유기인제 중독 후 발생한 중간형 마비 증후군

고재욱,박준석,이경룡,정성필,이한식 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: Intermediate myasthenia syndrome(IMS) is thought to have clinical importance because it may cause sudden respiratory failure during the recovery phase of a cholinergic crisis of organophosphate poisoning. We designed this study to identify the prevalence, the inducing agent, clinical predictor, and the proposed treatment of IMS. Methods: Patients who had admitted with the diagnosis of acute organophosphate poisoning from 1992 to 1998 at two teaching hospitals were enrolled in this study. We selected the cases of IMS based on a review of medical records using modified He' s criteria. Results: Twelve(12) out of 110 patients with acute organophosphate poisoning were diagnosed for a prevalence at 10.9%. The drug inducing IMS were identified as dichlorvos, fenthion, EPN, methidathion, and phosphamidon. The occurrence of IMS was not related to either the initial treatment with atropine and pralidoxime, or the level of serum cholinesterase. Complications were pneumonia, sepsis, pancreatitis, and pseudomembranous colitis, etc. Eleven(11) patients were discharged without sequelae, and one patient was discharged as a hopeless case. Conclusion: This study suggests that IMS is not rare, so close observation is required to detect IMS in organophosphate-poisoning patients. Also, more studies are required to find predictors and treatments.

Optimization of the <tex> $\hbox{BaSnO}_{3}$</tex> Doping Content in <tex> $\hbox{GdBa}_{2}\hbox{Cu}_{3}\hbox{O}_{7-\delta}$</tex> Coated Conductors by Pulsed Laser Deposition

Kyung-Pil Ko,Soon-Mi Choi,Jung-Woo Lee,Rock-Kil Ko,Seung-Hyun Moon,Chan Park,Sang-Im Yoo IEEE 2014 IEEE transactions on applied superconductivity Vol.24 No.6

<P>We tried to optimize the BaSnO<SUB>3</SUB> (BSO) doping content in GdBa<SUB>2</SUB>Cu<SUB>3</SUB>O<SUB>7-δ</SUB> (GdBCO) coated conductors (CCs) on CeO<SUB>2</SUB>-buffered ion-beam assisted deposition (IBAD)-MgO templates. The BSO-doped GdBCO CCs with various x vol% ( x=0, 2, 3, 4, 5, and 6) relative to GdBCO were prepared at 800°C with the oxygen pressure of 300 mtorr by pulsed laser deposition (PLD), and their pinning properties were characterized by measuring magnetic hysteresis curves for the applied field parallel to the c-axis of GdBCO (B//c) up to 5 T and field-orientation dependence of transport critical currents for 1, 3, and 5 T at 65 and 77 K, respectively. Among all samples, a 5 vol% BSO-doped GdBCO CC exhibited the highest maximum pinning force density (F<SUB>p,max</SUB>) values of 32.5 GN/m<SUP>3</SUP> near 4 T at 65 K and 6.5 GN/m<SUP>3</SUP> near 3.2 T at 77 K, for B//c (θ = 180 <SUP>°</SUP>), and also the highest minimum transport critical current density (Jc,min) of 0.39 MA/cm<SUP>2</SUP> at 77 K in 1 T and 0.68 MA/cm<SUP>2</SUP> at 65 K in 3 T, for θ = 120<SUP>°</SUP>, evidencing that 5 vol% is the optimum BSO content. Observation of BSO-doped GdBCO CCs by transmission electron microscopy revealed that the effective flux pinning of BSO-doped GdBCO CC was attributed to the BSO nanorods of ~ 10-nm diameters roughly aligned along the c-axis of the GdBCO matrix.</P>

Epitaxial Growth of CeO2 Buffer Layers on IBAD-Textured MgO Templates by Pulsed Laser Deposition

Kyung-Pil Ko,Soon-Mi Choi,Won-Jae Oh,Insung Park,Seung-Hyun Moon,Sang-Im Yoo IEEE 2017 IEEE transactions on applied superconductivity Vol.27 No.4

<P>Epitaxial growth of CeO<SUB>2</SUB> buffer layers on the ion-beam assisted deposition (IBAD)-textured MgO templates could be successfully achieved by an annealing heat treatment prior to CeO<SUB>2</SUB> deposition by pulsed laser deposition (PLD). The annealing process was performed in a tube furnace (ex-situ annealing) or in a PLD chamber (in-situ annealing). Analyses by x-ray photoelectron spectroscopy on the surface of ex-situ annealed MgO single crystals revealed that Mg(OH)<SUB>2</SUB> formed on the MgO surface in air was gradually decomposed into MgO with increasing annealing temperature and period. The CeO<SUB>2</SUB> layer on the IBAD MgO template ex-situ annealed for 6 h at 750 °C was only c-axis oriented in comparison with that on the nonannealed IBAD MgO template. However, some 45°-rotated grains were observed in the CeO<SUB>2</SUB> layer on ex-situ annealed IBAD MgO template. In contrast, in-situ annealing for 1 h at 800 °C was found effective to grow CeO<SUB>2</SUB> layer with a cube-on-cube orientation, suggesting that Mg(OH)<SUB>2</SUB> and MgCO<SUB>3</SUB> phases on the MgO surface were fully decomposed into MgO phase with (001) (a//[100]) orientation. TEM analyses supported that a high degree of biaxial alignment of CeO<SUB>2</SUB> layer was deposited on in-situ annealed IBAD MgO template.</P>

