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Miji Lee,Duhak Yoon,전진태,어성국,강성호 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.11
A breed of cattle, i.e., Korean cattle (Hanwoo), was identified based on the DNA mobilities of their microsatellites (MSs) by capillary gel electrophoresis (CGE) with a laser-induced fluorescence (LIF) detector. The MS markers were used for the accurate identification of species-specific genes. The DNA mobilities of the MS markers of Hanwoo and Holstein were measured using a CGE system with a fused-silica capillary (inner diameter of 75 μm, outer diameter of 365 μm, and total length of 50 cm). The capillary was dynamically coated with 1.0% (w/v) polyvinylpyrrolidone (Mr = 1,000,000) and then filled with a mixture of 1.3% (w/v) poly(ethylene oxide) (Mr = 600,000) and 1.9% (w/v) poly(ethylene oxide) (Mr = 8,000,000) as a sieving gel matrix. The species-specific genes of Hanwoo and Holstein were clearly distinguished within 33 min. This CGE assay technique is expected to be a useful analytical method for the fast and accurate identification of breeds of cattle.
Lee, Miji,Lee, Hyang Ah,Park, Mira,Park, Hee Kyoung,Kim, Yeon Sun,Yang, Seung Chel,Kim, Hye-Ryun,Kim, Jayeon,Song, Haengseok CSIRO Publishing 2018 Reproduction, fertility, and development Vol.30 No.11
<P> Decay accelerating factor (DAF) is upregulated in the fetoplacental trophoblast, which protects the fetus from maternal complement injury. DAF was found to be downregulated in the endometrium of patients with repeated implantation failure. Thus, we examined the molecular mechanisms of DAF expression regulation by ovarian steroid hormones in the mouse uterus. Immunofluorescence staining demonstrated its exclusive localisation in the apical region of the epithelium in the uterus. Oestrogen (E2) significantly induced Daf mRNA in a time-dependent manner. Progesterone (P4) did not have any significant effect on Daf expression; however, it negatively modulated E2-induced DAF expression and RU486 effectively interfered with the inhibitory action of P4 in the uterus. During early pregnancy DAF was higher on Day 1 of pregnancy, but significantly decreased from Day 3, which is consistent with its E2-dependent regulation. Interestingly, DAF expression seemed to be influenced by the implanting blastocyst on Day 5 and it was gradually increased during preimplantation embryo development with peak levels at blastocyst stages. We demonstrated that E2-dependent DAF expression is antagonised by P4-progesterone receptor signalling in the uterine epithelium. Spatiotemporal regulation of DAF in the uterus and preimplantation embryos suggest that DAF functions as an immune modulator for embryo implantation and early pregnancy in mice. </P>
The Association Between Alcohol Use and Suicidal Ideation Among Employees
Miji Lee,Ung Lee,Jae-Hyun Park,Young-Chul Shin,Mikyung Sim,Kang-Seob Oh,Dong-Won Shin,Sang-Won Jeon,Jinmi Seol,Sung Joon Cho 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.10
Objective The risk of suicide is assessed by identifying the relationship between alcohol-use patterns and suicidal ideation in Korean employees. Methods The study involved 13,858 employees who underwent workplace mental health screening at the Workplace Mental Health Institute of Kangbuk Samsung Hospital over a 6-year period between 2014 and 2019. Analysis was performed separately for Alcohol Use Disorders Identification Test-Korea (AUDIT-K) items related to the frequency/volume of alcohol consumption (items 1 to 3, AUDIT-C) and those regarding alcohol dependence/related problems (items 4 to 10, AUDIT-D/P). Subjects were then classified into three groups on the basis of the presence or absence of clinical depression and suicidal ideation. The groups’ sociodemographic factors and clinical features of depression, anxiety, and alcohol-use patterns were analyzed with a chi-square test as well as one-way analysis of variance, followed by a post hoc test using the Bonferroni correction. Results AUDIT-K and AUDIT-D/P scores were significantly associated with the presence or absence of clinical depression as well as the presence or absence of suicidal ideation (p<0.05). However, no significant differences were found among the three groups with regard to the AUDIT-C score (p=0.054). Conclusion Identifying or treating alcohol dependence/related problems can help lower the occurrence of mental health problems, and suicidal ideation in particular, in employees and reduce social costs.
