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명정구,조선형,박정호,백상규,김종만,강필선 한국어류학회 2003 韓國魚類學會誌 Vol.15 No.3
1. 2002년 10월 16∼17일에 스쿠버다이빙, 수중 촬영을 통하여 전라남도 신안군 가거도 주변 가을철 연안의 어류상을 조사한 결과 총 5목 23과 40종이 확인되었고, 지금까지 기재 된 어종 이외에 18종이 추가로 확인되었다. 2. 어종 구성으로 보면 양볼락과가 7종으로 가장 많았으며, 그 다음으로 둑중개과가 4종, 자리돔과가 3종 순이었다. 3. 가거도 주변에서 지금까지 확인된 어종들은 온대성 어종이 대부분이었지만, 그 외에 노랑자리돔, 청황베도라치 및 파랑돔 등 난류성 또는 아열대 어종이 확인되어 제주도나 독도와 마찬가지로 대마난류의 영향도 받고 있음을 나타내었다. The fish fauna in the coastal waters of Gageodo Island, South-west Sea, was investigated by SCUBA diving in October 16 and 17, 2002. The fishes observed were classified into 40 species in 23 families. In Autumn, subtropical fishes in such as families as Pomacentridae, Pomacanthidae and Apogonidae, represented 12.5% of the total, while eurythermal species represented 72.5%.
Paik, Man-Jeong,Kim, Kyoung-Rae The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.5
An efficient analytical method was devised for the accurate L-muscone assay in aqueous samples. It involves solid-phase extraction of L-muscone in adsorption mode using XAD-4 as the sorbent and dichloromethane modified with 10% (v/v) methanol as the eluting solvent. The gas chromatographic analysis of the eluate residue dissolved in toluene on a DB-5MS capillary column provided complete resolution of L-muscone from the co-extracted interferences. The overall method showed excellent linearity ($r^2{\geq}$ 0.9994) in the range of 0.1 to 2.0 $\mu\textrm{g}$/mL with good intra- and inter-day precisions (% RSD = 2.5~7.3) and with high extraction recovery rates ($\geq$ 98.1 %). When the present method was applied to a L-muscone herbal drink product, the within-batch RE (%) in the labeled concentration (1.5 $\mu\textrm{g}$/mL) for the three randomly chosen bottles were -2.4, -1.3 and -3.3 with high precision (% RSD $\leq$ 3.1). The present method is considered to be suitable for quality control evaluation on liquid drinks and other complex formulations fortified with L-muscone.
Paik, Man-Jeong,Nguyen, Duc-Toan,Kim , Kyoung-Rae The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.12
The enantiomeric composition tests on flurbiprofen and ketoprofen present in patch products and in urine excretions following patch applications were performed as diastereomeric (R)-(+)- 1-phenylethylamides by achiral gas chromatography and by gas chromatography-mass spectrometry in selected ion monitoring mode. The method for determination of (R)- and (S)-enantiomers in the range from 0.1 to 5.0 ${\mu}$g was linear (r ${\ge}$ 0.9996) with acceptable precision (% RSD ${\le}$5.2) and accuracy (% RE = 0.6 ~ -2.4). The enantiomeric compositions of flurbiprofen in one patch product and of ketoprofen in five different products were identified to be racemic with relatively good precision (${\le}$ 6.4%). The urinary excretion level of (R)-flurbiprofen was two times higher than its antipode, while the comparable excretion levels of (R)- and (S)-enantiomers for ketoprofen were observed.
Optical Purity Determination of (S)-Ibuprofen in Tablets by Achiral Gas Chromatography
Paik, Man-Jeong,Kim, Kyoung-Rae The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.8
An optical purity test was indirectly performed on (S)-ibuprofen as its diastereomeric (R)-(+)-1-phenylethylamide derivative using achiral gas chromatography (GC). The method for the determination of trace (R)-ibuprofen (optical impurity), within the range 1.0 to 50 ng, from a racemic ibuprofen standard was linear (r=0.9997) with acceptable precision (% $RSD{\leq}5.3$) and accuracy (% RE=0.7~-3.9). Similar results were obtained with the method validation for the quantification of (S)-ibuprofen within the range 0.1 to 2.0 $\mu\textrm{g}$ using a (S)-ibuprofen stan-dard. When applied to seven different commercial (S)-ibuprofen products, their optical purities (98.7~99.1%) were determined with good precision (% $RSD{\leq}4.0$).
