Endocrine disruption potentials of several pharmaceuticals in H295R cell and a freshwater fish Oryzias latipes

Choi Kyungho(최경호) 한국환경독성학회 2010 한국독성학회 심포지움 및 학술발표회 Vol.2010 No.11

Current status of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) exposure among mothers and their babies of Korea-CHECK cohort study

Choi, Sooran,Kim, Hai-joong,Kim, Sunmi,Choi, Gyuyeon,Kim, Sungjoo,Park, Jeongim,Shim, Soon-sup,Lee, Inae,Kim, Sungkyoon,Moon, Hyo-Bang,Choi, Kyungho,Lee, Jeong Jae,Kim, Su Young Elsevier 2018 Science of the Total Environment Vol.618 No.-

<P><B>Abstract</B></P> <P>Despite the global ban, organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) have been a persistent and significant environmental health issue worldwide. Prenatal exposure to these persistent organic pollutants (POPs) has been identified as a major route of exposure among developing fetuses and newborn infants. Among Children's Health and Environmental Health of Korea (CHECK) cohort population, pregnant females (<I>n</I> =148) and their matching newborn infants (<I>n</I> =117) recruited from four cities of Korea in 2011 were investigated. The blood serum and cord blood serum were sampled at delivery, and measured for 19 OCPs and 19 PCBs. In addition, a questionnaire regarding demographic characteristics, and dietary habits were conducted. The most frequently detected POPs in both maternal blood and cord blood were <I>p,p</I>′-dichlorodiphenyl dichloroethylene (DDE) (99% detection in maternal, and 98% in cord blood serum) and PCB153 (95% in maternal, 74% in cord blood serum). The levels of dichlorodiphenyl trichloroethanes (DDTs) in both maternal (average 82.5ng/g lw) and cord blood serum (average 77.5ng/g lw) were comparable to or greater than those reported in Japan about a decade ago. Approximately two thirds of the pregnant women and newborn infants showed the <I>p,p</I>′-DDE concentrations exceeding the biological equivalent (BE) corresponding to 10<SUP>−6</SUP> excess cancer risk. In addition, less chlorinated PCBs were detected higher in both maternal and cord serum. Less chlorinated PCBs also showed greater transplacental ratio. Dairy consumption among the subjects was positively associated, and tea consumption was negatively associated with serum levels of several POPs. Our results show that the exposure to legacy POPs, especially DDTs, among pregnant women and newborn infants is still prevailing, thus warrants measures for exposure mitigation among these vulnerable populations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> OCPs and PCBs were measured in serum of Korean mothers and their matching newborns. </LI> <LI> Levels of most OCPs in maternal and cord serum are correlated. </LI> <LI> Less chlorinated PCBs are detected higher in cord serum than maternal serum. </LI> <LI> DDTs are of potential health concern, with 67% of subjects potentially at risk. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Characterization and regulated naproxen release of hydroxypropyl cyclosophoraose-pullulan microspheres

Choi, Jae Min,Lee, Benel,Jeong, Daham,Park, Kyeong Hui,Choi, Eun-Ji,Jeon, Yong-Joon,Dindulkar, Someshwar D.,Cho, Eunae,Do, Sun Hee,Lee, Kyungho,Lee, Im-Soon,Park, Seyeon,Jun, Bong-Hyun,Yu, Jae-Hyuk,Ju THE KOREAN SOCIETY OF INDUSTRIAL AND ENGINEERING 2017 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY -S Vol.48 No.-

<P><B>Abstract</B></P> <P>Hydroxypropyl cyclosophoraose-pullulan (HPCys-Pul) microspheres were designed as a novel hybrid system of biocompatible pullulan matrice and pendant hydroxypropyl cyclosophoraoses with drug complexing ability. The HPCys-Pul microspheres were prepared by emulsion crosslinking method, and characterized using thermogravimetric analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, and solid state NMR spectroscopy. By virtue of hydroxypropyl cyclosophoraoses, the developed microspheres can encapsulate 4.2-fold more naproxen than pullulan microspheres. Korsmeyer–Peppas model was introduced for describing release kinetics. <I>In vivo</I> naproxen release analysis was carried out in Sprague-Dawley (SD) rats. From those results HPCys-Pul microsphere will be a promising platform for controlled drug delivery.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hybrid microspheres of biocompatible polysaccharide pullulan (Pul) and hydroxypropyl cyclosophoraoses (HPCys) were prepared. </LI> <LI> The HPCys-Pul microspheres showed both effective encapsulation and controlled release of naproxen (NPX). </LI> <LI> Those microspheres were completely characterized by TGA, XRD, FE-SEM, FT-IR, and solid-state NMR spectroscopy. </LI> <LI> Hybrid HPCys-Pul microspheres resulted in a pH-regulated release system as well as enhanced entrapment efficiency for NPX. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Acute toxicity of four alkylphenols (3-tert-butyl-, 2-isopropyl-, 3-propropyl-, and 4-isopropyl-phenol) and their binary mixtures to Microtox, with comparisons to Ceriodaphnia dubia and Pimephales promelas

