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Minjeong Lee(Minjeong Lee),Hyojung Bae(Hyojung Bae),Hokyun Rho(Hokyun Rho),Vishal Burungale(Vishal Burungale ),Pratik Mane(Pratik Mane ),Chaewon Seong(Chaewon Seong),Jun-Seok Ha(Jun-Seok Ha) 한국마이크로전자및패키징학회 2020 마이크로전자 및 패키징학회지 Vol.27 No.4
The Cu/Cu2O/CuO photoelectrode has been successfully fabricated by Rapid Thermal Annealing technique. The structural characterization of fabricated photoelectrode was performed using X-Ray diffraction, while elemental composition of the prepared material has been checked with X-Ray Photoelectron Spectroscopy. The synthesis parameters are optimized on the basis of photoelectrochemical performance. The best photoelectrochemical performance has been observed for the Cu/Cu2O/CuO photoelectrode fabricated at 550 ℃ oxidation temperature and oxidation time of 50 seconds with highest photocurrent density of -3 mA/㎠ at -0.13 V vs. RHE.
( Minjeong Kim ),( Gyo Jeong Gu ),( Yun-sook Koh ),( Su-hyun Lee ),( Yi Rang Na ),( Seung Hyeok Seok ),( Kyung-min Lim ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.6
Fasiglifam (TAK-875) a G-protein coupled receptor 40 (GPR40) agonist, significantly improves hyperglycemia without hypoglycemia and weight gain, the major side effects of conventional anti-diabetics. Unfortunately, during multi-center Phase 3 clinical trials, unexpected liver toxicity resulted in premature termination of its development. Here, we investigated whether TAK-875 directly inflicts toxicity on hepatocytes and explored its underlying mechanism of toxicity. TAK-875 decreased viability of 2D and 3D cultures of HepG2, a human hepatocarcinoma cell line, in concentration- (>50 μM) and time-dependent manners, both of which corresponded with ROS generation. An antioxidant, N-acetylcysteine, attenuated TAK-875-mediated hepatotoxicity, which confirmed the role of ROS generation. Of note, knockdown of GPR40 using siRNA abolished the hepatotoxicity of TAK-875 and attenuated ROS generation. In contrast, TAK-875 induced no cytotoxicity in fibroblasts up to 500 μM. Supporting the hepatotoxic potential of TAK-875, exposure to TAK-875 resulted in increased mortality of zebrafish larvae at 25 μM. Histopathological examination of zebrafish exposed to TAK-875 revealed severe hepatotoxicity as manifested by degenerated hypertrophic hepatocytes with cytoplasmic vacuolation and acentric nuclei, confirming that TAK-875 may induce direct hepatotoxicity and that ROS generation may be involved in a GPR40-dependent manner.
Kim, MinJeong,Gu, Gyo Jeong,Koh, Yun-Sook,Lee, Su-Hyun,Na, Yi Rang,Seok, Seung Hyeok,Lim, Kyung-Min The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.6
Fasiglifam (TAK-875) a G-protein coupled receptor 40 (GPR40) agonist, significantly improves hyperglycemia without hypoglycemia and weight gain, the major side effects of conventional anti-diabetics. Unfortunately, during multi-center Phase 3 clinical trials, unexpected liver toxicity resulted in premature termination of its development. Here, we investigated whether TAK-875 directly inflicts toxicity on hepatocytes and explored its underlying mechanism of toxicity. TAK-875 decreased viability of 2D and 3D cultures of HepG2, a human hepatocarcinoma cell line, in concentration-(>$50{\mu}M$) and time-dependent manners, both of which corresponded with ROS generation. An antioxidant, N-acetylcysteine, attenuated TAK-875-mediated hepatotoxicity, which confirmed the role of ROS generation. Of note, knockdown of GPR40 using siRNA abolished the hepatotoxicity of TAK-875 and attenuated ROS generation. In contrast, TAK-875 induced no cytotoxicity in fibroblasts up to $500{\mu}M$. Supporting the hepatotoxic potential of TAK-875, exposure to TAK-875 resulted in increased mortality of zebrafish larvae at$25{\mu}M$. Histopathological examination of zebrafish exposed to TAK-875 revealed severe hepatotoxicity as manifested by degenerated hypertrophic hepatocytes with cytoplasmic vacuolation and acentric nuclei, confirming that TAK-875 may induce direct hepatotoxicity and that ROS generation may be involved in a GPR40-dependent manner.