예비교사의 장애인에 대한 태도가 다문화 수용성에 미치는 영향: 통합교육, 관련교과목수강 경험의 조절효과
이미지 ( Lee Miji ) 부산대학교 과학교육연구소 2020 교사교육연구 Vol.59 No.3
본 연구의 목적은 대학교에 재학 중인 예비교사들을 대상으로 장애인에 대한 태도가 다문화 수용성에 미치는 영향을 알아보고, 두 변인 간의 관계에 통합교육 경험과 관련 교과목 수강경험이 미치는 조절효과에 대해 알아보는 것에 있다. 이를 위하여 서울ㆍ경기 소재 대학의 사범대, 교직이수과정 재학 중인 307명의 예비교사를 대상으로 설문을 실시하고, SPSS 21.0을 사용하여 상관분석, 단계적 회귀분석, 조절회귀분석을 수행하였다. 분석 결과, 예비교사의 장애인에 대한 태도와 다문화 수용성은 .6이상의(p<.001) 상관성을 가지는 것으로 나타나 장애인에 대한 태도가 긍정적일수록 다문화 수용수준도 높은 것으로 파악되었다. 둘째, 예비교사의 장애인에 대한 태도가 다문화 수용성에 미치는 영향을 알아본 결과, 장애인에 대한 태도 하위 변인 가운데 행동 오해 변인이 가장 높은 영향력을 가지는 것으로 나타났으며, 손상된 성격 고정관념과 낙관주의ㆍ인권이 순차적으로 영향력을 가지는 것으로 나타났다. 셋째, 예비교사의 장애인에 대한 태도가 다문화 수용성에 미치는 영향에 조절효과를 가지는 변인은 다문화 관련 통합교육과 교과목수강경험인 것으로 분석되었다. 본 연구는 장애인에 대한 태도와 다문화 수용성이 근본적으로 타(他)문화적인 관점에서 배제, 부정, 차별적인 관념을 가지고 있는가를 측정하는 공통된 개념을 가지고 있다고 보고, 예비교사의 장애인에 대한 태도가 긍정적일수록 다문화 수용성이 높아지며, 예비교사가 다문화 관련통합교육 경험이나 교과목 수강 경험이 있을 때 다문화수용성에 미치는 영향이 더욱 강력해질 수 있다는 결론을 도출하였다. 본 연구의 결과는 예비교사의 장애인권 및 다문화 감수성 중진의 필요성을 시사하고, 대학에서의 전문적이고 의도적인 교육의 중요성을 시사한다. The purpose of this study was to investigate the effect of pre-service pre-school teachers attitudes toward people with disabilities and toward multi-cultural acceptance, and to investigate the moderating effect of the experience of inclusive education and the experience of taking related courses on the relationship between the two variables. To accomplish the research purposes two questionnaires were conducted for 307 pre-school teachers enrolled in the teacher training course at the universities in Seoul and Gyeonggi, with a correlation analysis, stepwise regression analysis, and controlled regression analysis performed using SPSS 21.0. Results found that the attitude toward people with disabilities and the multi-cultural acceptance of pre-service teachers had a correlation of more than .6 (p<.001), and the more positive the attitude toward people with disabilities, the higher the level of multi-cultural acceptance. Second, as a result of examining the effect of pre-service teachers' attitudes toward the disabled on multi-cultural acceptance, among the sub-variables of attitude toward people with disabilities, the behavioral misunderstanding variable was found to have the highest influence, and then, it was found that the impaired personality stereotypes and optimism and human rights have sequential influence. Third, it was analyzed that the variable having a moderating effect on the influence of pre-service teachers' attitudes toward people with disabilities on multi-cultural acceptance was the experience of inclusive education and taking courses related to multi-cultural. This study has shown that the attitude toward people with disabilities and multi-cultural acceptability have a common concept to measure whether the attitude toward people with disabilities and multi-cultural acceptability fundamentally has the notion of exclusion, denial, and discrimination from the perspective of other cultures. In conclusion, the multi-cultural acceptance increased, and that the effect on multi-cultural acceptance could be stronger when pre- teachers take the inclusive education and courses related with multi-cultural. The results of this study suggest the necessity of enhancing the disability rights and multi-cultural sensibilities of pre-teachers, and the importance of professional and intentional education in college.