Canadian Study

Molloy DW 대한임상노인의학회 2000 대한임상노인의학회지 Vol.1 No.2

Nomination Committees and National Sport Organizations: Designing the Way to Democracy?

Tracy Molloy,Lesley Ferkins,Geoff Dickson 글로벌지식마케팅경영학회 2024 Journal of Global Sport Management Vol.9 No.1

The director selection processes of nonprofit national sport organizations underpin board composition and hence board and organizational performance. In the New Zealand context, this study verifies the emergence of nomination committees (NCs) and critically examines, from a democratic theory perspective, the extent to which democratic legitimacy is promoted within the NC structures of national sport organizations’ director selection processes. An analysis of national sport organization (NSO) constitutions affirms the NC emergence as a governance phenomenon and results in the development of an NC (constitutional powers-based) classification system. This NC classification contributes to a largely unexamined area of nonprofit sport governance by providing a foundational description of NC structural design features then used to reflect on the extent to which the identified design features may serve to protect member voice (community logic) in the face of increasing pressures on NSOs to adopt professionalized governance structures (corporate logic). A holistic system objectives approach to democratic theory is used to better understand how NC structural design may support such member voice. In this way, the article offers both scholars and practitioners an insight into a range of NC strategic design choices and potential implications for democratic legitimacy.

Patterning potential of the terminal system in the Drosophila embryo

이건용,Kate Molloy O'Neill,Jayoung Ku,Stanislav Yefimovic Shvartsman,김유식 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.2

Segmentation of the Drosophila embryo is initiated by localized maternal signals. In this context, anteriorly localized Bicoid activates the gap genes in the anterior half of the embryo while posteriorly localized Nanos represses the translation of maternal hunchback mRNA to pattern the posterior half. The non-segmented termini are patterned by the localized activation of mitogen-activated protein kinase. Yet, the spatial extent of the terminal patterning system in regulating gap genes beyond poles remains unknown. We investigated the patterning potential of the terminal system using mutagenized embryos that lack both the anterior and the posterior maternal signaling systems. Using a combination of quantitative imaging and mathematical modeling, we analyzed the spatial patterns of gap genes in the early Drosophila embryo. We found that this mutant embryo develops symmetric cuticle patterns along the anteroposterior axis with two segments on each side. Notably, the terminal system can affect the expression of Krüppel in the torso region. Our mathematical model recapitulates the experimental data and reveals the potential bistability in the terminal patterning system. Collectively, our study suggests that the terminal system can act as a long-range inductive signal and establish multiple gene expression boundaries along the anteroposterior axis of the developing embryo.

Electronic structure design for nanoporous, electrically conductive zeolitic imidazolate frameworks

Butler, Keith T.,Worrall, Stephen D.,Molloy, Christopher D.,Hendon, Christopher H.,Attfield, Martin P.,Dryfe, Robert A. W.,Walsh, Aron Royal Society of Chemistry 2017 Journal of Materials Chemistry C Vol.5 No.31

<▼1><P>Electronic structure calculations are used to develop design rules for enhanced electrical conductivity in zeolitic imidazolate frameworks.</P></▼1><▼2><P>Electronic structure calculations are used to develop design rules for enhanced electrical conductivity in zeolitic imidazolate frameworks. The electrical resistivity of Co<SUP>2+</SUP> based zeolitic imidazolate frameworks has previously been found to be ∼1000 times lower than that of Zn<SUP>2+</SUP> based materials. The electrical conductivity of the frameworks can also be tuned by ligand molecule selection. Using density functional theory calculations, this controllable electrical conductivity is explained in terms of tuneable conduction band edge character, with calculations revealing the improved hybridisation and extended band character of the Co<SUP>2+</SUP> frameworks. The improvements in the methylimidazolate frameworks are understood in terms of improved frontier orbital matching between metal and ligand. The modular tuneability and previously demonstrated facile synthesis provides a route to rational design of stable framework materials for electronic applications. By outlining these design principles we provide a route to the future development of stable, electrically conductive zeolitic imidazolate frameworks.</P></▼2>

Synthesis, Thermal Decomposition Pattern and Single Crystal X-Ray Studies of Dimeric [Cu(dmae)(OCOCH3)(H2O)]2

Muhammad Mazhar*,S. M. Hussain,Faiz Rabbani,Gabriele Kociok-Kohn,Kieran C. Molloy 대한화학회 2006 Bulletin of the Korean Chemical Society Vol.27 No.10

