Model Determination of Delayed Causes of Analgesics Prescription in the Emergency Ward in Arak, Iran

( Ali Cyrus ),( Mehrdad Moghimi ),( Abolfazle Jokar ),( Mohammad Rafeie ),( Ali Moradi ),( Parisa Ghasemi ),( Hanieh Shahamat ),( Ali Kabir ) 대한통증학회 2014 The Korean Journal of Pain Vol.27 No.2

According to the reports of the World Health Organization 20% of world population suffer from pain and 33% of them suffer to some extent that they cannot live independently. Methods: This is a cross-sectional study which was conducted in the emergency department (ED) of Valiasr Hospital of Arak, Iran, in order to determine the causes of delay in prescription of analgesics and to construct a model for prediction of circumstances that aggravate oligoanalgesia. Data were collected during a period of 7 days. Results: Totally, 952 patients participated in this study. In order to reduce their pain intensity, 392 patients (42%) were treated. Physicians and nurses recorded the intensity of pain for 66.3% and 41.37% of patients, respectively. The mean (SD) of pain intensity according to visual analogue scale (VAS) was 8.7 (1.5) which reached to 4.4 (2.3) thirty minutes after analgesics prescription. Median and mean (SD) of delay time in injection of analgesics after the physician``s order were 60.0 and 45.6 (63.35) minutes, respectively. The linear regression model suggested that when the attending physician was male or intern and patient was from rural areas the delay was longer. Conclusions: We propose further studies about analgesics administration based on medical guidelines in the shortest possible time and also to train physicians and nurses about pain assessment methods and analgesic prescription. (Korean J Pain 2014; 27: 152-161)

Theoretical Study of Thiazole Adsorption on the (6,0) zigzag Single-Walled Boron Nitride Nanotube

Moradi, Ali Varasteh,Peyghan, Ali Ahmadi,Hashemian, Saeede,Baei, Mohammad T. Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.10

The interaction of thiazole drug with (6,0) zigzag single-walled boron nitride nanotube of finite length in gas and solvent phases was studied by means of density functional theory (DFT) calculations. In both phases, the binding energy is negative and presenting characterizes an exothermic process. Also, the binding energy in solvent phase is more than that the gas phase. Binding energy corresponding to adsorption of thiazole on the BNNT model in the gas and solvent phases was calculated to be -0.34 and -0.56 eV, and about 0.04 and 0.06 electrons is transferred from the thiazole to the nanotube in the phases. The significantly changes in binding energies and energy gap values by the thiazole adsorption, shows the high sensitivity of the electronic properties of BNNT towards the adsorption of the thiazole molecule. Frontier molecular orbital theory (FMO) and structural analyses show that the low energy level of LUMO, electron density, and length of the surrounding bonds of adsorbing atoms help to the thiazole adsorption on the nanotube. Decrease in global hardness, energy gap and ionization potential is due to the adsorption of the thiazole, and consequently, in the both phases, stability of the thiazole-attached (6,0) BNNT model is decreased and its reactivity increased. Presence of polar solvent increases the electron donor of the thiazole and the electrophilicity of the complex. This study may provide new insight to the development of functionalized boron nitride nanotubes as drug delivery systems for virtual applications.

Impact of Metabolic Syndrome on Response to Medical Treatment of Benign Prostatic Hyperplasia

Ali Cyrus,Ali Kabir,Davood Goodarzi,Afsaneh Talaei,Ali Moradi,Mohammad Rafiee,Mehrdad Moghimi,Elham Shahbazi,Elaheh Farmani 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.12

Purpose: To investigate the effect of metabolic syndrome (MetS) on the response to medicaltherapy of benign prostatic hyperplasia (BPH) after a 3-month period of treatment. Materials and Methods: This was a cohort study of 100 patients, 47 with MetS and 53without MetS, referred to either the primary care unit or referral hospital with BPHwho had moderate lower urinary tract symptoms of prostate involvement and were candidatesfor medical treatment. Our main outcome was response to medical treatmentwith prazosin 1 mg twice a day and finasteride 5 mg daily in patients with BPH on thebasis of International Prostate Symptom Score (IPSS). Multivariate analysis of covariancewas used to compare BPH treatment response in patients with and withoutMetS before and after receiving treatment. Results: The mean volume of the prostate was significantly higher in MetS patientsthan in patients without MetS (57±32.65 mL compared with 46.00±20.19 mL, p=0.036). The control group demonstrated an 11-unit reduction in IPSS, whereas those with MetSshowed a reduction in the symptom score of only 6 units (p<0.001). Regarding the componentsof MetS separately, triglyceride (p<0.001), fasting blood sugar (p=0.001), andwaist circumference (p=0.028) significantly affected the clinical progression of BPH. The observational nature of this study may be a limitation in comparison with an interventionalstudy. Conclusions: The results of the present study showed that MetS can negatively affectthe response to medical treatment of BPH. Therefore, it is necessary to consider MetSin selecting patients with BPH for drug therapy.

