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김영석,이승규,이민재,백병준,오천환 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2
Aspiration of foreign bodies into the airway is a common problem in spite of efforts to educate the public and it can be sometimes fatal accidents. A retrospective study has been performed for 34 cases of airway foreign bodies, which were obtained from April 1994 to August 1998 at Chunan hospital of Soonchunhyang University. The results were as follows: 1) Among the 34 cases, 26 cases(76.4%) were under the age of 3. The ratio of male and female was 1.4:1. 2) The most common symptom after foreign body aspiration was intractable cough(38.2%). 3) Abnormal findings in the chest X-ray films were found 24 cases(70.6%) and the most common abnormal radiologic feature was combination of pneumonia and atelectasis(37.5%), followed by combination of pneumonia and emphysema(16.6%), pneumonia alone(16.6%). 4) The nature of foreign body was vegetables in 20 cases(58.8%), miscellaneous in 11 cases(32.4%), metals in 2 cases(5.9%) and plastics in 2 cases(5.9%). 5) By distribution of the location of foreign bodies, 26 cases(76.4%) were located in the main bronchus(20 cases in right side and 6 cases in left side), 5 cases were in trachea, 2 cases were in larynx and 1 case was located at carina level. 6) By duration of foreign body lodgement in the airway, 15 cases(44.1%) were found within 24 hours, 9 cases(26.5%) were within 7 days, 7 cases(20.6%) were within 30 days and 3 cases(8.8%) were found over 1 month. 7) In mode of treatment, ventilating bronchoscopic removal under general anesthesia was performed in 29 cases(85.3%), thoracotomy with bronchotomy in 2 cases, thoracotomy with lobectomy in 1 case and postural drainage in 2 cases. 8) Complication rate according to the nature of foreign body was most high in vegetables(68.2%). 9) Correlation between complication rate and the duration of the foreign bodies in situ was definite.
오동백,노민석,장우일,최국진,홍대선 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-
Titanium alloys have been mainly used for aircraft components as well as implant materials. Although a number of cutting tools and cutting methods have been developed for improving the cutting processes, they have difficulties such as tool wear and failure. This study considers a novel approach to on-line monitoring of tool wear and failure in titanium alloy cutting processes. The on-line monitoring system mainly consists of two parts: The one is on-line data acquisition with sensors and a DSP board through LabView and a web server, and the other is learning and prediction of tool wear and failure using an ART2 neural network algorithm. The system is installed at an on-site machine tool to monitor high speed steel(HSS) tools for cutting titanium alloy. A number of experiment are carried out to demonstrate the effectiveness of the proposed system.
비부비동 반정성 유두종의 전산화 단층촬영상과 자기공명영상의 분석
배창훈,서영중,이석춘,천승민,백운희,정은채,송시연,김용대 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2
Background: Computed tomography (CT) is commonly used to evaluate the degree of sinus involvement in case of inverted papilloma (IP). However, CT cannot differentiate tumor from adjacent inflammatory mucosa or retained secretions. By contrast, magnetic resonance imaging (MRI) has been reported to be useful in distinguishing IP from paranasal sinusitis. This study investigated whether preoperative assessment with MRI and CT accurately predict the extent of IP. Materials and methods: CT and MRI were retrospectively reviewed in 9 case of IP. Patients were categorized into staged based on CT and MRI findings according to the staging system proposed by Krouse. The involvement of IP in each sinus was also assessed. Results: Differentiation of IP from inflammatory disease may be more successful in routine case where the inflammatory mucosa has low signal intensity on T1-weighted images and very high signal intensity on T2-weighted images. CT imaging could not differentiate tumor from adjacent inflammatory mucosa or retained secretions. Conclusion: Preoperative MRI of IP can predict the location and extent of the tumor involvement in the paranasal sinuses and sometimes predicts malignant changes.
