Significance of Strip Biopsy on the Therapy of Early Gastric Cancer

Tada, Masahiro 대한소화기내시경학회 1990 Clinical Endoscopy Vol.11 No.1

Screening for sarcopenia and obesity by measuring thigh muscle and fat thickness by ultrasound in patients with rheumatoid arthritis

Masahiro Tada,Yutaro Yamada,Koji Mandai,Noriaki Hidaka 대한골다공증학회 2021 Osteoporosis and Sarcopenia Vol.7 No.2

Objectives: Sarcopenia is relatively common in rheumatoid arthritis (RA) patients. Thicknesses of the quadriceps muscle and fat are easily measured by ultrasound (US) and are known to be related to skeletal muscle mass and fat mass, respectively. Methods: Eighty-four patients enrolled in the prospective correlation research of sarcopenia, skeletal muscle, and disease activity in rheumatoid arthritis study (UMIN000023744) underwent US examinations of anterior thigh muscle thickness (MT) and fat thickness (FT). Muscle and body fat (BF) mass were also examined by a body composition analyzer. Whether MT and FT were related to sarcopenia and obesity was examined. Results: MT was significantly lower in RA patients with sarcopenia than in those without (23.8 vs 28.2 mm, P = 0.001). MT was related to sarcopenia (men: r = 0.56, P = 0.02, women: r = 0.32, P = 0.01). The cut-off value of MT for sarcopenia was 24.7mm in men and 19.7 mm in women on receiver operating characteristic curve analyses. FT was correlated with BF percentage (%BF; men: r = 0.66, P < 0.01, women: r = 0.62, P < 0.001), which was estimated by 2.04xFTþ8.53 in men and 1.2xFTþ17.42 in women by a simple linear regression model. This means that FT ≥ 8.1 mm in men and FT ≥ 14.6 mm in women indicated obesity. Conclusions: US examination of the anterior thigh was useful to detect sarcopenia and obesity in RA patients.

Osteosarcopenia synergistically increases the risk of falls in patients with rheumatoid arthritis

Masahiro Tada,Yutaro Yamada,Koji Mandai,Yoshinari Matsumoto,Noriaki Hidaka 대한골다공증학회 2021 Osteoporosis and Sarcopenia Vol.7 No.4

Objectives: Osteosarcopenia is defined as osteoporosis with sarcopenia. The impacts of osteosarcopenia on falls and fractures in rheumatoid arthritis (RA) patients were investigated using 4 years of data from a longitudinal study (CHIKARA study). Methods: The patients were divided into 4 groups by their baseline status: no sarcopenia and no osteoporosis (SP-OP-); only sarcopenia (SP + OP-); only osteoporosis (SP-OP+); and both sarcopenia and osteoporosis (SP + OP+). Survival rates and Cox hazard ratios were analyzed using falls and fractures as endpoints, adjusted by age, sex, and body mass index. Results: A total of 100 RA patients (SP-OP-: 44%, SP + OP-: 17%, SP-OP+: 28%, and SP + OP+: 11%) were enrolled; 37 patients had falls, and 19 patients had fractures. The fall-free and fracture-free survival rates were significantly lower in SP + OP+ (36.4%, 54.5%) than in SP-OP- (75.0%, 86.4%). The hazard ratio of falls was significantly increased in SP + OP+, by 3.32-fold (95%CI: 1.01-10.9), whereas in SP + OP- and SP-OP+, there were no differences compared to SP-OP-. Conclusions: The survival rates with the endpoints of falls and fractures in RA patients with osteosarcopenia were lower during 4-year follow-up. The risk of falls increased with the synergistic effect of osteoporosis and sarcopenia.

Lifestyle and body composition changes in patients with rheumatoid arthritis during the COVID-19 pandemic: A retrospective, observational study

Masahiro Tada,Yutaro Yamada,Koji Mandai,Yoshinari Matsumoto,Noriaki Hidaka 대한골다공증학회 2023 Osteoporosis and Sarcopenia Vol.9 No.1