Phase Field Model Simulation of Abnormal Grain Growth by Solid-State Wetting

Ko, Kyung Jun,Cha, Pil Ryung,Hwang, Nong Moon Scientific.Net 2007 Materials Science Forum Vol.539-543 No.1

자궁원발성 비호지킨 악성림프종 -3예 보고-

박찬필,고영혜,이중달,박문일,김경태,조삼현 대한병리학회 1995 Journal of Pathology and Translational Medicine Vol.29 No.3

Phase Field Model Simulation of Grain Growth in Three Dimensions under Isotropic and Anisotropic Grain Boundary Energy Conditions

Ko, Kyung Jun,Cha, Pil Ryung,Park, Jong Tae,Kim, Jae Kwan,Hwang, Nong Moon Trans Tech Publications, Ltd. 2007 Materials science forum Vol.558 No.-

<P>Phase-field model (PFM) in multiple orientation fields was used to simulate the grain growth in three-dimensions (3-D) for isotropic and anisotropic grain boundary energy. In the simulation, the polycrystalline microstructure was described by a set of non-conserved order parameters and each order parameter describes each orientation of grains. For isotropic grain boundary energy, the simulation showed the microstructure evolution of normal grain growth. For anisotropic grain boundary energy, however, the simulation showed that certain grains which share a high fraction of low energy grain boundaries with other grains have a high probability to grow by wetting along triple junctions and can grow abnormally with a growth advantage of solid-state wetting. The PFM simulation shows the realistic microstructural evolution of island and peninsular grains during abnormal grain growth by solid-state wetting.</P>

안와내에 발생한 신경초종 : Case Report

고경철,은종필,권창영 예수병원 1998 예수병원학술지 Vol.19 No.-

Original Article : Rifaximin Plus Levofloxacin-Based Rescue Regimen for the Eradication of Helicobacter pylori

( Sang Pil Yun ),( Han Gyung Seon ),( Chang Soo Ok ),( Kwang Ho Yoo ),( Min Kyung Kang ),( Won Hee Kim ),( Chang Il Kwon ),( Kwang Hyun Ko ),( Seong Gyu Hwang ),( Pil Won Park ),( Sung Pyo Hong ) The Editorial Office of Gut and Liver 2012 Gut and Liver Vol.6 No.4

Background/Aims: This study assessed the efficacy of a rifaximin plus levofloxacin-based rescue regimen in patients that had failed both triple and quadruple standard regimens for the eradication of Helicobacter pylori. Methods: We treated patients for H. pylori between August 2009 and April 2011. The triple regimen consisted of combined treatment with amoxicillin, clarithromycin, and pantoprazole for 1 week. For failed cases, a quadruple regimen of tetracycline, metronidazole, bismuth dicitrate, and lansoprazole for 1 week was administered. The rescue regimen for persistently refractory cases was rifaximin 200 mg t.i.d., levofloxacin 500 mg q.d., and lansoprazole 15 mg b.i.d. for 1 week. Results: In total, 482 patients were enrolled in this study. The eradication rates associated with the first and second regimens were 58% and 60%, respectively. Forty-seven out of 58 patients who failed with the second-line regimen received rifaximin plus levofloxacin-based third-line therapy. The eradication rate for the third regimen was 65%. The cumulative eradication rates were 58%, 85%, and 96% for each regimen, respectively. Conclusions: A rifaximin plus levofloxacin-based regimen could be an alternative rescue therapy in patients with resistance to both triple and quadruple regimens for the eradication of H. pylori. (Gut Liver 2012;6:452-456)

한국인 폐암 환자에서 RRM1 유전자 Promoter의 다형성

고경행 ( Kyung Haeng Ko ),김은정 ( Eun Joung Kim ),오인재 ( In Jae Oh ),김수옥 ( Soo Ock Kim ),손준광 ( Jun Gwang Son ),정종필 ( Jong Pil Jung ),조계중 ( Gye Jung Cho ),주진영 ( Jin Young Ju ),김규식 ( Kyu Sik Kim ),김유일 ( Yu Il 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.61 No.3

