모성 직업활동이 조산과 저체중출생 및 자연유산에 미치는 영향

신용덕,이태용,이영수,이동배 大韓産業醫學會 1994 대한직업환경의학회지 Vol.6 No.1

모성 직업활동이 조산, 저체중 출생아 및 자연유산에 미치는 영향을 알아보기 위해 1991년 1월부터 1992년 12월까지 대전에 위치한 C대학병원에서 출생한 1,646명의 산모를 대상으로 하여 조사한 결과는 다음과 같다. 1. 조사 대상자 1,646명의 산모중 임신중 직업을 가진 군이 20.3%, 직업을 갖지않은 군이 79.7%였으며, 직업여부의 분포에 통계적으로 유의한 차이를 보인 변수는 산모의 연령, 교육정도, 임신전 체중, 신장, 유산횟수였다. 2. 임신중 직업을 가진군의 평균 임신기관과 조산율은 39.1주, 7.8%였고, 비직업군은 39.0주, 9.7%였다. 직업군에서 평균 출산아 체중과 저체중 출생아율은 3.228g, 5.4%였고 비직업군은 3,140g, 10.6%였으며, 통계적으로 유의한 차이를 보였다(p<0.05). 평균 자연유산 횟수와 자연유산 경험율은 직업군이 0.2회, 15.0%, 비직업군이 0.3회, 17.4%였다. 3. 연령이 35세 이상, 미숙아 출산력이 있는 경우 및 유산횟수가 2회 이상인 경우는 직업군의 조산율과 저체중 출생아율이 비직업군에 비해 높았으나 통계적 유의성은 없었다. 산과적 합병증이 없는 경우 조산율이 직업군에서 비직업군보다 높았으나 역시 통계적 유의성은 없었다. 4. 자연유산 경험률은 연령이 35세 이상, 학력이 중졸 이하 및 고졸, 산모의 신장이 163cm이상에서 직업군에서 비직업군보다 높게 나타났으나, 통계적 유의성은 없었다. 5. 조산과 관련성이 있는 요인의 영향을 고려했을 때 직장활동군에서 조산의 위험도가 낮았으나 통계적 유의성은 없었다. 6. 임신주수 및 저체중 출생에 관련이 있는 요인의 영향을 고려한 후 직업군에서 저체중 출산의 위험도가 낮았으며 통계적 유의성을 보였다(p<0.05). 7. 과거 유산에 관련이 있는 요인의 영향을 고려한 경우 직업군에서 유산경험율이 낮았으나 통계적 유의성은 없었다. 8. 직업이 교사, 의료인, 은행원, 공무원인 군은 비직업군보다 조산율과 저체중 출생아율이 낮았으며, 회사원은 비직업군에 비해 조산율은 낮았으나 저체중 출생아율은 높았다. 상업군은 조산율과 저체중 출생아율이 15.2%로 비직업군 및 다른 직업군보다 비교적 높았다. 유산경험율은 은행원, 의료인,공무원에서는 비직업군의 17.0%보다 낮았으나, 교사군과 회사원은 17.8, 17.9%로 높았고, 상업군은 33.3%로 다른 직업군에 비해 현저히 높았으며 비직업군에 비해 교차비가 1.42로 통계적 유의성이 있었다(p<0.05). To investigate the effect of maternal job activity on the preterm delivery, low birth weight infant and spontaneous abortion, 1646 delivery data were analyzed from Jan. 1991 to Dec. 1992 in Chungnam University Hospital. The results obtained were as follows; 1. The percentage of subjects who had job during pregnancy was 20.3% and the variables of maternal age, education level, prepregnancy weight, maternal height, number of abotion showed significant difference in the distribution of subjects whether they had job or not. 2. There were no significant difference between the group who had job during pregnancy and those who had no job in the mean gestational period, number of spontaneous abortion, rate of preterm delivery and spontaneous abortion. However mean birth weight and rate of low birth weight showed significant difference between the groups. 3. The rate of preterm delivery of the group who had job were higher than those who had no job activity in the subgroup of 35 years or more age, prematurity history presence, 2 or more abortion history, obstetric complication presence, but there were no significant difference. The rate of low birth weight also higher in the group who had job than those who had no job activity in the same subgroup except obstetric complication presence. 4. The rate of spontaneous abortion of the group who had job were higher than those who had no job activity in the subgroup of 35 years or more age, below high school, height of 163cm or above, but there were no significant difference. 5. Rate of preterm delivery still showed better results in the group who had job than the group who had no job when adjusted for variables related, but there was no statistical significance. 6. Rate of low birth weight still showed better results with statistical significance in the group who had job than the group who had no job when adjusted for variables related. 7. Spontaneous abortion had occured less frequently in the group who had job than the group who had no job when adjusted for variables related. 8. Rate of preterm delivery and low birth weight were lower in the group of teacher, bank clerk, medical personnel, citizen servant than the group who had no job, but higher in the job of company employee, commerce. Spontaneous abortion was most frequent in group of commerce, and the group of teacher, company employee showed higher rate of abortion than the group who had no job.

