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Singariya Geeta,Malhotra Namita,Kamal Manoj,Jaju Rishabh,Aggarwal Shruti,Bihani Pooja 대한마취통증의학회 2022 Anesthesia and pain medicine Vol.17 No.2
Background: Allaying anxiety and providing calm children in the operating room is a challenging task for anesthesiologists. This study was designed to compare the use of nebulized dexmedetomidine and ketamine for premedication in pediatric patients under general anesthesia.Methods: Seventy patients, aged 2 to 8 years of both sexes, with American Society of Anesthesiologists physical status I/II scheduled for hernia repair surgery under general anesthesia, were randomized to two equal groups using a computer-generated random number table. Patients in group D received dexmedetomidine (2 µg/kg), and patients in group K received ketamine (2 mg/kg) by a jet nebulizer before the induction of anesthesia. The primary objective of the study was the level of sedation achieved at 30 min using the Ramsay sedation scale, and the secondary objectives were parental separation anxiety score, acceptance of the mask, hemodynamic variables, recovery time, incidence of emergence agitation, and adverse events. Results: Seventy patients were randomly divided into two equal groups and analyzed. The median Ramsay sedation score at 30 min was 3 (1–4) in group D and 3 (1–3) in group K (P = 0.002). Patients in group D had a more acceptable parental separation anxiety scale (P = 0.001) and a satisfactory mask acceptance scale (P = 0.042). Conclusions: Nebulized dexmedetomidine (2 µg/kg) provided better sedation along with smooth parental separation and satisfactory mask acceptance during induction of anesthesia with a similar emergence agitation profile and adverse reactions compared to nebulized ketamine.
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Neck dissection for oral squamous cell carcinoma: our experience and a review of the literature
Pooja Rani,Yogesh Bhardwaj,Praveen Kumar Dass,Manoj Gupta,Divye Malhotra,Narottam Kumar Ghezta 대한구강악안면외과학회 2015 대한구강악안면외과학회지 Vol.41 No.6
Objectives: This article describes our experience with neck dissection in 10 patients with oral squamous cell carcinoma. Materials and Methods: Between January 2007 and October 2009, 10 patients underwent primary surgery for the treatment of squamous cell carcinoma of the oral cavity. For patients with N 0 disease on clinical exam, selective neck dissection (SND [I-III]) was performed. In patients with palpable cervical metastases (N+), modified radical neck dissections were performed, except in one patient in whom SND (I-III) was performed. The histopath- ologic reports were reviewed to assess the surgical margins, the presence of extra-capsular spread, perineural invasion, and lymphatic invasion. Results: On histopathologic examination, positive soft tissue margins were found in three patients, and regional lymph node metastases were present in five of the ten patients. Perineural invasion was noted in five patients, and extra nodal spread was found in four patients. Regional recurrence was seen in two patients and loco-regional recurrence plus distant metastasis to the tibia was observed in one patient. During the study period, three patients died. Seven patients remain free of disease to date. Conclusion: Histopathological evaluation provides important and reliable information for disease staging, treatment planning, and prognosis. The philosophy of neck dissection is evolving rapidly with regard to the selectivity with which at-risk lymph node groups are removed. The sample size in the present study is small, thus, caution should be employed when interpreting these results.
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Preparation, characterization and application of polyaniline nanospheres to biosensing
Dhand, Chetna,Das, Maumita,Sumana, Gajjala,Srivastava, Avanish Kumar,Pandey, Manoj Kumar,Kim, Cheol Gi,Datta, Monika,Malhotra, Bansi Dhar Royal Society of Chemistry 2010 Nanoscale Vol.2 No.5
<P>Polyaniline nanospheres (PANI-NS) prepared by morphological transformation of micelle polymerized camphorsulfonic acid (CSA) doped polyaniline nanotubes (PANI-NT) in the presence of ethylene glycol (EG) have been characterized by X-ray diffraction, atomic force microscopy, transmission electron microscopy, scanning electron microscopy, Fourier transform infra-red and UV-Visible spectroscopy. A PANI-NS (60–80 nm) film deposited onto an indium-tin-oxide (ITO) coated glass plate by the solution casting method has been utilized for covalent immobilization of biomolecules (cholesterol oxidase (ChOx)) <I>via</I><I>N</I>-ethyl-<I>N</I>′-(3-dimethylaminopropyl) carbodiimide (EDC) and <I>N</I>-hydroxysuccinimide (NHS) chemistry for fabrication of a cholesterol biosensor. The ChOx/PANI-NS/ITO bioelectrode detects cholesterol in the concentration range of 25 to 500 mg dL<SUP>−1</SUP> with sensitivity of 1.3 × 10<SUP>−3</SUP> mA mg<SUP>−1</SUP> dL and regression coefficient of 0.98. Further, this PANI-NS based bioelectrode shows fast response time (10 s), low Michaelis–Menten constant (2.5 mM) and shelf-life of 12 weeks. The spherical nanostructure observed in the final morphology of the PANI-NS film is attributed to hydrogen bonding interactions between PANI-NT and EG.</P> <P>Graphic Abstract</P><P>Morphological transformation of CSA-PANI nanotubes to nanospheres in EG <I>via</I> solvation energy generated from hydrogen bonding interactions. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b9nr00346k'> </P>
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