Fe Dot Array by Using Polystyrene Beads

Kim, Myungjin,Hwang, Teajong,Kim, Dongho Korean Physical Society 2017 New Physics: Sae Mulli Vol.67 No.4

Binocular Visual Rehabilitation in Paralytic Strabismus by Botulinum A Toxin Chemodenervation

Myungjin Kim,Helen Lew 대한안과학회 2022 Korean Journal of Ophthalmology Vol.36 No.1

Purpose: To investigate the effect of botulinum A toxin (BTXA) chemodenervation in paralytic strabismus patients withoutsurgical correction. Methods: A retrospective chart review of 51 patients who were diagnosed as paralytic strabismus and underwent BTXA chemodenervationwas performed. The patients were divided into four groups according to the cause of paralytic strabismus ofvasculopathy, neoplasm, trauma, and idiopathic. They were also divided into two groups of early and late treatment accordingto the initiation time of BTXA chemodenervation after the onset of strabismus (3 months), and of the initial strabismustype of exotropia and esotropia. We investigated the changes of angle of deviation and diplopia after BTXA chemodenervation. Results: The average deviation of angles decreased by 25.2 prism diopter (PD) (35.1 to 9.9 PD) in total patients, and the overallsuccess rate was 64.7% (33 by 51), and the there was no statistically significant difference in success rate between eachgroup divided by the cause of paralytic strabismus. According to the treatment timing, the deviation of the angle decreasedby 28.0 PD (36.8 to 8.8 PD) in the early treatment group, and 21.3 PD (33.5 to 12.2 PD) in late treatment group at the time ofthe last postinjective follow-up. According to the initial strabismus type, the average angle of deviation decreased by 20.3 PD(35.6 to 15.3 PD) in exotropia group by cranial nerve 3 palsy, and 24.4 PD (32.5 to 8.1 PD) in esotropia by cranial nerve 6 palsy. Conclusions: BTXA chemodenervation reduced the angle of deviation and the number of patients with diplopia regardless ofthe cause of paralytic strabismus. Early BTXA chemodenervation can be considered as the first treatment of choice in paralyticstrabismus, especially in esotropia patients.

Simultaneous modeling of mean and variance in small area estimation

Kim, Myungjin,Kim, Dal Ho The Korean Data and Information Science Society 2016 한국데이터정보과학회지 Vol.27 No.5

When the sample size in a certain domain is too small to produce adequate information, small area model with random effects is usually used. Also, if we do not consider an inherent pattern which data possess, it considerably affects inference. In this paper, we mainly focus on modeling to handle increased variation of the Current Population Survey (CPS) median income as the Internal Revenue Service (IRS) mean income increases. In a hierarchical Bayesian framework, most estimations are carried out through the Gibbs sampler while the grid method is used to generate parameters from non-standard form. Numerical study indicates that the performance of proposed model is better than that of CPS method in terms of four comparison measurements.