Kyungho Choi,Leonard l. Sweet,Brian E. Olseski,Peter G. Meier 한국환경보건학회 2003 한국환경보건학회 학술대회 자료집 Vol.2003 No.-

Exposure to environmental chemicals among Korean adults-updates from the second Korean National Environmental Health Survey (2012–2014)

Choi, Wookhee,Kim, Suejin,Baek, Yong-Wook,Choi, Kyungho,Lee, Keejae,Kim, Sungkyoon,Yu, Seung Do,Choi, Kyunghee Elsevier 2017 International journal of hygiene and environmental Vol.220 No.2

<P><B>Abstract</B></P> <P>National biomonitoring program can offer solid scientific evidence on exposure profiles of environmental chemicals at a national level, and provide a snapshot of changing exposure level over time. Therefore, several countries have maintained such programs for developing environmental health policies. The Korean National Environmental Health Survey (KoNEHS) was designed to understand the level of human exposure to environmental chemicals by time and location, and to identify possible sources of such exposure. The 2nd stage of KoNEHS, which was conducted between 2012 and 2014, examined a total of 6478 adult subjects over 19 years of age, and measured 21 environmental chemicals of major policy concern. Compared to the findings from the first stage monitoring (2009–2011), slightly higher levels of blood lead were observed, while those of mercury remained similar. Blood metal concentrations, however, were higher than those reported from national biomonitoring programs of United States, Germany and Canada. The urinary concentrations of phthalates metabolites were lower, but those of t,t-muconic acid and BPA were higher than those reported in the first stage survey. The urinary cotinine level decreased perhaps reflecting general declining patterns of first- and second-hand smoking. The results of the second stage survey were made available for public use since April 2016.</P> <P>Some policy efforts appear to be at least in part effective on mitigating chemical exposure among people, e.g., urinary phthalate metabolites and cotinine, while further confirmations are warranted. In-depth assessments will be conducted to identify vulnerable groups and important exposure pathways.</P>

Uptake efficiencies of PCB 153 in fathead minnows through food chain of sediment-midge-fish

Kyungho Choi,Peter G. Meier 한국환경보건학회 2003 한국환경보건학회 학술대회 자료집 Vol.2003 No.-

Failure of a Rotation Control Gamma 3 Lag Screw Used to Treat a Trochanteric Fracture

( Kyungho Choi ),( Yongtae Kim ),( Shicheng Zhou ),( Jihyo Hwang ) 대한고관절학회 2018 Hip and Pelvis Vol.30 No.2

Gamma 3 rotation control lag screws (U-blade) are particularly useful when treating rotational and unstable fractures of the proximal femur. A 93-year-old woman who underwent closed reduction of a trochanteric fracture and internal fixation with a Gamma 3 nail rotation control lag screw. The patient presented with metal failure and U-blade bending following a fall occurring 4 weeks after surgery. Here, we present a case report summarizing removal of the failed lag screw.

