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Mina Ha(Mina Ha),Taehyun Park(Taehyun Park),Jong-Hyun Lee(Jong-Hyun Lee),Younghee Kim(Younghee Kim),Jungyun Lim(Jungyun Lim),Yong-Wook Baek(Yong-Wook Baek),Sol Yu(Sol Yu),Hyen-Mi Chung(Hyen-Mi Chung) 한국역학회 2023 Epidemiology and Health Vol.45 No.-
OBJECTIVES: Inhalation exposure to humidifier disinfectants has resulted to various types of health damages in Korea. To determine the epidemiological correlation necessary for presuming the legal causation, we aimed to develop a method to synthesize the entire evidence. METHODS: Epidemiological and toxicological studies are systematically reviewed. Target health problems are selected by criteria such as frequent complaints of claimants. Relevant epidemiologic studies are reviewed and the risk of bias and confidence level of the total evidence are evaluated. Toxicological literature reviews are conducted on three lines of evidence including hazard information, animal studies, and mechanistic studies, considering the source-to-exposure-to-outcome continuum. The confidence level of the body of evidence is then translated into the toxicological evidence levels for the causality between humidifier disinfectant exposure and health effects. Finally, the levels of epidemiological and toxicological evidence are synthesized. RESULTS: Under the Special Act revised in 2020, if the history of exposure and the disease occurred/worsened after exposure were approved, and the epidemiological correlation between the exposure and disease was verified, the legal causation is presumed unless the company proves the evidence against it. The epidemiological correlation can be verified through epidemiological investigations, health monitoring, cohort investigations and/or toxicological studies. It is not simply as statistical association as understood in judicial precedents, but a general causation established by the evidence as a whole, i.e., through weight-of-the-evidence approach. CONCLUSIONS: The weight-of-the-evidence approach differs from the conclusive single study approach and this systematic evidence integration can be used in presumption of causation.
Polarized micro-cavity organic light-emitting devices
Park, Byoungchoo,Kim, Mina,Park, Chan Hyuk The Optical Society 2009 Optics express Vol.17 No.9
<P>We present the results of a study of light emissions from a polarized micro-cavity Organic Light-Emitting Device (OLED), which consisted of a flexible, anisotropic one-dimensional (1-D) photonic crystal (PC) film substrate. It is shown that luminous Electroluminescent (EL) emissions from the polarized micro-cavity OLED were produced at relatively low operating voltages. It was also found that the peak wavelengths of the emitted EL light corresponded to the two split eigen modes of the high-energy band edges of the anisotropic PC film, with a strong dependence on the polarization state of the emitting light. For polarization along the ordinary axis of the anisotropic PC film, the optical split micro-cavity modes occurred at the longer high-energy photonic band gap (PBG) edge, while for polarization along the extraordinary axis, the split micro-cavity modes occurred at the shorter high-energy PBG edge, with narrow bandwidths. We demonstrated that the polarization and emission mode of the micro-cavity OLED may be selected by choosing the appropriate optical axis of the anisotropic 1-D PC film.</P>
Positive regulation of apoptosis signal-regulating kinase 1 by dual-specificity phosphatase 13A
Park, Jae Eun,Park, Byoung Chul,Kim, Hyun-A,Song, Mina,Park, Sung Goo,Lee, Do Hee,Kim, Hyeoung-Joon,Choi, Hyung-Kyoon,Kim, Jong-Tae,Cho, Sayeon Springer-Verlag 2010 Cellular and molecular life sciences Vol.67 No.15
A study on the factors affecting the follow-up participation in birth cohorts
Park, Bohyun,Choi, Eun Jeung,Ha, Eunhee,Choi, Jong Hyuk,Kim, Yangho,Hong, Yun-Chul,Ha, Mina,Park, Hyesook The Korean Society of Environmental Toxicology 2016 환경독성보건학회지 Vol.31 No.-
Objectives A stable follow-up participation rate is a very important factor for validity in a cohort study. This study analyzed the factors that affect the participation rate at one hospital-based birth cohort in South Korean. Methods The participants were recruited from the Mothers' and Children's Environmental Health study between 2006 and 2010. The analysis targeted 1751 mothers who participated in a birth cohort. We conducted analyses of general characteristics during pregnancy and those of infants at birth that affect the participation rate of the 6-month follow-up survey. Results The participation rate for the 6-month follow-up survey was 60.4%. The participation rate in the follow-up of the subsequent period decreased within a 5% to 10% range compared to the number of subjects. The participation rate of premature infants was 16.9% lower than that of a full-term infant (52.6% vs. 69.5%). Analysis showed a 16.7% difference between the participation rate of low-birthweight infants in follow-ups (53.7%) and the participation rate of infants with normal weight (70.4%). The participation rate of mothers who were employed during pregnancy was significantly lower for the 6-month follow-up compared to the participation rate of mothers who were unemployed during pregnancy. Conclusions In this study, factors such as premature birth, low-birthweight, and the employment status of the mother during pregnancy affected the participation rate of the follow-up survey for the birth cohort at six months. A specific strategy is needed to encourage survey participation for the high risk groups in the follow-ups.
