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- 저자 : Lingmin Zhang (검색결과 3 건)
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Renyu Zhang,Can Li,Shuai Zhang,Lingmin Kong,Zekun Liu,Yixiao Guo,Ying Sun,Cong Zhang,Yule Yong,Jianjun Lv,Meng Lu,Man Liu,Dong Wu,Tianjiao Zhang,Haijiao Yang,Ding Wei,Zhinan Chen,Huijie Bian 대한간학회 2024 Clinical and Molecular Hepatology(대한간학회지) Vol.30 No.4
Background/Aims: Ubiquitination is widely involved in the progression of hepatocellular carcinoma (HCC) by regulating various cellular processes. However, systematic strategies for screening core ubiquitin-related genes, clarifying their functions and mechanisms, and ultimately developing potential therapeutics for patients with HCC are still lacking. Methods: Cox and LASSO regression analyses were performed to construct a ubiquitin-related gene prediction model for HCC. Loss- and gain-of-function studies, transcriptomic and metabolomics analysis were used to explore the function and mechanism of UBE2S on HCC cell glycolysis and growth. Results: Based on 1,423 ubiquitin-related genes, a four-gene signature was successfully constructed to evaluate the prognosis of patients with HCC. UBE2S was identified in this signature with the potential to predict the survival of patients with HCC. E2F2 transcriptionally upregulated UBE2S expression by directly binding to its promoter. UBE2S positively regulated glycolysis in a HIF-1α-dependent manner, thus promoting the proliferation of HCC cells. Mechanistically, UBE2S enhanced K11-linkage polyubiquitination at lysine residues 171 and 196 of VHL independent of E3 ligase, thereby indirectly stabilizing HIF-1α protein levels by mediating the degradation of VHL by the proteasome. In particular, the combination of cephalomannine, a small molecule compound that inhibits the expression of UBE2S, and PX-478, an inhibitor of HIF-1α, significantly improved the anti-tumor efficacy. Conclusions: UBE2S is identified as a key biomarker in HCC among the thousands of ubiquitin-related genes and promotes glycolysis by E3 enzyme-independent ubiquitination, thus serving as a therapeutic target for the treatment of HCC.
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Consensus Tracking for Teleoperating Cyber-physical System
Lingmin Zhang,Jing Yan,Xian Yang,Xiao-yuan Luo,Fuxiao Tan,Xinbin Li 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.3
In this paper, we investigate the consensus tracking problem for teleoperating cyber-physical system (TCPS) under time-varying delay and actuator saturation constraints. Due to the introduction of communication network, variable propagation time delays are considered in cyber element. In addition, actuator saturation problem is investigated in physical element, which is caused by the physical restrictions on robots. Then, a novel distributed consensus tracking controller is proposed in the presence of time-varying delay and actuator saturation. Meanwhile, sufficient conditions are provided to show that the consensus tracking controller can stabilize the master-slave TCPS. Finally, simulations and experiments are performed to validate our proposed results. It is shown that the consensus controllers can guarantee the asymptotic stability of single-master-multi-slave TCPS.
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JianYan Huang,Lingmin Zhang,Peng Chen,Shitao Chen,Yueheng Wu,ShunQing Tang 한국물리학회 2011 Current Applied Physics Vol.11 No.3
Agarose-grafting-hyaluronan (Ag-g-HA) has been proved to be a potential carrier for oral insulin, but it needs to clarify that insulin loaded in Ag-g-HA microparticle is effectively transported across epithelial layer. In this paper, Caco-2 cell monolayer was used for imitation of epithelial layer in small intestine to evaluate Ag-g-HA copolymer enhanced insulin transportation crossing epithelial layer. Ag-g-HA/insulin polyelectrolyte complexes were formed via electrostatic interaction at pH 3e5.4 and could spontaneously form microparticles with average diameter of 2 μm. Caco-2 cells in transwell dish were attached in tight monolayer after 21 d proliferation, and some features of Caco-2 cell monolayer, such as trans-epithelial electrical resistance (TEER) value being over 400 Ω/cm^2, alkaline phosphatase (ALP) activity being 0.7184 ± 0.095, and apparent permeability coefficient value (Papp) of propranonol being 1 × 10^-6 cm/s,were similar to those of epithelial layer in small intestine. These results revealed that Caco-2 cellmonolayer was suitable to be a model of small intestine epithelium layer for imitation of insulin crossing small intestine. P_app of insulin crossing Caco-2 monolayer reached 0.592 ± 0.067 × 10^-6 cm/s, which was significantly greater than the control groups. This meant Ag-g-HA as insulin carrier significantly promoted insulin crossing Caco-2 cell monolayer. These findings demonstrate that Caco-2 cell monolayer is a suitable model for drug transportation crossing epithelial layer, and Ag-g-HA has a promise as oral insulin carrier.
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