급성기 가와사끼병 환아의 혈청 Vascular Endothelial Growth Factor 및 Endostatin에 대한 연구

송민섭,이승익 인제대학교 2008 仁濟醫學 Vol.29 No.-

Objective : Vascular Endothelial Growth Factor(VEGF) is an angiogenic growth factor that has been implicated in both physiological and pathological angiogenesis. Endostatin(ES) is a potent inhibitor of angiogenesis and exhibits antiangiogenic activity by inhibiting the proliferation and migration of endothelial cells(ECs) in addition to inducing endothelial cell apoptosis. Imbalance between angiogenic and antiangiogenic factor exists in subacute phase of KD, as pathologic angiogenesis occurs in subacute phase of Kawasaki disease(KD). The purpose of this study is to investigate whether an imbalance exists in the production between angiogenic and antiangiogenic growth factors in patients with acute phase of Kawasaki disease(KD), we measured the serum levels of VEGF and ES. Methods and Materials : Serum VEGF, ES levels and VEGF/ES ratio were measured in 30 KD patients, 10 incomplete KD patients and 12 febrile illness controls. Blood samples were drawn from each study group during acute phase before intravenous immunoglobulin(IVIG) therapy. Results : KD patients had higher VEGF levels(426.70 ± 479.63 pg/mL vs 297.71 ± 251.32 pg/mL, P=0.52) and VEGF/ES ratio(3.67 ± 5.69 vs 2.16 ±1.763, P=0.55 ) in the acute phase of KD than controls, but the difference was not significant. ES levels were within normal range and there was no difference of ES levels(132.65 ± 33.98 ng/mL vs 135.54 ± 25.95 ng/mL, P=0.97) between Kawasaki disease and controls in the acute phase. Conclusion : The findings in this present study indicate that an imbalance does not exist in the production between VEGF and ES in patients with acute phase of KD.

軟骨에 대한 洋方 學位論文 56編에 대한 考察

廉益煥,宋泰元,吳旼錫 대전대학교 한의학연구소 2001 한의학연구소 논문집 Vol.10 No.1

Clinically the arthritis occupies much part of musculoskeletal diseases. The arthritis is subordinate to Bi-jeung in the oriental medicine. No matter what is cause of the diseases, the lesions of the arthritis are mostly cartilages and bursa. But in process of the depravation bones, muscles, tendons, ligaments and blood are influenced and become new the lesions of the arthritis, it is important that the treatments of the oriental medicine must be objectified and we must absorb a good of the western medical treatments and understand the excellent study of the arthritis in the western medicine. This study was done to comply a reference of 56 master's theses on the cartilage of the western medicine. And these theses were classified by the college, time, treatments and topics. The following resutls were obtained in this study: 1. Whereas In the theses on the cartilages of the western medicine, Jung-ang and Catholic university have the more theses than any other universities. 2. Analysing the theses on the cartilages of the western medicine, we can classify them by the topics with the influence on the regeneration and culture of the cartilages, observation of the historical structure and the influence on the cartilages by the operation. 3. The theses of the influence on the regeneration and culture of the cartilages were the most, 48%, and the second was the influence on the cartilages by the operation.(22%) However the theses on the observation of the historical structure occupied 16%.

大田大學校 大田韓方病院의 中風早期檢診 實態調査

염익환,송인선,유호상,손원택,오민석,송태원 대전대학교 한방병원 2001 惠和醫學 Vol.10 No.1

This study was done to investigate the distribution of disease, which belongs to the people who came to the Daejon Oriental Hospital for the examination of CVA. The results were as follows : 1. It shows the highest ratio in his 40's and in her 50's. 2. The Hypertension patient is 26% and 40's is the highest, by 35%. 3. The Obesity patient is 51% and 50's is the highest, by 57%. 4. The Diabet mellitus patient is 5% and 30's is the highest, by 9%. 5. The Hyperlipidemia patient is 44% and 60's is the highest, by 52%. 6. The Liver disease patient is 18% and 40's, 50's is the highest, by 21%. 7. Abnormal EKG patient is 39% and 60's is the highest, by 57%. 8. 16% patient have abnormalities in brain CT and 70's is the highest, by 42%. 9. 70% patient have abnormalities in C-spine series and 70's is the highest, by 85%. 10. 32% patient have abnormalities in Chest PA and 70's is the highest, by 99%. 11. Soyang type is 32%, Soyum type is 25%, Taeyum type is 43% and Taeyang type is 0%.

