고요산혈증의 위험인자 : 아산시 지역 주민을 대상으로

김용배,장원기,황보영,김화성,안규동,이병국,이용진,이종은,이준숙,이찬구,이한정,이성수 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Objective : Serum uric acid has now been identified as a marker for a number of metabolic and hemodynamic abnormalities. The aim of this study is to evaluate risk factors which influence hyperuricemia in the citizens of Asan. Method : The study design was cross-sectional and research subjects were 1086 citizens of Asan. General characteristics, cigarette smoking, alcohol consumption, and past history were obtained by interview using a structural questionnaire. Also, we measured height, weight and blood pressure, and serum uric acid of the subjects. Results : The mean serum uric acid level was 5.27 ㎎/㎗ in men and 4.01 ㎎/㎗, in women, In the multiple logistic regression analysis, statically significant risk factors of hyperuhcemia were gender, body mass index, blood lead concentration, and serum creatinine. Conclusion : Our results suggest that gender, body mass index, blood lead concentration, and serum creatinine might be the most important risk factors of hyperurcemia. Education program as well as routine check-up for serum uric acid was highly recommended for the effective prevention of hyperuricemia.

Safety of subtotal or total colectomy with primary anastomosis compared to Hartmann procedure for left-sided colon cancer obstruction or perforation

Eun-Do Kim,Jin-Kwon Lee,Jin-Kyu Cho,Jae-Myung Kim,Ji-Ho Park,Ju-Yeon Kim,Sang-Ho Jeong,Young-Tae Ju,Chi-Young Jeong,Eun-Jung Jung,Young-Joon Lee1,Soon-Chan Hong,곽승진 대한종양외과학회 2019 Korean Journal of Clinical Oncology Vol.15 No.2

Purpose: Whether subtotal or total colectomy with primary anastomosis (PA) is safer than Hartmann procedure (HP) for left-sided colon cancer obstruction or perforation remains controversial. The purpose of this study was to compare postoperative morbidity, mortality, and defecation frequency between PA and HP for left-sided colon cancer obstruction or perforation. Methods: This retrospective study enrolled 54 patients from January 2014 to February 2018 who underwent emergency surgery due to left-sided colon cancer obstruction or perforation. Results: PA was carried out in 20 patients while HP was performed for 34 patients. Thirty-day mortality did not show significant difference between the two groups (15.0% vs. 14.7%, P=1.000). No anastomotic leakage occurred in PA group while three (8.8%) cases of stump leakage occurred in HP group. Stoma repair was performed for 13 cases (44.8%) and stoma reformation was performed for one case in HP group (7.7%). Stoma related complications occurred in five cases (17.24%). For patients after stoma repair, defecation frequency at 3 months after operation was 2.91±2.88 times per day in PA group and 2.86±2.63 times per day in HP group. At 1 year after operation, defecation frequency was changed to 1.40±1.12 times per day in PA group and 1.17±0.39 times per day in HP group. Conclusion: Primary ileosigmoid or ileorectal anastomosis for left-sided colon cancer obstruction or perforation is safe, and shows similar outcome of defecation frequency compared to H

대전시 노은 도매시장 채소류의 농약 잔류 실태 및 식이섭취량 추정

한국탁,이규승,이은경,이용재,고광용,원동준,이정원,권순덕 한국환경농학회 2003 한국환경농학회지 Vol.22 No.3

대전시 노은 도매시장에서 채취한 6종의 채소류 중 농약잔류량을 조사한 후 이에 대한 위해성 평가를 실시하였다. 전체 100건의 분석시료 중 농약이 검출된 시료의 비율은 46.0%이었고, 잔류허용기준 초과비율은 6.0% 이었다. 검출비율이 높은 시료는 상추(85.0%), 깻잎(80.0%), 오이(60.0%) 순이었고, 상추 3건, 깻잎 3건이 허용기준을 초과하였다. 살균제는 dicar-boximide계, 유기염소계, azole계 농약, 살충제는 유기인계, 합성 pyrethroid계 농약이 많이 검출되었다. 검출빈도가 높은 성분은 procymidone, chlorpyrifos, chlorothalonil, cypermethrin, EPN의 순이었다. 위해성을 평가하기 위해서 각 농작물에 대한 농약의 추정 섭취량과 ADI를 비교한 결과, 허용기준을 초과한 깻잎의 bitertanol, triflumizole, iprobenphos가 다른 성분에 비하여 높은 비율을 보였다. 그러나 각 농산물의 식이섭취량이 적어 ADI에 대한 추정섭취량의 비율이 0.46%이하로 나타나 그 영향이 매우 낮은 것으로 판단되었다. Pesticide residues in some vegetables collected at Noeun wholesale market in Daejeon were surveyed and assessed their risk In 100 samples, the detection rate of pesticide was 46.0% and the rate exceed MRL was 6.0%. Commodities showing high detection rate were lettuce(85.0%), perilla leaf(80.0%) and cucumber(60.0%). Dicarboximide, organochlorine, and azole fungicides and organophosphorus and pyrethroid insecticides were detected. Detection frequency of pesticide was in the order of procymidone, chlorpyrifos, chlerothalonil, cypermethrin and EPN. When the estimated intake amount of the pesticides were compared with ADI to assess their risk, bitertanol, triflumizole and iprobenphos in perilla leaf were higher rate than the other vegetables. However the total amounts of intake of pesticides were estimated to less than 0.46% of ADI.

