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Muto, Momotaro,Nakata, Hirotaka,Ishigaki, Kenichi,Tachibana, Shion,Yoshida, Moe,Muto, Mizue,Yanagawa, Nobuyuki,Okumura, Toshikatsu The Korean Gastric Cancer Association 2021 Journal of gastric cancer Vol.21 No.3
The abscopal effect refers to the phenomenon in which local radiotherapy is associated with the regression of metastatic cancer that is distantly located from the irradiated site. Here, we present a case of a patient with advanced gastric cancer and brain metastases who was successfully treated with brain radiotherapy and anti-programmed death-1 (PD-1) therapy-induced abscopal effect. Although anti-PD-1 therapy alone could not prevent disease progression, the metastatic lesions in the brain and also in the abdominal lymph node showed a drastic response after brain radiotherapy and anti-PD-1 therapy. To our knowledge, this is the first reported case of successful treatment of advanced gastric cancer with multiple brain and abdominal lymph node metastases, possibly through anti-PD-1 therapy combined with brain radiotherapy-induced abscopal effect. We suggest that the combination of brain radiotherapy and anti-PD-1 therapy may be considered as a therapeutic option for advanced gastric cancer, especially when there is brain metastasis.
SOME EIGENFORMS OF THE LAPLACE-BELTRAMI OPERATORS IN A RIEMANNIAN SUBMERSION
MUTO, YOSIO Korean Mathematical Society 1978 대한수학회지 Vol.15 No.1
It is given in the Lecture Note [1] of Berger, Gauduchon and Mazet that, if ${\pi}$n: (${\tilde{M}}$, ${\tilde{g}}$)${\rightarrow}$(${\tilde{M}}$, ${\tilde{g}}$) is a Riemannian submersion with totally geodesic fibers, ${\Delta}$ and ${\tilde{\Delta}}$ are Laplace operators on (${\tilde{M}}$, ${\tilde{g}}$) and (M, g) respectively and f is an eigenfunction of ${\Delta}$, then its lift $f^L$ is also an eigenfunction of ${\tilde{\Delta}}$ with the common eigenvalue. But such a simple relation does not hold for an eigenform of the Laplace-Beltrami operator ${\Delta}=d{\delta}+{\delta}d$. If ${\omega}$ is an eigenform of ${\Delta}$ and ${\omega}^L$ is the horizontal lift of ${\omega}$, ${\omega}^L$ is not in genera an eigenform of the Laplace-Beltrami operator ${\tilde{\Delta}}$ of (${\tilde{M}}$, ${\tilde{g}}$). The present author has obtained a set of formulas which gives the relation between ${\tilde{\Delta}}{\omega}^L$ and ${\Delta}{\omega}$ in another paper [7]. In the present paper a Sasakian submersion is treated. A Sasakian manifold (${\tilde{M}}$, ${\tilde{g}}$, ${\tilde{\xi}}$) considered in this paper is such a one which admits a Riemannian submersion where the base manifold is a Kaehler manifold (M, g, J) and the fibers are geodesics generated by the unit Killing vector field ${\tilde{\xi}}$. Then the submersion is called a Sasakian submersion. If ${\omega}$ is a eigenform of ${\Delta}$ on (M, g, J) and its lift ${\omega}^L$ is an eigenform of ${\tilde{\Delta}}$ on (${\tilde{M}}$, ${\tilde{g}}$, ${\tilde{\xi}}$), then ${\omega}$ is called an eigenform of the first kind. We define a relative eigenform of ${\tilde{\Delta}}$. If the lift ${\omega}^L$ of an eigenform ${\omega}$ of ${\Delta}$ is a relative eigenform of ${\tilde{\Delta}}$ we call ${\omega}$ an eigenform of the second kind. Such objects are studied.
Jun Muto,Hidetoshi Murata,Seiji Shigekawa,Takafumi Mitsuhara,Daisuke Umebayashi,Ryo Kanematsu,Masahiro Joko,Tatsushi Inoue,Tomoo Inoue,Toshiki Endo,Yuichi Hirose 대한척추신경외과학회 2023 Neurospine Vol.20 No.3
Objective: The characteristics, imaging features, long-term surgical outcomes, and recurrence rates of primary spinal pilocytic astrocytomas (PAs) have not been clarified owing to their rarity and limited reports. Thus, this study aimed to analyze the clinical presentation, radiological features, pathological findings, and long-term outcomes of spinal PAs. Methods: Eighteen patients with spinal PAs who were surgically treated between 2009 and 2020 at 58 institutions were included in this retrospective multicenter study. Patient data, including demographics, radiographic features, treatment modalities, and long-term outcomes, were evaluated. Results: Among the 18 consecutive patients identified, 11 were women and 7 were men; the mean age at presentation was 31 years (3–73 years). Most PAs were located eccentrically, were solid or heterogeneous in appearance (cystic and solid), and had unclear margins. Gross total resection (GTR), subtotal resection (STR), partial resection (PR), and biopsy were performed in 28%, 33%, 33%, and 5% of cases, respectively. During a follow-up period of 65 ± 49 months, 4 patients developed a recurrence; however, the recurrence-free survival did not differ significantly between the GTR and non-GTR (STR, PR, and biopsy) groups. Conclusion: Primary spinal PAs are rare and present as eccentric and intermixed cystic and solid intramedullary cervical tumors. The imaging features of spinal PAs are nonspecific, and a definitive diagnosis requires pathological support. Surgical resection with prevention of neurological deterioration can serve as the first-line treatment; however, the resection rate does not affect recurrence-free survival. Investigation of relevant molecular biomarkers is required to elucidate the regrowth risk and prognostic factors.
Satoru Muto,Kousuke Kitamura,Takeshi Ieda,Fumitaka Shimizu,Masayoshi Nagata,Shuji Isotani,Hisamitsu Ide,Raizo Yamaguchi,Shigeo Horie 대한비뇨의학회 2017 Investigative and Clinical Urology Vol.58 No.3
Purpose: Robot-assisted radical cystectomy (RARC) was originally intended to replace open radical cystectomy (ORC) as a minimally invasive surgery for patients with invasive bladder cancer. The purpose of this study was to evaluate the advantages of robotic surgery, comparing perioperative and oncologic outcomes between RARC and ORC. Materials and Methods: Between June 2012 and August 2016, 49 bladder cancer patients were given a radical cystectomy, 21 robotically and 28 by open procedure. We compared the clinical variables between the RARC and ORC groups. Results: In the RARC group, the median estimated blood loss (EBL) during cystectomy, total EBL, operative time during cystectomy, and total operative time were 0 mL, 457.5 mL, 199 minutes, and 561 minutes, respectively. EBL during cystectomy (p<0.001), total EBL (p<0.001), and operative time during cystectomy (p=0.003) in the RARC group were significantly lower compared with the ORC group. Time to resumption of a regular diet (p<0.001) and length of stay (p=0.017) were also significantly shorter compared with the ORC group. However, total operative time in the RARC group (median, 561 minutes) was significantly longer compared with the ORC group (median, 492.5 minutes; p=0.015). Conclusions: This Japanese study presented evidence that RARC yields benefits in terms of BL and time to regular diet, while consuming greater total operative time. RARC may be a minimally invasive surgical alternative to ORC with less EBL and shorter length of stay.