연구배경: 약 75%의 비소세포 폐암에서 loss of heterozygosity (LOH)를 보이는 11p15.5에 위치한 ribonucleotide reductase M1 subunit gene(RRM1) 유전자는 ras transformed fibroblast를 이용한 실험에서 암세포의 전이능력을 감소시키는 것으로 보고되어 있어서 암억제 유전자로서의 가능성이 높다. RRM1의 promoter 부위인 exon 1 시작에서 (-)37과 (-)524번째 염기에 A/C 그리고 C/T 다형성이 발견되었는데 이 다형성의 양상에 따라 RRM1 유전자의 발현 정도가 조절될 수 있어서 폐암 발생의 위험도가 다를 수 있다. 대상 및 방법: 전남대학교 병원에 내원한 폐암환자들과 비폐암 대조군 환자 127예와 미국인 폐암 환자 140예의 말초혈액 백혈구로부터 얻은 DNA를 이용하여 미국인과 한국인에서의 유전자 다형성의 분포 및 임상적 의의를 조사하였다. 결과: RRM1 유전자의 Exon 1으로 부터 (-)37 염기에서 A/C 유전자 다형성은 127예 중 CC가 64예(50.4%), AC는 55예(43.3%), 그리고 AA는 8예(6.3%)에서 발견되었다. Allele A의 빈도는 미국인들의 27.9%에 비하여 한국인에서 28.0%로 차이가 없었고, 폐암군과 비폐암군 간에도 유의한 차이는 관찰되지 않았다. RRM1 유전자의 (-)524 염기에서 C 또는 T 유전자 다형성의 양상은 CC가 24예(18.9%), CT는 44예(34.6%), 그리고 TT는 59예(46.5%)에서 발견되었다. Allele C의 빈도는 36.2%로써 미국인의 34.6%와 차이가 없었고, 폐암군과 비폐암군 간에도 차이는 관찰되지 않았다. RRM1 유전자의 (-)37 염기는 인종에 관계없이 70% 이상에서 C 이었고, (-)524 염기는 65% 정도에서 T를 보이고 있었다. 또한 (-)37과 (-)524 염기는 서로 밀접한 상관관계를 보이고 있었다. 즉 (-)37염기가 모두 C인 경우 (-)524 염기도 모두 T인 빈도가 높았고, (-)37 염기가 한 개라도 A를 가지고 있는 경우 (-)524 염기도 C를 가지고 있는 빈도가 높았다 (p<0.001). 결론: RRM1 유전자의 발현을 조절하는 promoter 부위의 두 개의 유전자 다형성의 빈도는 인종 간에 그리고 폐암군과 비폐암군 간에 차이가 없어서 폐암 발생의 위험인자는 아니었다. 그러나 두 유전자 다형성이 서로 특정 조합을 보임으로 그 조합 양상에 따른 promoter 활성도에 대한 연구가 뒤따라야 할 것이다. Background: LOH11A is a region with frequent allele loss (>75%) in lung cancer that is located on the centromeric part of chromosome 11p15.5. Clinical and cell biological studies suggest that this region contains a gene associated with metastatic tumor spread. RRM1 encoding the M1 subunit of ribonucleotide reductase, which is an enzyme that catalyses the rate-limiting step in deoxyribonucleotide synthesis, is located in the LOH11A region. Methods: Polymorphisms were found at nucleotide position (-)37 (C/A) and (-)524 (C/T) from the beginning of exon 1 of the RRM1 gene that might regulate the expression of RRM1. We studied the polymorphisms in 127 Korean individuals (66 lung cancer and 61 normal controls) and compared with those of 140 American patients with lung cancer. Results: CC, AC and AA were found at the (-)37 position in 64(50.4%), 55(43.3%), and 8(6.3%) out of 127 Korean individuals (66 cancer, 61 non-cancer patients), respectively. There was a similar frequency of allele A at (-)37 in the American(27.9%) and Korean population(28.0%). CC, CT and TT was found at the (-)524 position in 24(18.9%), 44(34.6%), and 59(46.5%) out of the 127 Korean individuals, respectively. There was a similar frequency of allele C at (-)524 in the American(34.6%) and Korean population(36.2%). There was no difference in the frequency of the (-)37 and (-)524 genotypes between the cancer and non-cancer group. However there was a significant correlation of the genotypes between (-)37 and (-)524 (p<0.001), which suggests the possible coordination of these polymorphisms in the regulation of the promoter activity of the RRM1 gene. Conclusion: RRM1 promoter polymorphisms were not found to be significant risk factors for lung cancer. However, a further study of the promoter activity and expression of the RRM1 gene according to the pattern of the polymorphism will be needed. (Tuberc Respir Dis 2006; 61: 248-255)

Use of meso-Rex shunt with transposition of the coronary vein for the management of extrahepatic portal vein obstruction

Yong-Pil Cho,Tae-Yong Ha,Gi-Young Ko,Kyung-Mo Kim,Sung-Gyu Lee 대한외과학회 2014 Annals of Surgical Treatment and Research(ASRT) Vol.86 No.2

The meso-Rex shunt is used to safely and effectively treat patients with portal hypertension due to extrahepatic portal vein obstruction. In the standard meso-Rex shunt technique, the patient’s own internal jugular vein is used as a vascular autograft. Inevitably, such a procedure requires neck exploration and sacrifice of the internal jugular vein. Here, we present a case of a 20-year-old man with idiopathic extrahepatic portal vein obstruction, who was treated with a new technique of transposition of the coronary vein, which is enlarged in most cases of portal hypertension, as an alternative to the standard meso-Rex shunt technique. The transposition of the coronary vein into the Rex recessus is more efficient and less invasive than harvesting an autologous vein graft. Therefore, this technique simplifies the procedure and should be used when possible.