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Characteristics of Biochemical Sensors Based on Thin-Film Waveguide
Minamitani, Haruyuki,Kim, Kyungho,Matsumoto, Kunihiro,Kang, Shinwon 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1
In this paper, biochemical sensors based on thin-film waveguide are proposed which can measure the concentration of sample solutions. The waveguide was fabricated with 3 layers, that is, substrate layer (Pyrex glass), waveguide layer(sputtered with corning 7059 glass) and sample layer having PVC sensing membrane and/or sample chamber. In order to investigate the applicability of these sensors to Ca^(2+) and glucose measurement, we used sample solution whose CaCl_(2) concentration was gradually altered, and also used glucose solution prepared by the GOD-POD enzyme method. In this experiment, we found that the thin-film waveguide sensor showed high sensitivity at 488nm of Argon laser. In addition, the glucose sensor could be measured over wide range of glucose concentrations from 0 mg/dl to 750 mg/dl and Ca^(2+) sensor also could be measured from 10^(-5) mol to 1 mol. Sensitivity of the sensor increased with increase in the interaction length which means the reaction area between the evanescent field of propagated light and the sampler layer. These findings suggested that the proposed waveguide biochemical sensors could be applicable to measurement of various sample concentrations.
Minamitani, Haruyuki,Ehara, Hiroyuki,Sekizuka, Eiichi,Oshio, Chikara 경북대학교 센서기술연구소 1994 센서技術學術大會論文集 Vol.5 No.1
An optical-fiber-array spatial filtering velocimeter (SFV) was developed and applied to the flow velocity measurement in the microscopic region. A frequency shifter was assembled in the signal processing unit of the velocimeter, and it enabled detection of the direction of flow which often changed reversely. The structure of the SFV was very simple and was available to be installed in a microscope. Output signals of the SFV were detected by photodetectors and processed by means of FFT to obtain the spectral frequency related to the flow velocity. The whole system was tested both in vitro and in-vivo, and especially used to measure the velocity changes of lymph flow and blood flow in the microcirculatory system of the rats. The results showed that the developed SFV was conspicuously useful for the velocity measurement even in the microscopic region.
Noninvasive measurement of the tissue oxygen uptake using near-infrared spectroscopy
NAKAGAWA, Emiko,MINAMITANI, Haruyuki,YAMAZAKI, Hajime 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1
To determine the change in muscle oxygenation, muscle oxygen saturation and hemoglobin volume was measured transcutaneously with near-infrared spectroscopy (MRS) in the skeleton muscle during cycle ergometry. A new NIRS system is presented for noninvasive evaluation of the tissue oxygenation. To measure more simply, a reflectance sensor that consists of one photodiode (PD) and light emitting diodes (LEDs) with three wavelengths was designed. This instrument monitors and evaluates the regional oxygen saturation (rSO_(2)) and volume of hemoglobin (HbI) using hemoglobin index (HbI) more simply and inexpensively for clinical application. Blood volume and oxygen supply to skeletal muscle is a potentially important factor to maintain muscular oxidative metabolism. The vastus lateralis muscle and the brachioradialis muscle of nine healthy men were monitored by NIRS, using cycle ergometry. The oxygen uptake (VO_(2)) was also monitored to evaluate oxidative metabolism. The calculation results of oxidative metabolism with NIRS correlated with both the VO_(2) and work fate. The purpose of this study was to determine whether the O_(2) consumption measured by NIRS with rSO_(2) and HbI can be a quantitative measure of muscle oxidative metabolism.
Ogino, Hirokazu,Minamitani, Haruyuki,Souma, Takeshi 경북대학교 센서기술연구소 1994 센서技術學術大會論文集 Vol.5 No.1
Pulse oximeter is a noninvasive equipment for monitoring of arterial oxygen saturation (SaO_(2)), and commonly utilize a transmittance sensor on peripheral locations of the body. In this study, A new reflectance pulse oximeter sensor (RPS) was developed as a part of the multi sensor system which intends to monitor physiological data from mouth. The RPS consists of a photodiode (PD) and two light emitting diodes (LEDs) of which wavelengths are 660 and 940nm. Elastic gum optical shield (GOS) and reflectance optical shield (ROS) were also used to improve stability and signal-to-noise (S/N) ratio of the sensor. The RPS was evaluated by breath holding experiment, and it showed good correlation with SaO_(2) measured from ear-lobe by using conventional transmittance sensor. The result indicates that the RPS is available to measure SaO_(2) from mouth and can use for monitoring of physical condition.
