The Evolving Policy Debate on Border Closure in Korea

Su-Jin Kang,Jihyun Moon,Heewon Kang,Heekyoung Nam,Sangwoo Tak,Sung-Il Cho 대한예방의학회 2020 예방의학회지 Vol.53 No.5

302 Copyright © 2020 The Korean Society for Preventive Medicine J Prev Med Public Health 2020;53:302-306 • https://doi.org/10.3961/jpmph.20.213 The Evolving Policy Debate on Border Closure in Korea SuJin Kang1, Jihyun Moon2, Heewon Kang1, Heekyoung Nam3, Sangwoo Tak1, Sung-il Cho1,3 1Institute of Health and Environment, Seoul National University, Seoul, Korea; 2Samsung Advanced Institute of Health Science and Technology, Sungkyunkwan University, Seoul, Korea; 3Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea Brief Report Objectives: In this paper, we aimed to investigate the evolving debate over border closure in Korea during the coronavirus disease 2019 (COVID-19) pandemic, to address the main themes associated with border closure, and to discuss the factors that need to be considered when making such decisions. Methods: We collated and reviewed previously conducted review studies on border closures during infectious disease outbreaks to derive relevant themes and factors. Results: According to our systematic review on border closures and travel restrictions, the effects of such containment efforts are limited. We suggest considering the following factors when determining whether to impose border closure measures: (1) disease characteristics, (2) timeliness of implementation, (3) transmission delay and the basic reproduction number, (4) globalization and pandemics, and (5) social and economic costs. Conclusions: Our assessment indicates that the effects of border closures are at best temporary and limited. Alternative measures must be contemplated and implemented to suppress the spread of COVID-19 in particular and infectious diseases more broadly.

근막 결손의 복원과 자궁천골인대 고정을 통한 전자궁적출술 후 질탈출의 성공적 교정

문화숙(Hwa Sook Moon),최진국(Jin Koo Choi),김경서(Kyung Seo Kim),박근식(Kyun Sik Park),황지영(Ji Young Hwang),문성은(Sung Eun Moon),한지원(Ji Won Han),김상국(Sang Gook Kim),김상갑(Sang Gap Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.7

Objective : To report the method and efficacy of the site specific-defects repair in the endopelvic fascia and uterosacral ligament suspension for the correction of posthysterectomy vaginal vault prolapse. Methods : This study was performed in 3 patients with posthyterectomy vaginal vault prolapse who underwent the surgery for the reconstruction of endopelvic fascia and the correction of vault prolapsed vagina by using uterosacral ligament suspension at the department of Obstetrics and Gynecology in Moon-Hwa Hospital. Among them, 1 patient was treated by laparotomy, and 2 patients were treated by laparoscope. Results : The age of patients ranged from 49 to 67 years. The mean operation time was 111 minutes (105-120 minutes). The status of postoperative vagina was normal in all 3 patients, who were discharged 9 days after operation without symptoms. No complication or recurrence were found in them despite long-term follow-up for 24 months, 12 months, 7 months, respectively after operation. One patient has been treated with HRT therapy. Conclusion : The reconstruction of the defect of endopelvic fascia and uterosacral ligament fixation may be very safe, effective, and functional in the correction of vaginal vault prolapse. This study reports the treatment of vaginal vault prolapse using uterosacral ligament within Korea for the first time.

달 궤도 진입 목표값 변화에 따른 궤도요소 변화 연구

최수진,김인규,문상만,민승용,류동영,Choi, Su-Jin,Kim, In-Kyu,Moon, Sang-Man,Min, SeungYong,Rew, Dong-Young 항공우주시스템공학회 2015 항공우주시스템공학회지 Vol.9 No.4

Korea Aerospace Research Institute(here after KARI) has a plan to launch experimental lunar orbiter in 2018, and lunar orbiter and lander in 2020. There are several ways to go to the moon. Which one is direct transfer trajectory and another one is phasing loop transfer trajectory and the other one is WSB trajectory. Regardless of the transfer trajectories, LOI maneuver is the most important maneuver of all mission sequences because if this burn is failed, it is too difficult to get into the lunar orbit in the future. This paper describes first LOI target value of foreign lunar orbiters and analyzes orbital variations of experimental lunar orbiter according to various target values. By analyzing the variation of orbiter parameter after first LOI, proper orbital period for LOI target value are recommended to meet the inclination, apoapsis and periapsis altitude constraints.

