Species Diversity of Caterpillars on Feeding on the foliage Willow Trees (Salix spp.) in the Korean Penninsula

Kyoung Nan Park,Kang Woon Lee,Hong Yul Seo 한국응용곤충학회 2014 한국응용곤충학회 학술대회논문집 Vol.2014 No.10

Most caterpillars, the larvae of butterflies and moths(Lepidoptera), are herbivorous. Sometimes they are regarded as serious agricultural pest that cause to damage agricultural produce, whereas some species such as Bombyx mori is known to be valued as sources of silk. Even though their major role in the ecosystem, details of biology are poorly known for most species. This study has been carried out to identify larvae and to acquire useful biological information of insect larvae through rearing from 1997 to 2014 in HECRI(Holoce Ecosystem Conservation Research Institution). From 2012 HECRI are carrying out ‘Larvae Identification and Specimen Security of Primary Endemic Moths in Korea Peninsula through Rearing’ supported by National Institute of Biological Resources(NIBR). Of these this study is the list about special caterpillars feeding on the foliage Willow Trees (Salix spp.) Total 143 species belonging to 13 families were collected and identified 69 species belonging to 12 families. Among them Willow Treesdependent monophagous caterpillars are 34 species belonging to 5 families, oligophagous 36 species belonging to 3 families and polyphagous 16 species belonging to 12 families. The dominant family is Geometridae(51 species), second is Noctuidae(35 species) and followed by Notodontidae(21 species).

Regulation of Membrane-Associated Mucins in the Human Corneal Epithelial Cells by Dexamethasone

Seo, Kyoung Yul,Chung, So-Hyang,Lee, Joon H,Park, Mi Young,Kim, Eung Kweon Masson Pub. USA 2007 Cornea Vol.26 No.6

PURPOSE:: To study the influence of dexamethasone on membrane-associated mucins produced by human corneal epithelial cells. METHODS:: Human corneal epithelial cells were cultured in medium supplemented with various concentrations of dexamethasone (ranging from 10 to 10 M). Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analysis using monoclonal antibodies specific for human MUC1 (HMFG-1), MUC4 (1G8), and MUC16 (OC125) were performed to evaluate the effect of dexamethasone on membrane-associated mucin expression. The effect of glucocorticoid receptor antagonist (RU38486) on dexamethasone-induced mucin expression was estimated. RESULTS:: RT-PCR revealed that MUC1 and MUC16 gene expression were upregulated 48 hours after addition of dexamethasone and that MUC4 gene expression was downregulated in the same condition. Western blot analysis showed that MUC1 and MUC16 proteins were increased after addition of dexamethasone. However, MUC4 was not detected by anti-MUC4 monoclonal antibody (1G8) for ASGP-2 under our conditions. Treatment with RU38486 inhibited the changes of MUC1, MUC4, and MUC16 by dexamethasone; thus, the effect of dexamethasone on mucin expression is mediated by glucocorticoid receptors. CONCLUSIONS:: This study shows that MUC1, MUC4, and MUC16 are regulated differently by dexamethasone in human corneal epithelial cells. External application of dexamethasone might affect the precorneal mucin.

Visual Phenotyping Analysis of Korean Wild Mouse KWM/Hym

Kyoung Yul Seo 한국실험동물학회 2023 한국실험동물학회 학술발표대회 논문집 Vol.2023 No.2

백내장 수술시 수정체 상피세포의 제거 범위에 따른 전방 염증도의 변화

서경률(Kyoung Yul SEO),임승정(Seung Jeong Lim),이윤성(Yun Seon Lee),김홍복(Hong Bok Kim) 대한안과학회 1998 대한안과학회지 Vol.39 No.10

Effects of Y-27632, a Rho-associated Kinase Inhibitor, on Human Corneal Endothelial Cells Cultured by Isolating Human Corneal Endothelial Progenitor Cells

Haeeun Shin(Haeeun Shin),Joon Ki Min(Joon Ki Min),Na Rae Kim(Na Rae Kim),Kyoung Yul Seo(Kyoung Yul Seo),Hee Seung Chin(Hee Seung Chin),Soyoung Lee(Soyoung Lee),Ji Won Jung(Ji Won Jung) 대한안과학회 2023 Korean Journal of Ophthalmology Vol.37 No.1

