Stabilization of 11/9-helical α/β-peptide foldamers in protic solvents

Lee, Mihye,Shim, Jihyun,Kang, Philjae,Choi, Moon-Gun,Choi, Soo Hyuk The Royal Society of Chemistry 2016 Chemical communications Vol.52 No.35

<P>alpha/beta-Peptides with alternating alpha-amino acid and cis-2-aminocyclohexanecarboxylic acid (cis-ACHC) residues adopt 11/9-helical conformations, the folding propensity of which decreases as the solvent polarity increases. We report a new cis-ACHC analogue, cis-2-amino-cis-4-methylcyclohexanecarboxylic acid, which significantly stabilizes the 11/9-helix propensity in protic solvents.</P>

대학생의 취업스트레스 경험에 관한 연구: 근거이론을 중심으로

최미혜 ( Choi Mihye ) 한국학교사회복지학회 2017 학교사회복지 Vol.0 No.39

본 연구는 대학생들의 취업 스트레스와 그에 따른 어려움에 대해 어떻게 느끼고 경험하는지를 깊이 이해하고자 근거이론을 적용한 질적 연구이다. 본 연구 참여자는 서울과 경기도에 재학 중인 대학교 3-4학년으로 취업을 앞두고 있는 예비 취업준비생들 11명이다. 이 연구자들을 대상으로 심층면접을 통해 얻은 자료로부터 최종적으로 85개 개념, 18개 하위범주, 상위범주 9개가 도출되었다. 본 연구 결과의 인과적 조건은 ‘현실과 이상 사이’, 중심 현상은 ‘짓누르는 스트레스’이며, 맥락적 조건은 ‘대학생활 적응을 위한 노력’과 ‘취업 정보 찾기’로 중재적 조건은 ‘자격 갖추기’와 ‘지지체계들’로 나타났다. 작용/ 상호작용 전략은 ‘진정한 나로 살아가기’와 ‘취업연습의 의지적 활동’이며, 결과는 ‘미래를 향해 진취적으로 나가기’로 나타났다. 이런 과정은 ‘혼란스러운 단계’, ‘현실을 인정하고 발전을 탐색하는 단계’, ‘추구와 선택의 단계’, 그리고 ‘끈기와 주체성’의 단계를 거치는 것으로 나타났다. 이러한 연구 결과를 통해 대학생들의 취업스트레스와 그에 따른 그들의 반응과 대처 전략을 이해하며 그들의 정신 건강증진을 위한 기초자료로 활용하고자 한다. This research is a qualitative research using a grounded theory which explains for college students how they deal with their job search stress and difficulties, and what their experiences are regarding them. The participants are 11, third grade and fourth grade college students in Seoul and Kyoungido who have been preparing for employment. Collected data by depth-interviews has derived 85 concepts, 18 subcategories, and 9 categories. The result of this study shows ‘between the reality and the idea’ as a casual condition, ‘heavy stress in hiring process’ as a phenomenon, ‘making efforts sincerely to adjust to college life’ and ‘seeking the employment information’ as contextual conditions, and ‘preparing for the job requirement’ and ‘several supports’as intervening conditions. It is also analyzed ‘living and finding my true self’ as a action/interaction and ‘going forward into the future’ as a consequence. This process has passed through first stage: ‘feeling of confusion’, second stage: ‘accepting the reality and exploring the development’, third stage: ‘pursuing and selecting’, and fourth stage: ‘patience and subjectivity’. The result of this study leads us to understand the job search stress, response, and coping strategies of college students. Also, it can be used for improving their mental health as a basic data.

음소 지각 발달 연구 고찰 및 관련한 한국어 연구의 동향과 과제

최영은(Youngon Choi),최미혜(Mihye Choi) 한국언어청각임상학회 2016 Communication Sciences and Disorders Vol.21 No.1

