Successful Treatment of Genital Warts with Ingenol Mebutate Monitored with Optical Coherence Tomography and Reflectance Confocal Microscopy

( Markus Reinholz ),( Benjamin M. Clanner-engelshofen ),( Markus V. Heppt,Yoji Hirai1 ),( Thomas Ruzicka ),( Carola Berking ),( Tanja Von Braunmuhl ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.4

Ingenol mebutate (IM) is approved for the treatment of actinic keratosis and induces cell death in precancerous lesions. The efficacy of IM in the treatment of genital warts was investigated in a therapy-refractory patient. The 74-year-old male was treated with IM gel for three consecutive days. Treatment course and efficacy were evaluated by clinical inspection and non-invasive diagnostics namely optical coherence tomography (OCT) and reflectance confocal microscopy (RCM). Within 24 to 48 hours IM induced a strong local inflammatory reaction. One week later a complete response was observed. OCT and RCM showed a strong reaction after treatment with erosions, swelling of cells, and a subepidermal dark band in representative lesions. IM has the advantage of a short treatment period in contrast to other topical treatments and shows a promising clinical outcome. Larger studies are needed to validate the data. (Ann Dermatol 31(4) 434∼437, 2019)

Experimental studies of control concepts for a parallel manipulator with flexible links

Markus Burkhardt,Robert Seifried,Peter Eberhard 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.7

Control of flexible multibody systems, such as flexible manipulators, is a challenging task. This is especially true if end-effector trajectorytracking is aspired. On the one hand, these systems require a large number of generalized coordinates to describe their dynamicalbehavior accurately. On the other hand, only a small subset of these values can be measured or reconstructed on-the-fly. Hence, it is difficult,if not nearly impossible, to use a state controller. In addition, flexible systems are underactuated, i.e. they possess less control inputsthan generalized coordinates. In case of a non-collocated output controller, which is the case for end-effector trajectory tracking, theclosed loop of the system might lose passivity and is non-minimum phase. In order to achieve end-effector trajectory tracking, exact andapproximate feed-forward controls can be applied. In this work, two different versions of such concepts are compared experimentally. These model-based concepts are computed off-line and they supply, next to the required input values, a C1-continuous solution of thecomplete state vector which can be used for feedback control. If the system is non-minimum phase, a two-sided boundary value problemhas to be solved and the solution includes a pre-actuation as well as a post-actuation phase. While the exact method incorporates all dynamicaleffects of the flexible multibody system, the approximate concepts neglect certain implications, for example the dynamical effectsdue to the flexibility. In addition to the presentation of the theoretical basics of the control approaches and the underlying models,this contribution addresses some of the crucial obstacles, which have to be overcome for the operation of the test bench, e.g., signal conditioning,state reconstruction and friction compensation. Since the installed sensors do not allow the direct measurement of the endeffectorposition, image tracking is used to judge the quality of the different control approaches.

HOW DO MANAGERS USE MARKETING AND FINANCIAL METRICS IN THE CONTEXT OF MARKETING MIX DECISION MAKING?

Markus Lamest,Mairead Brady 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7

The amount of data in companies today in terms of volume, velocity and variety is unique in the history of business. Despite on-going calls for more accountability of the marketing function, there is a lack of studies that examine the role of metrics in order to interpret this data. This study focuses on how marketing metrics and financial metrics are used within organizations to both quantify and to explore data relevant for marketing mix decision-making. An analysis of primary data from six case studies and 29 marketing mix decisions promises to provide a rich understanding of the activities and metrics that are used to trigger and inform managerial decision-making. The aim is to contribute to the body of knowledge on metrics use with the aim of improving managerial decision-making, marketing mix performance and the standing of the marketing function in the firm.