달 탐사선의 발사 요구조건 및 임무궤도 사례연구

석병석(Suk, Byong-suk),민승용(Min, Seung-yong),권재욱(Kwon, Jae-wook),김창균(Kim, Chang-kyoon),문상만(Moon, Sang-man),최수진(Choi, Su-jin),구철회(Koo, Cheol-hea),김인규(Kim, In-kyu),류동영(Ryu, Dong-young) 한국항공우주연구원 2015 항공우주산업기술동향 Vol.13 No.2

시험용 달 궤도선의 발사 요구조건 사전 분석 단계로 최근 외국에서 발사한 달 탐사선의 발사 요구조건을 분석하였다. 일반적으로 달 탐사선의 발사 요구조건은 달 임무 궤도를 결정하는 중요한 요소이며, 또한 지구, 달, 태양의 상대적인 운동으로 인해 임무궤도 요구조건을 만족하는 발사 가능 시간이 주기적으로 반복되는 경향이 있다. 분석 결과 설정된 발사 요구조건들로부터 달 궤도선의 주 임무가 달의 남/북극 지역의 광학 관측 임을 간접적으로 알 수 있었다. 향후 우리나라 달 궤도선 발사 요구 조건 설정에 본 논문이 도움이 되길 기대한다. In the preliminary study on launch window requirement for Korea Path-finder Lunar Orbiter(KPLO), the recent foreign lunar orbiter’s lauch window requirement was analyzed. Normally, the launch requirements depends on the mission orbit. Based on the relationship between Moon, Earth, and Sun, the launch time will be available periodically to meet requirements. In this paper, it is understood that the launch window requirements come from payload mission requirements to take picture each poles of Moon. This paper might be a practical example to derive KPLO launch requirements in the future.

Densities of Riptortus pedestris and other pentatomid stinkbugs at different plant development stages in soybean and mungbean fields

Jin Kyo Jung,Bo Yoon Seo,Sang-Gyu Kim,Jung-Kyung Moon 한국농약과학회 2018 한국농약과학회 학술발표대회 논문집 Vol.2018 No.10

Survey of experts on therapeutic policies and proposals for the optimal timing for allogeneic peripheral blood stem cell transplantation in transfusion-dependent patients with myelodysplastic syndrome-refractory anemia

Sang Kyun Sohn,Joon Ho Moon,Yoo Jin Lee,Sung Woo Park,Ji Yoon Kim 대한혈액학회 2016 Blood Research Vol.51 No.1

BackgroundMost hypomethylating agent (HMA) responders with myelodysplastic syndrome (MDS) eventually need allogeneic stem cell transplantation (SCT) because they often acquire re-sistance to HMAs within two years of treatment. Considering the nature of MDS and the poor outcomes of SCT when performed after confirming the progression of MDS to acute myeloid leukemia (AML), allogeneic SCT should be performed with caution in patients with low-risk MDS.MethodsTo address low-risk MDS, the Korean AML/MDS working party group designed a survey for 34 MDS experts in Korea on therapeutic HMA and allogeneic SCT policies for low-risk MDS. The level of consensus was defined as the percentage of agreement among the experts.ResultsWith regard to the optimal time for allogeneic SCT for HMA responders with MDS-RA, 76% experts agreed that allogeneic SCT should be performed when a patient has a low platelet count. With regard to the relapse pattern that was most commonly found during HMA treatment in responding patients with MDS-RA, 54% experts agreed that the most common pattern that indicated HMA failure was the gradual worsening of cytopenia. ConclusionThe optimal time to perform allogeneic SCT in RA patients who achieved hematologic complete remission during HMA treatment is when the platelet count decreases. However, these suggestions need to be evaluated in larger future studies. Therefore, care-ful decisions should be taken at each step of allogeneic SCT to maximize the outcomes for patients with MDS-RA and iron overload.

