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Wang Xianyao,Wang Huizhen,Lu Junhou,Feng Zhanhui,Liu Zhongshan,Song Hailiang,Wang Heng,Zhou Yanhua,Xu Jianwei 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.5
BACKGROUND: Mesenchymal stem cell (MSC)-based cell transplantation is an effective means of treating chronic liver injury, fibrosis and end-stage liver disease. However, extensive studies have found that only a small number of transplanted cells migrate to the site of injury or lesion, and repair efficacy is very limited. METHODS: Bone marrow-derived MSCs (BM-MSCs) were generated that overexpressed the erythropoietin (EPO) gene using a lentivirus. Cell Counting Kit-8 was used to detect the viability of BM-MSCs after overexpressing EPO. Cell migration and apoptosis were verified using Boyden chamber and flow cytometry, respectively. Finally, the anti-fibrosis efficacy of EPO-MSCs was evaluated in vivo using immunohistochemical analysis. RESULTS: EPO overexpression promoted cell viability and migration of BM-MSCs without inducing apoptosis, and EPO-MSC treatment significantly alleviated liver fibrosis in a carbon tetrachloride (CCl4) induced mouse liver fibrosis model. CONCLUSION: EPO-MSCs enhance anti-fibrotic efficacy, with higher cell viability and stronger migration ability compared with treatment with BM-MSCs only. These findings support improving the efficiency of MSCs transplantation as a potential therapeutic strategy for liver fibrosis.
Windproof ability of aerodynamic measures to improve the wind environment above a truss girder
Zewen Wang,Haojun Tang,Yongle Li,Junjie Guo,Zhanhui Liu 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.32 No.5
Aerodynamic measures have been widely used for improving the flutter stability of long-span bridges, and this paper focuses their windproof ability to improve the wind environment for vehicles. The whole wind environment around a long-span bridge located in high altitude mountainous areas is first studied. The local wind environment above the deck is then focused by two perspectives. One is the windproof effects of aerodynamic measures, and the other is whether the bridge with aerodynamic measures meets the requirement of flutter stability after installing extra wind barriers in the future. Furthermore, the effects of different wind barriers are analyzed. Results show that aerodynamic measures exert potential effects on the local wind environment, as the vertical stabilizer obviously reduces wind velocities behind it while the closed central slot has limited effects. The suggested aerodynamic measures have the ability to offset the adverse effect of the wind barrier on the flutter stability of the bridge. Behind the wind barrier, wind velocities decrease in general, but in some places incoming flow has to pass through the deck with higher velocities due to the increase in blockage ratio. Further comparison shows that the wind barrier with four bars is optimal.