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Polarimeter를 이용한 Unnatural Amino Acid 유도체의 선광도 측정
박명숙,박해선,권순경 德成女子大學校 藥學硏究所 2001 藥學論文誌 Vol.12 No.1
For the development of new COX-2 inhibitor, novel unnatural amino acids, key intermediates were synthesized through induction an arylsulfonyl group to 1-position, an aralkyl group to 4-position of 4-hydroxy L-proline. The 4-aralkyloxy-1-(4-tosyl)-L-prolines 5a-d were synthesized through N-tosylation, esterification, O-alkyl-(or aryl)ation, base-hydrolysis (deprotection of carboxylic acid) from 4-hydroxy-L-proline. The optical activity of unnatural amino acids were studied how the specific rotation was related with their structure. The optical rotation of unnatural amino acids were determined by polarimeter.
박춘명,임순범 건국대학교 자연과학연구소 1999 建國自然科學硏究誌 Vol.10 No.2
This paper presents a method of constructing the highly efficient adder/multiplier over Galois Field. First, we obtain addition and multiplication arithmetic operation algorithm by using mathematical properties over Galois Field. Next for the purpose of realizing the arithmetic unit modules (adder module and multiplier module), we construct basic cells using addition and multiplication arithmetic operation algorithms. Also we propose distributor module for merging the adder and multiplier module.
Silver(Ⅰ) Oxide 존재에 의한 N-치환된 1,2-Benzothiazine 유도체의 비대칭 중합반응
박명숙,권순경 德成女子大學校 藥學硏究所 1998 藥學論文誌 Vol.9 No.1
Asymmetric dimer of N-substituted 1,2-benzothiazines were obtained from oxidative dimerization in the presence of silver(I) oxide. Optimal reaction was sucessfully proceeded through stirring of distilled acetone using 100mol% of silver(I) oxide at room temperature for 40 h. Totomerization of 4-hydroxy moiety took place during the first course of dimerization, which followed 3-hydroxy of 1,2-benzothiazine through oxidative radical reaction between carbon-hydrogen bond with silver(I) oxide. Nucleophillic attack of another oxygen nucleophile molecules gave to dimer 6a-g with dehydration A mechanism for the dimerization have been proposed.
BT(Bluetooth) IP에서의 핸드오프 지원 방안
박홍성,정명순 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.A
In this paper, we propose handoff scheme for BT(Bluetooth) IP and define signaling for the handoff scheme. In local area, BT IP use the concept of Cellular IP and the operation property of Bluetooth system. In case of accessing external internet, use the concept of Mobile IP. IP-based Mobility of Blutooth Terminal provides efficient and rapid mobility in local area and flexibility on the internet.
다기관 기능부전을 초래한 치명적인 삼일열 말라리아 증례
박상원,김동우,박주원,이순일,신영학,김의종,오명돈,최강원 대한감염학회 2005 감염과 화학요법 Vol.37 No.2
삼일열 말라리아는 국내에서 재유행하고 있는 감염질환으로, 일반적으로 양성의 임상경과를 거친다. 저자들은 특이한 질병력이 없이 건강하였던 젊은 성인이 국내에서 삼일열 말라리아에 걸린 후 다기관기능부전과 폐출혈으로 사망한 증례를 경험하였다. 환자의 중증 임상경과를 설명할 만한 특이한 인자가 발견되지 않았다. Vivax malaria is a re-emerging infectious disease in Korea with cumulating 19,416 cases as of December 2003 since 1993. Vivax malaria is generally a benign disease with few severe complications. Even in the worldwide literature, there are only small number of case reports on severe complications. We experienced a fatal vivax malaria in a previously healthy young adult with severe multi-organ failure and fatal massive pulmonary hemorrhage. The patient presented with abdominal pain and shock. There were splenic hemorrhage, disseminated intravascular coagulation, oliguric acute renal failure requiring dialysis, and pulmonary hemorrhage leading the patient finally to death. The initial parasitemia was 2,046/μL. Thin smear and PCR revealed only Plasmodium Vivax. There was no explainable cause of death except for the only serological suggestion of Mycoplasma pneumoniae infection without correlating clinical evidence. This is a first case of fatal vivax malaria in Korea since its re-emergence in 1993. Further case monitoring is needed to define whether this is a index case or an isolated one.
COX-2 Inhibitors를 위한 새로운 1,2-치환된 피롤리딘 유도체의 합성
박명숙,신혜순 德成女子大學校 藥學硏究所 2000 藥學論文誌 Vol.11 No.1
For the development of new COX-2 inhibitor, novel compounds were synthesized through induction an arylsulfony group to 1-position, an arylcarboxamidyl group to 2-position and an aralkyl group to 4-position of L-proline. The 4-aralkyloxy-1-(4-methylphenylsulfonyl)-L-prolines 5a-d were synthesized through N-tosylation, esterification, O-alkyl-(or aryl)ation, base-hydrolysis (deprotection of carboxylic acid) from 4-hydroxy-L-proline. Final 4-aralkyloxy-1-(4-methylphenylsulfonyl)-2-phenylcarboxamidyl-L-prolines 6a-d were synthesized through the condensation of aniline with 5a-d using DCC.
유한체 상에서 결정다이아그램에 기초한 다치논리 디지탈 시스템의 구성 방법
박춘명,임순범 건국대학교 자연과학연구소 1998 建國自然科學硏究誌 Vol.9 No.2
This paper presents a method a constructing Multiple-Valued Logic Digital Systems(MVLDS) based on the Decision Diagram(DD) over Finite Fields(FF). First, we discuss a method of constructing Ordered Multiple-Valued Logic Decision Diagram (OMVLDD) by the multiple-valued Shannon's expansion theorem. Next, we define identity isomorphism, tautology isomorphism, and constant isomorphism in order to simplify OMVLDD, and then discuss a method of selecting the variable ordering that is applied to the proposed several isomorphism relationships. The simplification method applies the proposed isomorphism after decomposing OMVLDD into subgraph, and then the vertex exchange and vertex substitution is considered in order to apply effective isomorphism relationship. We also discuss the don't care term and the case of multiple-output for digital systems. Finally, we implement the logic circuit design using T-gate that is used to construct multiple-valued logic systems after obtaining Reduced OMVLDD(ROMVLDD) from OMVLDD.
박홍성,정명순 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.A
This paper analyzes the performance of the several types of ACL(Asynchronous ConnectionLess) packets used in Bluetooth according to a BER(Bit Error Rate) and a packet length and proposes an optimal packet type and an optimal size of the packet being able to be used under the given BER. This paper proposes how to obtain the optimal packet type and the optimal size of the packet maximizing the performance measure under the given BER. In addition, this paper shows that the optimal type and size of the packet maximizing the throughput are different from those maximizing the mean transmission time. This occurs because the Bluetooth uses not only one type of packet bet also various types of packets.