본 연구는 지난 수십여 년간 많은 발전을 이룬 음소 지각 발달에 대한 연구를 심도 있게 개괄하고 종합하여 음소 지각 발달 이론의 검증과 구축에 한국어와 한국어 습득 영아들에 대한 연구가 지닌 역할과 의미를 도출하고자 하는 것이다. 방법: 이를 위해 지난 40여 년 이상의 국내외 관련 문헌을 고찰하였다. 이러한 분석에는 행동 측정 연구만이 아니라 대뇌 측정법을 이용한 연구들도 포함하였고, 최근 비롯된 한국어 관련 연구 시도들도 포함하였다. 결과: 문헌 고찰 결과, 최근 다양한 언어들에서 추가적으로 얻어진 결과들은 기존의 발달 이론만으로는 음소 지각 발달을 모두 설명할 수 없음을 드러내었고, 음소 지각 발달에 보다 다양한 요인들이 개입되어 있을 가능성을 시사하였다. 이러한 맥락에서 한국어 습득 연구는 아직까지는 미미하지만 기존 이론의 수정에 매우 중요한 기여를 할 가능성을 볼 수 있었다. 그리고 한국어 음운 발달에 대한 연구가 매우 부족하여 추가 연구가 중요함을 볼 수 있었다. 논의 및 결론: 한국어에서 사용되는 음소들과 이를 습득하는 아동들에 대한 추후 연구는 음소 지각 발달 이론의 검증과 구축에 있어서 중요한 역할을 할 것으로 보인다. 더불어 비장애 아동의 발달 과정에 대한 자료 구축은 조기 의사소통장애의 진단과 치료에도 매우 유용할 것으로 보인다. The goal of the present article is to provide an in-depth review of past studies on infant speech perception. Based on an extensive review, we aim to provide an overview of the field and to propose important roles that research on Korean and Korean-learning infants can play to further test and advance exiting theories. Methods: We conducted an extensive literature review, encompassing papers published in the past four decades or so, including behavioral studies as well as brain research, and studies conducted with various languages, including recent efforts made towards testing Korean babies. Results: Our re¬view showed that the existing theories are largely drawn from a few languages, mostly Indo-European and Romance languages, and how recent data from various other lan¬guages have challenged the existing model. This suggests that more data from languages such as Korean are essential to further test the development of speech perception theory. Furthermore, our review shows how little has been done to understand Korean babies’ na¬tive phonology development. Conclusion: Studies involving Korean phonology will not only play an important role for developing speech percepton theory, they will also provide developmental normative data for diagnosis/therapy of individuals having difficulty devel¬oping Korean phonology.

갱년기 우울증에 대한 중약 중재 임상연구 고찰 -CNKI에서 검색된 무작위배정 비교임상시험을 중심으로

최성률 ( Sung Ryul Choi ),정성엽 ( Sung Yub Jung ),홍두현 ( Doo Hyun Hong ),유진실 ( Jin Sil Yu ),최종호 ( Jong Ho Choi ),김미혜 ( Mihye Kim ) 대한한방신경정신과학회 2020 동의신경정신과학회지 Vol.31 No.1

Objectives: The objective of this study is to analyze clinical reports of treatment of menopausal depression in traditional Chinese medicine (TCM). Methods: This study included randomized controlled trials (RCT) in treating menopausal depression. Literature studies of Chinese National Knowledge Infrastructure Database(CNKI) were performed. Clinical reports on menopausal depression treatment were searched using the following key words in the CNKI: ‘menopausal depression’ and ‘postmenopausal depression’. Results and Conclusions: A total of 24 RCT articles on menopausal depression were selected. The most widely used diagnostic tool for menopausal depression was CCMD-3. Effective rate and HAMD were the most commonly used assessment tools. Bosinhaeultang-gagam (Bushenjieyu-tang jiajian) and Gami-gammaegdaejotang(Jiawei ganmaidazao-tang) were used much more than other prescriptions, while Bupleuri Radix was the most used single medicine herb. Additionally, the Chinese medicine treatment group showed less adverse reactions than the control group. As a result, we could know frequently used herbal prescription and single medicinal herbs and this can be helpful in developing more advanced studies in future.

One-step Microwave Synthesis of Hierarchical Structured LiFePO4 using Citric Acid

Mihye Wu,Sungho Choi,Yongku Kang,정하균 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.10

The hierarchical-structured LiFePO4 cathode materials were synthesized by one-step microwave synthesis, and their electrochemical properties were investigated. Addition of citric acid during the reaction lead to the formation of hierarchical structured LiFePO4, which has both nano- and micron-characteristics advantageous for energy density and electrode fabrication. Adjusting the molar ratio of Fe to citric acid enhanced the electrochemical properties of LiFePO4.

Synthesis and characterization of photo-crosslinkable poly(amic acid ester)s with 2-hydroxy-4-oxo-hept-5-enyl side chain

Choi, Sung Mook,Ahn, Taek,Kim, Jin Soo,Yi, Mihye John WileySons, Ltd. 2010 Polymers for advanced technologies Vol.21 No.6

