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백서 심근경색모델에서 시간경과와 경색의 크기에 따른 심자도의 변화
김미성(Mi Sung Kim),박영선(Young Sun Park),권순길(Sun Gil Kwon),지정훈(Jeong Hoon Ji),신종성(Jong Sung Shin),오광식(Kwang Sik Oh),양용모(Yong Mo Yang),연태진(Tae Jin Youn),김동운(Dong Woon Kim),조명찬(Myeong Chan Cho),이용호(Yong Ho 대한내과학회 2002 대한내과학회지 Vol.62 No.1
N/A Background: Magnetocardiogram (MCG), which records the changes of magnetic fields generated by the heart`s electrical activity, theoritically can provide unique data for clinical application. To date, MCG has been investigated only at a single time point after myocardial infarction (MI) with severe left ventricular dysfunction in rats. The purpose of the present study was to investigate sequential changes of MCG after MI and to evaluate effects of infarct size on MCG. Methods: Acute MI were induced by the permanent ligation of left coronary artery in 22 rats. Magnetic fields were recorded just above a rat with Nb Superconducting Quantum Interference Device (SQUID) gradiometer inside a magnetically shielded room. MCG was measured before and immediately after surgery and it was subsequently recorded at the time points of 1, 4 and 6 hours post operatively. MCG was also measured at 1, 3, 7 and 21 days after surgery. Results: Elevation of ST segment and appearance of pathological Q wave on the MCG were evident immediately after the ligation of coronary artery and persisted to 6 hours after MI. On MCG, ST segment was depressed and T wave was inverted from 1 day after MI. In rats with small-and moderate- sized MI (infarct size〈30%), ST depression returned to near the isoelectric level and Q wave disappeared from 7 days after MI. However, ST depression and Q wave were still present in rats with larger infarct (infarct size≥30%). Conclusion: Evolutional changes of MCG were well-recognized up to 21 days after MI. Furthermore, the infarct size can be expressed by the extent of Q wave and ST segment depression on MCG. Taken together, these data indicate that MCG is a helpful modality for the diagnosis, evaluation of infarct size and follow up after MI.(Korean J Med 62:42-48, 2002)
Kwon, Sun-Mi,Baik, Hyoung-Seon,Choi, Sung-Hwan Korean Academy of Dental Science 2018 Journal of korean dental science Vol.11 No.1
As the adult population continues to increase, orthodontic treatment for adult patients is becoming more common. This case report describes comprehensive orthodontic treatment of a middle-aged patient with closure of the extraction space without prosthetic restoration. A 55-year-old woman with her maxillary left first premolar extracted because of a periodontal problem, wanted to close the space with orthodontic treatment. Since she had generalized crowding and mild skeletal discrepancy, we planned comprehensive orthodontic treatment, including closure of the extraction space by protraction of the left maxillary molars using miniscrews and aesthetic alignment of anterior teeth. The total treatment period was 28 months. As a result of these treatments, the extraction space was successfully closed, good tooth alignment and satisfactory occlusion were achieved.
Sung Eun Shin,Hongliang Li,Han Sol Kim,Hye Won Kim,Mi Seon Seo,Kwon-Soo Ha,Eun-Taek Han,Seok-Ho Hong,Amy L. Firth,Il-Whan Choi,Young Min Bae,Won Sun Park 대한생리학회-대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.2
We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent K<sup>+</sup> (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Nortriptyline inhibited Kv currents in a concentration-dependent manner, with an apparent IC<sub>50</sub> value of 2.86±0.52 µM and a Hill coefficient of 0.77±0.1. Although application of nortriptyline did not change the activation curve, nortriptyline shifted the inactivation current toward a more negative potential. Application of train pulses (1 or 2 Hz) did not change the nortriptyline-induced Kv channel inhibition, suggesting that the effects of nortiprtyline were not use-dependent. Preincubation with the Kv1.5 and Kv2.1/2.2 inhibitors, DPO-1 and guangxitoxin did not affect nortriptyline inhibition of Kv channels. From these results, we concluded that nortriptyline inhibited Kv channels in a concentration-dependent and state-independent manner independently of serotonin reuptake.
