신이식후 발생하는 감염에 대한 고찰

김재필(Jae Phil Kim),조대옥(Dae Ok Cho),고경식(Kyung Sik Ko),안재형(Jai Hyung Ahn),이태원(Tae Won Lee),임천규(Chun Gyoo Ihm),김명재(Myung Jae Kim) 대한내과학회 1995 대한내과학회지 Vol.49 No.1

Objectives: Renal transplantation is a major therapeutic advance for patients with chronic renal failure. But recipients of renal transplantation are prone to infection with both common and unusual organisms. And infectious diseases remain a major cause of morbidity and mortality in renal transplant recipients. This study was to analyze the infections in renal transplant recipients; its occurrence according to sites and organisms; comparison among immunosuppressive agents; prognostic differences of urinary tract infections(UTI) between those developed during 1 month after transplantation and those not developed; graft outcome; and patients mortality. Mothods: 181 renal transplant recipients were examined. They received renal transplantion between january 1979 and December 1992 at the Kyung-Hee University Hospital. 158 of them received transplantation from living-related donors, 22 from living-unrelated donors, and 1 from cadaver donor. Their age at the time of transplantation ranged from 14 to 66 years(mean 35.6 years), and the male to female ratio was 2.3: 1. The observation period ranged from 1 to 144 months(41.26±31.71, mean±S. D.). Results: 1) 110 recipients(60.7% of total) had 232 episodes of infectious complications whereas 71(39.3% of total) had no infectious episodes. About half of infectious episodes(128 episodes, 55.2% ) occurred during 1 month after transplantation. 2) The most common site of infection was urinary tract(138 episodes, 59.2%) whth the next sites coming in this order, bacteremia(32 episodes, 13.8%), pulmonary(21 episodes, 9.1%), and skin(21 episodes, 9.1%). 3) The causative organisms of UTI ranked in this order E. coli 21.7%, staphylococcus spp 14.5%, and pseudomonas spp 13.0%. 4) The causative organisms of bacteremia ranked in this order E. coli 34.4% salmonella spp 18.8%, pseudomonas spp 12.5 %, and staphylococcus spp 12.5%. 5) There was no significant differences of infectious episodes among immunosuppressive regimens. 6) Early UTI group(UTI occurred during 1 month after transplantation) recorded significantly higher incidence of urinary tract infections after 1 month that followed than non-UTI group. But there was no differences between two groups on graft and patients outcome. 7) The major cause of death was life-threatening infections(63.2 %). Conclusion: Most infections due to various organisms may occur during 1 month after transplantation. And still they constitute a major cause of death in renal transplant recipients.

사람 YB-1 유전자의 프로모터에 결합하는 핵인자에 관한 연구

김유리,한상원,류필열,김경근,안봉환,신부안 全南大醫大 2001 전남의대학술지 Vol.37 No.1

DRAM에서의 고전압 발생기

김필중,윤중현,라경태,김경호 木浦大學校 情報産業硏究所 1999 情報産業硏究誌 Vol.7 No.-

Abandoned bad DRAM chips have increased by 1-2 bit defective cells after package with high integrated memory. To repair this 1-2 bit defective cells. an antiques repair method of electrical repair method is using instead of laser repair method. This antiques repair method require high voltage over 7v to program antiques element. In this paper, the high voltage generated in chip without added pin or pad. The high voltage generator was designed using not conventional MOS devices but pn diodes and stacked comb capacitors. Threshold voltage of pn diode is about 0.8v. and stacked comb capacitor have much capacitance of 5-6 times than conventional planar capacitor. The output voltage of designed high voltage generator are 7.4-8.4v. and the output current driveability is maximum 480㎂.

Clozapine이 인체내에서 인간조직적합성항원에 미치는 영향

강병조,김문두,곽경필 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

The histocompatibillty antigen (human leukocyte antigen : HLA) has been used for organ transplantation, discrimination of one's real children and transfusion, etc. The objective of this study was to find out how dozapine affects HLA class I and II type in the humanbody when therapeutic doses are applied. The subject consists of 3 persons for lass I and class II They were administered for about 3 months with clozapine 157-250mg/day (mean dally dose 200mg). Analysis of HLA lass I type was the microcytotoxicity test of Terasaki and class II type was PCR method of Erhich. The results were as followings: Two of 3 were changed in HLA-A, B, C type. All three were not chanced in HLA-DR type. In conclusion, the short-term application, about 3 months, of therapeutic dose of clozapine is not considered to bring about changes in DNA level.

