정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

방사선 센서의 동작특성

임영화,한상효,김도성,강희동 경북대학교 센서기술연구소 1995 센서技術學術大會論文集 Vol.6 No.1

A Geiger-M□ller(GM) radiation sensor is fabricated by using the vacuum system and gas feeding system. The base pressure of the vacuum system is 1X10^(-7)torr, and two MFCs(0~10sccm, ±1% accuracy of the full scale) are used to control the composition of filling gas exactly. The fabricated GM radiation sensor is simultaneously filled with the mixture of neon and clorine. The mica window(7.43mg/cm^(2)) is attached to the GM radiation sensor. The optimized GM radiation sensor has about 660V starting voltage, 125V plateua length, and 10%/100V plateau slope.

화상을 입힌 생쥐의 흉선과 비장 임파구아형과 조직학적 소견의 변화

한기택,안상태,강윤섭,임 풍 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.4

Due to various documented abnormalities of cell mediated immunity, sepsis still remains the major cause of morbidity and mortality after initial survival from extensive thermal burn. However, the exact mechanisms of immunosuppression after extensive thermal burn remains uncertain. For th observation of immune state, changes of lymphocyte subpopulation have been usually measured in lymphocyte samples from peripheral blood by many reports, but it is only a small fraction of the total lymphocyte pool in the body, and may not present valid picture of the immunological state of the individual. Therefore, analysis of lymphocyte phenotype in thymus and spleen is thought to be necessary in understanding more exact mechanism of immunological changes in extensive thermal burn. The aim of this study is to evaluate the changes of immunocompetency by observing the changes of subpopulation of spleen and thymus lymphocyte using monoclolnal antibodies and changes of tissue with light microscope in burned mice. Cell populations were isolated from spleen and thymus of control and burned mice on the 1st, 3rd, 5th, 7th, 14th and 21st postburn days(PBD). The cell populations were measured with monoclonal antibody by flow cytometry. The results were as follows: 1.In thymus, Thy 1.2+, L3T4+ and LYt2+ cells decreased markedly on the 3rd PBD. Thy 1.2+ and L3T4+ cells decreased also on 5th, 7th, 14th PBD and returned to control level on 21st PBD, but Lyt2+ cells increased more significantly than control after 3rd PBD and returned to normal on 21st PBD. Qa2+ cells revealed most significant reduction on 7th PBD. 2.In spleen, Thy 1.2+, L3T4+ and Ia+ cells increased on 3rd PBD and then decreased on 7th and 14th PBD. Lyt2+ cells increased in all the burned groups. Qa2+ cells increased on 3rd, 5th PBD and returned to normal level. L3T4+ cell/Lyt2+ cell ratio revealed signicant reduction, but they recovered by the 21st PBD. 3.In histopathologic findings of the spleen & thymus, the all cell subpoulations decreased at 1st PBD, but more increased than that of group of 3rd PBD. And then they revealed normal architecture after 5th PBD.

광산 폐석의 알칼리 반응성에 대한 광물.암석학적 연구

임한욱,최성범,백환조,김덕현 강원대학교 석재복합신소재제품연구센터 1997 석재연 논문집 Vol.2 No.-

석회암을 이용한 골재의 알칼리 반응성을 측정하기 위하여 한국공업규격의 표준시험 방법에 의한 팽창성을 측정하였다. 기존의 연구결과에 의하면 특히 백운석을 포함하는 석회암의 경우 골재-알칼리 반응이 상당한 것으로 알려지고 있으나, 본 연구에 사용된 석회암 시료의 경우는 알칼리 반응성이 매우 작은 것으로 나타났다. 또한, 역학적 특성의 결과도 매우 양호하며 골재로서의 활용성이 충분한 것으로 판단된다. An experimental program was undertaken to investigate the alkali-aggregate reaction of limestone aggregates, following the standard testing method for potential alkali reactivity of carbonate rocks for concrete aggregates. It is generally known tat dolomitic limestones may exhibit high potential of alkali-aggregate reaction. However, the limestone samples employed in this study showed negligible effect of the alkali reaction, even with substantial dolomite content. It is also concluded that the mechanical properties of the limestone aggregates are adaptable for concrete aggregates

식생활 의식과 식습관이 음식물 쓰레기의 감량과 재활용에 미치는 영향

한재숙,홍상욱,김정숙,이정림,허성미 동아시아식생활학회 1996 동아시아식생활학회지 Vol.6 No.3

The main purpose of this study is to investigate the effect of housewives' dietary awareness and habits on the reduction and recycling of food waste products. We have done statistical analyses of 501 questionnaires answered by housewives living in Taegu city. The results are as follows: The dietary awareness is significantly different according to the housewives' ages. The group of above 50's age, and the group of housewives and their husbands with a lower education level have a more traditional awareness and eating up habits. Also the younger group, and those with a higher education level who grew up in a big city have a more progressive dietary awareness. But the younger, higher income, small family, higher education level groups, and also employed housewives, produced more food waste products than the other groups. The groups those have traditional or rational awareness concerning dietary awareness, and those with good eating up and accurate cooking habits turned out to have more affirmative effects on the reduction and recycling of food waste products.

