조산의 예측 지표로서의 fetal fibronectin의 유용성

정집광,이해혁,이정재,이석민,이순곤,남계현,이임순,이권해 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Objective: The purpose of this study was to evaluate clinical efficacy of fetal fibronectin as a marker to predictor of preterm labor. Materials & Methods: The study group consisted of sixty-eight healthy pregnant women, at gestational age between 24 and 36 weeks, who visited our department with vaginal discharge from April, 1995 to December, 1997. For comparison, we divided all of the pregnant women into two groups by the result of ROM-Check^®, positive groups(N=21) and negative groups(N=47). When preterm labor appeared, 50mg of ritodrine hydrochloride(Yutopar^®) mixed I liter of 5% dextrose solution was administered slowly intravenously. Results: 1) The gestational age at delivery and the interval time from admission to delivery in the positive groups were significantly shorter than those of the negative groups(p<0.05). 2) The positive groups had significantly lower birth weight and Apgar scores than the negative groups(p<0.05). 3) Among the negative groups, in case of tocolytics administration, the interval time from admission to delivery significantly delayed more than that time in case of no tocolytics administration(p<0.05). Conclusions: The detection of the fetal fibronectin in vaginal discharge had a useful method as a predictor of preterm labor. Tocolytics was more effective in the negative groups than in the positive groups.

폐경기 여성에서 호르몬 대치 요법시 병행 투여된 프로제스토젠 투여 방법에 따른 혈청 지질 및 지단백에 미치는 영향

이임순,전섭,이순곤,이해혁,이권해,정집광,이석민 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

Objective : The purpose of our study is to evaluate the effect of different administration method of progestogen on lipid profiles including total cholesterol, LDL(low density lipoprotein)-cholesterol, HDL(high density lipoprotein)-cholesterol, triglycerides during hormone replacement therapy in postmenopausal women. Methods and Materials : Seventy-one postmenopausal women who were assigned to following groups (Group I : conjugated equine estrogen(CEE), 0.625 mg/day plus continuous medroxyprogesterone acetate (MPA), 2.5mg/day, Group II : CEE, 0.625 mg/day plus cyclic MPA, 5mg/day for 12days/month. And we measured serum total cholesterol, high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol, and triglycerides before hormone replacement therapy(HRT) and 12 months later after hormone replacement therapy. Results: 1. Total cholesterol decreased in group I,III. 2. HDL-cholesterol increased in group I,II,III. 3. LDL-cholesterol decrease in group I,II. 4. Triglycerides increased in group I,II,III. There was significance in serum total cholesterol and LDL-cholestrerol among three groups. Conclusions : Estrogen alone or in combination with progestogen both in cyclic and continuous use improves lipid profiles, so medroxyprogesterone acetate(MPA) does not seem to blunt estrogenic effect on lipid profiles.

전격성 경과를 취한 만성 호산구성 폐렴 환자 1예

윤호상,진춘조,유광하,이상엽,이수인,정상만,김선두,이순제,이길도,전혜정 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Chronic eosinophilic pneumonia(CEP) is a rare disease of unknown etiology characterized by chronic infiltration of the lung with eosinophils. It presents with profound systemic symptoms comprising fever, night sweats, weight loss, dyspnea and blood eosinophilia with nonsegmental air-space consolidation confined to the outer third of the lung, the "photographic negative of pulmonary edema". Histopathologic features of chronic eosinophilic pneumonia are intraalveolar and interstitial infiltrations with eosinophils, histiocytes, giant cells, scattered lymphocytes and plasma cells. Glucocorticoid therapy cause prompt resolution of symptoms as well as disappearans of blood eosinophils, elevated serum Ig E levels and the roentgenographic lesions. Infrequent radiographic findings include nodular infiltrates, consolidations, cavitations, atelectasis and pleural effusions. Deaths from CEP although rare, have been reported, but the majorities of CEP have benign courses and do not need a therapy with ventilator. We report a case of chronic eosinophilic pneumonia, which had a sudden course associated with diffuse pneumonic consolidations on the both lung and bilateral pleural effusion.

Rocuronium의 애별투여방법이 모지내전근의 이완에 미치는 영향

최영균,김승수,이원진,조광래,이상은,김영환,임세훈,이정한,이근무,정순호,김영재,신치만 인제대학교 2009 仁濟醫學 Vol.30 No.-

Objective : There are controversies in pnmmg technique of rocuronium whether it can or can't shorten the onset time. We want to compare the effects of two different priming doses and intervals of rocuronium. Materials and Methods : After giving propofol, 50 patients were randomly assigned to 5 groups. Group I received a placebo, followed 3 min later by rocuronium 0.6 mg/kg. Priming doses and intervals of Group II, Ill, N, V were 0.06 rng/kg and 2 min, 0.12 mg/kg and 2 min, 0.06 rug/kg and 3 min, 0.12 mg/kg and 3 min, respectively. Total dose of rocuronium was 0.6mg/kg. Train of four (TOF) count or ratio and 1st twitch height of TOF (T1) were monitored with 15 secondsintervals. TOF ratio of each groups just before bolus injection, duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were compared. Results : Duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were decreased in priming groups compared to Group 1 (P < 0.01) In group V, significant depression of TOF ratio just before bolus injection was seen (P < 0.05). Conclusion : Priming technique with rocuronium is effective method to shorten the onset of neuromuscular block. But priming dose of rocuronium itself could cause hypoxia and aspiration in awake patients and should be used carefully. Priming dose of rocuronium 0.06 mg/kg and 2 minutes interval maybe relatively safe method.