율법과 질서에 대한 바울의 이해(1)

Markus Barth 한신대학교 신학사상연구소 1974 신학사상 Vol.6 No.-

A New “Spirit” of Capitalism? - Globalization and its Impact on the Diffusion of Neoliberal Management Thinking in Germany and the East Asian Economies

Markus Pohlmann,임현진 서울대학교 사회발전연구소 2014 Journal of Asian Sociology Vol.43 No.1

Mainstream globalization literature is quite clear in its assumptions of howglobalization affects industrial enterprise. It is presumed to give rise to transnationalcompanies and subsequently, to a transnational class of managers, who use neoliberalmanagement thinking to accelerate the neoliberal transformation of the economy. Thearticle puts these engrained assumptions to strong empirical test by analysing howtransnational the life courses of 475 CEOs of the Top 100 industrial company groups inGermany as well as in Korea, Japan, and China are. Furthermore, having carried out 148in-depth interviews with Top CEOs, the article asks if in fact a neoliberal spirit ofcapitalism is at work. The findings indicate that neoliberal management thinking is notemerging and that top managers are not the switchmen leading towards a financialmarket-driven economy. Although neoliberal management thinking has had some impacton German top managers, the various business systems in East Asia indicate thedominance of more indigenous cultural frames.

CORPORATE BRAND POSTS ON FACEBOOK THE ROLE OF INTERACTIVITY, VIVIDNESS, AND INVOLVEMENT

Markus Kick 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7

By means of a field experiment, corporate brand posts on Facebook are analyzed regarding their effect on brand fans’ post recall capability, attitude toward the brand, and purchase intention. Results indicate that Facebook brand posts are able to positively influence fans’ attitude toward the brand. A significant interaction effect between the level of product involvement and the degree of brand posts’ interactivity and vividness is found. Implications for marketing research and practitioners are discussed.

Intracellular synthesis of gold nanoparticles with antioxidant activity by probiotic <i>Lactobacillus kimchicus</i> DCY51^T isolated from Korean kimchi

Markus, Josua,Mathiyalagan, Ramya,Kim, Yeon-Ju,Abbai, Ragavendran,Singh, Priyanka,Ahn, Sungeun,Perez, Zuly Elizabeth Jimenez,Hurh, Joon,Yang, Deok Chun Elsevier 2016 Enzyme and microbial technology Vol.95 No.-

<P>A straightforward synthesis of gold nanoparticles (AuNps) is achieved by novel probiotic Lactobacillus kimchicus DCY51(T) isolated from Korean kimchi via an intracellular membrane-bound mechanism. The bioreduction of HAuCI4 into AuNps was verified by ultraviolet-visible spectrophotometry at similar to 540 nm. AuNps were spherical with varying sizes of 5-30nm. AuNps maintained an average crystallite size of 13 nm and demonstrated long-term stability in physiological buffer and biological media. Furthermore, the protective capping layer consisted of amino acid residues and surface-bound proteins rendered them non-toxic to murine macrophage (RAW264.7) and human colorectal adenocarcinoma (HT29) cell lines. Finally, biosynthesized AuNps served as superior free radical scavengers against 2,2-diphenyl1-picrylhydrazyl (DPPH) in contrast to their corresponding gold salt. In short, this green synthesis is cost-effective and advantageous for the development of a new class of probiotics mediated and nontoxic carriers in targeted drug delivery systems, cancer diagnostic, photothermal therapy, biosensing, and medical imaging. (C) 2016 Elsevier Inc. All rights reserved.</P>

DESTINATION BRAND EQUITY OF SWITZERLAND TOURISM AS PERCEIVED BY CANTONESE TOURISTS IN CHINA

Markus Schuckert,Seongseop Kim,Hyungjung Im 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.3