Kwon, Yong-Hyun,Jang, Sung Ho,Lee, Mi Young,Byun, Woo Mok,Cho, Yoon Woo,Ahn, Sang Ho 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.1
뇌성마비로 인해 오른 손에서 단부전마비를 호소하는 환자를 대상으로 기능적 자기공명영상 장치와 경두개 자기 자극기를 사용하여 운동신경의 회복기전을 연구하였다. 대상자는 21세 된 남자 환자로 오른손에 경미한 운동 기능의 손상을 보였고, 자기공명영상의 소견에서 좌반구의 precentral knob에서 병변을 보였다. 기능적 자기공명영상 촬영은 한 명의 대상자와 여덟 명의 정상인을 대상으로 표준화된 헤드코일을 사용하여 1.5 T의 장치에서 BOLD 기술을 적응하여 실시하였다. 대상자들의 운동수행은 1 ㎐ 주기로 손가락의 굴곡과 신전을 반복하는 과제가 제시되었다. 경두개 자기 자극은 원형 코일을 사용하여 코일의 앞쪽 부분이 대상자의 두피에서 1 ㎝ 정도 떨어진 정접부위에 적용되었고 양측의 짧은엄지벌림근에서 발생된 운동 유발 전위가 동시에 측정되었다. 자기공명영상의 결과에서 환자의 비손상측(좌 측) 손과 정상군의 좌측 손의 운동 수행 시 오른쪽의 일차운동감각영역(SMI)의 precentral knob에서 활성도가 나타났다, 그러나, 환자의 손상측(우측) 손의 운동 수행 시, 좌측 일차운동감각영역의 손상된 precentral knob 내측 부위에서 활성도를 보였다. 또한, 경두개 자기 자극의 결과에서 손상측 짧은엄지벌림근에서 발생된 운동 유발 전위에 해당하는 뇌 부위가 환자의 정상측과 비교하여 1 ㎝ 내측에서 발견되었다. 그러므로 손상측 손의 운동 기능이 손상된 precentral knob의 내측 부분으로 전위되어 신경재구성이 이루어진 것으로 추정되는 결론을 얻었다. The motor recovery mechanism of a 21-year-old male monoparetic patient with cerebral palsy, who had complained of a mild weakness on his right hand since infancy, was examined using functional Magnetic Resonance Imaging (fMRI) and Transcranial Magnetic Stimulation (TMS). The patient showed mild motor impairment on the right hand. MRI located the main lesion on the left precentral knob of the brain. fMRI was performed on this patient as well as 8 control subjects using the Blood Oxygen Level Dependent technique at 1.5 T with a standard head coil. The motor activation task consisted of finger flexionextension exercises at 1 ㎐ cycles. TMS was carried out using a round coil. The anterior portion of the coil was applied tangentially to the scalp at a 1.0 ㎝ separation. Magnetic stimulation was carried out with the maximal output. The Motor Evoked Potentials (MEPs) from both Abductor Pollicis Brevis muscles (APB) were obtained simultaneously. fMRI revealed that the unaffected (right) primary sensori-motor cortex (SM1), which was centered on precentral knob, was activated by the hand movements of the control subjects as well as by the unaffected (left) hand movements of the patient. However, the affected(right) hand movements of the patient activated the medial portion of the injured precentral knob of the left SM1. The optimal scalp site for the affected (right) APB was located at 1 ㎝ medial to that of the unaffected (left) APB. When the optimal scalp site was stimulated, the MEP characteristics from the affected (right) APB showed a delayed latency, lower amplitude, and a distorted figure compared with that of the unaffected (left) APB. Therefore, the motor function of the affected (right) hand was shown to be reorganized in the medial portion of the injured precentral knob.