<P>Photosensitive poly(amic acid ester)s (PAEs) with 2-hydroxy-4-oxo-hept-5-enyl side group were simply synthesized from a non-photosensitive polyamic acid (PAA), which was prepared from cyclobutane-1,2,3,4-tetracarboxylic dianhydride (CBDA) and 4,4′-diaminodiphenyl ether (DDE) in N-methyl-2-pyrrolidinone (NMP). 1-oxiranyl-pent-3-en-2-one was added to the poly(amic acid) solution to give the photosensitive PAEs by a ring opening esterification of the poly(amic acid). The esterification reaction was conducted with changing a reaction time and amounts of 1-oxiranyl-pent-3-en-2-one. The degree of esterification (DOE) increased with increasing esterification reaction time and amounts of 1-oxiranyl-pent-3-en-2-one. A photo-lithography evaluation for the PAE-D4 with the highest DOE was conducted in the presence of 1-[4-(phenylthio)phenyl]-2-(O-benzoyloxime)-1,2-octanedione (PPBO) as a photoinitiator at a wavelength of 365 nm using a high-pressure mercury lamp. The normalized film thicknesses for PAE-D3 were measured with various post-exposure baking (PEB) temperatures, which showed that the optimum PEB temperature was 120°C. The resolution of the resulting polyimide film cured at 250°C for 60 min was 25 µm. The initial decomposition temperature of the polyimide film was around 354°C and there was no weight loss at the temperature of 250–350°C. Copyright © 2009 John Wiley & Sons, Ltd.</P>

Post-Stroke Fatigue May Be Associated with the Promoter Region of a <b><i>Monoamine Oxidase A </i></b>Gene Polymorphism

Choi-Kwon, Smi,Ko, Mihye,Jun, Sang-Eun,Kim, Juhan,Cho, Kyung-Hee,Nah, Hyun-Wook,Song, Hasup,Kim, Jong S. S KARGER AG 2017 Cerebrovascular Diseases Vol.43 No.1

<P><B><I>Background:</I></B> Post-stroke fatigue (PSF) is a common sequela of stroke. Despite reports of serotonergic involvement in the etiology of PSF, the potential contribution of serotonergic genes in the development of PSF needs to be investigated. <B><I>Methods:</I></B> A total of 373 patients, who experienced ischemic stroke for PSF, were evaluated 3 months after the stroke. PSF was assessed using the Fatigue Severity Scale. The genomic DNA collected and stored in a -70°C freezer was genotyped for 6 polymorphisms in genes associated with serotonin synthesis (tryptophan hydroxylase 1 (TPH1) A218C, TPH2 rs10879355, and TPH2 rs4641528), transport (the promoter region of the serotonin transporter protein), and catabolism (the 30-bp functional variable number tandem repeat) polymorphism in the promoter region of <I>monoamine oxidase A (MAO-A)</I>. <B><I>Results:</I></B> Among the 373 patients, 164 (44%) had PSF. All patients were ethnic Koreans. Of the 6 polymorphisms examined, only one marker, that is, low-activity <I>MAO-A</I> was associated with PSF (p < 0.05) in female patients. Multiple logistic regression analyses showed that post-stroke depression (PSD; 95% CI 1.561-14.323, p = 0.006) and low <I>MAO-A</I> activity (95% CI 0.166-0.722, p = 0.005) were factors associated with PSF in female patients, whereas only PSD (95% CI 5.511-65.269, p = 0.000) was associated with PSF in male patients. <B><I>Conclusions:</I></B> Our findings suggest that PSF may be associated with a genetic polymorphism involving <I>MAO-A</I>, at least in female stroke patients.</P>

국내 농약중독 사망사고 현황분석과 사고 예방대책

정미혜(Mihye Jeong),김진화(Jin-Hwa Kim),박경훈(Kyung-Hun Park),이희동(Hee-Dong Lee),유아선(Are-Sun You),김병석(Byung Seok Kim),최주현(Ju-Hyun Choi),권오경(Oh-Kyung Kwon) 한국농약과학회 2008 농약과학회지 Vol.12 No.2

One-step Microwave Synthesis of Hierarchical Structured LiFePO₄ using Citric Acid

Wu, Mihye,Choi, Sungho,Kang, Yongku,Jung, Ha-Kyun Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.10

The hierarchical-structured $LiFePO_4$ cathode materials were synthesized by one-step microwave synthesis, and their electrochemical properties were investigated. Addition of citric acid during the reaction lead to the formation of hierarchical structured $LiFePO_4$, which has both nano- and micron-characteristics advantageous for energy density and electrode fabrication. Adjusting the molar ratio of Fe to citric acid enhanced the electrochemical properties of $LiFePO_4$.

실천적 전문인 양성을 위한 스포츠 지도자 교육과정 분석

조미혜(Mihye Cho),최희진(Heejin Choi),김진희(Jinhee Kim),김선희(Sunhee Kim) 한국코칭능력개발원 2007 코칭능력개발지 Vol.9 No.3