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Kim Hee-Hoon,Shim Young-Ri,Choi Sung Eun,Kim Myung-Ho,Lee Giljae,You Hyun Ju,Choi Won-Mook,Keungmo Yang,Ryu Tom,Kim Kyurae,김민정,Woo Chaerin,Chung Katherine Po Sin,Hong Song Hwa,Eun Hyuk Soo,Kim Seok-Hw 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Chronic alcohol consumption often induces hepatic steatosis but rarely causes severe inflammation in Kupffer cells (KCs) despite the increased hepatic influx of lipopolysaccharide (LPS), suggesting the presence of a veiled tolerance mechanism. In addition to LPS, the liver is affected by several gut-derived neurotransmitters through the portal blood, but the effects of catecholamines on KCs have not been clearly explored in alcohol-associated liver disease (ALD). Hence, we investigated the regulatory roles of catecholamine on inflammatory KCs under chronic alcohol exposure. We discovered that catecholamine levels were significantly elevated in the cecum, portal blood, and liver tissues of chronic ethanol-fed mice. Increased catecholamines induced mitochondrial translocation of cytochrome P450 2E1 in perivenous hepatocytes expressing the β2-adrenergic receptor (ADRB2), leading to the enhanced production of growth differentiation factor 15 (GDF15). Subsequently, GDF15 profoundly increased ADRB2 expression in adjacent inflammatory KCs to facilitate catecholamine/ADRB2-mediated apoptosis. Single-cell RNA sequencing of KCs confirmed the elevated expression of Adrb2 and apoptotic genes after chronic ethanol intake. Genetic ablation of Adrb2 or hepatic Gdf15 robustly decreased the number of apoptotic KCs near perivenous areas, exacerbating alcohol-associated inflammation. Consistently, we found that blood and stool catecholamine levels and perivenous GDF15 expression were increased in patients with early-stage ALD along with an increase in apoptotic KCs. Our findings reveal a novel protective mechanism against ALD, in which the catecholamine/GDF15 axis plays a critical role in KC apoptosis, and identify a unique neuro-metabo-immune axis between the gut and liver that elicits hepatoprotection against alcohol-mediated pathogenic challenges.
A large-scale screening analysis for the evaluation of Bakanae disease in rice
Myung-Hee Kim,Saet-Byeol Lee,Tackmin Kwon,Un-Ha Hwang,Soo-Kwon Park,Yeong-Nam Youn,Jong-Hee Lee,Jun-Hyun Cho,Dongjin Shin,Sang-Ik Han,Un-Sang Yeo,You-Chun Song,Min-Hee Nam,Dong-Soo Park 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
Bakanae disease of rice, caused by Fusarium moniliforme Sheldon, the imperfect stage of Gibberella fujikuroi, is one of the most important rice diseases worldwide, but no rice variety has been found to be completely resistant to this fungus. Cultivation of resistant cultivars is the most beneficial way of reducing quantitative or qualitative losses to for bakanae disease in rice. To facilitate the study of this disease, accurate and large scale screening methods were developed for the inoculation and evaluation of Bakanae disease. Even and large scale infection was achieved by using F. moniliforme spore in tissue embedding cassette and seedling tray. The efficiency of F. moniliforme infection with the concentration of 1×106 spore/ml caused better distribution (F-value=33.96) than 1×102 (F-value=10.69), and 1×104 spore/ml (F-value=2.63). We established new criteria of healthy and non-healthy plant, and introduced calculation of proportion of healthy plants to meet fast evaluation of resistance level of each variety. The effect of F. moniliforme strains containing different genetic background was also evaluated with rice varieties to figure out the stability of resistance level. GA3 response of rice variety was significantly correlated with bakanae disease, but it did not adequate for direct indicator of bakanae disease resistance. These results indicated that a large scale infection method developed in this study is fast and reproducible, as well as a disease evaluation system provides an accurate measurement of bakanae disease resistance of rice.