운동부하 흰쥐에서 포도당 증합체가 심근 당원에 미치는 영향

이석강,조성현,김용운,박덕일,김종연,장용찬 대한스포츠의학회 1994 대한스포츠의학회지 Vol.12 No.1

운동부하전 섭취한 탄수화물이 운동흰쥐의 심근 및 골격근이 당원량에 미치는 영향을 측정하여 심근과 골격근의 대사적 차이점의 일단을 연구한 본 논문의 결과는 다음과 같다. 심근과 골격근 당원량(mg/ g wet tissue, 이하 단위 동일)은 정상군에서 심근 2.62±0.51로서 골격근의 3.37±0.58보다 낮았다(p<0.01). 심근 당원량은 정상군이 2.62±0.51이었다. 운동 30분에서 대조군은 정상군의 63%수준으로 감소하였으며(p<0.01), 탄수화물섭취군은 정상군의 86 및 90%수준으로 감소하였으나 통계적으로 유의한 차이는 없었다. 탄수화물 섭취군의 당원량은 대조군의 142 및 137%정도로 양군 모두 대조군보다 유의하게(p<0.01) 높았다. 운동 60분에는 대조군은 운동30분의 78%(정상군의 49%)수준으로 감소하였으며(p<0.05) 탄수화물섭취군은 포도당중합체 및 포도당섭취군에서 각각 운동 30분에 비하여 72(p<0.01, 정상군의 62%), 81%정도(p<0.05, 정상군의 73%)로 감소하였다. 포도당 섭취군의 당원량은 대조군의 147% 정도로 대조군보다 유의하게(p<0.01) 높았다. 운동 120분에서 대조군은 운동 60분에 비하여 63%(정상군의 33%) 수준으로 감소하였으며 (p<0.01) 포도당섭취군은 운동 60분의 69%(정상군의 50%)수준으로 유의하게 감소하였으나, 포도당 중합체 섭취군은 차이가 없었다. 탄수화물 섭취군의 당원량은 포도당 중합체 및 포도당섭취군에서 각각 대조군의 202 및 162% 정도로 양군 모두 대조군보다 유의하게(p<0.01)높았다. 골격근 당원량은 정상군이 3.37±0.58 이었다. 운동 30분에서 대조군은 정상군의 69% 수준으로 감소하였으며(p<0.01) 탄수화물섭취군은 포도당 중합체 및 포도당섭취군에서 각각 정상군의 85 및 88% 수준으로 감소하였으나 통계적으로 유의한 차이는 없었다. 탄수화물 섭취군의 당원량은 포도당 중합체 및 포도당섭취군에서 각각 대조군의 125 및 129% 정도로 양군 모두 대조군보다 유의하게(p<0.05) 높았다. 운동 60분에는 대조군은 운동 30분의 77%(정상군의 53%) 수준으로 감소하였으며(p<0.05)탄수화물섭취군은 포도당중합체 및 포도당섭취군에서 각각 30분에 비하여 93(정상군의 80%), 89(정상군의 78%) %정도로 감소하였으나 통계적으로 유의하지는 않았다. 포도당중합체 및 포도당 섭취군의 당원량은 각각 대조군의 152 및 149% 정도로 대조군보다 유의하게 (p<0.001) 많았다. 운동 120분에서 대조군은 운동 60분에 비하여 50%(정상군의 26%) 수준으로 감소하였으며(p<0.001) 포도당 섭취군은 운동 60분의 75%(정상군의 58%)수준으로 유의하게(p<0.05) 감소하였으나 포도당 중합체 섭취군은 대조군의 84%(정상군의 67%)정도로 감소하는 경향을 보였다. 탄수화물 섭취군의 당원량은 포도당 중합체 및 포도당섭취군에서 각각 대조군우ㅢ 255 및 221% 정도로 양군 모두 대조군보다 유의하게(p<0.001) 높았다. 이상의 결과로 미루어 보아 심근과 골격근 간의 생리, 생화학적 특성의 차이에도 불구하고 탄수화물의 섭취후 중등도 정도의 달리기 운동시 근 당원의 함량에 미치는 영향은 정도의 차이는 있으나 같은 경향을 나타내었으며, 골격근에서 심근보다 더 많은 근 당원 절감효과를 나타내었다. 또한 운동전 탄수화물의 섭취시 이러한 근 당원 절감 효과로 장시간의 운동시 심근 및 골격근 당원의 고갈 지연으로 운동수행능력의 증가가 기대되며, 특히 포도당 보다는 포도당 중합체의 섭취시 효과가 더 크리라고 사료된다. The purpose of this study was to investigate the effect of glucose and glucose plymer ingestion on the concentration of the cardiac muscle glycogen at 30, 60 and 12 minutes of the treadmill running in rats. Rats were randomly assinged to normal, control, and carbohydrate groups. Carbohydrate group was divided into glucose, and glucose polymer ingested rats. The experiment was carried out after overnight fasting. Rats were administrated either water (control) of carbohydrates of formulated