Park, Byoungchoo,Park, Chan Hyuk,Kim, Mina,Han, Mi-young The Optical Society 2009 Optics express Vol.17 No.12
<P>We present the results of a study of highly linear polarized light emissions from an Organic Light-Emitting Device (OLED) that consisted of a flexible Giant Birefringent Optical (GBO) multilayer polymer reflecting polarizer substrate. Luminous Electroluminescent (EL) emissions over 4,500 cd/m(2) were produced from the polarized OLED with high peak efficiencies in excess of 6 cd/A and 2 lm/W at relatively low operating voltages. The direction of polarization for the emitted EL light corresponded to the passing (ordinary) axis of the GBO-reflecting polarizer. Furthermore, the estimated polarization ratio between the brightness of two linearly polarized EL emissions parallel and perpendicular to the passing axis could be as high as 25 when measured over the whole emitted luminance range.</P>
Clinical Outcomes of Renal Pelvis Dilatation in Very Low Birth Weight Infants
( Mina Jeon ),( Juhyun Jin ),( Jeong Eun Shin ),( Soon Min Lee ),( Ho Seon Eun ),( Min Soo Park ),( Kook In Park ),( Ran Namgung ) 대한주산의학회 2016 大韓周産醫學會雜誌 Vol.27 No.4
Purpose: The aim of this study was to evaluate this clinical outcome of neonatal pelvis dilatation in very low birth weight (VLBW) infants. Methods: The medical records of 127 VLBW infants admitted to two neonatal intensive care units from January 2012 to December 2014 were retrospectively analyzed. Renal pelvis dilatation was diagnosed via ultrasound examination with cases divided into 3 groups: mild (dilatation of 5-10 mm), moderate (11-15 mm) and severe (≥15 mm). The correlation between the 3 dilatation groups and progression into hydronephrosis was evaluated. Results: Among the 127 premature infants, renal pelvis dilatation was identified in 29 (22.8%) on ultrasound examination performed, on average 13.3 days after birth, combined with calyceal ectasia in 5 (3.9%) infants. At a postmenstrual age of 40 weeks, 18 infants (14.2%) had renal pelvis dilatation, 6 (5%) infants accompanied by a dilatation of the calyx. On the last follow-up performed when children were not older than 2 years old, renal pelvis dilatation had resolved to within normal limits in 23 (79%) infants while persisting in 6 (21%) infants; 1 mild, 3 moderate, and 2 severe pelvis dilatation. The median time-to-recovery of dilatation was 10.5 months (Kaplan-Meier curve), regardless of the severity of dilatation at birth. Based on receiver operating curve analysis, a cutoff diameter of renal dilatation at birth of 11.35 mm predicted persisting severe dilatation at the final follow-up (sensitivity 83.3%, specificity 82.6%). Conclusion: Although premature infants with dilatation of mild severity were all recovered, some of those with moderate-to-severe dilatation progressed to hydronephrosis. Therefore careful follow-up of premature infants with renal pelvis dilatation is recommended.
Large area thermal light emission from autonomously formed suspended graphene arrays
Park, Mina,Lee, Aram,Rho, Ho Kyun,Lee, Seoung-Ki,Bae, Sukang,Jeon, Dae-Young,Lee, Dong Su,Kim, Tae-Wook,Im, Yeon-Ho,Lee, Sang Hyun Elsevier 2018 Carbon Vol.136 No.-
<P><B>Abstract</B></P> <P>Since its discovery, the existence of graphene, a 2D extract of graphite, has been in the spotlight in the field of optoelectrical physics. Suspended graphene is potentially an ideal structure for utilizing intrinsic properties of the graphene by reducing the hindrance due to interaction with substrate. Here, an autonomous fabrication of suspended graphene is proposed where it only requires a single transfer which yields multiple arrays of micron-scale suspended graphenes all at once. Large area graphene sheets transferred onto a substrate of array-patterned 3D-electrodes easily tear into pieces due to the strain gradients induced by the step heights of the electrode patterns, and each torn graphene piece takes its position between individual electroplated Cu-microgap electrode pairs. With the absence of long-range scattering from randomly charged impurities in the substrate and the correspondingly enhanced carrier mobility of suspended graphene, our novel structure is demonstrated for the application of a visible light-emitting device. It is observed that the electrically driven thermal emission spectra spans the blue side of the visible band, which corresponds to a temperature of above 3000 K. The facile access to mass production of suspended graphene can bridge the current 2D materials research to the wide field of electronics and optoelectronics.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>