The branding concept has been burgeoning from product branding and extending to service, corporate, and further nation branding (Papadopoulous & Heslop, 2002). The concept found in the tourism literature has been mostly adapted to a tourism destination (e.g., Gartner & Konecnik Ruzzier, 2011; Im, Kim, Elliot & Han, 2012). However, unlike characteristics of a manufactured product, a tourism destination has difficulties in terms of definition, measurement, and conceptualization (Murphy, Moscardo & Benckendorff, 2007). As a consequence, there has been a shortage of empirical research relating to the application of the branding concept to tourism destination management organizations spanning from national to local tourism organizations (Blain, Levy & Ritchie, 2005; Pike, 2010). To understand tourism destination branding, recently, studies have been conducted in the context of destination branding as a part of destination marketing strategy (Morgan, Prichard & Pride, 2001), brand identity and personality (Morgan et al., 2001; Murphy, Moscardo & Benckendorff, 2007), and brand logos and slogans (Blain et al., 2005; Hem & Iversen, 2004). The concept of the destination brand equity will be applied to Hong Kong tourists who are traveling to Switzerland. Switzerland is becoming a hot spot for Chinese long-haul trips following European destinations like UK, France, or Italy. Since a decade the core countries of the European Alps Switzerland concentrates more specifically on the Chinese market and with a time lag of a few years the overnight stays have started growing (Schmid, 2012). Since 2008 the overnight stays of Chinese touristsindicated a double- digit jump over the last five years and resulted in an accumulated growth rate of 246.9 percent, that is, the overnight stays per year climbed from 214,000 (2008) to 744,000 (2012) (BFS, 2009 & 2013). The Swiss Tourism Board estimated 2 million overnight stays from China in 2020. In this case China would overturn the neighboring country Italy as one of the key source markets for Switzerland (Schmid, 2012). The high increase in Chinese tourists led to marketing efforts of Switzerland Tourism and the Swiss Hotel Association hotelleriesuisse with their initiative “Hallo China” (Switzerland Tourism, 2004). At first, the main purpose of this study is to conceptualize destination brand equity. Second, it is to propose a destination brand equity model. Third, it is to test the model using a sample of Hong Kong tourists who travel to Switzerland. Fourth, it is to investigate characteristics of tourism products preferred by Hong Kong tourists. Fifth, it is to explore how their preferences for tourism products are different according to their travel-related or demographic variables. This study expects those outcomes and benefits. Frist, components consisting of destination brand equity model and conceptual model will be generated. Second, brand equity of Switzerland as perceived by Hong Kong tourists will be tested. Third, better understanding of Hong Kong tourists regarding their perception of Swiss image, level of awareness, overall quality, loyalty, and overall brand equity will be facilitated. Fourth, most previous studies focused only on preference, behavior or attitudes of Hong Kong tourists who travel in a short-haul distance. On the contrary, this study attempts to understand Hong Kong tourists to a long-haul tourism destination, here Europe. Fifth, according to specialization theory, more specialized tourists tend to select more far-way and more risky destination because their knowledge is growing and a range of their selection is diverse. In an increasing future trend in demand of overseas Chinese tourists, this study attempts to identify long-haul Hong Kong tourists’ preference, attitude or behavior in Europe.

Identification and Characterization of CMTM4, a Novel Gene with Inhibitory Effects on HeLa Cell Growth through Inducing G2/M Phase Accumulation

Markus Plate,Ting Li,Yu Wang,Xiaoning Mo,Yingmei Zhang,Dalong Ma,Wenling Han 한국분자세포생물학회 2010 Molecules and cells Vol.29 No.4

Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 could be detected. CMTM4-v2 is the full length cDNA product, which has been highly conserved during evolution. CMTM4-v1 and -v2 are broadly ex-pressed in normal types of tissue. They are distributed on the cell membrane and across the cytoplasm in a speckled pattern. Overexpression of CMTM4-v1 and -v2 can inhibit HeLa cell growth via G2/M phase accumulation without inducing apoptosis. Therefore, CMTM4 might be an impor-tant gene involved in cell growth and cell cycle regulation.

TAILORED SOLUTIONS FOR FUEL EFFICIENT POWERTRAINS FUTURE TECHNOLOGIES AND AND DEVELOPMENT PROCEDURES

Markus Schonen 한국자동차공학회 2017 한국자동차공학회 Workshop Vol.2017 No.08