glucose(6%), and glucose polymer(6%) via polyethylene tube to the stomaach before treadmill run. Exercise was loaded by a treadmill run at the speed of I ㎞/hr for 30, 60, and 120 minutes. The results of experiment were as follows: Glycogen content of the cardiac muscle was lower than that of the skeletal muscle (plantaris) in normal rats. Glycogen content of the cardiac muscle was decreased in proportion to the exercise time compared to normal in control and carbobydrates ingested rats. It decreased in control, glucose, and glucose polymer compared to normal rats in decreasing order at 120 minutes treadmill running (% change of glycogen content of control, glucose, and glucose polymer compared to normal rats were 33, 50, and 63% in the cardiac muscle at 120 minutes of treadmill running respectively). Glycogen content of the skeletal muscle was decreased in proportion to the exercise time compared to normal in control and corbohydrates ingested rats. It decreased in control, glucose, and glucose polymer compared to normal rats in ecreasing order 120 minutes treadmill running(% change of glycogen content of control, glucose, and glucose polymer compared to normal were 26, 58, and 67% in the cardiac muscle at 120 minutes of treadmill running respectively). Change of the glycogen content of the cardiac and the skeletal muscle during treadmill running after glucose and glucose polymer ingestion showed that both muscles had tendency to decrease in proportion to exercise time similarly in control and carbohydrates ingested rats. Decreasing rate of glycogen content of cardiac and skeletal muscles during treadmill running compared to normal in carbohydrates ingested rats was lower than that of control. From these results, it is suggested glycogen content of cardiac and skeletal muscles had tendency to decrease in proportion to exercise time similarly in control and carbohydrate ingested rats. Glycogen content of cardiac and skeletal muscles in carbohydrate singested rats less decreased than that of control during treadmill running compared to normal. Glucose polymer of the carbohydrates ingested rats in considered as the most effective for glycogen sparing according to exercise time in both muscles. Therefore, intake of carbohydrate, especially glucose polymer, before exercise may be increase performance of the prolonged moderate exercise.

