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Surgical Outcomes of Adrenocortical Carcinoma; 20 Years of Experience in a Single Institution
Min Jhi Kim,Eun Jeong Ban,Soo Jung Jung,Hai Young Son1,Cho Rok Lee,Sang-Wook Kang,Jong Ju Jeong,Kee-Hyun Nam,Woong Youn Chung,Cheong Soo Park 대한갑상선-내분비외과학회 2014 The Koreran journal of Endocrine Surgery Vol.14 No.4
Purpose: Adrenocortical carcinoma (ACC) is a rare malignant tumor. Early detection is difficult and prognosis is poor. We report on 20 years of ACC surgical experience at our institution. Methods: This study included 32 ACC patients who underwent surgical resection at the Department of Surgery of the Yonsei University Health System in South Korea between January 1990 and February 2012. We reviewed these 32 patients and retrospectively analyzed long-term clinical outcomes and prognosis after radical surgery for ACC. Results: The median age of the 32 patients at diagnosis was 42.25 years (range 3∼81 years). There were 16 (50%) female and 16 (50%) male patients. Mean tumor size was 12.36 cm (range 1.8∼20 cm). Twenty-five patients (78.12%) had nonfunctioning tumors while the other seven patients (21.87%) had functioning tumors. Seventeen patients (53.12%) were classified as stage II, two (6.25%) as stage III, and 13 (40.62%) as stage IV. Fourteen patients underwent radical surgical resection, while 14 patients received adjuvant chemotherapy, two received adjuvant radiotherapy, and two received adjuvant chemoradiation. Four patients were lost to follow-up. Among the remaining 28 patients, 15 patients survived. The 5- and 10-year overall survival was 60.6% and 37.8%, respectively (median survival=85±24.3 months). Seventeen patients (53%) experienced disease recurrence. Five- and 10-year recurrence-free survival was 41.5% and 29.7%, respectively (median survival=18±5.5 months). Conclusion: Early stage at diagnosis and surgical resection were the most important prognostic factors associated with prolonged survival. The role of additional therapy remains controversial and new agents should continually be evaluated for efficacy.
김덕후,김효곤,조국,강민성,박상덕,손웅희 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-
The purpose of maintaining of bridges was to secure of them and expend its life. They wereneeded to have a regular safety check. But, most parts of a bridge were not able to access easily for people so it was difficult to maintain. To improve it, the flight mechanism and mobile mechanism were combined to examine with moving when they were attaching to bridges up and down. The flight mechanism is a co-axial-rotor-helicopter shape that cut the body down and can be done hovering. The mobile mechanism was shaped to move every direction with holding the position of a robot. These robot platforms showed possibilities to use them not only for observation and patrol but they could be used for a new usage with transformation of flying robots. This paper was focused on location maintaining when a robot was examined a bridge. The flight mechanism would only have thrust and adhesive force, the mobile mechanism would be used for moving. Therefore, defining the mechanistic model of the mobile mechanism has proved the validity of the model through simulations and experiments.
MicroRNA Expression Profiles in Korean Non-Small Cell Lung Cancer
Son, Ji Woong,Kim, Young Jin,Cho, Hyun Min,Lee, Soo Young,Jang, Jin Sung,Choi, Jin Eun,Lee, Jung Uee,Kang, Min Gyu,Lee, Yu Mi,Kwon, Sun Jung,Choi, Eugene,Na, Moon Jun,Park, Jae Yong The Korean Academy of Tuberculosis and Respiratory 2009 Tuberculosis and Respiratory Diseases Vol.67 No.5
Background: MicroRNAs (miRNAs) play an important role in the regulation of cell proliferation, apoptosis, development and differentiation. Several studies have shown that aberrant expression of miRNAs is involved in cancer development and progression by regulating the expression of proto-oncogenes or tumor suppressor genes. In this study, we investigated miRNA expression profiles in Korean patients with non-small cell lung cancer (NSCLC). Methods: We performed miRNA microarray analysis containing 60~65 bp oligonucleotide probes representing human 318 miRNAs and validated the results of the microarray with Northern blot analysis or quantitative RT-PCR. Next, we examined the correlation between miRNA expression and the target gene transcriptional profile using a human whole-genome-expression microarray. Results: We showed that 35 miRNAs were expressed differentially in the NSCLCs and corresponding non-malignant lung tissues. We showed that 35 miRNAs were expressed differentially in the NSCLCs and corresponding nonmalignant lung tissues. Thirteen of the 35 differentially expressed miRNAs were newly identified in the present study. Of the 35 miRNAs, 2 (miR-371 and miR-210) were over-expressed in lung cancers, and 33 miRNAs, including miR-145, were under-expressed in lung cancers. miR-99b expression consistently showed a negative correlation with FGFR3 expression. Conclusion: Albeit a small number of patients were examined, these results suggest that miRNA expression profiles in Korean lung cancers may be somewhat different from the expression profiles reported on lung cancers in Western populations. The findings suggest that miR-99b might be a tumor suppressor through its up-regulation of FGFR3.