베이지안 강건성에 대한 고찰

윤용화,김경무,송필준 대구대학교 부설 과학교육연구소 1993 과학교육 Vol.6 No.-

림프구에 대한 clozapine의 생체내 유전독성

임정호,곽경필,김문두,강병조 대한생물치료정신의학회 1997 생물치료정신의학 Vol.3 No.1

최근 난치성 정신분열증 환자에서 가장 효과적인 약으로 알려진 clozapine은 골수에 작용하여 심각한 부작용인 무과립 구증을 일으킬 수 있다. 무과립구증의 원인 및 기전에 대한 연구는 매우 많으나 현재까지 확실한 결론이 나지 않은 상태이다. 저자들은 clozapine의 이러한 골수 독성에 근거하여 clozapine이 인체내에서 염색체에 어떤 변화를 주는지 아닌지를 알아보기 위해 clozapine 단독치료를 시행한 환자에게서 치료전과 치료중에 얻어진 말초혈액 림프구를 배양하여 염색체에 어떤 변화가 생기는지를 조사하였으나, clozapine에 의한 염색체의 자발적인 변이는 관찰되지 않았다. Objective : Many drugs and environmental chemicals can induce aneuploidy or chromosome instability in vivo or in vitro. Modification of the fidelity of cellular division may occur via a variety of mechanisms and chemical interactions. The clozapine is new antipsychotic drug with superior effect than classic antipsychotics. But, it may produce agranulocytosis and seizure in some patients. Agranulocytosis is a serious side effect of this drug but the cause and mechanism of this side effect is not clearly explained. Some study suggested that oxidative stress can induce chromosome aberration and the other study suggested that clozapine produce free radical and it can induce oxidative stress on some kind of cells. Therefore we decided to investigate whether clozapine and its metabolites can induce genotoxic effect in vivo. Method : The patients were chronic schizophrenic patients without a treatment at least one year. Diagnosis was made by DSM-IV criteria and agreed by both of two psychiatrists. Blood sampling was done before the treatment and during the treatment with considerable time interval. We used peripheral blood lymphocyte culture method and we counted the numerical aberrations, sister chromatid exchanges. Results : Chromosome aberration was not detected in all samples. Conclusion : Clozapine did not induce spontaneous chromosome aberration to human lymphocytes in vivo.

임신 입덧에 의해 발증한 베르니케뇌증 환자에서 스테로이드 다량요법과 FLAIR MR기법

한영민,유도성,김영주,허필우,조경석,김달수,강준기 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.12

FET형 반도체 마이크로센서 개발(Ⅲ)

손병기,이흥락,박이순,조진호,이성필,최평,서화일,박재윤,송경은,김창수 경북대학교 센서기술연구소 1995 연차보고서 Vol.1995 No.-

현재 의료진단, 화학공정의 모니터링이나 환경공학적 감시 및 제어 등의 분야에서 사용되고 있는 기존의 센서는 고가이며 용적이 클 뿐만 아니라 분석시간이 길고 사용하기 까다로운 것 등 여러 가지 문제점이 있다. 또한 측정환경에 영향을 주지 않을 만큼 충분히 작으며 빠른 분석시간을 가진 센서를 필요로 하고 있다. 본 연구에서는 기존의 센서들의 난점을 극복할 수 있는 새로운 형태의 FET형 전해질(electrolyte : H^+, K^+, Ca^2+, Na^+)센서소자 및 분석 시스템, 용존가스(O_2, CO_2)센서의 개발을 중점적으로 추진하였으며, FET형 압력센서, 습도센서 둥의 개별 FET형 센서에 관한 기초연구도 병행하였다. The conventional sensors have many problems such as high cost, large dimension, long analysis time and troublesome handling to apply to the fields of medical diagnosis, monitoring of chemical process and environmental monitoring/control. The main objects of this research are to develope a new FET type electrolyte(H^+, K^+, Ca^2+, Na^+)sensors, analysis system, and dissoved gas(O_2, CO_2)senors that can overcome the problems of the conventional sensors, and parallel basic researches on FET. type sensors such as pressure and humidity are also in progress.