운동훈련이 흰쥐 노화심근에 미치는 영향 : I. 장기간 지구력 운동 훈련 I. Long Term Endurance Exercise

이용덕,이상선,박원학 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1996 Journal of biomedical laboratory sciences Vol.2 No.1

장기간 반복 주행운동이 흰쥐의 심근에 미치는 효과를 규명하기 위하여 생후 3개월, 10개월 및 20개월된 흰쥐를 운동군과 대조군으로 대별하여 motor driven treadmill을 이용하여 Park등이 사용한 방법에 준해서 5개월간, 주 5일 20분간 운동을 시킨 후 심근의 조직 및 세포학적 변화를 관찰하고 심근 세포 내 미세구조 변화를 입체해석학적으로 비교 분석하였다. 연령 증가에 따라 장기간 반복운동이 흰쥐 심근 미세구조에 미치는 영향은 8, 15개월의 운동군과 대조군 사이에 뚜렷한 차이를 인정할 수 없으며, 15개월의 운동군에서 대조군에 비하여 변성된 사립체, 리소조옴, 지방적, 공포, 노화색소 등이 증가하는 경향이 있었다. 25개월 운동군은 같은 연령 대조군에 비하여 근원섬유 수축대, 근원섬유 소실, 윤반분리, 세포간질 증식, 핵의 변성, 교원섬유 근섬유내 침입 등 매우 심한 변화를 보였다. 조직상에 나타나는 early lipofusin과 미세구조상에 나타나는 노화색소는 8, 15개월의 운동군과 대조군 사이에 유의한 차이는 없었으며, 25개월 운동군은 같은 연령 대조군에 비하여 유의한 차이로 증가하였다. Glucose-6-phosphatase 활성도 8, 15개월군에서 운동군과 대조군에서 모두 활성이 높았으며 25개월의 대조군과 운동군에서는 모두 활성이 거의 나타나지 않았다. 미세구조 변화를 입체해석학적으로 분석한 결과 8,15개월의 대조군과 운동군에서 체적 밀도의 모든 항은 양군사이에 유의한 차이가 없었다. 25개월에서는 세포간질이 대조군에 비하여 운동군이 유의한 증가를 나타내었고, 근원섬유는 유의한 차이는 없지만 증가하는 경향을 보였으며, 사립체는 대조군에 비하여 유의한 감소를 나타내었고 근형질세망의 체적밀도는 감소하는 경향을 보였다. 사립체와 근원섬유 비는 8개월 운동군에서 유의한 차이는 없지만 대조군에 비하여 높게 나타났으며, 15개월의 운동군과 대조군 사이에서는 차이를 인정할 수 없었다. 그러나 25개월 운동군은 대조군에 비하여 유의한 차이로 감소하였다. 연령증가에 따른 사립체 내막 표면밀도와 사립체수는 대조군과 운동군 사이에는 유의한 변화는 없었다. 본 연구의 성적을 검토한 결과 젊은층(3개월군)과 중령층(10개월군)의 흰쥐에서는 반복된 지구력 운동이 심장에 미치는 역효과를 인정할 수 없었으며 젊은층의 흰쥐에서는 오히려 심장기능 강화를 보이는 경향이 나타났으며, 노화층(20개월군)에서 운동군에서는 스트레스로 작용하여 심장기능의 저하를 초래 하였다고 생각된다. There is considerable current interest in the effect of regular vigorous exercise and in particular endurance-running as a possible measure in improving myocardial function. Some data indicate that the aging heart may actually suffer from vigorous endurance exercise. On the contrary, appropriate exercise in aged animals improves myocardial function and aerobic energy metabolism. So far there is relatively little data to indicate that endurance exercise is in fact beneficial in improving myocardial function or damaging to heart of aged animals. The present investigation aimed to study the possible effect of a long range treadmill training program on the heart in aging rats. Male rats aged 3, 10, and 20 months were divided at random into a control (sedentary) and an exercise group. The training group was exercised for 5 days a week on an automated treadmill for 20minutes at 18m/min over a period of 5 months. The exercise regimen of our experiments did not cause any significant changes in the tissues and ultrastructural as compared with sedentary age-matched control. Tissues and ultrastructures of myocardial cells in trained group aged 8 months are intact and well organized as well as sedentary control group. Age associated tissue and ultrastructural changes of trained group aged 15 months included : an increase in transformed mitochondria, vacuoles, lysosomes, lipid droplets and early lipofuscin. But the trained heart did not show significant difference in tissue and ultrastructural properties from those of sedentary controls. Endurance-trained group aged 25 months showed significant qualitative tissue and ultrastructural difference as compared with age-matched controls. In addition to those found in 25 months control group, focal necrosis, myofibril fraying, hypercontraction band, seperation of intercalated discs, degenerating nucleus and infiltration of collagenous fiber into myocyte were noted in trained 25 months group. The stereological examination of the micrographs disclosed no significant difference in the myofibril, mitochondrion, sarcotubule and interstitium volume density and surface density of mitochondrial cristae and numerical density of mitochondria between trained and control group aged 8 and 15 months. In the trained 25 months group, significant increase in volume density of interstitium, lipofucsin granule were shown as compared to untrained agematched control. On the other hand, significant decrease in mitochondrion volume density was shown. The myofibril volume density did not differ between trained and control group although trained group showed slight increase. From the data obtained, a reduced mitochondria/myofibrils ratio was found in trained rat heart aged 25 months and there was no difference between trained and control rat aged 15 months. But a slight but not significant increase was found in the trained group aged 8 months as compared with same age control group. Such increase in the ratio in young animals is considered to be of great importance to cardiac pumping and adaptability. Whereas such adaptations don't seem to occur in aged heart muscle. This study proposed that repeated endurance exercise do not cause any significant qualitative and quantitative ultrastructural change of heart muscle in young(3months) and adult(10months) suggesting that the heart is able to adapt to the exercise. On the contrary, the repeated endurance exercise stress may actually induce degenerative changes in the aged heart muscle(20months).

