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( Wataru Ando ),( Hiroaki Yokomori ),( Nobuhiro Tsutsui ),( Eigoro Yamanouchi ),( Yutaka Suzuki ),( Masaya Oda ),( Yutaka Inagaki ),( Katsuya Otori ),( Isao Okazaki ) 대한간학회 2018 Clinical and Molecular Hepatology(대한간학회지) Vol.24 No.1
Background/Aims: Nonalcoholic steatohepatitis (NASH) is prevalent in both economically developed and developing countries. Twenty percent of NASH progresses to cirrhosis with/without hepatocellular carcinoma, and there is an urgent need to find biomarkers for early diagnosis and monitoring progression of the disease. Using immunohistochemical and immunoelectron microscopic examination we previously reported that expression of matrix metalloproteinase-1 (MMP- 1) increased in monocytes, Kupffer cells and hepatic stellate cells in early stage NASH. The present study investigated whether serum MMP-1 levels reflect disease activity and pharmaceutical effects in NASH patients. Methods: We measured the serum levels of MMPs, tissue inhibitors of metalloproteinases (TIMPs), and several cytokines/ chemokines in patients with histologically proven early and advanced stages of NASH and compared them with those in healthy controls. Results: Serum MMP-1 levels in stage 1 fibrosis, but not in the more advanced fibrosis stages, were significantly higher than in healthy controls (P=0.019). There was no correlation between serum MMP-1 level and fibrosis stage. Serum MMP- 1 levels in NASH patients represented disease activity estimated by serum aminotransferase values during the followup period. In contrast, MMP-2, MMP-9 and TIMPs did not change with disease activity. Consistent with the finding that MMP-1 is expressed predominantly in monocytes and Kupffer cells, serum levels of monocyte chemotactic protein-1 and granulocyte-colony stimulating factor were significantly increased in NASH with stage 1 fibrosis. Conclusions: These results suggest that serum MMP-1 levels represent disease activity and may serve as a potential biomarker for monitoring the progression of NASH. (Clin Mol Hepatol 2018;24:61-76)
Study on Evaluation in Service Engineering From the View of MONODZUKURI
Hiroshi Hashimoto,Masaya Ando,Katsutoshi Otsubo,Shintaro Ishijima 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
This paper considers the evaluation of several factors in Service Engineering from the view of MONOD-ZUKURI. First of all, the definition of the new trend technical term MONODZUKURI is considered in points of view from the several terms and the industrial site of Japan, and its factors are revealed. Next, by investigating the action ac-complishment of human internal, the difficulties of measuring the usability as the factors of Service Engineering is dis-cussed. Then, the admissible measurement method based on the bio-informatics is presented.