A dimeric precursor, [Cu(dmae)(OCOCH3)(H2O)]2 for the CVD of copper metal films, (dmaeH = N,N-dimethylaminoethanol) was synthesized by the reaction of copper(II) acetate monohydrate (Cu(OCOCH3)2H2O) and dmaeH in toluene. The product was characterized by m.p. determination, elemental analysis and X-ray crystallography. Molecular structure of [Cu(dmae)(OCOCH3)(H2O)]2 shows that a dimeric unit [Cu(dmae)(OCOCH3)(H2O)]2 is linked to another through hydrogen bond and it undergoes facile decomposition at 300 C to deposit granular copper metal film under nitrogen atmosphere. The decomposition temperature, thermal behaviour, kinetic parameters, evolved gas pattern of the complex, morphology, and the composition of the film were also investigated.

Synthesis, Thermal Decomposition Pattern and Single Crystal X-Ray Studiesof Dimeric [Cu(dmae)(OCOCH₃)(H₂O)]₂: A Precursor for the Aerosol Assisted Chemical Vapour Deposition of Copper Metal Thin Films

Mazhar, Muhammad,Hussain, S.M.,Rabbani, Faiz,Kociok-Kohn, Gabriele,Molloy, Kieran C. Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.10

A dimeric precursor, $[Cu(dmae)(OCOCH_3)(H_2O)]_2$ for the CVD of copper metal films, (dmaeH = N,N-dimethylaminoethanol) was synthesized by the reaction of copper(II) acetate monohydrate ($Cu(OCOCH_3)_2{\cdot}H_2O$) and dmaeH in toluene. The product was characterized by m.p. determination, elemental analysis and X-ray crystallography. Molecular structure of $[Cu(dmae)(OCOCH_3)(H_2O)]_2$ shows that a dimeric unit $[Cu(dmae)(OCOCH_3)(H_2O)]_2$ is linked to another through hydrogen bond and it undergoes facile decomposition at 300 C to deposit granular copper metal film under nitrogen atmosphere. The decomposition temperature, thermal behaviour, kinetic parameters, evolved gas pattern of the complex, morphology, and the composition of the film were also investigated.

High Coronary Shear Stress in Patients With Coronary Artery Disease Predicts Myocardial Infarction

Kumar, Arnav,Thompson, Elizabeth W.,Lefieux, Adrien,Molony, David S.,Davis, Emily L.,Chand, Nikita,Fournier, Stephane,Lee, Hee Su,Suh, Jon,Sato, Kimi,Ko, Yi-An,Molloy, Daniel,Chandran, Karthic,Hossein Elsevier 2018 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - Vol.72 No.16

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Coronary lesions with low fractional flow reserve (FFR) that are treated medically are associated with higher revascularization rates. High wall shear stress (WSS) has been linked with increased plaque vulnerability.</P> <P><B>Objectives</B></P> <P>This study investigated the prognostic value of WSS measured in the proximal segments of lesions (WSS<SUB>prox</SUB>) to predict myocardial infarction (MI) in patients with stable coronary artery disease (CAD) and hemodynamically significant lesions. The authors hypothesized that in patients with low FFR and stable CAD, higher WSS<SUB>prox</SUB> would predict MI.</P> <P><B>Methods</B></P> <P>Among 441 patients in the FAME II (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation II) trial with FFR ≤0.80 who were randomized to medical therapy alone, 34 (8%) had subsequent MI within 3 years. Patients with vessel-related MI and adequate angiograms for 3-dimensional reconstruction (n = 29) were propensity matched to a control group with no MI (n = 29) by using demographic and clinical variables. Coronary lesions were divided into proximal, middle, and distal, along with 5-mm upstream and downstream segments. WSS was calculated for each segment.</P> <P><B>Results</B></P> <P>Median age was 62 years, and 46 (79%) were male. In the marginal Cox model, whereas lower FFR showed a trend (hazard ratio: 0.084; p = 0.064), higher WSS<SUB>prox</SUB> (hazard ratio: 1.234; p = 0.002, C-index = 0.65) predicted MI. Adding WSS<SUB>prox</SUB> to FFR resulted in a significant increase in global chi-square for predicting MI (p = 0.045), a net reclassification improvement of 0.69 (p = 0.005), and an integrated discrimination index of 0.11 (p = 0.010).</P> <P><B>Conclusions</B></P> <P>In patients with stable CAD and hemodynamically significant lesions, higher WSS in the proximal segments of atherosclerotic lesions is predictive of MI and has incremental prognostic value over FFR.</P> <P><B>Central Illustration</B></P> <P>[DISPLAY OMISSION]</P>