인체 심근막 구성섬유의 배열 양상

이용덕 대구보건전문대학교 2006 대구보건대학 論文集 Vol.26 No.-

This study examined the running patterns of deep fascia around muscles in a human cadaver. After the skin and superficial fascia were removed, the holistic fascia arrangement was investigated with the naked eye. In order to make an observation, the interconnection of fasciae on both sides and muscles were lifted. To make an estimation of running direction and tension of the subject fasciae of each body part, epimysium along with muscle fibers of the subject muscles were held and lifted with tweezers. The running direction and tension correlation of the deep fascial fibers were observed parallel to the muscle fibers of the subject muscles. In the back, four rhomboid shape fascial profiles were observed around the vertebral column. The rhomboid profiles are composed of a fascia of trapezius, a fascia of latissimus dorsi, a fascia of Michaelis rhombod, and an innominated rhomboid, which were located between a fascia of trapezius and a fascia of latissimus dorsi. Upon observation of the connection of fascial fibers, they appeared with a thin and loose formation between muscles, appeared with a thin and dense formation between a muscle and soft tissue around the bone, and appeared with a thick and loose formation between muscle groups.

全北 地方의 降水氣候 特性에 對한 硏究

李光浩,金龍德 全北大學校 敎育大學院 1994 敎育論叢 Vol.14 No.-

Statistics, Trends and periodicities in the seasonal and annual area precipitation for two standard weather stations and five auxiliary stations in Chonbuk, on the basis of precipitation records of over 70 years, were analysed primarily by using correlation coefficient, regression and power spectrum analysis. It was shown that secular variations of seasonal precipitation by five-year moving average is tended to increase for all seasonal precipitation except for summer. Secular variations of seasonal precipitation by five-year moving average using. Thiessen method have the same tendency above mentioned. It Means that abnormally much precipitation would be occurred once during the 24 years to 37 years for each season. The power spectrum analysis indicates four significant cycles of 2.6-3.6 year, 5.6 year, 12.5 year and 20.0 year oscillations for annual and seasonal values. Particularly, 2.6, 5.6, 12.5, 20.0 year cycles occur more clearly in spring, summer and annual, autumn and winter, winter, respectively.