Ji Woong Roh,Sanghoon Shin,Young-Guk Ko,Nak-Hoon Son,Chul-Min Ahn,Pil-Ki Min,Jae-Hwan Lee,Chang-Hwan Yoon,Cheol Woong Yu,Seung Whan Lee,Sang-Rok Lee,Seung Hyuk Choi,In-Ho Chae,Donghoon Choi 대한심장학회 2022 Korean Circulation Journal Vol.52 No.7
Background and Objectives: Limited data are available regarding long-term clinical outcomes of iliac artery endovascular therapy (EVT) in real-world practice. This study investigated long-term outcomes according to Trans-Atlantic Inter-Society Consensus (TASC) classifications. Methods: We analyzed data from 1,705 limbs of 1,364 patients from the retrospective cohort of the multicenter Korean Vascular Intervention Society Endovascular Therapy in Lower Limb Artery Disease registry. The primary endpoint was target lesion revascularization (TLR)-free survival. Results: TASC A, B, C, and D lesions were present in 19.4%, 26.2%, 28.7%, and 25.7% of the treated limbs, respectively. The technical success rate was 96.2% and did not differ between TASC lesion types. Complications occurred in 6.8% of cases and more occurred in TASC D (11.8%). Iliac artery EVT showed a 5-year TLR-free survival of 89.2%. The TASC D group had the lowest TLR-free rate of 79.3%. TASC D (hazard ratio [HR], 1.75; 95% confidence interval [CI], 1.12–2.73; p=0.014), plain old balloon angioplasty (HR, 4.25; 95% CI, 2.03–8.88; p<0.001), current smoker (HR, 1.89; 95% CI, 1.26–2.83; p=0.002), previous bypass surgery (HR, 3.04; 95% CI, 1.28–7.19; p=0.011), combined femoropopliteal treatment (HR, 4.89; 95% CI, 3.19–7.50; p<0.001), combined below the knee treatment (HR, 2.20; 95% CI, 1.25–3.89; p=0.007), and complications (HR, 1.86; 95% CI, 1.07–3.24; p=0.028) were predictors for TLR. Conclusions: Iliac artery EVT achieved excellent technical success and 5-year TLR-free survival. TASC D showed a favorable but lower 5-year TLR-free survival rate and higher complication rate compared with other TASC groups.