민영일(Young Il Min),이성구(Sung Koo Lee),김명환(Myung Hwan Kim),이승규(Sung Gyu Lee),김태형(Tae Hyeoung Kim),서동완(Dong Wan Seo),명승재(Seung Jae Myung),박광민(Kwang Min Park),이영주(Young Joo Lee),성규보(Gyu Bo Sung),이미화(Mee Hw 대한소화기학회 1997 대한소화기학회지 Vol.30 No.1
A case of prirnary pure cholesterol hepatolithiasis is reported. A 30-year-old man with right upper quadrant pain and fever turned out to have intrahepatic stones. Stone composition was documented by infrared spectroscopy and the presence of cholesterol crystal in hepatic bile was demonstrated using polarized microscope. The patient was treated with choledochoscopic stone extraction and oral dissolution therapy. The cholangioscopic finding showed only mild inflammation and no remarkable stricture in stone-bearing duct. We advocate biochemical analyses of both stone and. bile for the optimal therapy of primary hepatolithiasis. (Korean J Gastroenterol 1997; 30:136- 139)
Ji-Ae Lim,Ho-Jang Kwon,Mina Ha,Ho Kim,Se Young Oh,Jeong Seon Kim,Sang-Ah Lee,Jung-Duck Park,Young-Seoub Hong,Seok-Joon Sohn,Heesoo Pyo,Kyung Su Park,Kwang-Geun Lee,Yong Dae Kim,Sangil Jun,Myung Sil Hw 환경독성보건학회 2015 환경독성보건학회지 Vol.30 No.-
Objectives: This survey was designed to conduct the first nationwide dietary exposure assessment on hazardous substances including the intakes of functional food and herbal medicine. In this paper, we introduced the survey design and the results of the dietary exposure status and internal exposure levels of lead (Pb), cadmium (Cd), and mercury (Hg). Methods: We selected 4867 subjects of all ages throughout Korea. We conducted a food survey, dietary survey, biomonitoring, and health survey. Results: Pb and Cd were the highest (median value) in the seaweed (94.2 μg/kg for Pb; 594 μg/kg for Cd), and Hg was the highest in the fish (46.4 μg/kg). The dietary exposure level (median value) of Pb was 0.14 μg/kg body weight (bw)/d, 0.18 μg/kg bw/d for Cd, and 0.07 μg/kg bw/d for Hg. Those with a blood Pb level of less than 5.00 μg/dL (US Centers for Disease Control and Prevention, reference value for those 1 to 5 years of age) were 99.0% of all the subjects. Those with a blood Cd level with less than 0.30 μg/L (German Federal Environmental Agency, reference value for non-smoking children) were 24.5%. For those with a blood Hg level with less than 5.00 μg/L (human biomonitoring I, references value for children and adults, German Federal Environmental Agency) was 81.0 % of all the subjects. Conclusions: The main dietary exposure of heavy metals occurs through food consumed in a large quantity and high frequency. The blood Hg level and dietary exposure level of Hg were both higher than those in the European Union.
( Woo Hyun Paik ),( Do Hyun Park ),( Joon Hyuk Choi ),( Shin Na ),( Yang Soon Park ),( Hyeyoung Kim ),( Myong Sook Lee ),( Seung Mo Hong ),( Sang Soo Lee ),( Dong Wan Seo ),( Sung Koo Lee ),( Myung Hw 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: The aim of this study was to determine whether technical factors including suction, non-suction, capillary suction, and various number of to-and-froneedle movement (TFNM) may affect the accuracy of EUS-FNA for pancreatic solid masses without on-site cytopathology. Methods: The diagnostic yield of malignancy, blood contamination and cellularity at each sample acquired from EUS-FNA with or without suction and different number of TFNM (10, 15 and 20) were measured (study I). After determining optimal TFNM number, a head-to-head comparison trial between suction and capillary suction was performed (study II). Results: In study I, Signifi cant blood contamination was seen in 20 TFNM comparedwith 15 TFNM in suction (P = 0.002). Diagnostic yield of malignancy was statistically higher in 15 TFNM compared with 10 TFNM in nonsuction (P = 0.001). TFNM number = 15 was the signifi cant factor affecting the diagnostic yield of EUS-FNA in multivariate analysis (OR 1.59, P = 0.02). In study II with the assumed optimal TFNM number as 15, there was no difference in diagnostic yield between suction and capillary suction (88% vs. 90%, P = 0.74). Conclusions: When suction is not applied, the optimal TFNM may be a major determinant for specimen quality and diagnostic yield of EUS-FNA for pancreatic solid masses in centers without on-site cytopathology. With optimal number of TFNM, the diagnostic yield is similar between suction and capillary suction. (Clinical trial registration number: NCT01576497, NCT01923883)