분산 어플리케이션의 정보보호 서비스를 위한 CAPI 설계 모델

이상기,김영덕,최용락 대전대학교 산업기술연구소 1998 산업기술연구소 論文集 Vol.9 No.2

Until recently, the integration of cryptographic functionality into application program has required that developers tightly couple the application to the cryptographic module. This approach forces each new combination of application and cryptography to be treated as a distinct development effort, and does not provide the modularity and maintainability. An approach that can provide flexibility and cost saving is the use of a standardized CAPI(Cryptographic Application Prigram Interface) suite. This Paper analyze the CAPI for the development of various types of security application programs in distributed environment. The analysis of CAPI are considered with the respect of 7 criteria items such as algorithm independence, application independence, cryptomodule independence, the degree of cryptographic awareness, modular design and auxiliary services, safe programming and security perimeter. In this paper, we suggested the basis of utilization to be selected for develope the cryptographic modules in distributed applications.

한국인에서 Quadruplex PCR을 이용한 8종류 상염색체 STR 유전좌의 다형성 분석

장영길,김기범,신창호,이숭덕,이윤성,이정빈 大韓法醫學會 2001 대한법의학회지 Vol.25 No.1

Two quadruplex PCR reactions were designed for 7 tetrameric (D3S2406, D4S2368, D5S818, D7S821, D9S925, D13S317, D19S253) and one trimeric (D6S1043) short tandem repeats loci to study the allele frequency and the applicability of genetic variation in these loci in forensic case works. For 310 unrelated Koreans DNA was isolated from peripheral blood using phenol/chloroform method. Quadruplex I was consisted of D4S2368, D6S1043, D7S821, D9S925 and quadruplex II D3S2406, D5S818, D13S317, D19S253. The amplified products were analyzed by 5% polyacrylamide gel electrophoresis followed by silver staining. The heterozygosity in each loci ranged 92.91-66.13%, and PD(Power of Discrimination) was above 085 in each loci. Every loci except D6S1043 followed hardy-Weinberg expectation. The cumulative PI was low as 1.65×10-10. Two mutations were noted, one in D19S253 and the other in D9S925 among 234 gametes. With these results above eight STR loci studied here preyed to be highly polymorphic enough to be used in forensic field. This study provides valuable population data in these loci for Korean.