Man-Jeong Paik,Gwang Lee,Kyoung-Rae Kim,Han Seung Chae,Jaehwan Yoon,Duc-Toan Nguyen,Pyung Cheon Lee 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.7
The enantiomeric separation of lactic acid for its absolute configuration has become important task for understanding its biological origin and metabolic process involved in the formation of lactic acid. It involves the conversion of enantiomers as diastereomeric O-pentafluoropropionylated (S)-(+)-3-methyl-2-butyl ester and the direct separation by gas chromatography-mass spectrometry on a achiral capillary column. The (R)-and (S)-lactic acids were completely separated with a high resolution of 1.9. The newly developed method showed good linearity (r ≥ 0.999), precision (% relative standard deviation = 3.4-6.2), and accuracy (% relative error = −7.7-1.4) with the detection limit of 0.011 μg/mL. When the method was applied to determine the absolute configuration of lactic acid in Lactobacillus delbrueckii subsp. lactis 304 (LAB 304), the composition (%) of (R)-lactic acid in the cell pellet and in the culture medium were 89.0 ± 0.1 and 78.2 ± 0.4, respectively. Thus, it was verified that the present method is useful for the identification and composition test of lactic enantiomers in microorganisms.
Altered Amino Acid Metabolic Patterns in the Plasma of Rat Models with Adenovirus Infection
Man Jeong Paik,,최상돈,Jeom Soon Shim,Sun A Kim,Kyoung-Rae Kim,김동완,Yeon Mi Kim,Seung Min Moon,심우영,이광 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.5
The presence of replication-competent adenovirus (RCA) subpopulations in adenoviral vector products raises a variety of safety issues for development of therapies based on gene therapy. To analyze the differing effects of adenoviral vector and RCA in vivo, we examined alterations in amino acids (AAs) using rat plasma following injection of β-galactosidase expressing recombinant adenovirus (designated rAdLacZ) or RCA. Plasma AAs were examined by gas chromatography-mass spectrometry. A total of 16 AAs were positively measured. In the rAdLacZ group compared to the control group, the level of aspartic acid was significantly increased (Student's t-test), while the level of glutamic acid was significantly reduced. Additionally, in the RCA group compared to the control group, the level of four AAs, valine, leucine, and isoleucine as branched-chain amino acids, and proline were significantly increased, whereas the levels of three AAs, glycine, threonine, and glutamic acid were significantly reduced. Altered plasma free AA metabolic patterns in rAdLacZ and RCA groups, compared with the control group, may explain the disturbance of AA metabolism related to viral infection.
Man-Jeong Paik,Duc-Toan Nguyen,Jaehwan Yoon,In-Seon Cho,심우영,Kyoung-Rae Kim,조기홍,Sangdun Choi,Gwang Lee 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.3
A new analytical method for measurement of 3,4-dihydroxyphenylalanine (DOPA) in human urine was developed. DOPA from an aqueous solution was converted into an ethoxycarbonyl (EOC) derivative. A tertbutyldimethylsilyl (TBDMS) reaction under anhydrous conditions was then attempted for analysis by gas chromatography-mass spectrometry in selected ion monitoring mode. A new mass spectral data on DOPA as a tri-EOC/mono-TBDMS derivative was built. This method showed good linearity (r ≥ 0.999), precision (%relative standard deviation = 3.1-9.2), and accuracy (% relative error = −7.2-8.8), with a detection limit of 0.05ng/mL. This selective and accurate method of DOPA analysis will be useful for biochemical monitoring of various neurological disorders including Parkinson’s disease in biological fluids.
Paik, Man-Jeong,Nguyen, Duc-Toan,Yoon, Jae-Hwan,Cho, In-Seon,Shim, Woo-Young,Kim, Kyoung-Rae,Cho, Ki-Hong,Choi, Sang-Dun,Lee, Gwang Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.3
A new analytical method for measurement of 3,4-dihydroxyphenylalanine (DOPA) in human urine was developed. DOPA from an aqueous solution was converted into an ethoxycarbonyl (EOC) derivative. A tertbutyldimethylsilyl (TBDMS) reaction under anhydrous conditions was then attempted for analysis by gas chromatography-mass spectrometry in selected ion monitoring mode. A new mass spectral data on DOPA as a tri-EOC/mono-TBDMS derivative was built. This method showed good linearity (r ${\geq}$ 0.999), precision (% relative standard deviation = 3.1-9.2), and accuracy (% relative error = -7.2-8.8), with a detection limit of 0.05 ng/mL. This selective and accurate method of DOPA analysis will be useful for biochemical monitoring of various neurological disorders including Parkinson's disease in biological fluids.