Baek, Kwang Min,Kim, Jaehoon,Kim, Shinho,Cho, Seunghee H.,Jang, Min Seok,Oh, Jihun,Jung, Yeon Sik American Chemical Society 2018 Chemistry of materials Vol.30 No.17
<P>To realize a more rapid and accurate detection technique for diverse trace molecules, surface-enhanced Raman scattering (SERS) analysis has been extensively investigated in recent decades. However, a practical fabrication method to scalably and reproducibly produce SERS substrates with highly effective SERS-active sites and extensive optical tunability still remains an important research target. Here, we present an electrochemical pathway to generate a high-performance SERS substrate. This method provides not only ultrahigh-density hot spots as a form of nanogaps for strong and uniform SERS signal enhancement but also tunable plasmonic properties for capability of matching the plasmonic resonance wavelength with that of the Raman excitation laser. The unique Au nanopillar array decorated with ultrafine Au nanoparticles records a high SERS signal enhancement effect, which enables trace-molecule detection on the entire measured area with highly reproducible signal intensity. Also, via aptamer-functionalization on this substrate, an extremely sensitive and highly selective SERS-based Hg<SUP>2+</SUP> ions detection sensor is demonstrated. Trace-amount (10 ppb) Hg<SUP>2+</SUP> ions can be selectively identified in a mixture solution containing six different metallic ion species as well as in a beverage containing numerous other components.</P> [FIG OMISSION]</BR>
( Min Seong Kim ),( Min Kyung Baek ),( Myung Hee Kim ),( Jae Ho Park ),( Deok Yeong Kim ),( Hyuk Soo Eun ),( Woo Sun Rou ),( Jong Seok Joo ),( Eaum Seok Lee ),( Seok Hyun Kim ),( Byung Seok Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Autologous cytokine-induced killer cells were used to reduce recurrence in hepatocellular carcinoma as an adjuvant therapy. Our study aimed to evaluate the efficacy of Autologous cytokine-induced killer Cells after curative therapy in primary hepatocellular carcinoma(HCC) in CNUH cases retrospectively. Methods: The study included HCC patients who visited CNUH after surgery, Radiofrequency ablation(RFA), or Transarterial chemoembolization(TACE) from Jan. 2016 to Mar. 2018. The autologous CIK(created by incubation of patient’s peripheral blood mononuclear cells with interleukin 2 and an antibody against CD3) were treated as an adjuvant drug within 2.3 months after curative therapy. Clinical characteristics at baseline and after CIK treatment, and adverse events and recurrence free survival period were collected. Results: Eight of HCC patients were treated with CIK immunotherapy. Patient’s median age was 50 (range 45-67) and 6 of 8 patients were HCC stage II according to the AJCC staging system (7th ed). Before taking immunotherapy, 6 patients received surgery, one patient received RFA and the other received TACE. All patients received average 10 months of CIK as an adjuvant therapy. The median time of recurrence-free survival (RFS) was 10.0 months. 5 patients experienced tumor recurrence or death by the time of the data cut-off date. 4 patients who experienced tumor recurrence underwent additional RFA or TACE and three of these 4 patients were constantly receiving one to eight CIK treatments after additional therapy. There was one death in the study period, which was due to recurrence of liver cancer. Adverse events were reported for 2 and were mild to moderate grade of diarrhea and vomiting. No patient discontinued treatment due to an adverse event. Conclusions: In this CNUH case series using the autologous CIK cells for HCC patients as an adjuvant therapy, the median time of recurrence-free survival (RFS) was 10.0 months. It also offers a new option that can be used as an ongoing therapy even after the first recurrence.
메타모델 기반 다단계 해석을 이용한 순차적 최적설계 알고리듬
백석흠(Seok-Heum Baek),김강민(Kang-Min Kim),조석수(Seok-Swoo Cho),장득열(Deuk-Yul Jang),주원식(Won-Sik Joo) 대한기계학회 2009 大韓機械學會論文集A Vol.33 No.9
An efficient sequential optimization approach for metamodel was presented by Choi et al.(13) This paper describes a new approach of the multilevel optimization method studied in Refs. [2] and [20,21]. The basic idea is concerned with multilevel iterative methods which combine a descent scheme with a hierarchy of auxiliary problems in lower dimensional subspaces. After fitting a metamodel based on an initial space filling design, this model is sequentially refined by the expected improvement criterion. The advantages of the method are that it does not require optimum sensitivities, nonlinear equality constraints are not needed, and the method is relatively easy to understand and use. As a check on effectiveness, the proposed method is applied to an engineering example.
초 고온·고압 소결된 다결정 다이아몬드 컴팩트의 미세조직 및 마모 특성에 미치는 다이아몬드 입자 크기의 영향
백민석 ( Min-seok Baek ),박희섭 ( Hee-sub Park ),이재일 ( Jae-il Lee ),이기안 ( Kee-ahn Lee ) 대한금속ㆍ재료학회 2017 대한금속·재료학회지 Vol.55 No.11
A polycrystalline diamond compact (PDC) is a two-stage sintered body manufactured by placing diamond powders on a WC-Co hard material and then applying the high pressure high temperature (HPHT) sintering process. This study investigated the microstructure and wear properties of the PDC depending on initial diamond particle size. Three different sizes (12-22 μm, 10-20 μm, and 8-16 μm) of initial diamond powders were used to manufacture PDCs with the HPHT sintering process. Some Co and WC were observed along the boundaries between the diamond particles in the three manufactured PDCs. The diamond layer formed using small diamond particles showed finer and more even area distribution of Co along the diamond particles. VTL equipment was used to conduct a granite cutting wear test. The result confirmed that smaller initial diamond particle size leads to greater wear resistance properties. Observation of the PDC wear surface confirmed that the PDC made with larger diamond particles was more prone to be weak along the boundaries between the diamond particles, and there were instances where the diamond particles were displaced as a whole. For PDCs of smaller diamond particle size, abrasive wear occurred where the diamond particles were gradually worn away. (Received July 19, 2017; Accepted July 26, 2017)