200m 달리기시 곡선 구간과 직선 구간 동작의 운동학적 변인 비교 분석

김용운,정철수,은선덕,이영석 한국운동역학회 2000 한국운동역학회지 Vol.10 No.1

본 연구는 단거리 달리기(200 m)의 곡선 구간과 직선 구간의 동작을 비교 · 분석하여, 운동학적 변인의 차이를 규명하고, 곡선 구간의 동작 메카니즘에 대한 기초적인 정보를 제공하기 위해, 서울체육고등학교의 100 m 및 200 m 달리기 선수 5명을 대상으로 하여, 3차원 영상 분석법을 통하여 동작을 분석하였다. 본 연구에서 도출된 결론은 다음과 같다. 1. 신체중심의 높이는 직선 구간이 곡선 구간보다 높았으며, 신체중심 변위의 변화는 곡선 구간에서 더 컸다. 2. 신체중심의 수평속도는 곡선 구간이 직선 구간보다 컸으며, 곡선 구간에서 내측 스트라이드 국면이 외측 스트라이드 국면보다 컸다. 3. 신체중심의 수평 측면속도는 평균값에서 곡선 구간과 직선 구간이 차이가 없었으나, 속도의 절대값에서는 곡선 구간이 직선 구간보다 컸다. 4. 곡선 구간 내, 외측 스트라이드 국면의 이지, 착지시 접선속도는 차이가 없었다. 5. 스트라이드 길이는 곡선 구간의 외측 스트라이드가 가장 길었으며, 직선 구간, 곡선 구간의 내측 스트라이드 순서로 길었다. 6. 스트라이드 빈도는 곡선 구간과 직선 구간에서 차이가 없었다. 7. 상체 전경각의 평균값은 곡선 구간과 직선 구간에서 차이가 없었으나, 범위는 곡선 구간이 직선 구간보다 컸다. 8. 상체 측경각은 평균값에서 곡선 구간이 직선 구간보다 컸으나, 범위는 차이가 없었다. 9. 상완의 운동범위는 곡선 구간과 직선 구간에서 차이가 없었다. 10. 무릎거양각은 곡선 구간이 직선 구간보다 운동범위가 컸다. 이상의 결과, 단거리 달리기의 곡선 구간에서 직선 구간과는 차별화된 수행 형태를 보였으며, 내, 외측 스트라이드 간에도 상이한 수행 형태를 보였다. This study was conducted to make a comparative analysis of running motion and to examine the differences of kinematice in curved and straight track portion during the 200m sprinting. In this study, five skilled male sprinters of high school served as subjects. The running motions were analyzed using the method of three-dimensional cinematography The conclusions of this study were as follows. 1. Height of the center of gravity in straight portion was higher than that in curved portion, but displacement of the center of gravity in curved portion was higher than that in straight portion. 2. Horizontal velocity of the center of gravity in curved portion was faster than that in straight portion, and in curved portion that of left stride phase was faster than that in fight stride phase. 3. There was no difference in mean value of lateral component of horizontal velocity between both portions, but absolute value of that in curved portion was faster than that in straight portion. 4. There was no difference in tangential velocity at the instant of touchdown and takeoff of both strides on curved portion. 5. Stride length in right stride of curved portion was the longest, and next to that, that of straight portion was, and left stride of curved portion was the shortest. 6. There was no difference in stride frequence between curved and straight portion. 7. There was no difference in mean value of forward lean angle between both portions, but active range of that in curved portion was larger than that in straight portion. 8. Mean value of inward lean angle in curved portion was larger than that in straight portion, but no difference in active range of that between both portions. As the conclusion of this study, it was clear that there were significantly different running patterns between curved and straight portion, and between left and right stride of curved portion.

씨름선수에서 체중 감량과 회복기의 Leptin과 PAI-1 변화

김용운,도경오,권태동,박덕일,장응찬,박소영,김종연,이석강 대한스포츠의학회 2000 대한스포츠의학회지 Vol.18 No.2

Obesity which is defined as accumulation of excess body fat, is central factor of insulin resistance syndrome. Recently, it is revealed tat adipose tissue is not simply an energy storage organ but it also secretes a variety of molecules which affect the metabolism of the whole body, those are leptin and plasminogen activator inhibitor-1(PAI-1). Therefore, leptin and PAI-1 are increased in the obese state. Leptin regulates energy homeostasis and satiety and PAI-1 regulates fibrinolytic system. For these reasons, elevated levels of leptin and PAI-1 are considered as link factors between obesity and insulin resistance syndrome. However, the exact regulating mechanism for serum levels of leptin and PAI-1 is not fully understood yet. In this study, to evaluate the regulating mechanisms of serum levels of leptin and PAI-1 according to the weight changes, we measured leptin, PAI-1, physical, metabolic, and endocrine parameters during 10 days of weight reduction and 10 days of regain period in 7 young athletes. The mean body weight change was -4.7 kg(5.0%) in the weight reduction period and -2.4 kg(2.5%) in the weight regain period compared to baseline value. Baseline level of leptin in athletes was 1.7±0.66 ng/ml, which was significantly correlated with body weight, BMI, percent body fat, body fat mass, triglyceride, insulin, and PAI-1. Baseline level of PAI-1 in athletes was 16.6±5.26 ng/ml, which was significantly correlated with body weight, BMI, triglyceride, insulin, and leptin. Leptin was decreased to 0.7±0.39(44% of the basaline value) in the weight reduction period, and increased to 1.9±0.64(119% of the baseline value) in the regain period. PAI-1 was decreased to 7.4±2.72(44% of the basaline value) in the weight reduction period, and increased to 22.8±7.33(138% of the baseline value) in the regain period. The changes of leptin during weight reduction period were significantly correlated with the changes of insulin(r=0.890, P<0.01) and triglycerides(r=0.874, P<0.01). The changes of PAI-1 during weight reduction period were significantly correlated with the changes of FFA(r=0.889, P<0.01) and triglycerides(r=0.869, P<0.05). The changes of both leptin and AAI-1 during weight regain period were significantly correlated with the changes of insulin(r=0.755 and 0.849, P<0.05, respectively). In summary, these results suggest that serum levels of leptin and PAI-1 were affected by weight cycling, the percentages of change were more greater than that of weight change, and rebound phenomena were occurred during weight regain period.