Objectives: Behavioral restrictions and staying at home during the COVID-19 pandemic have affected lifestyles. It was hypothesized that patients with rheumatoid arthritis (RA) decreased their activities of daily living (ADL) and exercise during the pandemic. The aim of this study is to investigate the changes in lifestyle and body composition. Methods: Data were obtained from an observational study (CHIKARA study). Of 100 RA patients, 70 (57 women, 13 men) were followed-up with measurements of grip strength, as well as muscle mass, fat mass, and basal metabolic rate by a body composition analyzer. Changes in ADL and exercise were evaluated using a visual analog scale. The relationships between changes in ADL or exercise and body composition were investigated. Results: Muscle mass and grip strength were significantly lower after behavioral restrictions compared to the periods before restrictions (34.0 vs 34.7 kg, P < 0.001; 16.2 vs 17.2 kg, P = 0.013, respectively). Fat mass was significantly greater after behavioral restrictions compared to the periods before restrictions (16.2 vs 15.5 kg, P = 0.014). The mean decrease in ADL was 44%, whereas that of exercise was 20%. The change in muscle mass (β = -0.335, P = 0.007) was the only independent factor for the change in exercise on multivariate analysis. Conclusions: Muscle mass and grip strength decreased and fat mass increased in RA patients with the behavioral restrictions of the COVID-19 pandemic. Muscle mass decreased in patients without exercise. Maintenance of muscle mass may be important during the COVID-19 pandemic.

乱流撹拌槽における羽根板面積が同じパドル翼の所要動力の差異

Kato, Yoshihito,Tada, Yutaka,Urano, Kunihiko,Hattori, Masahiro,Nagatsu, Yuichiro,Koh, Song-Tae,Lee, Young-Sei 社団法人 化学工学会 2010 化學工學論文集 Vol.36 No.1

<P>Numerous studies on power consumption in mixing vessels have been reported, and several power correlations have been developed for non-baffled mixing vessels, for example, Nagata's correlations. However, baffled mixing vessels with different impeller geometries have different power numbers. In this paper, the effects of vessel bottom shape, number of blades, and impeller position on power number were measured for several impellers with geometries that had been assumed to have the same power in Nagata's concept. It was found that power numbers in baffled vessels varied greatly with impeller geometry, while Nagata's concept is valid for non-baffled vessels, regardless of impeller position.</P>

HUMAN INTERFACE TO MULTIMEDIA DATABASE SYSTEMS

( Kazuhide Higuchi ),( Masahiro Tada ),( Akihiro Ogino ),( Ayumi Sato ),( Emi Yano ),( Hayato Kobayashi ),( Toshikazu Kato ) 한국감성과학회 2002 춘계학술대회 Vol.2002 No.-

To transmit users`` intentions that vary with each person, intuitive and bi-directional interactions between users and a computer are necessary. We considered these interactions by dividing them into two spaces, physical space and informational space. Informational space supports human thinking process by arranging and visualizing much information. Physical space reproduces the real world where various restrictions exist to virtual space. From the viewpoint of three aspects - contents model, kansei model and context model - we defmed the style of the interaction between user and multimedia database. In this paper, for the purpose of examining the way to realize the interaction based on these models, we developed interior design coordination support system and garden coordination system, and then evaluated them.

Suppressive Effects of Mesenchymal Stem Cells in Adipose Tissue on Allergic Contact Dermatitis

( Sota Kikuchi ),( Koichi Yanaba ),( Yoshimasa Nobeyama ),( Shigeharu Yabe ),( Masahiro Kiso ),( Hidehisa Saeki ),( Yayoi Tada ),( Hidemi Nakagawa ),( Hitoshi Okochi ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.4

Background: Allergic contact dermatitis (ACD), which is ac-celerated by interferon (IFN)-γ and suppressed by inter-leukin (IL)-10 as regulators, is generally self-limited after re-moval of the contact allergen. Adipose tissue-derived multi-potent mesenchymal stem cells (ASCs) potentially exert im-munomodulatory effects. Considering that subcutaneous adipose tissue is located close to the site of ACD and includes mesenchymal stem cells (MSCs), the MSCs in adipose tissue could contribute to the self-limiting course of ACD. Objective: The aims of the present study were to elucidate the effects of MSCs in adipose tissue on ACD and to examine any cyto-kine- mediated mechanisms involved. Methods: Ear thick-ness in a C57BL/6 mouse model of ACD using contact hyper-sensitivity (CHS) elicited by 2,4,6-trinitro-1-chlorobenzene was evaluated as a marker of inflammation level. Five and nine mice were injected with ASCs and phosphate-buffered saline (PBS), respectively. After ASC or PBS injection, re-al- time reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay were performed. Results: Histology showed that CHS was self-limited and ear thickness was suppressed by ASCs in a dose-dependent manner. IFN-γ expression in the elicited skin site and re-gional lymph nodes was significantly lower in ASC-treated mice than in control mice. IL-10 expression did not differ be-tween treated and control mice. The suppressive effects of ASCs on CHS response did not differ between IL-10 knock-out C57BL/6 mice and wild-type mice. Conclusion: The present findings suggest that MSCs in adipose tissue may contribute to the self-limiting course of ACD through de-creased expression of IFN-γ, but not through increased ex-pression of IL-10. (Ann Dermatol 29(4) 391∼399, 2017)