Theoretical Study of Thiazole Adsorption on the (6,0) zigzag Single-Walled Boron Nitride Nanotube

Ali Varasteh Moradi,Ali Ahmadi Peyghan,Saeede Hashemian,Mohammad T. Baei 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.10

The interaction of thiazole drug with (6,0) zigzag single-walled boron nitride nanotube of finite length in gas and solvent phases was studied by means of density functional theory (DFT) calculations. In both phases, the binding energy is negative and presenting characterizes an exothermic process. Also, the binding energy in solvent phase is more than that the gas phase. Binding energy corresponding to adsorption of thiazole on the BNNT model in the gas and solvent phases was calculated to be −0.34 and −0.56 eV, and about 0.04 and 0.06 electrons is transferred from the thiazole to the nanotube in the phases. The significantly changes in binding energies and energy gap values by the thiazole adsorption, shows the high sensitivity of the electronic properties of BNNT towards the adsorption of the thiazole molecule. Frontier molecular orbital theory (FMO) and structural analyses show that the low energy level of LUMO, electron density, and length of the surrounding bonds of adsorbing atoms help to the thiazole adsorption on the nanotube. Decrease in global hardness, energy gap and ionization potential is due to the adsorption of the thiazole, and consequently, in the both phases, stability of the thiazole-attached (6,0) BNNT model is decreased and its reactivity increased. Presence of polar solvent increases the electron donor of the thiazole and the electrophilicity of the complex. This study may provide new insight to the development of functionalized boron nitride nanotubes as drug delivery systems for virtual applications.

Model Determination of Delayed Causes of Analgesics Prescription in the Emergency Ward in Arak, Iran

Cyrus, Ali,Moghimi, Mehrdad,Jokar, Abolfazle,Rafeie, Mohammad,Moradi, Ali,Ghasemi, Parisa,Shahamat, Hanieh,Kabir, Ali The Korean Pain Society 2014 The Korean Journal of Pain Vol.27 No.2

Background: According to the reports of the World Health Organization 20% of world population suffer from pain and 33% of them suffer to some extent that they cannot live independently. Methods: This is a cross-sectional study which was conducted in the emergency department (ED) of Valiasr Hospital of Arak, Iran, in order to determine the causes of delay in prescription of analgesics and to construct a model for prediction of circumstances that aggravate oligoanalgesia. Data were collected during a period of 7 days. Results: Totally, 952 patients participated in this study. In order to reduce their pain intensity, 392 patients (42%) were treated. Physicians and nurses recorded the intensity of pain for 66.3% and 41.37% of patients, respectively. The mean (SD) of pain intensity according to visual analogue scale (VAS) was 8.7 (1.5) which reached to 4.4 (2.3) thirty minutes after analgesics prescription. Median and mean (SD) of delay time in injection of analgesics after the physician's order were 60.0 and 45.6 (63.35) minutes, respectively. The linear regression model suggested that when the attending physician was male or intern and patient was from rural areas the delay was longer. Conclusions: We propose further studies about analgesics administration based on medical guidelines in the shortest possible time and also to train physicians and nurses about pain assessment methods and analgesic prescription.

Vitamin C restores ovarian follicular reservation in a mouse model of aging

Mohammad-Amin Abdollahifar,Nahid Azad,Ensieh Sajadi,Zahra Shams Mofarahe,Fatemeh Zare,Ali Moradi,Fatereh Rezaee,Mohammad Gholamin,Shabnam Abdi 대한해부학회 2019 Anatomy & Cell Biology Vol.52 No.2

Ovarian aging is related to the reduction of oocyte quality and ovarian follicles reservation leading to infertility. Vitamin C is a natural antioxidant which may counteract with adverse effects of aging in the ovary. The aim of this study was to evaluate the possible effect of vitamin C on NMRI mice ovarian aging according to the stereological study. In this experimental study, 36 adult female mice (25–30 g) were divided into two groups: control and vitamin C. Vitamin C (150 mg/kg/day) were administered by oral gavage for 33 weeks. Six animals of each group were sacrificed on week 8, 12, and 33, and right ovary samples were extracted for stereology analysis. Our data showed that the total volume of ovary, cortex, medulla and corpus luteum were significantly increased in vitamin C group in comparison to the control groups (P≤0.05). In addition, the total number of primordial, primary, secondary, and antral follicles as well as granulosa cells were improved in vitamin C group in compared to the control groups (P≤0.05). No significant difference was observed in total volume of oocytes in antral follicles between control and vitamin C groups. Our data showed that vitamin C could notably compensate undesirable effects of ovarian aging in a mouse model.

