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( Jia Cheng ),( Na Sun ),( Xin Zhao ),( Li Niu ),( Mei Qin Song ),( Yao Gui Sun ),( Jun Bing Jiang ),( Jian Hua Guo2 ),( Yuan Sheng Bai ),( Jun Ping He ),( Hong Quan Li ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.8
Seventeen compounds derived from traditional Chinese medicines (TCMs) were tested for their antiviral activity against porcine reproductive and respiratory syndrome virus (PRRSV) in vitro. Visualization with the cytopathologic effect (CPE) assay and the 3-(4, 5-dimethyithiazol- 2-yl)-2,5-diphenyltetrazolium bromide test were used to determine the 50% cytotoxic concentration (CC50) and 50% effective concentration (EC50) in cultured Marc-145 cells. Among the tested compounds, chlorogenic acid and scutellarin showed potential anti-PRRSV activity. The EC50 values were 270.8 ± 14.6 μg/ml and 28.21 ± 26.0 μg/ml and the selectivity indexes were >5.54 and 35.5, respectively. The time-of-addition and virucidal assay indicated that the anti-PRRSV activity of the two compounds could be due to their inhibiting the early stage of virus replication and/or inactivating the virus directly. The inhibition of the virus attachment was not observed in the adsorption inhibition assay. The inhibition ratios of chlorogenic acid and scutellarin were, respectively, 90.8% and 61.1% at the maximum non-cytotoxic concentrations. The results have provided a basis for further exploration of their antiviral properties and mechanisms in vivo. We believe that the chlorogenic acid and scutellarin have a great potential to be developed as new anti-PRRSV drugs for clinical application.
One-dimensional consolidation with asymmetrical exponential drainage boundary
Mei, Guo-Xiong,Lok, Thomas M.H.,Xia, Jun,Wu, Sheng Shen Techno-Press 2014 Geomechanics & engineering Vol.6 No.1
In this paper, asymmetric drainage boundaries modeled by exponential functions which can simulate intermediate drainage from pervious to impervious boundary is proposed for the one-dimensional consolidation problem, and the solution for the new boundary conditions was derived. The new boundary conditions satisfy the initial and the steady state conditions, and the solution for the new boundary conditions can be degraded to the conventional solution by Terzaghi. Convergence study on the infinite series solution showed that only one term in the series is needed to meet the precision requirement for larger degree of consolidation, and that more terms in the series for smaller degree of consolidation. Comparisons between the present solution with those by Terzaghi and Gray are also provided.
Guo, Huan-Mei,Wang, Xian,Jian, Fang Fang,Xiao, Hai Lian,Zhao, Pu Su Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.5
Two fluoro-substituted 2-pyrazoline derivatives, 1-phenyl-3-(4-methoxyphenyl)-5-(4-fluorophenyl)-2-pyrazoline (1) and 1-phenyl-3-(4-methoxyphenyl)-5-(2-fluoro-phenyl)-2-pyrazoline (2) have been synthesized and characterized by elemental analysis, IR, UV-Vis and fluorescence spectra. The crystal structure of 1 has been determined by X-ray single crystal diffraction. For the two compounds, density functional theory (DFT) calculations of the structures and natural population atomic charge analysis (NPA) have been performed at B3LYP/6-311G** level of theory. By using TD-DFT method, electron spectra of 1 and 2 have been predicted, which are very approximate with the experimental ones. Comparative studies on 1 and 2 indicate that the location change of fluorine atom in 5-position phenyl ring of 2-pyrazoline does not make significant change of geometries and electronic transition bands, but it leads to evident change of atomic charge distributions and peak intensities of UV and fluorescence spectra.
Guo, Xui Mei,Hidajat, Kus,Ching, Chi Bun 한국화학공학회 1998 Korean Journal of Chemical Engineering Vol.15 No.5
A solid oxide fuel cell with 1 wt%Sr/La₂O₃-Bi₂O₃-Ag-YSZ membrane was applied to oxidative coupling of methane, Membrane composition had a great effect on the reaction and current generated. An increase in the current generated was accompanied by a decrease in C₂ selectivity and an increase in CH₄ conversion. There is an optimal temperature for C₂-selectivity. CH₄ conversion decreased, C₂-selectivity increased and current generated decreased slightly with a rise in total flow rates. CH₄ conversion and the current generated increased with a rise in oxygen concentration. If only C₂-selectivity and current were concerned, the higher the methane concentration, the more favourable for the cogeneration of electrical energy and ethane and ethylene. Stability of the membrane was also tested.