무인 항공기의 자동 착륙 접근 알고리즘 설계 및 비행시험
정민정(Minjeong Jeong),류한석(Han-seok Ryu),박상혁(Sanghyuk Park) 한국항공우주학회 2013 韓國航空宇宙學會誌 Vol.41 No.6
본 논문에서는 무인 항공기의 활주로 자동 접근 알고리즘에 대해 기술하였다. 본 연구에서 자동 접근의 주요 목적은 야간에 항공기의 안전한 착륙을 돕기 위함이다. 자동 접근 기능을 사용하게 되면 항공기가 어느 위치에 있던 초기 위치를 기준으로 경로 명령이 생성된다. 경로 명령은 최단거리를 가지는 원호-직선-원호로 구성되어있다. 경로 명령을 통해 생성된 경로를 따라 이동한 다음 활주로에 접근하도록 알고리즘을 설계하였다. 항공기의 다양한 초기 위치에 대한 경로 생성 알고리즘의 시뮬레이션을 통해 1차 검증을 하였으며 이를 기반으로 실제 비행시험을 수행하여 본 연구에서 제안한 알고리즘의 타당성을 실증적으로 검증하였다. This paper presents an algorithm for autonomous landing approach of a unmanned aerial vehicle. The main purpose of the autonomous landing approach in this study is to help a safe landing at night. From any initial position of the aircraft when this function is engaged, a flight path command is generated from the initial position. The shortest combination of an initial circular arc, a straight line segment, and a final circular arc is chosen for the flight path that will lead the aircraft to one end of runway for a landing. The algorithm is initially validated through numerous simulations with various initial conditions of aircraft. Then it is successfully validated through a number of flight tests.
Functional Data Classification of Variable Stars
Park, Minjeong,Kim, Donghoh,Cho, Sinsup,Oh, Hee-Seok The Korean Statistical Society 2013 Communications for statistical applications and me Vol.20 No.4
This paper considers a problem of classification of variable stars based on functional data analysis. For a better understanding of galaxy structure and stellar evolution, various approaches for classification of variable stars have been studied. Several features that explain the characteristics of variable stars (such as color index, amplitude, period, and Fourier coefficients) were usually used to classify variable stars. Excluding other factors but focusing only on the curve shapes of variable stars, Deb and Singh (2009) proposed a classification procedure using multivariate principal component analysis. However, this approach is limited to accommodate some features of the light curve data that are unequally spaced in the phase domain and have some functional properties. In this paper, we propose a light curve estimation method that is suitable for functional data analysis, and provide a classification procedure for variable stars that combined the features of a light curve with existing functional data analysis methods. To evaluate its practical applicability, we apply the proposed classification procedure to the data sets of variable stars from the project STellar Astrophysics and Research on Exoplanets (STARE).
Rhododenol Activates Melanocytes and Induces Morphological Alteration at Sub-Cytotoxic Levels
Kim, Minjeong,Lee, Chang-Seok,Lim, Kyung-Min MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.22
<P>Rhododenol (RD), a whitening cosmetic ingredient, was withdrawn from the market due to RD-induced leukoderma (RIL). While many attempts have been made to clarify the mechanism underlying RIL, RIL has not been fully understood yet. Indeed, affected subjects showed uneven skin pigmentation, but the features are different from vitiligo, a skin hypopigmentary disorder, alluding to events more complex than simple melanocyte cytotoxicity. Here, we discovered that rhododenol treatment reduced the number of melanocytes in a pigmented 3D human skin model, Melanoderm™, confirming the melanocyte toxicity of RD. Of note, melanocytes that survived in the RD treated tissues exhibited altered morphology, such as extended dendrites and increased cell sizes. Consistently with this, sub-cytotoxic level of RD increased cell size and elongated dendrites in B16 melanoma cells. Morphological changes of B16 cells were further confirmed in the immunocytochemistry of treated cells for actin and tubulin. Even more provoking, RD up-regulated the expression of tyrosinase and TRP1 in the survived B16 cells. Evaluation of mRNA expression of cytoskeletal proteins suggests that RD altered the cytoskeletal dynamic favoring cell size expansion and melanosome maturation. Collectively, these results suggest that RD not only induces cytotoxicity in melanocytes but also can lead to a profound perturbation of melanocyte integrity even at sub-cytotoxic levels.</P>
New Record of Two Non-Native Sternotherus Turtles in The Wild of South Korea
백혜준,석민정(Minjeong Seok),송종원,김수환 국립생태원 2024 국립생태원회보(PNIE) Vol.5 No.2
The remarkable economic growth achieved in the modern era has revitalized various industries, including pet trade. More than 2,000 species of non-native species have been introduced to South Korea and approximately 7.7 tonnes of alien turtles are imported annually. Turtles belonging to the family Kinosternidae. They are mostly small and popular pets, although they are designated as Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) species. In the present study, we present the first two species of musk turtles found in the wild in South Korea. On April 5, 2023 and July 8, 2023, an eastern musk turtle (Sternotherus odoratus) and a razorbacked musk turtle (Sternotherus carinatus) were captured in Ilsandong-gu, Goyang-si, Gyeonggi-do and Jung-gu, Daejeon, respectively. The carapace length was 88.6 mm for S. odoratus and 105.68 mm for S. carinatus. They were identified based on their morphological characteristics and mtDNA cytochrome b gene. These turtles were found in waterfront areas with over 1.4 million annual visitors. Both sites were found to have threatened amphibians and reptiles. There is an urgent need to continue monitoring and conducting risk assessments for the protection of endemic species in Korea.