MicroRNA Expression Profiles in Korean Non-Small Cell Lung Cancer
( Ji Woong Son ),( Young Jin Kim ),( Hyun Min Cho ),( Soo Young Lee ),( Jin Sung Jang ),( Jin Eun Choi ),( Jung Uee Lee ),( Min Gyu Kang ),( Yu Mi Lee ),( Sun Jung Kwon ),( Eu Gene Choi ),( Moon Jun N 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.5
Background: MicroRNAs (miRNAs) play an important role in the regulation of cell proliferation, apoptosis, development and differentiation. Several studies have shown that aberrant expression of miRNAs is involved in cancer development and progression by regulating the expression of proto-oncogenes or tumor suppressor genes. In this study, we investigated miRNA expression profiles in Korean patients with non-small cell lung cancer (NSCLC). Methods: We performed miRNA microarray analysis containing 60∼65 bp oligonucleotide probes representing human 318 miRNAs and validated the results of the microarray with Northern blot analysis or quantitative RT-PCR. Next, we examined the correlation between miRNA expression and the target gene transcriptional profile using a human whole-genome-expression microarray. Results: We showed that 35 miRNAs were expressed differentially in the NSCLCs and corresponding non-malignant lung tissues. We showed that 35 miRNAs were expressed differentially in the NSCLCs and corresponding nonmalignant lung tissues. Thirteen of the 35 differentially expressed miRNAs were newly identified in the present study. Of the 35 miRNAs, 2 (miR-371 and miR-210) were over-expressed in lung cancers, and 33 miRNAs, including miR-145, were under-expressed in lung cancers. miR-99b expression consistently showed a negative correlation with FGFR3 expression. Conclusion: Albeit a small number of patients were examined, these results suggest that miRNA expression profiles in Korean lung cancers may be somewhat different from the expression profiles reported on lung cancers in Western populations. The findings suggest that miR-99b might be a tumor suppressor through its up-regulation of FGFR3.
SON, JI WOONG,KIM, YOUNG JIN,CHO, HYUN MIN,LEE, SOO YOUNG,LEE, SU MAN,KANG, JAE‐,KU,LEE, JUNG UEE,LEE, YU MI,KWON, SUN JUNG,CHOI, EUGENE,NA, MOON JUN,PARK, JAE YONG,KIM, DONG SUN Blackwell Publishing Asia 2011 RESPIROLOGY Vol.16 No.8
<P><B>ABSTRACT</B></P><P><B>Background and objective: </B> The exact role of the cystic fibrosis transmembrane conductance regulator (CFTR) in pathophysiology, and the mechanisms regulating its expression are poorly understood. The <I>CFTR</I> gene is known to be genetically or epigenetically associated with several cancers. In the present study, the methylation status of the promoter region of the <I>CFTR</I> gene and its expression in primary non‐small cell lung cancer (NSCLC) were investigated.</P><P><B>Methods: </B> The methylation status of the promoter region of the <I>CFTR</I> gene in NSCLC tissue was assessed by pyrosequencing and methylation‐specific PCR. Expression of the <I>CFTR</I> gene was analysed by real‐time PCR, and <I>CFTR</I> gene reactivation was investigated using 5‐aza‐2′‐deoxycytidine. The correlation between methylation of the <I>CFTR</I> gene and the clinical features of the patients was assessed.</P><P><B>Results: </B> Methylation of the <I>CFTR</I> gene in NSCLC was quantitatively high by pyrosequencing analysis and qualitatively frequent by methylation‐specific PCR analysis. Expression of the <I>CFTR</I> gene was significantly lower in NSCLC compared with normal lung tissue. In addition, the demethylating agent 5‐aza‐2′‐deoxycytidine increased <I>CFTR</I> gene expression. Methylation of the <I>CFTR</I> gene was significantly greater in squamous cell carcinomas than in adenocarcinomas. <I>CFTR</I> gene methylation was associated with significantly poorer survival in young patients, but not in elderly patients.</P><P><B>Conclusions: </B> These findings suggest that DNA methylation may be important for downregulation of <I>CFTR</I> gene expression in lung cancer. Promoter hypermethylation of the <I>CFTR</I> gene may be an important prognostic factor in younger patients with NSCLC.</P>
손재웅,변선민,심재동,양철기 대한금속재료학회(대한금속학회) 1985 대한금속·재료학회지 Vol.23 No.3
With the data of steel and slag compositions obtained by the oxygen sensor, emission spectrometer and fluorescent X-ray, the behavior of oxygen, phosphorus and manganese at LD end-point were studied. For a quantitative determination a multiple regression analysis was made. The results of a statistical investigation comprising about 100 heats indicated the effects of the molten steel compositions, slag compositions and temperature on the behaviors of oxygen, managnese and phorphorus at LD end-point.