http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Aijia Wei,Wen Li,Lihui Zhang,Xiaohui Li,Xue Bai,Zhenfa Liu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.5
Zn2+ and F- ions are successfully used to modify pure Li4Ti5O12 via a co-precipitation method followed by calcination at 400℃ for 5 h in an Ar atmosphere in order to further investigate the reaction mechanism of the fluoride modification process. Zn2+ and F- co-modified Li4Ti5O12 samples are characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and electrochemical measurements. After the modification process, no ZnF2 coating layer is formed on the surface of Li4Ti5O12, instead, F- ions react with Li4Ti5O12 to generate a new phase, composed of a small amount of anatase TiO2, rutile TiO2, LiF, and Zn2+ ions are suspected to form a ZnO coating layer on Li4Ti5O12 particles. The electrolyte reduction decomposition is suppressed in Zn2+ and F- co-modified Li4Ti5O12 due to the ZnO coating layer. 1 wt.% Zn2+ and F- co-modified Li4Ti5O12 exhibits the best rate capability, which leads to a charge capacity of 236.7, 227.8, 222.1, 202.7, 188.9 and 150.7 mAh g -1 at 0.2C, 0.5C, 1C, 3C, 5C and 10C, respectively, between 0 V and 3 V. Furthermore, 1 wt.% Zn2+ and F- comodified Li4Ti5O12 exhibits 96.0% charge capacity retention at 3C rate after 200 cycles, which is significantly higher than that of pure Li4Ti5O12 (78.4%).
Yingmei Wang,Shiqian Zhang,Lihui Wei,Zhongqiu Lin,Xinyu Wang,Jianliu Wang,Keqin Hua,Manhua Cu,Jiandong Wang,Shixuan Wang,Wen Di,Yudong Wang,Ruifang An,Mingrong Xi,Ruixia Guo,Qi Zhou,Xing Xie,Fengxia X 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.4
The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratorysyndrome coronavirus 2 has rapidly spread globally. Cancer patients are at a higher risk ofbeing infected with the coronavirus and are more likely to develop severe complications, ascompared to the general population. The increasing spread of COVID-19 presents challengesfor the clinical care of patients with gynecological malignancies. Concerted efforts should beput into managing gynecological malignancies in an orderly manner by strictly implementingthe measures that are specifically developed for controlling the spread of COVID-19. We havedrafted Recommendations on Management of Gynecological Malignancies during the COVID-19 Pandemicbased on our experience on controlling COVID-19 pandemic in China. We recommendthat patients with gynecological malignancies should be managed in hierarchical andindividualized manners in combination with local conditions related to COVID-19. Medicalcare decision should be balanced between controlling COVID-19 pandemic spread and timelydiagnosis and treatment for gynecologic oncology patients.
강지현,박동진,이정원,이경은,Lihui Wen,김태종,박용욱,이신석 대한의학회 2014 Journal of Korean medical science Vol.29 No.9
We investigated the compliance of Korean patients using tumor necrosis factor (TNF)inhibitors to treat rheumatoid arthritis (RA) and ankylosing spondylitis (AS), and identifiedpotential predictors associated with treatment discontinuation. The study populationcomprised 114 RA and 310 AS patients treated with TNF inhibitors at a single tertiary centerfor at least 1 yr from December 2002 to November 2011. Of the 114 RA patients, 64(56.1%) discontinued their first TNF inhibitors with a mean duration of 18.1 months. Bycontrast, 65 of 310 patients (21.0%) with AS discontinued their first TNF inhibitors, with amean duration of 84 months. Although the survival rate did not differ among the threeTNF inhibitors in the AS patients, the etanercept group had a lower discontinuation ratethan the infliximab group in the RA patients. In addition, RA patients who receivedcorticosteroids in combination with TNF inhibitors were more likely to discontinue their TNFinhibitors. The independent predictors of drug discontinuation in AS patients were malegender and complete ankylosis on radiographs of the sacroiliac joint. Our results providefurther evidence that real-life treatment outcomes of RA and AS patients may be differentfrom those observed in randomized clinical trials.
