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Kim Taehee,Choi Hayoung,Kim Sang Hyuk,Yang Bumhee,Han Kyungdo,Jung Jin-Hyung,Kim Bo-Guen,Park Dong Won,Moon Ji Yong,Kim Sang-Heon,Kim Tae-Hyung,Yoon Ho Joo,Shin Dong Wook,Lee Hyun 대한의학회 2024 Journal of Korean medical science Vol.39 No.11
Background: Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD). This study assessed the risk of COPD development and COPD-related hospitalization in TB survivors compared to controls. Methods: We conducted a population-based cohort study of TB survivors and 1:1 age- and sex-matched controls using data from the Korean National Health Insurance Service database collected from 2010 to 2017. We compared the risk of COPD development and COPD-related hospitalization between TB survivors and controls. Results: Of the subjects, 9.6% developed COPD, and 2.8% experienced COPD-related hospitalization. TB survivors had significantly higher COPD incidence rates (36.7/1,000 vs. 18.8/1,000 person-years, P < 0.001) and COPD-related hospitalization (10.7/1,000 vs. 4.3/1,000 person-years, P < 0.001) than controls. Multivariable Cox regression analyses revealed higher risks of COPD development (adjusted hazard ratio [aHR], 1.63; 95% confidence interval [CI], 1.54–1.73) and COPD-related hospitalization (aHR, 2.03; 95% CI, 1.81–2.27) in TB survivors. Among those who developed COPD, the hospitalization rate was higher in individuals with post-TB COPD compared to those with non-TB COPD (10.7/1,000 vs. 4.9/1,000 person-years, P < 0.001), showing an increased risk of COPD-related hospitalization (aHR, 1.84; 95% CI, 1.17–2.92). Conclusion: TB survivors had higher risks of incident COPD and COPD-related hospitalization compared to controls. These results suggest that previous TB is an important COPD etiology associated with COPD-related hospitalization.
Association of Weight Change Following Smoking Cessation with the Risk of Tuberculosis Development
( Seung Hoon Kim ),( Seung Hyun Ko ),( Kyungdo Han ),( Shin Young Kim ),( So Hyang Song ),( Chi Hong Kim ),( Sung Kyoung Kim ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Current smokers are at risk of tuberculosis (TB) development. However, the impact of weight change after smoking cessation on the occurrence of TB remains elusive. We aimed to determine the relationship between weight change after smoking cessation and the risk of TB development. Methods We conducted a population-based cohort study using the National Health Insurance Service database in South Korea. Of the 10,490,491 subjects who underwent health check-up from January 1, 2009 to December 31, 2009, we enrolled 9,953,124 subjects without a previous TB history and followed them until December 31, 2017. We divided all study participants into the following 3 groups: never, former, and current smokers. The primary endpoint was newly developed TB. Results Among 9,953,124 subjects analyzed, 5,922,845 (59.5%) were never smokers, 1,428,209 (14.4%) were former smokers, and 2,602,080 (26.1%) were current smokers. The risk of TB development was significantly higher in current smokers than in never smokers (aHR 1.158; 95% CI 1.131-1.186), and the association was strengthened with increasing amount and duration of smoking. The risk of TB development was significantly lower in former smokers than in never smokers (aHR 0.947; 95% CI 0.921-0.973), especially in those with fewer than 1 pack per day of smoking amount or 30 years of smoking duration. Among current smokers, individuals who stopped smoking and maintained weight after baseline evaluation had a significantly lower risk of TB development compared with those who continued to smoke (aHR 0.795; 95% CI 0.723-0.874). However, even after smoking cessation, individuals who lost weight were at a significantly higher risk of TB development (aHR 1.351; 95% CI 1.094- 1.670). Conclusions Our findings suggest that smoking cessation may be associated with decreased risk of TB development. Furthermore, weight maintenance (neither gaining or losing) after quitting smoking might reduce the risk of TB development.
