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이정우,김두형,이무하,전광인 三陟大學校 2003 論文集 Vol.36 No.-
This paper presents dynamics of spreader suspended by four flexible cables. This kind of spreader is widely used in dock side container terminals. To derive dynamic equations with Lagrange method, we derive gravitational energy of spreader and elastic energy of suspension cables. The dynamics of spreader is found to be lightly coupled with planar motion and rotational motion. With the dynamic equations, natural frequency of spreader motion is compared with the previous researches, and the results are proven to be more accurate. Simulation of spreader with and without external disturbance are shown.
수용액에서 N-[(4,6-Disubstituted Pyrimidin-2-yl)Aminocarbonyl] Saccharin 유도체의 합성
윤무홍,이천수 啓明大學校 産業技術硏究所 1997 産業技術硏究所 論文報告集 Vol.20 No.-
N-[(4,6-Disubstituted pyrimidin-2-yl)aminocarbonyl]saccharin derivatives can be easily synthesized by treating the basic solution of alkyl or phenyl (2-methoxycarbonyl phenyl sulfonyl)carbamate is dissolved in excess potassium hydroxide aqueous solution, with the acidic solution of 2-amino-4,6-disubstituted pyrimidine ammonium chlorides. Their corresponding chemical structures are identified by IR, ¹H-NMR and ¹³C-NMR as follows: N-[(pyrimidin-2-yl)aminocarbonyl]saccharin(5), N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]saccharin(6),N-[(4-methoxy-6-methylpyrimidin-2-yl)amino-carbony]saccharin(7), N-[(4,6-dimethoxypyrimidin-2-yl) aminocarbonyl]saccharin(8), N-[(4-ethoxy-6-methylpyrimidin-2-yl]aminocarbonyl]saccharin(9), N-[(4-i-propoxy-6-methylpyrimidin-2-yl)aminocarbonyl]saccharin(10), N-[(4-butoxy-6-methylpyrimidin-2-yl)aminocarbonyl]saccharin(11).
宋重千,李相大,宋武錫 홍익대학교 산업기술연구소 1996 産業技術 Vol.6 No.-
The characteristics of disphragm-type gas meter has been investigated experimentally. For a better control of experimental environment fresh water was used as flowing fluid. Flow rate, inlet pressure and mass of disphragm were varied as controlling parameters and the corresponding pressure drop was measured and summarized as function of several dimensionless parameters chosen. Also over-all function of the gas meter during operation was video taped and analysed for better understanding of mechanical links used. Based on the experimental and numerical results a design procedure of gas meter's possible reading or functional errors are addressed with their practical remedies.
Nicotine이 배양된 정상 인체 멜라닌세포의 멜라닌화에 미치는 영향
최천필,김영일,이진우,이무형 경희대학교 동서의학연구소 2006 東西醫學硏究所 論文集 Vol.2006 No.-
Nicotine, the active ingredient of tobacco, causes increased platelet aggregation, endothelial cell damage and alterations in prostacyclin and thromboxane metabolism. Skin changes with nicotine include brown pigmentary staining of hands and nails, leg ulcers, cyanosis, decreased skin temperature and other signs of arterial insufficiency. However, the effect of nicotine on melanization is not well established. The purpose of this study is to evaluate the effect of nicotine on melanization in cultured normal human melanocytes. In order to evaluate non-cytotoxic dose of nicotine, we exposed various concentrations (0.01, 0.1, 1, 10, 100, and 1000 μg/ml) of nicotine to melanocytes and examined cell cytotoxicity using MTT assay. There was no cytotoxicity below 0.1 μg/ml of nicotine. After exposure to 0.1μg/ml nicotine on cultured normal human melanocytes, we investigated the effects of nicotine on the expression of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), DOPAchrome tautomerase (DCT) at the protein levels in human skin melanocytes. There was no significant difference in the expression of TYR, TYRP1, and DCT protein after treatment with nicotine compared to the untreated control. These results suggest that short-term nicotine exposure had no direct melanogenic effect, in vitro.