한약의 毒性연구(최근 보고된 문헌을 中心으로)

李仙童,姜舜洙 圓光大學校 韓醫學硏究所 1991 원광한의학 Vol.1 No.1

Herbal Drugs polluted by peaticide and Heavy Metal have been not only threated Human Health but also Drug Safety Severely as environmental pollution. Although Herbal Drugs have thought very safety by oriental medicine Doctors and Patiants, but I found it was not correctly in My study these problems by solve. Example, Tale found be Carcinogenic and slice gold (as Mineral Material) be nephropathologic agents if there were nontoxicity in the past. In order to people's Health stand and rise, and Oriental Medicine Doctors have to use the most safety prescription. For these Method oriental Medicine Doctors have to reduce Herbal Drug Dose and concern Herbal Drug toxicity needed study and Correct education.

企業文化와 成果의 관계에 관한 硏究

李光純 충남대학교 경상대학부설 경영경제연구소 1994 경영논집 Vol.10 No.1

미기상규모 영역의 온실기체 승온효과에 관한 수치연구

이순환,서광수,김동희,황수진 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.3

The change of land use such as the construction of way in mountainous area and tunnel leads to the quantitative change of the greenhouse gas. This study tried to clarify the effect of the change of land use around Miryang Ice Valley on thermal environment of micro-meteorological scale by numerical experiment. We carried out several numerical experiment under different atmospheric conditions with different amount of greenhouse gases. Heating rate increased by the greenhouse gas in the ground level is average of 0.0073 K/day. And the increasing rate is smaller than the daily average heat crossing quantity.

TiO₂미세분말 제조에 관한 연구

이광래,안순철,송근호,김종수 강원대학교 석재복합신소재제품연구센터 1998 석재연 논문집 Vol.3 No.-

역마이셀 기법에 의하여 TiO₂ 분말을 제조하였으며, TiO₂ 분말 제조에 미치는 공정변수들인 계면활성제의 종류 및 보조계면활성제가 생성입자의 입도분포에 미치는 영향을 규명하였다. 비이온계면활성제인 Span 80을 사용하였을 경우에는 입도분포가 unimodal형태였으나, 음이온계면활성제인 Aerosol-OT(AOT)를 사용하였을 경우, bimodal형태를 나타내었다. 에탄올(ethanol)을 cosurfactant로 첨가한 계로 부터 생성된 입자는 평균입경이 0.12㎛ 으로서 미세할 뿐아니라 입도분포도 매우 좁은 것을 알 수 있다. Titanium dioxide (TiO₂) fine particles were produced by the reverse micelle technique. The effects of process variables such as surfactant and cosurfactant on particle size distribution were investigated. The particle size distribution curve was unimodal for a nonionic surfactant (Span80), but was bimodal for an anionic surfactant (AOT). The addition of ethanol as a cosurfactant resulted in narrow particle size distribution and 0.12㎛ of smaller average particle diameter.

확장된 Huckel 이론에 의한 이원자 분자의 고찰

李廣純,洪宗基 聖心女子大學校 1987 論文集 Vol.19 No.-

원자간의 반발력을 고려하여 이원자 분자의 에너지와 전화분포등을 확장된 Huckel이론으로 구하였다. 이들 반발에너지는 Hellmann-Feynnlnn 이론으로 계산하였으며 전자의 비편재에너지는 일-전자 문제로 처리하여 구하였다. 이들 결과를 근거로 이 이론으로 고체표면에 흡착된 분자상태를 고찰하고 있다. Molecular energies of N₂ and CO isoelectron molecule are calculated by using the ASED -MD theory which is take into account of repulsion energy resulting from a molecule followed by the superposition of the rigid atom. The repulsion energies are calculated by Hellmann-Feyman electrostatic theorem. The electron delocalization energy ?? give rise by the Extended Huckel theory using one-electron Hamiltionian. We are now testing an applying this theory to the solid surface systems.

유구치 Stainless Steel Crown 주위의 치은염 치은열구 삼출액 및 치면세균막 부착도에 관한 연구

이광기,손동수 大韓小兒齒科學會 1985 大韓小兒齒科學會誌 Vol.12 No.1

The study was performed to evaluate the status of the marginal gingival tissue surrounding the Stainless Steel Crowned teeth comparing to the overall marginal gingival tissue of the same children use of plaque Index, Gingival Index and Gingival Crevichlar Fluid flow rate. The selected subjects for this study were 38 children (boys 18, girls 20) aged from 3 year - 5 month to 12 year - 3 month who have more than one Stainless Steel Crown in their mouth. The obtained results were as follows; 1. There was little deleterious effect on the marginal gingiva after delivery of Stainless Steel Crown. 2. In case of Satisfactory Stainless Steel Crown there was no deleterious effect on the marginal gingiva but in case of Unsatisfactory Stainless Steel Crown there was a little deleterious effect on the marginal gingiva. 3. In Plaque Index Stainless Steel Crowned teeth exhibited a little lower score than the natural teeth of control group but statistically there was no significant differences (p>0.05). 4. A strong positive correlation existed between the two of Gingival Index, Plaque Index and Gingival Crevicular Fluid flow rate. 5. 38.03% of examined Stainless Steel Crown was satisfactory and errors in crown crimp were the most common, with defects in crown length, position, contour, polish, contact and cementation following in order of decreasing frequency.