Mental Health Status and Bronchiectasis Incidence: Nationwide Population-based Cohort Study
( Seung Hoon Kim ),( Kyungdo Han ),( Seung-hyun Ko ),( Shin Young Kim ),( So Hyang Song ),( Chi Hong Kim ),( Sung Kyoung Kim ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background It has been suggested that patients with bronchiectasis are at increased risk for depression and anxiety. But, there are few studies on how mental health status influence the incidence rate of bronchiectasis. The aim of the present study was to examine the effect of mental health on the incidence rate of bronchiectasis using the national database in Republic of Korea. Methods In this study, data from the KNHANES between 2008 and 2013 were used. Of 24,419 KNHANES participants, adults over 40 years of age who underwent spirometry were included in our analysis. To evaluate newly diagnosed bronchiectasis, we used data derived from a cohort of the NHIS from 2008 with clinical follow-up for primary outcome through December 31, 2013. The mental health status of the study subjects was assessed through questions related to psychological stress, depressive mood, and suicidal ideation. One point was given to each question, and total mental health score of 3 points was calculated. The spirometry Results were classified into three groups such as normal, restrictive, and obstructive lung function impairment. Results All 24,419 KNHANES participants were reviewed and 8126 patients were excluded. Among 16,293 participants analyzed, 561 (3.4%) were newly diagnosed with bronchiectasis. In the analysis of the incidence rate of bronchiectasis according to the mental health score, the group with a mental health score of 2 or higher was significantly associated with a higher incidence rate of bronchiectasis (adjusted hazard ratio [aHR] 1.397; 95% confidence interval [CI] 1.116-1.748). Participants with restrictive (aHR 1.858; 95% CI 1.094-3.156) or obstructive lung function (aHR 3.192; 95% CI 2.073-4.912) impairment and a mental health score of 2 or higher was significantly associated with a higher incidence rate of bronchiectasis. Conclusions This study proposed that mental health status may influence the incidence rate of bronchiectasis.
Kim, Jaeryung,Lim, Dong Hui,Han, Kyungdo,Kang, Se Woong,Ham, Don-Il,Kim, Sang Jin,Chung, Tae-Young Elsevier 2019 American journal of ophthalmology Vol.205 No.-
<P><B>Purpose</B></P> <P>To investigate association between the development of retinal vein occlusion (RVO) and blood high-density lipoprotein cholesterol (HDL-C).</P> <P><B>Design</B></P> <P>A retrospective, nationwide, population-based cohort study.</P> <P><B>Methods</B></P> <P>This study was set in the Republic of Korea and included 23,149,403 people ≥20 years of age who underwent the Korean National Health Screening Program examination between January 2009 and December 2012. Among them, the RVO group was composed of patients with an initial diagnosis of RVO made between 2009 and 2015 (n = 117,639). The earliest claim with an RVO diagnostic code was considered as the incident time. The predictive value of HDL-C level for RVO was analyzed using hazard ratios. The primary outcome measure was the incident cases of RVO.</P> <P><B>Results</B></P> <P>Subjects with RVO were generally older; had high body mass index, waist circumference, fasting blood glucose, blood pressure, total and low-density lipoprotein cholesterol, and triglyceride values, and low glomerular filtration rate and HDL-C values; and were more likely to experience diabetes mellitus and hypertension compared with the non-RVO group. The fully adjusted hazard ratio of RVO was 1.12 (95% confidence interval 1.10–1.14) in the lowest quartile of HDL-C versus in the highest quartile. The association between the development of RVO and HDL-C was higher those with a younger age, male sex, current smoking habit, diabetes mellitus, and hypercholesterolemia. In addition, we observed a significant synergistic effect of low HDL-C level with obesity and hypertension.</P> <P><B>Conclusion</B></P> <P>This is the first nationwide population-based epidemiologic study evaluating the association between HDL-C level and the risk of RVO development. A significant association between low HDL-C and RVO development was found.</P>
Kim, Mee Kyoung,Han, Kyungdo,Koh, Eun Sil,Kim, Hun-Sung,Kwon, Hyuk-Sang,Park, Yong-Moon,Yoon, Kun-Ho,Lee, Seung-Hwan American Heart Association 2017 Arteriosclerosis, thrombosis, and vascular biology Vol.37 No.10
<P>Conclusions-Increasing TC variability was associated with an increasing incidence of ESRD. Visual Overview-An online visual overview is available for this article.</P>
Clinical Course of Chronic Spontaneous Urticaria in the Korean Adult Population
Kim, Yoon Seob,Park, Sang Hyun,Han, Kyungdo,Lee, Ji Hyun,Kim, Nack In,Roh, Joo Young,Seo, Seong Jun,Song, Hae Jun,Lee, Min-Geol,Choi, Jee Ho,Park, Young Min The Korean Academy of Asthma, Allergy and Clinical 2018 Allergy, Asthma & Immunology Research Vol.10 No.1
<P>Knowledge of the clinical course of chronic spontaneous urticaria (CSU) remains unclear. The purpose of our study was to investigate the clinical course of CSU in the Korean adult population. Each patient in the CSU group who was defined by disease codes between 2003 and 2007 was tracked whether he or she went into remission or not until 2013. Kaplan-Meier survival analysis was carried out to analyze remission, and log-rank tests were performed for between-group comparisons. Demographic differences between subjects who went into remission 1 year after the initial diagnosis and those who did not were analyzed using χ<SUP>2</SUP> tests. A total of 13,969 subjects were included in the CSU group. The 1-, 2-, 3-, 4-, and 5-year remission rates of CSU were 21.5%, 33.0%, 38.9%, 42.6%, and 44.6%, respectively. The proportion of subjects in the 65+ age group (<I>P</I>=0.050) and with male gender (<I>P</I>=0.002) was significantly higher among subjects who did not go into remission 1 year after the initial diagnosis. Our study indicates that CSU could have a more persistent course than previously reported.</P>
Kim, Sun-Hwa,Hong, Suk Young,Sudduth, Kenneth A.,Kim, Yihyun,Lee, Kyungdo The Korean Society of Remote Sensing 2012 大韓遠隔探査學會誌 Vol.28 No.6
Leaf area index (LAI) is important in explaining the ability of the crop to intercept solar energy for biomass production and in understanding the impact of crop management practices. This paper describes a procedure for estimating LAI as a function of image-derived vegetation indices from temporal series of IKONOS, Landsat TM, and MODIS satellite images using empirical models and demonstrates its use with data collected at Missouri field sites. LAI data were obtained several times during the 2002 growing season at monitoring sites established in two central Missouri experimental fields, one planted to soybean (Glycine max L.) and the other planted to corn (Zea mays L.). Satellite images at varying spatial and spectral resolutions were acquired and the data were extracted to calculate normalized difference vegetation index (NDVI) after geometric and atmospheric correction. Linear, exponential, and expolinear models were developed to relate temporal NDVI to measured LAI data. Models using IKONOS NDVI estimated LAI of both soybean and corn better than those using Landsat TM or MODIS NDVI. Expolinear models provided more accurate results than linear or exponential models.