Gate-to-Source/Drain Nonoverlap Device for Soft-Program Immune Unified RAM (URAM)

Jin-Woo Han,Chung-Jin Kim,Sung-Jin Choi,Dong-Hyun Kim,Dong-Il Moon,Yang-Kyu Choi IEEE 2009 IEEE electron device letters Vol.30 No.5

<P>A soft-program immune structure for a unified RAM (URAM) is presented. A unique feature of URAM is the multifunctionality of a flash and capacitorless 1T-DRAM in a single transistor. However, charge trapping into O/N/O during a cyclic 1T-DRAM operation can cause an undesirable threshold voltage shift, resulting in an unstable URAM operation called a soft program. In a gate-to-source/drain nonoverlap structure with a nonextended O/N/O layer under the gate spacer, the impact ionization region is steered out from the gate, which is located under the spacer. In the 1T-DRAM mode of URAM, the programming biases are selected so that impact ionization can occur under the gate spacer, thereby alleviating the soft program. The nonoverlap device relieves the operational voltage constraint imposed by the soft program. In addition, nonvolatile flash memory and capacitorless 1T-DRAM perform an acceptable performance without interference.</P>

Poster Session 2 : Prophylactic efficacy study of oral administered human papillomavirus type 16 L2 displayed on L. casei in mice

( Sung Jin Kim ),( Jong Soo Lee ),( Moon Hee Sung ),( Har Young Poo ) 생화학분자생물학회 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-

Optimization of the optical transparency of bones by PACT-based passive tissue clearing

Jin Byung-Ho,Woo Jiwon,Lee Mirae,Ku Seockmo,Moon Hyung Seok,Ryu Seung Jun,Hyun Young-Min,Park Jeong-Yoon,Kuh Sung Uk,Cho Yong Eun 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Recent developments in tissue clearing methods such as the passive clearing technique (PACT) have allowed three-dimensional analysis of biological structures in whole, intact tissues, thereby providing a greater understanding of spatial relationships and biological circuits. Nonetheless, the issues that remain in maintaining structural integrity and preventing tissue expansion/shrinkage with rapid clearing still inhibit the wide application of these techniques in hard bone tissues, such as femurs and tibias. Here, we present an optimized PACT-based bone-clearing method, Bone-mPACT+, that protects biological structures. Bone-mPACT+ and four different decalcifying procedures were tested for their ability to improve bone tissue clearing efficiency without sacrificing optical transparency; they rendered nearly all types of bone tissues transparent. Both mouse and rat bones were nearly transparent after the clearing process. We also present a further modification, the Bone-mPACT+ Advance protocol, which is specifically optimized for processing the largest and hardest rat bones for easy clearing and imaging using established tissue clearing methods.

Inhibition of human endothelial cell proliferation by Gami-Jeonggi-San (Jiawei-Zhenqi-San) is accompanied by transcriptional up-regulation of p53 and Waf1 tumor suppressor genes

Moon, Sang-Kwan,Jin, Hyung-Seok,Ko, Chang-Nam,Kim, Young-Suk,Bae, Hyung-Sup,Lee, Kyung-Sup,Cho, Ki-Ho KYUNG HEE UNIVERSITY MEDICAL CENTER 2006 고황의학상 수상논문집 Vol.21-22 No.-

The effects of Gami-Jeonggi-San (GJS) on proliferation of human endothelial cell (HUV-EC-C) were investigated using a flow cytometry and a quantitative RT-PCR analysis of gene expression. An accumulation of cells at G_(1) phase of the cell cycle was found at 72h after treatment (10 μl/ml) while no detectable reduction of PCNA expression was recognized. To elucidate that the cell cycle inhibitory effect of GJS stems from its capability of transcriptional regulation of the cell cycle-controlling genes, we investigated mRNA expression of p53, Waf1, PCNA, Cyclin D1, Cdc2, Histone H3, c-Myc, and c-Fos. Significantly elevated mRNA levels of the p53 tumor suppressor gene and its down-stream mediator gene, Waf1, whose increased expressions were known to trigger G_(1) cell cycle arrest, were observed. In contrast, a marked reduction of two early G_(1)-specific, cell cycle stimulating genes, c-Myc and c-Fos, were found at 24h after treatment, while there were no detectable changes in expressions of G_(1)-S or G_(2)-M transition-related genes, indicating the G_(1) specificity of GJS effect on the cell cycle. These results suggest that the pharmacological effects of GJS might be derived in part from inhibition of cellular proliferation of human endothelial cells, and that GJS inhibition of the cell cycle might stem from its regulatory capability on the transcription of the cell cycle-controlling genes, including p53 and Waf1 tumor suppressor genes.