직업적 연폭로가 일부 신경행동학적 검사수행에 미치는 영향

안익수,안현철,김용배,리갑수,김화성,황규윤,최은,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

In order to investigate that blood lead levels of lead exposed workers is associated with decreased performance in neurobehavioral tests in adults, we investigate 78 workers in a battery industry. Three items among neurobehavioral core test battery of World Health Organization, including digit span, Santa ana dexterity, digit symbol were administered to workers occupationally lead exposed workers by operational guide for the WHO neurobehavioral core test battery. Blood lead (PbB) and zinc protoporphyrin in whole blood (ZZP) were selected as an index of lead exposure. Detailed occupational history such as exposed agent, age, work duration, smoking and drinking habits, were recorded as confounding factors. After controlling age, the results of digit span and digit symbol among the neurobehavioral tests were significant contributed by PbB.

생선 가시로 인한 소장 천공 및 복강내 농양 1예

문성수,이수형,이은아,박성한,이준식,홍현진,신은경,김규종 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.1

A variety of swallowed foreign bodies are seen in gastrointestinal tract. However 80-90% of objects usually pass spontaneously through the alimentary tract and out in the feces and 10-20% removed without complication endoscopically. Therefore about less than 1% of foreign bodies ingested only require surgery due to complications, such as perforation, obstruction. Perforation of the gastrointestinal tract is a well-recognized complication of the foreign body ingestion. The most common site is ileum. Unfortunately, the diagnosis of small-bowel perforation by foreign bodies is rarely made preoperatively because the clinical symptoms are usually nonspecific or mimic other surgical conditions, such as appendicitis, diverticulitis, and perforated peptic ulcer etc. We report here a rare case of the small bowel perforation with mass-like intraabdominal abscess by fishbone ingestion in 59-year-old man who presented with a non-tender palpable mass in the left paramedian area and underwent abdominal computer tomography initially reported as showing intraabdominal mass.

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

중추성 요붕증이 동반된 랑게르한스 세포 조직구증 1예

김진호,문준성,문선중,이지은,최재원,은미정,천경아,조인호,윤지성,원규장,이경희 신덕섭,이형우 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Central diabetes insipidus (DI) is a syndrome characterized by thirst, polydipsia and polyuria. Langerhans cell histiocytosis is one of the etiologies of DI. Recently we experienced a central DI associated with Langerhans cell histiocytosis. The 44 years old female patient complained right hip pain polydipsia and polyuria. We carried out water deprivation test. After vasopressin injection, urine osmotic pressure was increased form 109mOsmol/Kg to 327mOsmol/Kg (300%). Brain MRI showed a thickened pituitary stalk and at hot bone CT.CT guided biopsy revealed abnormal histiocytes proliferation and abundant lymphocytes, The final diagnosis was central DI associated with systemic Langerhans cell histiocytosis invading hip bone, L-spine and pituitary stalk. Desmopressin and etoposide chemotherapy were performed to the patient.

經穴의 艾灸生體反應이 失血性貧血에 미치는 影響

李殷洪,박인규,임종국,김진택 東國大學校韓醫學硏究所 1992 東國韓醫學硏究所論文集 Vol.1 No.-

In order to observe the effects of moxibustion on anemic condition as a acute loss of blood, white rats were induced loss of blood by cadiac puncture. And then morphologically variation of The Bone Marrow was observed the following points of each rat were used : Shinsu(B23 or Ⅶ23), Hyeonjong(GB39 or XI39), and complex of shinsu(B23 or Ⅶ23) and Hyeon Jong(GB39 or XI39) Comparing these above method with the control group the results were as follow: 1. Moxibustion in Shinsu have an influence on activation of Normoblast and do for hematosis function of bone marrow 2. Formation ability of R·B·C(Red Blood Cell)turn up order a list of Mocibustion in Shinsu(B23 or Ⅶ23), Moxibustion in conplex of Shinsu(B23 or Ⅶ23) and Hyeon Jong(GB39 or XI39), moxibus-tion in Hyeon Jong(GB39 or XI39) 3. Moxibustion in complex of Shinsu(B23 or Ⅶ23) and Hyeon Jong(GB39 or XI39) moderately increase Megakaryocyte