위암 환자에서 세포성 면역 기능에 관한 연구

이재익,윤일국,이종선,김종완,장준,안정기,송민호,정현용,이헌영,김삼용,김영건 충남대학교 암연구소 1991 癌共同硏究所 硏究誌 Vol.1 No.1

We performed a variety of lymphocyte stimulation tests, delayed hypersensitivity skin tests, and enumeration of several lymphocyte subpopulations in 21 patients with gastric cancer who did not receive any form of anticancer therapy, and in 20 healthy controls. The gastric cancer patients had significantly decreased number and total score of positive reactions in delayed hypersensitivity skin tests compared with the healthy controls. The percent of CD_(4) positive lymphocytes in the gastric cancer patients was significantly decreased compared to the normal control subjects, but it had no correlation with the total score of delayed cutaneous hypersensitivity reactions. The ratio of helper to suppressor cells was lower in the cancer group. The uptake of 3H-thymidine was markedly depressed in cancer patients when stimulated with various mitogens. There was little correlation between any of the stimulation tests and any of the lymphocyte subpopulation proportions to delayed hypersensitivity cutaneous reactions. Optimal proliferative response was found in lymphocytes stimulated with 10 micrograms of concanavalin-A and 10 microgram of phytohemagglutinin. Advanced stage patients had greatly depressed delayed hypersensitivity skin reactions and proliferative responses to mitogens compared with localized diseases. These results suggest that gastric cancer patients have depressed cellular immune functions, which mainly result from the decreased helper cells and defects in functional proliferative response to mitogens. Interleukin-2 and interferon-gamma restored the in vitro proliferative response of lymphocyte in patients with gastric cancer.

위암 환자에게 세포성 면역 기능에 관한 연구

이재익,윤일국,이종선,김종완,장준,안정기,송민호,정현용,이헌영,김상용,김영건 忠南大學校 癌共同硏究所 1991 癌共同硏究所 硏究誌 Vol.1991 No.-

3次元 座標 測定機를 利用한 電子銃의 組立 精度 測定方法에 關한 硏究

盧日瑢,許玟碩,宋周翼 國立 昌原大學校 産業技術硏究所 1991 産技硏論文集 Vol.5 No.-

The alignment inferiority of the electron gun which is the principle element of the color picture tube (CPT) has caused the halo phenomenon at CPT. Through the close examination of the phenomenon the electron gun alignment measuring method using coordinate measuring machine has been developed. The results of the measuring by the developed method has been also proved that the alignment of the electron gun (perpendicularity, concentricity, torsion, etc) which has caused the halo phenomenon at CPT could be measured high precision. This study offers the ideas of the electron gun measuring method with coordinate measuring machine and shows the results of the actual measuring.

Immunohistochemical study on the expression of calcium binding proteins (calbindin-D28k, calretinin, and parvalbumin) in the cerebral cortex and in the hippocampal region of nNOS knock-out(−/−) mice

Yu Jin Cho,Jae Chul Lee,Bong Gu Kang1,2,Jaeyeol An,Hyeon Suk Song1,2,Onju Son,Do-Hyun Nam,Choong Ik Cha,Kyeung Min Joo 대한해부학회 2011 Anatomy & Cell Biology Vol.44 No.2

Nitric oxide (NO) modulates the activities of various channels and receptors to participate in the regulation of neuronal intracellular Ca2+ levels. Ca2+ binding protein (CaBP) expression may also be altered by NO. Accordingly, we examined expression changes in calbindin-D28k, calretinin, and parvalbumin in the cerebral cortex and hippocampal region of neuronal NO synthase knockout(−/−) (nNOS−/−) mice using immunohistochemistry. For the first time, we demonstrate that the expression of CaBPs is specifically altered in the cerebral cortex and hippocampal region of nNOS−/− mice and that their expression changed according to neuronal type. As changes in CaBP expression can influence temporal and spatial intracellular Ca2+ levels, it appears that NO may be involved in various functions, such as modulating neuronal Ca2+ homeostasis, regulating synaptic transmission, and neuroprotection, by influencing the expression of CaBPs. Therefore, these results suggest another mechanism by which NO participates in the regulation of neuronal Ca2+ homeostasis. However, the exact mechanisms of this regulation and its functional significance require further investigation.