DEVELOPMENT OF PVC WAVEGUIDE SENSOR FOR MEASUREMENT OF Ca^(++) CONCENTRATION
Kim, Kyung H.,Minamitani, H.,Hisamoto, H.,Suzuki, K.,Kang, S.W.,Sasaki, K. 경북대학교 센서기술연구소 1994 센서技術學術大會論文集 Vol.5 No.1
In this paper, a PVC optical thin film waveguide sensor is proposed which can select a specific ion and measure its concentration depending on materials added into waveguide. In order to investigate the applicability of this sensor to Ca^(++) measurement, the waveguide was fabricated with poly vinyl chloride (PVC), bis ethyl hexyl phthalate (BEHP), lipophilic anionic dye (LAD-3), and ionophore (K23E1) which reacts on Ca^(++). For this purpose, we applied the sensor to sample solution whose CaCl_(2) concentration was gradually altered. In this experiment, we found that this thin film waveguide possessed good light propagation. In addition, it showed the chemical reaction to Ca^(++) enough to select Ca^(++) and measure its concentration. These findings suggested that the proposed PVC optical thin film waveguide ion sensor was very effective in selecting Ca^(++) and measuring its concentration. Also, it will be expected that this sensor is applicable to various ions other than Ca^(++).
Nagao, Tomokazu,Matsuzaki, Kazuki,Takahashi, Miho,Minamitani, Haruyuki Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
In this study, we investigated apoptotic cell death induced by photodynamic therapy using 5-aminolaevulinic acid (ALA-PDT) in human promyelocytic leukemia cells (HL-60). ALA-PDT induced apoptosis in HL-60 cells as confirmed by DNA agarose gel electrophoresis and nuclear staining with Hoechst 33342. The apoptotic cell death was inhibited by addition of broad-spectrum caspase inhibitor Z-Asp-CH$_2$-DCB, indicating that the apoptotic cell death was induced in a caspase-dependent manner. Actually, western blotting analysis revealed that caspase-3 was processed as early as 1.5 h after ALA-PDT. Cytoplasmic cytochrome c released from mitochondria was detected by western blotting. However, inhibitor of caspase-9, a cysteine protease located in the downstream of cytochrome c release, was not able to reduce the apoptotic cell death. Therefore, the mitochondrial apoptotic pathway was not involved in the ALA-PDT-induced apoptosis. On the other hand, it was found that ALA-PDT-induced apoptosis was clearly inhibited by pretreatment of caspase-8 inhibitor. These data suggest that caspase-8-mediated apoptotic pathway is important in ALA-PDT-induced cell death.
Photodynamically induced endothelial cell injury and neutrophil-like HL-60 adhesion
Takahashi, Miho,Nagao, Tomokazu,Matsuzaki, Kazuki,Nishimura, Toshihiko,Minamitani, Haruyuki Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
Photodynamic therapy (PDT) is a treatment modality based on photochemical reaction and the resultant cytotoxic reactive oxygen species. The platelet thrombus formation leading to stasis observed in vivo during PDT is called vascular shut down (VSD) effect. To investigate the mechanism of the VSD effect, we observed Human Umblical Vein Endothelial Cell (HUVEC) injury induced by photochemical reaction. We observed cell retraction and blebbing after PDT. It seems that the injury was not fetal and only morphological change. Then, the cytoplasm was stained by Calcein-AM and subendothelial area was evaluated from fluorescence microscopy. The rate of subendothelial area after PDT increased significantly. Second, we investigated interaction between neutrophils and HUVEC. Human promyelocytic leukemia cells (HL-60) were differentiated into neutrophil by incubation with all-trans retinoic acid. Calcein-AM labeled neutrophil adhesion to HUVEC was evaluated from fluorescence microscopy. PDT-induced neutrophil adhesion to HUVEC depended more on the exposure of subendothlial area than on neutrophil activation. This result suggests that there is a certain interaction between neutrophil and HUVEC during PDT.