Mei Juan Guo,권만우,황미경,주이모 한국멀티미디어학회 2023 The journal of multimedia information system Vol.10 No.2
Emotions are essential in today's complex social media information environments. Emotions can catch readers' attention and affect how users process information. This study explored the effect of emotional content on attention on different social media through an eye-tracking experiment. Participants (N=40) in this study read different emotional content. We measured the effects of emotions on visual attention by comparing the fixation times and counts of participants of two experimental groups: TikTok and Twitter. As a result of this study, the study found that the emotional and negative contents would draw more visual attention than their opposed contents (non-emotional, positive). Emotional content on social media attracted more attention, especially text with negative emotions. Negative information attracted more attention (compared to neutral and positive information). Our results revealed differences in visual attention towards contents with emotional contents. The study also suggested that the relationship between emotional and cognitive attention has little to do with social platforms. These findings have great implications for the study of emotional messages on social media. Therefore, this research is meaningful in a way that it suggests an objective examination through experiments with emotional content on social media.
Guo-Bo Xu,Tao Yang,Jin-ku Bao,Dong-Mei Fang,Guo-You Li 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.5
Isochaetomium A2 (1), a new bis(naphthodihydropyran-4-one), along with chaetochromins A (2) and B(3), was isolated from the solid-state fermented rice cultureof Chaetomium microcephalum. The structure of compound1 was elucidated on the basis of 1D and 2D NMRspectral data, and the relative configuration was confirmedby CD spectrum. Compounds 1–3 possessed significantantimicrobial activity against Escherichia coli 1.044,Staphylococcus aureus 1.252, and Bacillus subtilis 1.079. Moreover, compounds 1–3 showed obvious inhibitoryeffects on mouse spleen cell proliferation with successiveIC50 values of 0.52, 0.19, and 0.24 lM.
A Study on Transnational Media Coverage of Sino-US Trade through Semantic Network Analysis
Mei Juan Guo,황미경,PengFei Zhu,주이모 한국멀티미디어학회 2023 The journal of multimedia information system Vol.10 No.2
This study was conducted to analyze the perspectives of transnational media reporting on Sino-US trade. News reports from Associated Press and Xinhua News Agency were collected from March 20, 2018, to October 31, 2018. Text mining and frequency analysis was performed by Python to examine significant keywords from the news reports. Eigenvector centralities and Modularity analysis were conducted by Gephi. QAP correlation analyses were conducted by Ucinet. As a result, Associated Press and Xinhua News Agency had different clusters. There was a significant correlation between the Xinhua News Agency Semantic Network and the Associated Press Semantic Network. This study supports the two perspectives of reporting from different aspects. Xinhua News Agency involved four sub-topics when reporting Sino-US trade frictions, namely China-related clusters, US-related clusters, trade-related clusters, and tariff-related clusters. The Associated Press involved three sub-topics, namely China-US Trade-related clusters, global economy-related clusters, and tariff-related clusters. Xinhua News Agency focused on China-related clusters, while Associated Press focused on Sino-US trade-related clusters. The network structure of Xinhua News Agency and AP shows a positive correlation, which to some extent indicates the global perspectives of Chinese and American media reporting. The division of the two network clusters and the difference in the choice and prominence of the words in the network indicates that the Chinese and American media are still affected by the political stance and culture when constructing the framework strategy. Based on these results, valuable implications are provided for media reporting across countries.
Zu-Guo Zhao,Yun Mei Yu,Bi Yu Xu,Shuang-Shuang Yan,Jun-Fa Xu,Fang Liu,Guo-Ming Li,Yuan Lin Ding,Shu Qing Wu 한국생물공학회 2013 Biotechnology and Bioprocess Engineering Vol.18 No.2
In Pseudomonas aeruginosa, a quorum sensing (QS) system regulates the expression of many virulence factors. N-acyl homoserine lactone (HSL) is the signal molecule of QS system. In order to find a novel HSL binder to interfere with QS signaling and to attenuate P. aeruginosa virulence, an amino lactam surrogate (ALS) of HSL was used as a target to screen HSL aptamers with the technique of systematic evolution of ligands by exponential enrichment (SELEX). Eight HSL aptamers with high affinities for 3O-C12-HSL (20 nM ≤ Kd < 35 nM) or C4-HSL (25 nM < Kd < 50 nM) were finally obtained. In vitro QS-inhibiting study of P. aeruginosa showed that HSL aptamers could inhibit virulence in a dose-dependent manner. ALSap-8 which bound C4-HSL primarily acted on the rhl system and inhibited the secretion of pyocyanin. ALSap-5 which bound 3O-C12-HSL not only showed strong inhibitory activity on biofilm formation as well as secretions of LasA protease and LasB elastase, but also reduced pyocyanin secretion. Since the las system is capable of activating the rhl system mildly, we speculated that ALSap-5 can simultaneously interfere with the las and rhl systems. High-affinity aptamers against HSL in this study are novel QS and virulence-inhibitors, and may have potential as drug candidates for the treatment of P. aeruginosa infection.