A Safety and Feasibility of Laparoscopic Left Side Liver Resection

( Ju Ik Moon ),( In Seok Choi ),( Jung Seok Lee ),( Sang Eok Lee ),( Nak Song Sung,),( Si Min Park ),( Dae Sung Yoon ),( Won Jun Choi ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Laparoscopic liver resection has become an alternative method for managing various liver tumors in the worldwide. However, the safety of laparoscopic liver resection still remains controversial. The aim of this study was to evaluate feasibility and a safety of laparoscopic left side liver resection based on 60 cases of laparoscopic liver resections in a single center. Methods: Between Jan. 2005 and Sept. 2016, 60 patients underwent laparoscopic left side liver resections at Konyang University Hospital, Daejeon, Korea. The following characteristics and results were retrospectively evaluated through the medical records. Results: A total of 60 cases were included in this study. The mean age of patients was 61.3 ± 11.0 years. The operations were performed left hemihepatectomy (LH) (n = 33, 55.0%), left lateral sectionectomy (LLS) (n = 27, 45.0%). During the follow periods left hemihepatectomy and left lateral sectionectomy were performed for IHD Stone (n = 37), HCC (n = 9), metastasis (n = 5), cholangiocarcinoma (n = 5), biliary cystadenoma (n = 2), hemangioma (n = 1) and angiomyolipoma (n = 1). Operative time was 318.4 ± 118.9 min and 217.5 ± 85.8 min in LH and LLS. A tendency of gradually decreased transecting time was observed in the left hemihepatectomy (R2 = 0.295; p < 0.001). There was no conversion to open surgery and no mortality. Complications occurred in the 6 (10.0 %) patients during the follow periods. Conclusions: According to our results, laparoscopic left hemihepatectomy and left lateral sectionectomy are safe and feasible procedures. We believe that laparoscopic left side liver resection has become the standard method for managing various liver tumors and diseases.

Propofol 마취 시 근이완제의 투여가 Entropy에 미치는 영향

김보성 ( Bo Song Kim ),이상익 ( Sang Ik Lee ),최성욱 ( Sung Uk Choi ),신혜원 ( Hye Won Shin ),임혜자 ( Hae Ja Lim ),이혜원 ( Hye Won Lee ),장성호 ( Seong Ho Chang ),윤석민 ( Suk Min Yoon ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.56 No.4

Background: The purpose of this study was to investigate whether muscle relaxant affect the values of Entropy, response entropy (RE) or state entropy (SE) during propofol anesthesia. Methods: Eighty patients (ASA I) scheduled for elective surgery under general anesthesia were randomly assigned to four groups. Anesthesia was maintained at a SE value of 80 (80±2) using target controlled infusion (TCI) of propofol. After maintaining SE 80 for 5 min, vecuronium 0.1 mg/kg was injected intravenously in group I and same volume of normal saline was intravenously injected in group II. After maintaining SE 60 for 5 min, vecuronium 0.1 mg/kg was injected intravenously in group III and same volume of normal saline was injected intravenously in group IV. The mean arterial pressure, heart rate, SE and RE were measured before anesthetic induction and up to 5 min after vecuronium or normal saline injection in each group. Results: SE and RE were not changed in group II, but significantly decreased in group I (P<0.05, respectively). In group III and IV, SE and RE were not changed in both groups. There were no significant hemodynamic changes among the four groups. Conclusions: These results suggest that the effect of muscle relaxant on Entropy vary according to the baseline values of RE or SE during propofol anesthesia. (Korean J Anesthesiol 2009;56:381~6)

Common genetic variants at 1q22 and 10q23 and gastric cancer susceptibility in a Korean population.

Song, Hye-Rim,Kim, Hee Nam,Kweon, Sun-Seog,Choi, Jin-Su,Shim, Hyun Jeong,Cho, Sang Hee,Chung, Ik Joo,Park, Young-Kyu,Kim, Soo Hyun,Choi, Yoo-Duk,Joo, Kyung Woong,Shin, Min-Ho Saikon Pub. Co 2014 TUMOR BIOLOGY Vol.35 No.4

<P>Genetic variants at 1q22 and 10q23 were identified as genetic markers of both gastric cancer and esophageal squamous cell carcinoma susceptibility by two genome-wide association studies. The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population. We conducted a large-scale case-control study of 3,245 patients with gastric cancer and 1,700 controls. The allele frequencies of rs4072037G and rs2274223G were 11.2 and 25.5% among patients with gastric cancer, compared with 12.8 and 26.4%, respectively, among controls. We found that the rs4072037 AG genotype was significantly associated with a reduced risk of gastric cancer [odds ratios (OR)?= 0.78; 95% confidence interval (CI)?= 0.67-0.91 for AG vs AA]. Compared with the rs2274223 AA genotype, we found a significant association between the rs2274223 AG genotype and a weakly reduced risk of gastric cancer (OR = 0.87; 95% CI = 0.76-0.99 for AG vs AA). Our data suggest that genetic variants at 1q22 and 10q23 play a role in gastric carcinogenesis.</P>