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Jenny (Jiyeon) Lee,Paul Patterson,Christine Mathies 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
As the worlds’ population ages, more frontline employees (FLEs) will be required in the aged care industry. Notably, workers at residential aged care services are susceptible to workplace stress (Biggins, 2019) due to the long hours, low wages, and physical and emotional demands of helping the elderly and incapacitated (Proust, 2019). This poses challenges for the industry to manage the welfare of its employees.
Microfluidic Linear Hydrogel Array for Multiplexed Single Nucleotide Polymorphism (SNP) Detection
Jung, Yun Kyung,Kim, Jungkyu,Mathies, Richard A. American Chemical Society 2015 ANALYTICAL CHEMISTRY - Vol.87 No.6
<P>A PDMS-based microfluidic linear hydrogel array is developed for multiplexed single nucleotide polymorphism (SNP) detection. A sequence of three-dimensional (3D) hydrogel plugs containing the desired DNA probes is prepared by UV polymerization within a PDMS microchannel system. The fluorescently labeled target DNA is then electrophoresed through the sequence of hydrogel plugs for hybridization. Continued electrophoresis provides an electrophoretic wash that removes nonspecific binders. The capture gel array is imaged after washing at various temperatures (temperature gradient electrophoresis) to further distinguish perfect matches from mismatches. The ability of this microdevice to perform multiplex SNP genotyping is demonstrated by analyzing a mixture of model <I>E. coli</I> bacterial targets. This microfluidic hydrogel array is ∼1000 times more sensitive than planar microarrays due to the 3D gel capture, the hybridization time is much shorter due to electrophoretic control of the transport properties, and the stringent wash with temperature gradient electrophoresis enables analysis of single nucleotide mismatches with high specificity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2015/ancham.2015.87.issue-6/ac5048696/production/images/medium/ac-2014-048696_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac5048696'>ACS Electronic Supporting Info</A></P>
Multiplex Mini Y Short Tandem Repeat Haplotyping using Fluorescence Energy Transfer Labeled Primers
서태석,신경진,최종영,Richard A. Mathies 한국바이오칩학회 2008 BioChip Journal Vol.2 No.3
A fluorescence energy transfer (ET) cassette labeled mini Y short tandem repeat (STR) genotyping system is presented. A capillary electrophoretic (CE) microdevice with a cross-injector design is used to determine the fluorescence intensities of ET and single dye-labeled STR amplicons, demonstrating a 2-12 fold higher fluorescence signal of ET cassette labels than the corresponding single dye-labeled ones. Eleven extended haplotype mini Y-STRs using ET cassette labeled primers are constructed, and sensitivity and mixed sample studies are performed. Due to the improved spectroscopic properties of ET labels, multiplex mini Y-STR typing is successful with as low as 30 pg of genomic male DNA, and in the high background of female DNA. These results indicate the practical advantage of ET cassette labels for low copy number and poor-quality DNA STR genotyping to be applied for criminal investigations, paternity testing, and evolutionary studies.