Global sensitivity analysis improvement of rotor-bearing system based on the Genetic Based Latine Hypercube Sampling (GBLHS) method

Mohammad Reza Fatehi,Afshin Ghanbarzadeh,Shapour Moradi,Ali Hajnayeb 국제구조공학회 2018 Structural Engineering and Mechanics, An Int'l Jou Vol.68 No.5

Sobol method is applied as a powerful variance decomposition technique in the field of global sensitivity analysis (GSA). The paper is devoted to increase convergence speed of the extracted Sobol indices using a new proposed sampling technique called genetic based Latine hypercube sampling (GBLHS). This technique is indeed an improved version of restricted Latine hypercube sampling (LHS) and the optimization algorithm is inspired from genetic algorithm in a new approach. The new approach is based on the optimization of minimax value of LHS arrays using manipulation of array indices as chromosomes in genetic algorithm. The improved Sobol method is implemented to perform factor prioritization and fixing of an uncertain comprehensive high speed rotor-bearing system. The finite element method is employed for rotor-bearing modeling by considering Eshleman-Eubanks assumption and interaction of axial force on the rotor whirling behavior. The performance of the GBLHS technique are compared with the Monte Carlo Simulation (MCS), LHS and Optimized LHS (Minimax. criteria). Comparison of the GBLHS with other techniques demonstrates its capability for increasing convergence speed of the sensitivity indices and improving computational time of the GSA.

Feasibility Study and Measuring Some Effects of the Activity Based ManAgement (ABM) in the Iran Railway

Mohammad Mehdi Movahedi,Mehdi Zaribaf,Mohammad Ali Moradi 한국철도학회 2010 International Journal of Railway Vol.3 No.1

The research is to develop cost methodology to support railway managers for identifying principles, tools and methods of activity based management correctly and precisely, and can be useful and effective for managers for realizing their goals. The research result a ministry can be suitable guideline in terms of how to execute activity based management. Since in this research, main and secondary activities are studied completely in the Railway organization, it can be an explanatory research. The research population is headquarter managers and experts of railway organization and the sampling procedure is goal ?oriented and judgmental. 74 people were selected by using a formula. All hypotheses were tested in 95% significance level. Meanwhile a proposed process of applying .activity based management was offered.

Effects of High White and Brown Sugar Consumption on Serum Level of Brain-Derived Neurotrophic Factor, Insulin Resistance, and Body Weight in Albino Rats

Ali Shamsi-Goushki,Zinat Mortazavi,Mohammad Ali Mirshekar,Fatemeh Behrasi,Nasroallah Moradi-Kor,Rasul Taghvaeefar 대한비만학회 2020 The Korean journal of obesity Vol.29 No.4

Background: In recent decades, consumption of simple sugars has increased dramatically, which contributes to health problems including insulin resistance and obesity. In this study, we investigated the effects of high concentrations of white sugar (WS) and brown sugar (BS) on serum concentration of brain-derived neurotrophic factor (BDNF), insulin resistance, and body weight in albino rats. Methods: Twenty-four male Wistar rats were randomly divided into three groups: control, a group treated with 15% WS, and a group treated with 15% BS. Rats were given WS and BS by gavage (daily) for 42 days. At the end of the intervention period, serum level of BDNF, insulin resistance, and body weight were measured. Results: Body weight and insulin resistance were significantly increased and serum BDNF level was decreased in both WS and BS groups compared to the control group (P<0.05). In the WS-treated rats, the amount of changes in the insulin resistance, body weight, and serum BDNF level was greater compared to that in BS-treated (P< 0.05). Conclusion: Due to the adverse effects of consuming high levels of WS and BS on serum level of BDNF, insulin resistance, and body weight, high intakes of these sweeteners are not recommended.

Feasibility Study and Measuring Some Effects of the Activity Based ManAgement (ABM) in the Iran Railway

Movahedi, Mohammad Mehdi,Zaribaf, Mehdi,Moradi, Mohammad Ali The Korean Society for Railway 2010 International Journal of Railway Vol.3 No.1

The research is to develop cost methodology to support railway managers for identifying principles, tools and methods of activity based management correctly and precisely, and can be useful and effective for managers for realizing their goals. The research result a ministry can be suitable guideline in terms of how to execute activity based management. Since in this research, main and secondary activities are studied completely in the Railway organization, it can be an explanatory research. The research population is headquarter managers and experts of railway organization and the sampling procedure is goal-oriented and judgmental. 74 people were selected by using a formula. All hypotheses were tested in 95% significance level. Meanwhile a proposed process of applying. activity based management was offered.