Purpose: Human corneal endothelial progenitor cells (HCEPs), which has been selectively isolated and differentiated into human corneal endothelial cells (HCECs), are crucial for repairing corneal endothelial damage. In this study, we evaluated the roles of a Rho-assisted kinase (ROCK) inhibitor, Y-27632, on the isolation and expansion of HCEPs, and assessed the in vitro effects of different concentrations of Y-27632 on the differentiated HCEPs. Methods: HCEPs were isolated and expanded in a medium with and without 10μM Y-27632, and then differentiated into HCECs in a medium with fetal bovine serum. The characteristics of HCEPs and differentiated HCEPs were confirmed by immunofluorescence staining. The proliferation, viability, morphology, and wound-healing ability of differentiated HCEPs were assessed in the presence of different concentrations of Y-27632. Results: Y-27632 enabled the isolation and expansion of HCEPs from the corneal endothelium. The differentiated HCEPs showed an optimal increase in proliferation and survival in the presence of 10μM Y-27632. As the concentration of Y-27632 increased, differentiated HCEPs became elongated, and actin filaments were redistributed to the periphery of cells. Y-27632 also caused a concentration-dependent enhancement in the wound-healing ability of differentiated HCEPs. Conclusions: Y-27632 enabled the isolation and expansion of HCEPs. It also enhanced the proliferation, viability, and migration of differentiated HCEPs.

불국사 상업지역의 정체성확보를 위한 간판 개선방안

이서율(Seo Yul Lee),이영경(Young Kyoung Yi) 한국디자인문화학회 2011 한국디자인문화학회지 Vol.17 No.4

간판은 도시의 이미지 형성과 정보전달에 큰 역할을 한다. 하지만 우리나라의 간판은 정체성과 미학적 특질이 부재하고 정보전달기능이 미약하기 때문에 경관을 훼손하는 요소이다. 이러한 현상은 역사문화지역에서 더 심각한 실정이다. 이는 역사도시에서 더욱 큰 영향을 초래하고 있다. 최근 많은 지자체는 간판개선을 실시하고 있으나 지역과 어울리지 않은 획일적인 디자인과 관련주체의 참여부족으로 인하여 그 효과는 미진한 것으로 나타나고 있다1)2)3)4). 본 연구는 불국사 상업지역을 대상으로 지역정체성 확보를 위한 간판개선방안을 제시하고자 한다. 구체적으로 본 연구에서는 불국사의 상업주와 방문자, 관련 공무원을 중심으로 설문조사가 진행되었다. 설문조사에서는 상업주 97명, 방문자 130명, 관련 공무원 32명이 참여하였다. 연구 결과는 세 가지로 요약할 수 있다. 첫째. 현재 간판현황에 대한 만족도는 3주체 모두 낮게 나타났으나, 방문자의 만족도가 다른 두 주체보다 더 낮게 나타나고 있다. 둘째, 모든 응답자들은 현 간판이 정보전달기능이 낮고 지역정체성도 반영하지 않는다고 인식하고 있어, 간판 개선이 필요함을 알 수 있다. 간판개선이 특히 시급한 것으로 인식하는 요소는 디자인 요소의 배치와 색상, 문구로 나타났다. 마지막으로, 관련 공무원들은 상업주의 의식부족과 현실에 맞지 않는 법규 등이 개선대상으로 인식하고 있었다. 이와 같은 연구에 근거하면 지역정체성확보를 위한 간판 개선을 위하여 제도적 방안과 디자인적 방안이 제시될 수 있다. 우선 제도적 방안으로는 현실과 지역에 맞는 이해하기 쉬운 법령의 개선이 필요하다. 또한 실제 적용에 필요한 구체적인 지침이 마련되어야 한다. 디자인적 방안으로는 지역 정체성을 나타내는 이미지의 개발이 우선되어야 한다. 이와 함께, 간판의 기능을 극대화 시킬 수 있는 디자인 요소의 배치와, 대상지 주변 색상의 활용 및 대상지 이미지와 알맞은 문구의 도입이 필요하다. Outdoor advertizing signs of the city plays an important role in formulating the image of the city and communicating information. But outdoor advertizing signs of Korea are more likely to damage urban landscape because of the lack of the aesthetic quality, local identity, and communicating ability. This negative effect is more serious in the historic city. Recently, many local governments plan and implement the projects for the improvement of outdoor advertizing signs, which are proved to be ineffective due to the uniformed design and the lack of participation of the related stakeholders 1)2)3)4). This study aims to suggest the guidelines for the improvement of outdoor advertizing signs in Bulguksa business district in order to establish the sense of identity in the street. Specifically, questionnaire survey was performed to the three stakeholders, such as 97 storeowners, 130 visitors, and 32 related public officials. The results revealed three important things. First, although the satisfaction for the present sings of the three stakeholders were low, the satisfaction of the visitors was found lowest, compared to the other two stakehoders. Second, all the participants thought that the present signs neither successfully communicated information nor reflected the regional identity, which indicated the need of improvement. The sign factors that found to need the urgent improvement were the disposition of design elements, colors, and wording. Lastly, the public officials pointed the lack of storeowners` sense on the good signs and the unrealistic regulations as the targets of improvement. Based on these results, two kinds of guidelines for sign improvement were suggested; one for regulation and the other for design. It is important that the regulation should be realistic and correspond to the characteristics of the region. Also specific information for implementation should be prepared. For design, the first and important thing is to develop the representative regional image. Then, endeavors are needed to find the ways to lay out the design elements, to utilize the surrounding colors, and to use the appropriate wordings.