비행운동 제한에 따른 비둘기 심근세포의 퇴행성 변화

문혜정,이용덕,박원학 대한의생명과학회 2000 Journal of biomedical laboratory sciences Vol.6 No.4

격렬한 운동유형으로 분류되는 비행이 습성화 되어 있는 조류를 대상으로, 인위적으로 비행을 제한시켰을 때 나타나는 심근의 퇴행성 변화를 살펴봄으로써, 운동량 감소가 심근에 미치는 영향에 대하여 검토하고자 하였다. 서식환경의 제한을 위해 자연상태에서 서식하는 비둘기를 1 m3 공간에 2달 동안 서식시킨 군 (confined type)과 자연상태의 군 (wild type)으로 나누어 심근의 변화앙상을 미세구조적, 세포화학적 방법 및 입체해석학적 방법으로 분석하였다. 체중은 confined type에서 증가되어 상대적으로 심장의 무게는 감소되었고, 흉근의 무게는 6.5% 감소 (p<0.05) 되었다. Confined type은 wild type과 비교해 볼 때, 미세구조적으로 더 적은 빈도의 심근의 파동형 변화와 지방소적의 침적이 관찰되었고, 근절의 길이는 길게 관찰되었다. Cytochrome oxidise의 활성을 알아보기 위해 실시한 세포화학적 반응 결과, confined type에서 활성이 15% 감소되었다. 또한 입체해석학적 분석 결과, confined type의 근원섬유 체적밀도는 높게 나타났으나, 근형질내세망의 체적밀도와 사립체 내막의 표면밀도는 각각 23%, 25% 낮게 (p<0,05, p<0.01) 나타났다. 사립체의 체적밀도는 confined type에서 낮게 나타난 반면, 수적밀도는 wild type과 비교하여 17% 높게 (p<0,05) 나타났다. 이러한 결과를 종합해보면 비행이라는 고에너지를 요구하는 격렬한 운동인 비행이 습성화 되어 있는 비둘기에서 비행을 제한시키면, 심근은 운동량의 감소에 따른 퇴행성 변화를 겪게 되므로, 운동의 지속성 여부는 심근기능유지에 매우 중요한 요소로 판단된다. This present study was investigated to elucidate degenerative changes according to the change of habitual environment on the myocytes of doves by restricting them from flight that is instinct behavior of this animal and strong exercise. To restrict doves from flight, they were confined in the cage (1 m3) far 2 months. After this period, the myocardium of the experimental group was compared to that of wild doves in the ultrastructural and cytochemical ways. In addition, stereological changes were also examined. The results were as followings: 1. The body weight of the confined experimental groups was higher than that of the wild doves, but the ratios of the pectoral muscle/body weight (p<0.05) and the heart/body weight were lower. 2. At the ultrastructural level, the myocardium of confined doves appeared as wavy fibers in the smaller area than in the myocardium of wild doves. Also, the length of sarcomeres was longer in the confined doves. The number of sarcoplasmic reticulum and capillary was smaller in the myocardium of confirmed doves. 3. Cytochemical examinations showed that the activities of cytochrome oxidase were lowered in the confuted doves. 4. Stereological analysis revealed that the density of myofibrils was greater in the confined doves, In contrast the volume density of sarcoplasmic reticulum (p<0.05) and the surface density of mitochondrial inner membrane (p<0.05) was lower in the confined doves, while the numerical density of mitochondrial inner membrane was higher (p<0.05). These results suggest that even the short period of restricted exercise can induce negative effects on the functions of myocytes of doves that are adapted for the strong exercise such as flight. Therefore, the maintenance of prolonged exercise seems to be one of the important factors that are critical to retain the functions of myocardiun.