박동진,강지현,이정원,이경은,Lihui Wen,김태종,박용욱,남태승,김명선,이신석 대한의학회 2013 Journal of Korean medical science Vol.28 No.7
The aim of this study was to assess and validate the Korean version of the Boston Carpal Tunnel Questionnaire (K-BCTQ) in patients with carpal tunnel syndrome (CTS). After translation and cultural adaptation of the BCTQ to a Korean version, the K-BCTQ was administered to 54 patients with CTS; it was administered again after 2 weeks to assess reliability. Additionally, we administered K-DASH and EQ-5D to assess construct-validity. In a prospective study of responsiveness to clinical change, 29 of 54 patients were treated by ultrasonography-guided local corticosteroid injection therapy. The internal consistency of the K-BCTQ was high (Cronbach’s alpha: 0.915) and the intra-class correlation coefficients were 0.931 for the symptom severity scale (P < 0.001) and 0.844 for the functional severity scale (P < 0.001). The construct-validity between the symptom severity scale and the K-DASH, and between the functional severity scale and the K-DASH were significantly correlated (both P < 0.001). Clinical improvement was noted in 29 patients with injection therapy. The effect size of symptom severity was 0.67, and that of functional severity was 0.58. In conclusion, the K-BCTQ shows good reliability, constructvalidity,and acceptable responsiveness after local corticosteroid injection therapy (Clinical trial number, KCT0000050).
이경은,강지현,임이랑,김지은,이정원,Lihui Wen,박동진,김태종,박용욱,윤경철,이지신,이신석 대한의학회 2016 Journal of Korean medical science Vol.31 No.2
We investigated the clinical and biological significance of germinal centers (GC) present in the minor salivary glands of patients with Sjögren’s syndrome (SS). Minor salivary gland tissue biopsies from 93 patients with SS were used to identify GC-like structures, which were confirmed by CD21-positive follicular dendritic cell networks. Patients were compared based upon sociodemographics, glandular and extraglandular manifestations, and laboratory findings including autoantibody profiles, complement, and immunoglobulin levels; EULAR SS disease activity index (ESSDAI) and SS disease damage index (SSDDI) were also measured. GC-like structures were observed in 28 of 93 SS patients (30.1%). Mean focus scores and CRP levels were significantly higher in GC-positive patients than in GCnegative patients; GC-positive patients also exhibit a higher prevalence of rheumatoid factor and anti-SS-A/Ro antibodies compared to GC-negative patients. No differences in glandular or extra-glandular manifestations were evident between groups. In conclusion, SS patients with GC-like structures in the minor salivary glands exhibited laboratory profiles significantly different from those of their GC-negative counterparts. Long-term follow-up of these patients will be necessary to determine whether these laboratory abnormalities are predictive of clinical outcomes.
( Ji Hyoun Kang ),( Dong Jin Park ),( Jeong Won Lee ),( Kyung Eun Lee ),( Lihui Wen ),( Tae Jong Kim ),( Yong Wook Park ),( Shin Seok Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: We investigated the compliance of Korean patients using tumor necrosis factor (TNF) inhibitors to treat rheumatoid arthritis (RA) and ankylosing spondylitis (AS), and identified potential predictors associated with treatment discontinuation. Methods: The study population comprised 114 RA and 310 AS patients treated with TNF inhibitors at a single tertiary center for at least 1 year from December 2002 to November 2011. Results: Of the 114 RA patients, 64 (56.1%) discontinued their first TNF inhibitors with a mean duration of 18.1 months. By contrast, 65 of 310 patients (21.0%) with AS discontinued their first TNF inhibitors, with a mean duration of 84 months. Although the survival rate did not differ among the three TNF inhibitors in the AS patients, the etanercept group had a lower discontinuation rate than the infiiximab group in the RA patients. In addition, RA patients who received corticosteroids in combination with TNF inhibitors were more likely to discontinue their TNF inhibitors. The independent predictors of drug discontinuation in AS patients were male gender and complete ankylosis on radiographs of the sacroiliac joint. Conclusions: Our results provide further evidence that real-life treatment outcomes of RA and AS patients may be different from those observed in randomized clinical trials.