초등학교 과학교실 및 과학동아리 관련 현장 조사 및 프로그램 개발 모형 설정

임청환,김남일,권성기,고한중,이성호 한국과학교육학회 2005 한국과학교육학회지 Vol.25 No.2

본 연구의 목적은 과학 교실 및 과학반, 과학동아리 활동과 관련하여 일선 학교 현장에서는 어떤 문제점을 갖고 있으며 어떤 요구가 있는지 조사연구를 통해 알아보고 그 결과를 바탕으로 활동 프로그램을 개발하기 위한 개발 모형을 제시하는 것이었다. 146개 초등학교의 과학 관련 교사를 대상으로 설문 조사하였으며 조사결과, 교사들은 다양한 문제점과 해결 덜'간을 제시하였는데 다음과 같은 시사점을 얻을 수 있었다. 첫째, 다양한 과학 활동에 대한 행·재정적 지원이 절실히 필요하다. 둘째, 과학비전공 교사도 쉽게 다룰 수 있는 활동 프로그램의 제공이 필요하다. 셋째, 재미있는 활동으로 구성된 프로그램이 있어야 한다. 넷째, 프로그램은 준비가 용이한 활동으로 이루어져야 한다. 다섯째, 탐구 활동 중심의 평가 방법이 제시되어야 한다. 이러한 조사 결과를 바탕으로, 교사, 학생, 운영 환경을 축으로 하는 프로그램 개발 맥락을 설정하고 주제 설정, 활동구성, 차시구성, 활동지 구성, 교사용 지침서 구성의 단계로 이루어진 개발 모형을 제안하였다. The purpose of this study was to investigate the needs of elementary school teachers on extra-science programs and to suggest development model for extra-science program. Survey research was conducted on 146 science-related teachers all over the country. As the result, teachers presented several problems and solutions on extra-science activities and programs. The suggestions from the results are as follows. First, more administrative and financial supports are required. Second, it must be the programs with which any teachers, regardless of their major fields, can execute easily. Third, the programs should be interesting for students to do. Fourth, it should be easy to prepare activities and materials, Finally, the inquiry-focused assessment method should be presented in each program. Based on these suggestions, the context of development of programs was established. Three axises of, students, teachers, and environment, were included in the context. The model of development of programs was set up based on the context. It was constructed with six process steps, Confirmation of theme, Composition of work frame, Organization of each period, Worksheets for students, Guidebook for teachers, Completion, and one or two assessment criteria in each process steps. It must be useful to development of extra-science programs that is appropriate to the need of teachers.

브랜드 인지도와 광고가 콘택트렌즈의 착용감과 가격만족도에 미치는 영향

임동규 ; 신상준 ; 한지선 ; 이익한 ; 김진숙 김천대학교 2016 김천대학교 논문집 Vol.36 No.-

The purpose of this research was to analyze the effects of brand awareness and brand advertising on price satisfaction and comfort in contact lens. We did a survey with 200 university students (85 male, 115 female) who have experience of wearing contact lens from April to May in 2015. The brand awareness of contact lens influences to purchasing intention of contact lens, it effects women more than men. Many respondents(53%) replied that the reliability is the most important elements of the advertising. This survey indicates that there is no statistically significant correlation between the brand awareness and advertisement with price satisfaction in contact lens. Therefore we could confirm they have dissatisfaction for prices of contact lens regardless to brand awareness or advertisement. The brand and advertising dependence group have more comfort of contact lens than non-dependence group when they are long time wear of contact lens. Therefore, there is statistically significant correlation between the brand awareness and advertisement with comfort of contact lens. As a result, brand awareness and reliability of advertising influences to purchasing intention of contact lens. But there is no statistically significant correlation with price satisfaction in contact lens. Whereas, brand awareness and advertisement have a statistically significant correlation with comfort of contact lens.

엔드밀 형상에 따른 가공특성 분석을 이용한 형상설계 S/W 개발

한창규,고성림,유중학,서천석,김경배 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-

The tool geometry parameters and cutting process have complex relationships. Until now, various cutting test were needed to acquire optimal design of end mill for the purpose of high speed machining, due to the insufficient knowledge about cutting process in high speed machining. Using various tools with different geometry, relationships between tool geometry parameter (rake angle, clearance angle, length of cutter) and cutting process (cutting force, surface accuracy, surface roughness) have been studied. Acquired data can be used to design optimal tool for high speed machining and developed tool geometry design S/W.

사회체육과 학생의 자원봉사와 자아존중감이 욕구수준에 미치는 영향

한권상,손창남,임상호 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

The purpose of this study was for investigating the relation between level of need and volunteer activity, self-esteem. The participants are students who are major in sport and leisure. The multiple regression was used for this study and the level of need explained by sex, volunteer experience and self-esteem. In the result of analysis, only stabilization need with sex is statistical significant. Then there are statistical significant in accomplishment need for volunteer experience and level of self-esteem. Using the MANOVA, the results are as following. There are significant differences in levels of need that according to sex, sources and self-esteem. And there is interaction effect in sex*self-esteem only for accomplishment need.

청소년의 태권도 참가동기와 학교생활 만족도 간의 관계

한권상,임상호 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.3

To develop the relationship study between lifestyle satisfaction of school and motivation of participation into taekwondo of the adolescents, this study was foused to develop the relationship among subscales of lifestyle satisfaction of school-committee of lifestyle satisfaction of school, satisfaction of department of school, and satisfaction of school environment and motivation of participation-emotional motivation, hobby motivation, physical motivation and social motivation of the adolescents. The study tool for measuring lifestyle satisfaction of school was a 5 point Likert Scale qusetionnaire adjusted for this research propose developed by sung-hee, Cho(2001) and chae-hee, Lee(2000). Analysis was done by the Multiple Co-variate Anlysis Method. The results of this study was a follows: Firstly, There was showed relationship between committee of lifestyle satisfaction of school and motivation of participation in taekwondo of the adolescents. Secondly, There was showed relationship between satisfaction of department of school and motivation of participation in taekwondo of the adolescents. Thirdly, There was showed relationship between satisfaction of school environment and motivation of participation in taekwondo of the adolescents.