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        Dielectric spectroscopy investigation of relaxation processes in the low-frequency regime and validity of the Stokes–Einstein–Nernst/Stokes–Einstein–Debye relation in poly(propylene glycol)

        Lokendra P. Singh,Gagan Sharma 한국고분자학회 2023 Macromolecular Research Vol.31 No.1

        Relaxation processes over the static permittivity frequency region present in poly(propylene glycol) [PPG] of average molecular weights Mn = 425 and 725 have been investigated in the temperature range (285–320 K) and frequency range (1 Hz–1 MHz) using broadband dielectric spectroscopy. The data have been compared in the form of complex dielectric permittivity (ε*), electric modulus (M*), conductance (σ*), and impedance (Z*) spectra of PPG. From the comparative analysis of the spectra of all the complex quantities, the temperature-dependent relaxation processes caused by the presence of electrode polarization and ionic conduction effects were explored. The temperature dependence of various dielectric parameters such as dc conductivity (σdc), relaxation time due to electrode polarization (τEP), conductivity relaxation time (τσ), and their activation energies have been critically examined. It was observed that the dependence of dc conductivity (σdc) on the viscosity (η) or structural relaxation time (τα) of both PPGs satisfies the Stokes–Einstein–Nernst/Stokes–Einstein–Debye quite well. This behavior is similar to those reported in lithium percolate (LiClO4) electrolyte solutions in PPG solvents. This demonstrates that the electrical conduction behavior of unknown ions impurities existing in pure PPG and extremely low known concentration added ions in pure PPG is the same.

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        Acupressure as an Adjunct to Pharmacological Treatment for Depression, Anxiety, and Stress in Patients with Knee Osteoarthritis

        Meenu Rani,Lokendra Sharma,Uma Advani,Susheel Kumar 사단법인약침학회 2020 Journal of Acupuncture & Meridian Studies Vol.13 No.4

        Background: Osteoarthritis is the most common type of arthritis. Depression, anxiety, and stress are associated with knee osteoarthritis. Objectives: The aim of the study was to check the effectiveness of acupressure therapy with pharmacological treatment on pain, depression, anxiety, and stress in patients with knee osteoarthritis and to assess the effect of pain improvement on psychological health. Methods: Eligible 212 patients with knee osteoarthritis were divided into two groups (intervention and control group). The intervention group (n = 106) received acupressure therapy in combination with pharmacological treatment, whereas the control group (n = 106) continued pharmacological treatment only. Pain and psychological symptoms were measured using the visual analog scale and Depression Anxiety Stress Scale-21. Pearson's correlation was used to check the effect of pain improvement on psychological health. Results: Patients of both groups reported severe pain initially. On analyzing the results after completion of the study, it was found that patients in the intervention group scored better on the pain scale (p < 0.001) and DASS-21 (p ≤ 0.0001). However, it may be noted that reduction in the DASS-21 score was not found to be significant for the control group (p = 0.08). Pearson's correlation coefficients value ranged from 0.231 to 0.412 for DASS-21 (p < 0.05). Conclusions: On analysis, it can be concluded that acupressure can be used as add-on therapy in combination with conventional treatment (pharmacological treatment), which may assist in pain reduction. The reduction in pain directly contributes to improvement in the physiological wellness among patients with knee osteoarthritis.

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