Exploring Genetic Susceptibility to Fibromyalgia
박동진,이신석,박용욱,김태종,강지현,임이랑,김지은,이정원,이경은,Lihui Wen 전남대학교 의과학연구소 2015 전남의대학술지 Vol.51 No.2
Fibromyalgia (FM) affects 1% to 5% of the population, and approximately 90% of theaffected individuals are women. FM patients experience impaired quality of life andthe disorder places a considerable economic burden on the medical care system. Withthe recognition of FM as a major health problem, many recent studies have evaluatedthe pathophysiology of FM. Although the etiology of FM remains unknown, it is thoughtto involve some combination of genetic susceptibility and environmental exposure thattriggers further alterations in gene expression. Because FM shows marked familial aggregation,most previous research has focused on genetic predisposition to FM and hasrevealed associations between genetic factors and the development of FM, includingspecific gene polymorphisms involved in the serotonergic, dopaminergic, and catecholaminergicpathways. The aim of this review was to discuss the current evidenceregarding genetic factors that may play a role in the development and symptom severityof FM.
Case Reports : A Case of Eosinophilic Polymyositis Treated with Immunosuppressants
최정호 ( Jung Ho Choi ),강지현 ( Ji Hyoun Kang ),온리휘 ( Lihui Wen ),이정원 ( Jeong Won Lee ),이경은 ( Kyung Eun Lee ),박동진 ( Dong Jin Park ),박용욱 ( Yong Wook Park ),김태종 ( Tae Jong Kim ),이신석 ( Shin Seok Lee ) 대한류마티스학회 2015 대한류마티스학회지 Vol.22 No.5
저자들은 사지의 부종, 근육통 및 근력저하를 주소로 내원한 환자를 호산구성 다발근염 진단 하에 고용량 글루코코르티코이드 치료를 시행하였으나, 이에 충분한 반응을 보이지 않아 면역억제제를 추가로 사용하여 성공적으로 치료한 호산구성 다발근염 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Eosinophilic polymyositis is a rare form of inflammatory muscle disease associated with peripheral blood and/or tissue eosinophilia. Most patients respond to glucocorticoids, however some show poor prognosis, leading to mortality. A 28-year-old female was admitted to our hospital because of myalgia and motor weakness of the upper and lower extremities. Laboratory findings showed significantly elevated levels of muscle enzymes and inflammatory lesions in both thigh muscles were demonstrated on magnetic resonance imaging. A diagnosis of eosinophilic polymyositis was based on histological findings, which showed diffuse eosinophilic infiltration into perivascular spaces in the endomysium and perimysium, and necrosis of myofibers. High-dose methylprednisolone treatment improved the clinical symptoms and muscle enzymes. However, on tapering the glucocorticoid dose, clinical and laboratory findings were exacerbated. After the addition of methotrexate and azathioprine, the symptoms and muscle enzymes recovered without relapse. Here, we report on a case of eosinophilic polymyositis, which responded to immunosuppressants. (J Rheum Dis 2015;22:308-312)
Lee, Kyung-Eun,Kang, Ji-Hyoun,Yim, Yi-Rang,Kim, Ji-Eun,Lee, Jeong-Won,Wen, Lihui,Park, Dong-Jin,Kim, Tae-Jong,Park, Yong-Wook,Yoon, Kyung Chul,Lee, Ji Shin,Lee, Shin-Seok The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.2
<P>We investigated the clinical and biological significance of germinal centers (GC) present in the minor salivary glands of patients with Sjögren’s syndrome (SS). Minor salivary gland tissue biopsies from 93 patients with SS were used to identify GC-like structures, which were confirmed by CD21-positive follicular dendritic cell networks. Patients were compared based upon sociodemographics, glandular and extraglandular manifestations, and laboratory findings including autoantibody profiles, complement, and immunoglobulin levels; EULAR SS disease activity index (ESSDAI) and SS disease damage index (SSDDI) were also measured. GC-like structures were observed in 28 of 93 SS patients (30.1%). Mean focus scores and CRP levels were significantly higher in GC-positive patients than in GC-negative patients; GC-positive patients also exhibit a higher prevalence of rheumatoid factor and anti-SS-A/Ro antibodies compared to GC-negative patients. No differences in glandular or extra-glandular manifestations were evident between groups. In conclusion, SS patients with GC-like structures in the minor salivary glands exhibited laboratory profiles significantly different from those of their GC-negative counterparts. Long-term follow-up of these patients will be necessary to determine whether these laboratory abnormalities are predictive of clinical outcomes.</P>