( Mi Jung Lee ),( Young Eun Kwon ),( Yung Ly Kim ),( Kyoung Sook Park ),( Han Jak Ryu ),( Youn Kyung Kee ),( Chang Yun Yoon ),( Eunyoung Lee ),( Young Su Joo ),( In Mee Han ),( Sung Gyu Han ),( Hyung 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Sarcopenia is an important cardiovascular risk factor in patients with end-stage renal disease. Recent studies have indicated that skeletal muscles mediate their protective effect by secreting myokines. However, to date, the pathophysiologic role of irisin, a novel myokine, has not been evaluated in peritoneal dialysis (PD) patients. In this study, therefore, we investigated the association of irisin with sarcopenia and carotid atherosclerosis in these patients. Methods: Serum irisin levels were assessed by enzyme-linked immunosorbent assay in 102 prevalent PD patients. To determine sarcopenia and carotid atherosclerosis, anthropometric indices including mid-arm muscle circumference (MAMC) and carotid intima-media thickness (cIMT) were measured. Linear and logistic regression analyses were performed to ascertain the independent association of irisin with sarcopenia and carotid atherosclerosis. Results: The mean serum irisin levels were 184.2 ± 88.0 ng/mL. Thirty-seven patients (36.3%) had carotid atherosclerosis. In univariate linear regression analysis, serum irisin concentrations were positively correlated with MAMC, thigh circumference, and serum creatinine levels, whereas negatively correlated with residual renal function and cIMT. Multivariate analysis revealed that MAMC [ß = 0.31, 95% confi dence interval (CI) = 1.89 to 17.85, P = 0.02] and cIMT (ß = -0.29, 95% CI = -92.53 to -17.11, P = 0.005) had independent association with serum irisin levels. In addition, serum irisin concentration was a signifi cant independent risk factor for carotid atherosclerosis after adjustment for confouding variables (per 1 ng/mL increase, odds ratio = 0.987, 95% CI = 0.979 to 0.996, P = 0.004). Conclusions: This study demonstrated for the fi rst time that circulating irisin levels were signifi cantly associated with sarcopenia and carotid atherosclerosis in PD patients, suggesting that irisin could mediate the detrimental effect of sarcopenia on cardiovascular disease.
( Sung Hye Eun ),( Hyun Jung Joo ),( Hyuk Sun Kwon ),( Han Mi Jung ),( Ji Hae Lee ),( Gyong Moon Kim ),( Jung Min Bae ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Idiopathic guttate hypomelanosis (IGH) is common acquired leukoderma characterized by discrete, tiny, white macules in the elderly. Until now, there was no definite therapeutic modality for IGH. Objectives: To investigate the effectiveness of low-fluence fractional CO<sub>2</sub> laser in the treatment of IGH Methods: A retrospective review was performed, and a total of 87 lesions on 26 body parts in 17 patients with IGH were included from October, 2016 to June, 2017. A CO<sub>2</sub> fractional laser treatment was performed on all lesions with 2 passes of 2-4 mJ, 400 spots/cm2 with no anesthesia at a 1-week interval. All lesions were classified into three body parts including face, chest, and extremities, and were evaluated according to the body parts. Clinical assessments were evaluated using 6-point scales (0, no; 1, mild; 2, moderate; 3, good; 4, excellent; 5, complete response). Results: Overall, 61.5% (21 out of 26 body parts) showed excellent or complete response after a median of 5.5 treatment sessions (range: 2-9). In the subgroup analysis, 80% (8/10) of face lesions showed excellent response, while 40% (4/10) of extremities reached excellent response. Transient erythema and crust after treatment was common, and one patient stopped treatment because of prolonged hyperpigmentation at irradiation site. Conclusion: Low-fluence fractional CO<sub>2</sub> laser therapy could be an effective option for IGH. It is convenient without need for anesthesia.