DMBA로 유발한 Mouse 피부암에 대한 Astaxanthin이 함유된 난황의 항암효과
이상호,박철우,이영춘,최의성,김무남,하영래,Lee, Sang-Ho,Park, Cheol-U,Lee, Yeong-Chun,Choe, Ui-Seong,Kim, Mu-Nam,Ha, Yeong-Rae 한국환경성돌연변이발암원학회 1998 한국환경성돌연변이·발암원학회지 Vol.18 No.1
Anticarcinogenic activity of astaxanthin-containing egg yolks (designate AEY) was investigated for 7,12-dimethylbenz[a]anthracene (DMBA)-induced two stage mouse epidermal carcinogenesis. Female ICR mouse (6-7 weeks of age) were house in a humidity-and-temperature-controlled facility and subjected to feed and water ad libitum. AEY (10 mg/0.2 ml acetone) was painted on the back of mice 7 days, 3 days and 5 min before DMBA treatment (50 nmole/0.2 ml acetone). One week later after DMBA treatment, 6 ${\mu}g$ tetradecanoyl 12-phorbol 13-O-acetate (TPA) dissolved in 0.2 ml acetone was applied on the mouse twice weekly over a period of 22 weeks. No sample was given to control mice. Control egg yolk (CEY) and astaxanthin-containing oil (designate AO) from Phaffia rhodozyma were used as positive controls. Mouse treated with AEY exhibited 10 tumors per mouse whereas control mouse exhibited 15 tumors per mouse, the fact that 33% reduction of tumor per mouse by AEY treatment. Tumor incidence was also reduced to 15% by AEY treatment when compared to that of control group. Such effects were also seen in CEY and AO treatment groups, but leaser extent. AO gave reduction of food intake and body weights relative to those of AEY and CEY, indicating toxicity of AO. These results suggest that AEY exhibits anticarcinogenic activity for DMBA-induced mouse epidermal carcinogenesis.
Urinary Levels of phthalate metabolites in Korean population: KorSEP data, 2009
( Kyoung Mu Lee ),( Young Lim Kho ),( Jae Buhm Chun ),( Pan Gyi Kim ),( Suk Hwan Park ),( Jin Heon Lee ) 대한보건협회 2011 대한보건협회 보건종합학술대회 Vol.2011 No.-
[Background] Phthalates are ubiquitous industrial chemicals used as plasticizers, solvents, lubricants, and stabilizers in the manufacture of consumer products such as children`s toys, medical equipment and medications, cosmetics, and food packaging. Assessing human exposure to phthalates is of interest because of their potential adverse health effects, particularly among the young. [Objective] The national survey for environmental exposure monitoring in 2009 were funded by Korea Food of Drug Administration (KFDA) with a view to assessing human exposure to selected chemicals including phthalates and identifying major sources of them. [Methods] The subjects of our study aged between 18 and 70 were selected through stratified sampling nationwide and interviewed by trained interviewers using structured questionnaire to collect information on general characteristics, use of plastics, dietary habits related with potential exposure to phthalates. Total 1,874 urine samples were collected and stored at -20℃ until measurement for 10 selected metabolites of phthalates using HPLC (high performance liquid chromatography). Out of 10 metabolites, six ones were selected for further statistical analyses based on proportion of samples over LOQ (limit of quantification), i.e, MnBP, MiBP, MbZP, MeHP, MeOHP, and MeHHP. For each urinary levels (ug per gram creatinine), geometric mean and 50th, 75th, 90th, 95th were represented. Given the distribution of response variable deviates from normal distribution, log transformation was performed, and then tested for its statistical significance. Differences by selected variables were analyzed for statistical significance by ANCOVA (analysis of covariance) adjusted for age, sex, income, and body mass index. [Results] Common phthalate metabolites included MnBP (GM=41.7, GSE=1.9), MeHHP (38.1, 1.9), MeOHP (17.5, 1.9), MiBP (17.0, 2.2), and MBzP (15.8, 2.8), whereas the proportion of data above LOQ was less than 20 for MCHP, MnOP, MiNP, and MiDP. The levels for the six metabolites tended to be higher compared to those from the national survey in US (NHANES), and lower compared to those from the national survey in Germany (GerES4). Significant correlations between the six urinary metabolites were observed. Urinary level of phthalates were observed to be higher among subjects with older age, females, subjects with higher body mass index (BMI), and lower income.