Fluorescence energy transfer-labeled primers for high-performance forensic DNA profiling
Yeung, Stephanie H. I.,Seo, Tae Seok,Crouse, Cecelia A.,Greenspoon, Susan A.,Chiesl, Thomas N.,Ban, Jeff D.,Mathies, Richard A. WILEY-VCH Verlag 2008 Electrophoresis Vol.29 No.11
<P>A fluorescence energy transfer (ET) dye-labeled STR typing system (ET 16-plex) is developed for the markers used in the commercial STR typing kit PowerPlex 16, and its performance assessed using a 96-lane microfabricated capillary array electrophoresis (μCAE) system. The ET 16-plex amplicons displayed 1.6–9-fold higher fluorescence intensities compared to those produced using the single-dye (SD)-labeled multiplex kits. The ET multiplex delivered full STR profiles from 62.5 pg of DNA; half the input required for the SD kits while maintaining a similar heterozygote allele balance. This increased sensitivity should improve typing of poor-quality DNA samples by making minor or imbalanced alleles more readily detectable at the low copy number (LCN) threshold. The ET 16-plex also generated complete profiles with only 28 PCR cycles; this capability should improve LCN typing by reducing the amplification time and drop-in allele incidence. To confirm the practical advantages of ET-labeled primers, six previously problematic casework samples were tested and only the ET 16-plex kit was able to capture additional allele data. The successful development and demonstration of ET primers for higher sensitivity STR typing offers a simple solution to improving current commercial multiplex typing capability. The superior spectral properties and universal compatibility with any primer sequence provided by ET cassettes will make future multiplex construction more facile and straightforward. The pairing of ET cassette technology with the μCAE system illustrates not only an enhanced STR typing platform, but a significant step toward a higher-efficiency forensic laboratory enabled by better chemistry and microfluidics.</P>
Controlled synthesis of mesoporous codoped titania nanoparticles and their photocatalytic activity
Mathis, John E.,Kidder, Michelle K.,Li, Yunchao,Zhang, Jinshui,Paranthaman, M.P. Techno-Press 2016 Advances in nano research Vol.4 No.3
The photocatalytic (PC) activity of anatase titania nanoparticles can be improved through codoping with transition metals and nitrogen. In addition, the PC activity can also be improved by creating monodisperse, mesoporous nanoparticles of titania. The question naturally arose as to whether combining these two characteristics would result in further improvement in the PC activity or not. Herein, we describe the synthesis and photocatalytic characteristics of codoped, monodisperse anatase titania. The transition metals tested in the polydisperse and the monodisperse forms were Mn, Co, Ni, and Cu. In each case, it was found that the monodisperse version had a higher PC activity compared to the corresponding polydisperse version.
Mathi Kannaiyan,Jinu GowthamiThankachi Raghuvaran,Karthikeyan Govindan,Elaya Perumal Annamalai 한양대학교 세라믹연구소 2020 Journal of Ceramic Processing Research Vol.21 No.1
In this present work, an attempt was made on optimising the Resistance Spot Welding (RSW) process parameters for joiningtwo dissimilar combinations of AISI 304 and AISI 1020 grade steel with each other. Experiments were conducted by varyingthe three weld process parameters such as welding current, pressure and welding time. The integrity of the weld joints wasevaluated mechanically and metallurgically. Tensile shear fracture, nugget diameter, and hardness properties were examined. Macrostructure, Microstructure, and Scanning Electron Microscopy (SEM) analysis were carried out on the tested samplesto validate the type of fracture occurred. Maximum nugget diameter and maximum tensile fracture of 6.666 mm and 10.5 kNwere achieved respectively. The experimental results confirmed the validity of the used Response Surface Methodology appliedfor optimising the welding process parameter in the RSW process. The Response Surface Methodology (RSM) results showthat the weld current is the most significant factor for Tensile Shear Fracture Load (TSFL) and nugget diameter, followed byweld pressure and time.
Mathi, Gangadhar Rao,Kang, Chung Hyo,Lee, Heung Kyoung,Achary, Raghavendra,Lee, Ha-Yeon,Lee, Joo-Youn,Ha, Jae Du,Ahn, Sunjoo,Park, Chi Hoon,Lee, Chong Ock,Hwang, Jong Yeon,Yun, Chang-Soo,Jung, Hee Jun Elsevier 2017 European journal of medicinal chemistry Vol.126 No.-
<P><B>Abstract</B></P> <P>The piperidine fragment in ceritinib was replaced with diverse aliphatic amines to improve inherent resistance issues of ceritinib. While most of the prepared compounds exhibit as similar in vitro activities as ceritinib, compound <B>10</B> shows encouraging activities against wild-type ALK as well as crizotinib-resistant mutants including extremely resistant G1202R mutant with an IC<SUB>50</SUB> of 1.8 nM. Furthermore, pharmacokinetic profiles of <B>10</B> is apparently better than that of ceritinib. In murine xenograft studies, compound <B>10</B> turns out to be as active as ceritinib, suggesting that further optimization of <B>10</B> may lead to clinical candidates overcoming ALK mutant issues.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The terminal piperidine in ceritinib was replaced with diverse alkyl amines. </LI> <LI> Most of the analogs were as active as crizotinib against ALK wild-type and L1196M mutant. </LI> <LI> Compound <B>10</B> has excellent ALK mutant activities including extremely resistant G1202R. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>