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Yokoyama, Yoshihito,Shigeto, Tatsuhiko,Miura, Rie,Kobayashi, Asami,Mizunuma, Makito,Yamauchi, Aisa,Futagami, Masayuki,Mizunuma, Hideki Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.2
Background: The current study examined the effectiveness of concurrent therapy using photodynamic therapy (PDT) and clofibric acid (CA) to treat peritoneal carcinomatosis resulting from ovarian cancer. Materials and Methods: Nude rats were used to create a model of peritoneal carcinomatosis resulting from ovarian cancer and the effectiveness of PDT with 5-aminolevulinic acid methyl ester hydrochloride (methyl-ALA-PDT) was determined. The survival time of rats receiving that therapy was compared to the survival time of a control group. Rats with peritoneal carcinomatosis resulting from ovarian cancer were divided into 3 groups: a group that received debulking surgery (DS) alone, a group that received DS+methyl-ALA-PDT, and a group that received DS+methyl-ALA-PDT+CA. The survival time of the 3 groups was compared. Protoporphyrin, a metabolite of methyl-ALA, produces a photochemical action when activated by light. The level of protoporphyrin (the concentration) that reached organs in the abdomen was measured with HPLC. Results: Rats receiving methyl-ALA-PDT had a significantly longer survival time compared to the controls. Rats with peritoneal carcinomatosis that received DS+methyl-ALA-PDT+CA had a significantly longer survival time compared to the rats that received DS alone. Some of the rats that received concurrent therapy survived for a prolonged period. Protoporphyrin was highly concentrated in peritoneal metastases, but only small amounts reached major organs in the abdomen. PDT was not found to result in necrosis in the intestines. Conclusions: The results indicated that concurrent therapy consisting of PDT with methyl-ALA and CA is effective at treating peritoneal carcinomatosis resulting from ovarian cancer without damaging organs.
Optimized Design of Low-power Adiabatic Dynamic CMOS Logic Digital 3-bit PWM for SSL Dimming System
Cho, Seung-Il,Mizunuma, Mitsuru,Yokoyama, Michio The Institute of Electronics and Information Engin 2013 IEIE Transactions on Smart Processing & Computing Vol.2 No.4
The size and power consumption of digital circuits including the dimming circuit part will increase for high-performance solid state lighting (SSL) systems in the future. This study examined the low-power consumption of adiabatic dynamic CMOS logic (ADCL) due to the principles of adiabatic charging. Furthermore, the designed low-power ADCL digital pulse width modulation (PWM) was optimized for SSL dimming systems. For this purpose, an ADCL digital 3-bit PWM was optimized in two steps. In the first step, the architecture of the ADCL digital 3-bit PWM was miniaturized. In the second step, the clock cut-off circuit was designed and added to the ADCL PWM. As a result, compared to the original configuration, 60 transistors and 15 capacitors of ADCL digital 3-bit PWM were reduced for miniaturization. Moreover, the clock cut-off circuit, which controls wake-up and sleep mode of ADCL D-FFs, was designed. The power consumption of an optimized ADCL digital PWM for all bit patterns decreased by 54 %.
日本語ㆍ日本文化の継承活動に關するアンケ-ト調査の結果と考察
奈須千佳子(Nasu, Chikako),水沼一法(Mizunuma, Kazunori),松浦惠子(Matsuura, Keiko),鄭起永(Jung, Gi-Young),金鐘?(Kim, Jong-Hee) 대한일어일문학회 2014 일어일문학 Vol.61 No.-
釜山に住む日系子女に日本語ㆍ日本文化を?承する??がなく、?承活動を續けるには親の負?ばかりが增える現狀장を踏まえ、「釜山日本村」が發足した。2011年度にパイロット的に活動を行い、日本語の授業や日本文化?驗などを實施した。この年の活動では子どものコントロ-ルがうまくいかない、敎材や資金の不足、對象年齡のずれなど、??な問題が浮かび上がった。 2011年度の活動を踏まえ、2012年度より保護者を中心に年?員を募り、?員自身が活動を??する形式で本格的な活動を開始した。11年度に比べ未就學兒が多くなり、會員全員が活動を進めていくことにより、活動內容がバラエティに富んだものとなった。2012年度の活動終了後に會員に行ったアンケ-ト調査を通じて、保護者として「釜山日本村」の活動をどのように受け止めたか、また活動??者としてどのような点に?づいたかを考察した。「釜山日本村」に?加した日系子女は未就學兒が多く、保護者は日本文化?承を期待していた。また活動を自ら??する際にも日本文化を意識し取り組んでいた。ただ、完全なボランティア活動??であるため、敎材調達が難しいことや、慣れない活動準備の時間がかかりすぎたなど、活動を??するのが大?であるとも感じている。交流の場としては??者同士や子どもを通じて機能しているが、全?的な交流には至っていないことが分かった。