4차 산업혁명 핵심기술을 활용한 기후변화 대응 및 관련 법제 연구 - 빅데이터를 중심으로 -

최경호(Kyungho Choi) 강원대학교 비교법학연구소 2019 江原法學 Vol.58 No.-

4차 산업혁명이라는 표현 자체의 적절성 여부에 대해서는 이견이 있을 수 있지만 그것이 예견하는 변화가 머지않아 보편적으로 확산되고 우리의 삶을 유의미하게 변화시킬 것이라는 점은 부정하기 어렵다. 인공지능, IoT, 빅데이터 분석 등 4차 산업혁명 핵심 기술을 기후변화 대응에 활용할 수 있는 전략에 대해 연구하고, 이를 활성화하기 위한 국내외 주요 활용사례를 소개하였다. 유엔 Big Data Climate Challenge, 기후스마트 농업빅데이터(Climate-Smart, Site-Specific Agriculture), 그린버튼 이니셔티브(미국 캘리포니아) 등 기후변화 대응에서 빅데이터가 활용되고 있는 주요 사례를 소개함으로서 참고할 수 있는 유형 모델을 제시하였다. 기후변화 빅데이터 연구에 있어서는 그 복잡성 및 기후 변수 등이 고려되어져야 한다. 또한 기후변화 빅데이터의 공감력 향상에 주목을 해야 한다. 기후변화 빅데이터 처리에 있어 인간의 학습방식과 다른 방식의 처리가 필요하다. 방대한 양의 정보, 즉 빅데이터는 인간의 정보 접근 및 학습방식과는 다르다는 점을 전제하고 이를 보완하려는 작업이 필요하다. 그 밖에도 본 논문에서는 빅데이터의 활용 전략으로 “기후변화 빅데이터의 중립성 확보”, “기후변화 빅데이터의 실시간 처리와 제공”, “체감형근린데이터의 활용 전략” 등의 중요성과 접근 방법을 제시하였다. 지구온난화 극복을 위해서는 친환경에너지 패러다임을 위한 기술 개발도 중요하지만 빅데이터의 활용은 현재 사용되고 있는 에너지원의 효율적 사용을 통해 온실 가스배출을 감축시키는 것도 함께 고려되어져야 한다. 에너지원의 효율적 사용을 통하여 발생할 수 있는 온실가스의 양을 최소화하고 이러한 과정에서 센서, IoT, 빅데이터 등을 활용하여 불완전연소 상황을 줄이고 완전연소에 가까운 상황을 만드는 것은 에너지 효율적 사용환경 조성에 도움이 된다. 본 논문에서는 저탄소녹색 성장기본법 및 도시교통정비촉진법에 빅데이터 등 4차산업 핵심기술 활용촉진을 위한 개정안을 제시하였다. 「저탄소녹색성장기본법」 제27조는 “정부는 에너지 절약, 에너지 이용효율 향상 및 온실가스 감축을 위하여 정보통신기술 및 서비스를 적극 활용하는 시책을 수립․시행하여야 한다”고 규정하고 있다. 동 규정은 정부차원에서 4차 산업혁명 핵심기술을 개발ㆍ적용하여 기후변화 완화에 적용할 수 있는 근거가 되는 조항으로 활용할 수 있을 것이다. 동법 동조 제4호에 “정보통신 연계 빅데이터(대용량의 정형 또는 비정형의 데이터세트를 말한다) 기술 개발 촉진”을 추가하여 정보통신 연계 빅데이터 기술 개발 촉진 관련 기술의 활용을 유도할 수 있다. 또한 교통분야의 온실가스배출 관련 빅데이터는 기후변화에 영향을 주는 빅데이터라 할 수 있고, 동 교통부분의 온실가스배출 저감에 빅데이터를 활용하는 방법을 검토할 필요가 있다. 도시교통정비촉진법 개정을 통하여 교통시설의 정비를 촉진하고 교통수단과 교통체계를 효율적으로 운영․관리는 차량의 불필요한 공회전을 줄일 수 있고, 온실가스배출 감축으로 연결을 위해 목적조항에 온실가스 감축을 적시함으로서 동법 및 그 하위법령에 이행을 위한 근거를 마련을 위한 개정안을 제시하였다. There may be disagreements about the appropriateness of the expression of the Fourth Industrial Revolution, but it is not easy to deny that the foreseeable change by the 4th Industrial Revolution will universally widespread and change our lives in meaningful ways. We can recognize that climate change can be both a real threat and a business opportunity. This research studies strategies to utilize key technologies of the fourth industrial revolution such as artificial intelligence, IoT, and big data analysis to cope with climate change. And this research can provide policy directions and legislative guidelines. Unlike many previous researches that had discussed Big Data, this research deeply discuss Big Data in the framework of climate change. Climate change data complexity and climate variables should be considered. Big data practitioners need to understand the variability and complexity of data. Rather than a general approach to the utilization of core technology in the 4th industrial age, it is necessary to conduct effective strategy research and promote utilization of the technology under the framework of climate change. Including technologies based on the Internet of things, big data, and artificial intelligence. The Earth system is made up of a number of variables interacting and influencing the climate. This article introduces the major cases where Big Data is being used in responding to climate change such as UN Big Data Climate Challenge, Climate-Smart, Site-Specific Agriculture and Green Button Initiative (California, USA). In order to overcome global warming, it is important to develop new technologies for environment-friendly energy paradigm. However, the use of Big Data should also consider reducing greenhouse gas emissions through efficient use of currently used energy sources. Minimizing the amount of greenhouse gas that can be generated through efficient use of energy source. This article proposes an amendment to promote the use of core technologies such as Big Data in the Low Carbon Green Growth Basic Law and Urban Traffic Maintenance Promotion Act. Rather than a general approach to the utilization of core technology in the 4th industrial age, it is necessary to conduct effective strategy research and promote utilization of the technology under the framework of climate change.

코로나19와 환경보건 - 당면한 과제와 전망

최경호(Kyungho Choi) 서울대학교 보건환경연구소 2020 보건학논집 Vol.57 No.2

화학물질의 갑상선 독성영향

최경호(Kyungho Choi),김수진(Sujin Kim),강하병(Ha-Byeong Kang),정다운(Dawoon Jung) 환경독성보건학회 2016 한국독성학회 심포지움 및 학술발표회 Vol.2016 No.6