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Shaghayegh Askarian-Amiri,Solmaz Nasseri Maleki,Seyedeh Niloufar Rafiei Alavi,Arian Madani Neishaboori,Amirmohammad Toloui,Mohammed I. M. Gubari,Arash Sarveazad,Mostafa Hosseini,Mahmoud Yousefifard 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.1
Background: Current therapies are quite unsuccessful in the management of neuropathic pain. Therefore, considering the inhibitory characteristics of GABA mediators, the present systematic review and meta-analysis aimed to determine the efficacy of GABAergic neural precursor cells on neuropathic pain management. Methods: Search was conducted on Medline, Embase, Scopus, and Web of Science databases. A search strategy was designed based on the keywords related to GABAergic cells combined with neuropathic pain. The outcomes were allodynia and hyperalgesia. The results were reported as a pooled standardized mean difference (SMD) with a 95% confidence interval (95% CI). Results: Data of 13 studies were analyzed in the present meta-analysis. The results showed that administration of GABAergic cells improved allodynia (SMD = 1.79; 95% CI: 0.87, 271; P < 0.001) and hyperalgesia (SMD = 1.29; 95% CI: 0.26, 2.32; P = 0.019). Moreover, the analyses demonstrated that the efficacy of GABAergic cells in the management of allodynia and hyperalgesia is only observed in rats. Also, only genetically modified cells are effective in improving both of allodynia, and hyperalgesia. Conclusions: A moderate level of pre-clinical evidence showed that transplantation of genetically-modified GABAergic cells is effective in the management of neuropathic pain. However, it seems that the transplantation efficacy of these cells is only statistically significant in improving pain symptoms in rats. Hence, caution should be exercised regarding the generalizability and the translation of the findings from rats and mice studies to large animal studies and clinical trials.
Ramin Ghorbani-Vaghei,Mostafa Amiri,Hojat Veisi 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.12
A new and facile protocol for the synthesis of dithiocarabamate in EtOH/H2O is described. Reaction of aromatic and aliphatic amines with CS2 and 3,4-dihydro-2H-pyran in the presence of N,N,N',N'-tetrabromobenzene- 1,3-disulfonamide [TBBDA] and poly(N-bromo-N-ethylbenzene-1,3-disulfonamide) [PBBS] gives the corresponding dithiocarbamates in good to high yields.
Ghorbani-Vaghei, Ramin,Amiri, Mostafa,Veisi, Hojat Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.12
A new and facile protocol for the synthesis of dithiocarabamate in EtOH/$H_2O$ is described. Reaction of aromatic and aliphatic amines with $CS_2$ and 3,4-dihydro-2H-pyran in the presence of N,N,N',N'-tetrabromobenzene-1,3-disulfonamide [TBBDA] and poly(N-bromo-N-ethylbenzene-1,3-disulfonamide) [PBBS] gives the corresponding dithiocarbamates in good to high yields.
Abdolmotaleb Seidmohammadi,Raheleh Amiri,Javad Faradmal,Mostafa Lili,Ghorban Asgari 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.3
Photocatalytic degradation of 4-chlrophenol (4-CP) using UVA-LED assisted persulfate and hydrogen peroxide activated by the nZVI (Nano Zero Valent Iron) in a batch photocatalytic reactor was investigated. The reaction involved a lab-scale photoreactor irradiated with UVA-LED light emitted at 390 nm. The efficiency of the reaction was evaluted in terms of 4-CP degradation and mineralization degree at different pH of solution, initial concentrations of nZVI, persulfate, hydrogen peroxide and 4-CP. In UVA-LED/H2O2/nZVI process, complete degradation of 4-CP (>99%) and 75% mineralization was achieved at pH of 3, hydrogen peroxide concentration of 0.75 mM, nZVI dosage of 1mM and initial 4-CP concentration of 25mg/L at the reaction time of 30 min. The optimum conditions obtained for the best 4-CP degradation rate were at an initial concentration of 25mg/l, persulfate concentration of 1.5mM, nZVI dosage of 1mM, pH of 3 and reaction time of 120min for UVA-LED/persulfate/nZVI process. It was also observed that the 4-CP degradation rate is dependent on initial 4-CP concentrations for both processes. The pseudofirst- order kinetic constant at 25mg/L initial concentration of 4-CP was found to be 1.4×10−1 and 3.8×10−2 in UVALED/ H2O2/nZVI and UVA-LED/persulfate/nZVI processes, respectively. Briefly, the UVA-LED/H2O2/nZVI process enhanced the degradation rate of 4-CP by 3.67-times in comparison to UVA-LED/persulfate/nZVI process at 30min contact time, which serves as a new and feasible approach for the degradation of 4-CP as well as other organic contaminants containing wastewater.