농식품 수출조직 운영성과 영향요인 분석

Kyung-Phil Kim,Sang-Hyo Kim,Jung-Hoon Han 한국유통과학회 2016 유통과학연구 Vol.14 No.10

Purpose - This study aims to derive directions and implications for improving performance in operating agrifood export organizations by identifying significant performance impact factors. Research design, data, and methodology - A seemingly unrelated regression (SUR) model was estimated using data from a survey conducted among 120 exporters including 16 leading export organizations. In the SUR estimation, the export volume and price are used as dependent variables and securing the quantity of products ordered and exported, quality management, and marketing activities are considered as explanatory variables for the operation performance. Results - The amount of farmer education, the manpower in charge of marketing, and the interaction terms between whether or not they belong to a leading export organization and the item dummy for mushrooms have a significant impact on the export volume where the export volume is specified as a dependent variable. The export volume is greater with a greater amount of farmer education and greater manpower in charge of marketing from the perspective of quality management. When the export price is estimated as a dependent variable, the manpower in charge of marketing is shown to have a significant impact on the export price. Conclusions - The government needs to strengthen its support of the performance of agrifood export organizations. The analysis indicates that the education of and consulting with farmers, and the manpower number in charge of marketing are key factors in the operation performance of export organizations. Therefore, supporting the export organizations in expanding their human resources in charge of marketing can increase the export volumes for agrifoods. Given, however, that the export volume associated with joint payments, human resources specialized in quality management, and the amount of participation in export exhibitions are not significant factors, it is essential to improve the supporting policies for those areas. The manpower in charge of marketing from the perspective of marketing has a significant impact on both the export volume and export price. Thus, we identify this as the most important category that should be supported to enhance performance in export organizations.

Ten Years of Korea-U.S. FTA: focusing on agri-food trade

Kim Kyung-Phil(김경필),Lee Hyun-Keun(이현근),Kwak Hye-Sun(곽혜선),Myeong Su-Hwan(명수환),Ku Hye-Min(구혜민),Park Seo-Yun(박서윤) 한국농촌경제연구원 2022 한국농촌경제연구원 농정포커스 Vol.- No.207

10 years have passed since the Korea-U.S. FTA came into force on March 15, 2012. Tariffs on 97.9% of agricultural products have since been abolished. • Seoul and Washington had eight negotiations with two additional rounds of talks before the treaty finally went into effect in March 2012. Through their talks, the two sides agreed to open 97.9% of agricultural items (based on the Harmonized System). The bilateral trade volume in agricultural products has increased since the effectuation of the Korea-U.S. FTA. Korea’s trade deficit has widened during the period, while FTA application for goods exported to the U.S. has been relatively low. • The agricultural and livestock products imported from America reached $10.32 billion in the 10<SUP>th</SUP> year (2021) of the treaty, up 73.8% from the average before the treaty went into effect. The average import volume between the 6<SUP>th</SUP> and 10<SUP>th</SUP> year of the treaty amounted to $9.07 billion, up 52.7% before the enforcement. • Korea’s agricultural and livestock exports to the U.S. posted $1.26 billion, 214% up from the average before the treaty. The average export between the 6<SUP>th</SUP> and 10<SUP>th</SUP> year reached $980 million, up 43.6% during the same period. • Korea’s trade deficit rose to $809 million in the 6<SUP>th</SUP>-10<SUP>th</SUP> year, up 46.1% from the average before the treaty. • The average import unit prices for American beef, pork, grape, and kidney beans in the 6<SUP>th</SUP>-10<SUP>th</SUP> year were up from the figures before the treaty. However, the imported volumes and their shares to the total expanded during the same period. • The fill rates of U.S. items subject to tariff rate quotas (TRQs) were around 50% due to changes in import sources and decreased demand for American products. ASG measures were triggered for five items. • FTA application for items imported from the U.S. amounted to 71.6% on average in the 10<SUP>th</SUP> year of the treaty. However, the application for items exported to the U.S. slightly rose from 42.9% in 2012 to 49.5% in 2021, with the livestock category at 70.7%, the highest of all. The Korean government has signed free trade agreements with various nations. While doing so, it should also pursue self-sufficiency by expanding the domestic output of high-quality agricultural and livestock products. At the same time, it must focus on education to increase FTA application to Korean products exported to America. • Korea should use digitalized, smart farming to expand high-quality product output. The government has to educate stakeholders to raise FTA applications for Korean agricultural and livestock products exported to the U.S.