중년여성의 우울, 신체증상 및 자아 존중감간의 관계

이규은 關東大學校 醫科大學 醫科學硏究所 1999 關東醫大學術誌 Vol.3 No.1

The purpose of this study was to investigate the relationship between depression, soimatic discomfort and self-esteem in middle-aged women. The subjects for this study were 246 middle-aged women. Data were collected from February 22 to April 24, 1999 by structured questionnaire. The instruments for this study dele CES-D(Radloff, 1977), somatic discomfort scale(Wittenborn, 1979) and self-esteem scale(Rosenburg, 1971). The data were analyzed SAS/PC program using descriptive statistics, ANOYA, Pearson correlation coefficient. The result of this study ere as follows: 1. The mean age of the subjects were 46.79 years. 2. The statistically significant difference in the score of the depression according to the age(F=3.46, p=.0049) and perceived health status(f= 7.11, p=.001) was obtaind. 3. The statistically significant difference in the level of soimatic discomfort according to the age was obtained muscular discomfort(F=4.11, p=.001). autonomic discomfort(F'=3.15, p=.0059), gastric discomfort(F= 3.16, p =.0089), wakefulness(F=2.69, p=.0218), eyes(F=3.30, p=.0066), climacteric discomfort(F=5,48, p=.0001), cold(F=2.33, p=.0433). 4. The somatic discomfort significantly different according to the level of education were muscular discomfort (F=7.46, p=.0001), autonomic discomfort(F=·1.55, p= .0015), intestinal discomfort(F=3.31, p=.0115), gastric discomfort(F=5.09, p=.0006), wakefulness(F=4.31, p=.0022), dry mouth(F=5.21, p=.0005), climacreric discomfort(F=3.65, p=.0063), cold (F=3.61, p=.0071). 5. The somatic discomfort significantly different according to the job were cutaneous discomfort (F=5.36, p =.0214), cold(F=3.90, p=.0493), fatigue(F=6.20, p=.0133), and others(F=4.65, p=.0,120). 6. The somatic discomfort significantly different according to the perceived health status were muscular discomfort (F=15.39, p=.0001), autonomic discomfort(F=4.80, p=.0010), circulation(F=7.74, p=.0001), intestinal discomfort (F=6.48, p=.0001), gastric discomfort(F= 14.00, p=.0001), wakefulness(F=4.57, p=.0014), eyes(F=B.49, p=.0095), rhinitis(F=6.22, p=.0001), menstrual discomfort (F=6.11, p=.0001), dry mouth(F=,3.59, p=.0073), climacteric discomfort(F=8.45, p=.0001), constipation(F=3.38, p=.0103), cold(F=4.47, p=.0017), fatigue(F=15.94, p=.0001), and others(F=3.56, p=.0076). 7. The statistically significant difference in the self-esteem according to the presence of Job(F=5.61, p=.0187) and perceived health status(F= 3.24, p=.0131) was obtined. 8. There were high correlation between depression and somatic discomfort(r=.4856, p=.0001), between depression and self-esteem(r=-.4200, p=.0001), and between somatic discomfort and self-esteem(r=-.2275, p=.0015).

Development of a Monitoring System for Water-borne Bacteria by a Molecular Technique, PCR-RELP-sequence Analysis

이혜영,--,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2003 Journal of biomedical laboratory sciences Vol.9 No.3

Since water borne infection causes acute diseases and results in spread of diseases by secondary infection, the prevention is very important. Therefore, it is necessary to have a method that is rapid and effective to monitor pathogenic bacteria in drinking water. In this study, we employed a systematic method, Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) analysis, to develop an effective monitoring system for possible bacterial contaminants in drinking water. For this purpose, PCR primers were derived from 992 bp region of the 16s rRNA gene that is highly conserved through the different species of prokaryotes. To test whether the PCR primers designed are indeed useful for detecting all the possible microbial contaminants in the water, the primers were used to amplify 16s rRNA regions of different microbial water-borne pathogens such as E. coli, Salmonella, Yersinia, Listeria, and Staphylococcus. As expected, all of tested microorganisms amplified expected size of PCR products indicating designed PCR primers for 16s rRNA indeed can be useful to amplify all different microbial water-borne pathogens in the water. Furthermore, to test whether these 16s rRNA based PCR primers can detect bacterial populations present in the water, water samples taken from diverse sources, such as river, tap, and sewage, were used for amplification. PCR products were for then subjected for cloning into a T-vector to generate a library containing 16s rRNA sequences from various bacteria. With cloned PCR products, RFLP analysis was done using PCR products digested with restriction enzyme such as Hae Ⅲ to obtain species-specific RFLP profiles. After PCR-RFLP, the bacterial clones which showed the same RFLP profiles were regarded as the same ones, and the clones which showed distinctive RFLP profiles were subsequently subjected for sequence analysis for species identification. By this PCR-RFLP analysis, we were able to reveal diverse populations of bacteria living in water. In brief, in unsterilized natural river water, over 60 different species of bacteria were found. On the other hand, no PCR products were detected in drinking tap-water. The results from this study clearly indicate that the PCR-RFLP-sequence analysis can be a useful method for monitoring diverse, perhaps pathogenic bacteria contaminated in water in a rapid fashion.