Kim, Yang-Hyun,Han, Kyungdo,Son, Jang-Won,Lee, Seong-Su,Oh, Sang Woo,Kwon, Hyuk-Sang,Shin, Soon-Ae,Kim, Yeon-Yong,Lee, Won-Young,Yoo, Soon Jib Korean Society for the Study of Obesity 2017 Journal of obesity & metabolic syndrome Vol.26 No.1
<P><B>Background</B></P><P>In Korea, the prevalence of obesity has steadily increased, and the socioeconomic burden of obesity has increased along with it. In 2015, the National Health Insurance Service (NHIS) signed a memorandum of understanding with the Korean Society for the Study of Obesity (KSSO), providing limited open access to its databases so that the status of obesity and obesity management could be investigated.</P><P><B>Methods</B></P><P>Using NHIS databases, we analyzed nationwide population-based studies for obesity using the definition of obesity (body mass index ≥25 kg/m<SUP>2</SUP>) in subjects over the age of 20. Age and sex standardization were used for all data.</P><P><B>Results</B></P><P>The KSSO released the ‘Obesity Fact Sheet 2016’ using the 2006–2015 NHIS Health Checkup database. The prevalence of obesity steadily increased from 28.7% in 2006 to 32.4% in 2015, and the prevalence of abdominal obesity also steadily increased from 18.4% in 2009 to 20.8% in 2015. The prevalence of class II obesity steadily increased from 2006 to 2015, such that the total prevalence was 4.8% in 2015 (5.6% in men and 4.0% in women). The highest prevalence of obesity was found in Jeju Island, while the lowest prevalence was found in Daegu City. The highest prevalence of abdominal obesity was also found in Jeju Island, while the lowest prevalence was found in Gwangju City.</P><P><B>Conclusion</B></P><P>Based on the Obesity Fact Sheet 2016, a strategy for reducing the prevalence of obesity is needed, especially in Korean men.</P>
Kim Kihyun,Bang Woo-Dae,Han Kyungdo,Kim Bongseong,Lee Jung Myung,Chung Hyemoon 한국지질동맥경화학회 2021 지질·동맥경화학회지 Vol.10 No.3
Objective: We compared the effects of high-intensity statin monotherapy versus moderateintensity statin and ezetimibe combination therapy on major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI). Methods: Using the Korean National Health Insurance Service database, we screened 82,941 patients with AMI who underwent percutaneous coronary intervention (PCI) between 2013 and 2016. Among them, we identified 9,908 patients treated with atorvastatin 40 mg (A40, n=4,041), atorvastatin 20 mg + ezetimibe 10 mg (A20+E10, n=233), rosuvastatin 20 mg (R20, n=5,251), or rosuvastatin 10 mg + ezetimibe 10 mg (R10+E10, n=383). The primary outcome was MACE, a composite of all-cause death, non-fatal myocardial infarction undergoing PCI, repeat revascularization, and ischemic stroke. Multivariable analyses were performed using the inverse probability of treatment weighting method. Results: The incidence rate of MACE in the overall population was 42.97 cases per 1,000 person-years. There was no significant difference in the risk of composite outcomes of MACE between the groups. However, the R10+E10 group showed a higher risk of all-cause death (hazard ratio, 2.07; 95% confidence interval, 1.08–3.94) than the A40 group (reference group) in the weighted multivariable model. Conclusions: In this study, there was no significant difference in the composite outcome of MACE between high-intensity statin monotherapy and moderate-intensity statin and ezetimibe combination therapy.