CD166 promotes the cancer stem-like properties of primary epithelial ovarian cancer cells

( Dae Kyoung Kim ),( Min Hee Ham ),( Seo Yul Lee ),( Min Joo Shin ),( Ye Eun Kim ),( Parkyong Song ),( Dong-soo Suh ),( Jae Ho Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2020 BMB Reports Vol.53 No.12

Cancer stem cells (CSCs) or tumor-initiating cells are thought to play critical roles in tumorigenesis, metastasis, drug resistance, and tumor recurrence. For the diagnosis and targeted therapy of CSCs, the molecular identity of biomarkers or therapeutic targets for CSCs needs to be clarified. In this study, we identified CD166 as a novel marker expressed in the sphereforming CSC population of A2780 epithelial ovarian cancer cells and primary ovarian cancer cells. The CD166+ cells isolated from A2780 cells and primary ovarian cancer cells highly expressed CSC markers, including ALDH1a1, OCT4, and SOX2, and ABC transporters, which are implicated in the drug resistance of CSCs. The CD166+ cells exhibited enhanced CSC-like properties, such as increased sphere-forming ability, cell migration and adhesion abilities, resistance to conventional anticancer drugs, and high tumorigenic potential in a xenograft mouse model. Knockdown of CD166 expression in the sphereforming ovarian CSCs abrogated their CSC-like properties. Moreover, silencing of CD166 expression in the sphere-forming CSCs suppressed the phosphorylation of focal adhesion kinase, paxillin, and SRC. These results suggest that CD166 plays a key role in the regulation of CSC-like properties and focal adhesion kinase signaling in ovarian cancer. [BMB Reports 2020; 53(12): 622-627]

Effect of Voriconazole and Ultraviolet-A Combination Therapy Compared to Voriconazole Single Treatment on <i>Fusarium solani</i> Fungal Keratitis

Choi, Kyoung Sub,Yoon, Sang Chul,Rim, Tyler Hyung Taek,Han, Soo Jung,Kim, Eun-Do,Seo, Kyoung Yul Mary Ann Liebert 2014 JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS Vol.30 No.5

남한산성 지역 간판개선에 대한 방문자와 상업주의 평가

이서율(Seo Yul Lee),이영경(Young Kyoung Yi) 한국디자인문화학회 2011 한국디자인문화학회지 Vol.17 No.1

간판은 도시민들에게 정보를 제공하고, 가로의 미관을 결정하며 지역의 문화와 정체성을 반영하는 역할을 한다. 우리나라에서 진행된 간판개선사업은 심미적 특성만을 강조하여 지역의 정체성을 적극적으로 반영하지 못하는 문제점이 있다. 본 연구에서는 정체성 반영을 목적으로 간판개선 사업이 진행된 남한산성 지역을 대상으로 개선사업의 효과를 파악하고 이를 바탕으로 정체성 반영을 위한 간판개선사업에 유용한 정보를 제공하고자 한다. 구체적으로 본 연구에서는 남한산성 방문자와 지역의 상업주를 중심으로 예비 인터뷰와 설문조사가 진행되었다. 예비인터뷰에는 방문자 15명과 상업주 5명이 참여하였으며, 설문조사에서는 방문자 108명과 상업주 48명이 참여하였다. 연구결과 간판개선사업에 대한 만족도와 간판개선으로 인한 가로경관의 향상효과는 있는 것으로 나타났으나, 간판이 전체가로와의 조화가 없고 지역의 정체성을 반영하지 못하고 있는 것으로 분석되었다. 또한 방문자와 상업주사이의 차이점이 발견되는데, 상업주의 개선사업과 정보제공에 대한 만족도가 방문자보다 높게 나타났다. 또한 간판의 지역정체성에 영향을 미치는 간판요소는 디자인요소의 배치와 색상, 글씨체, 형태, 문구로 인식되고 있었다. 이 같은 연구결과에 근거하면 만족도가 높은 간판개선을 위해서는 방문자와 상업주에 대한 균등한 의견수렴이 필요하다고 판단된다. 또한 간판개선에 있어서 전체 가로와의 조화를 조성하고 디자인요소의 배치와 색상, 글씨체, 형태, 문구에 대한 고려를 통해 지역 정체성을 반영하여야 할 것이다. Outdoor advertizement provides information about the city, formulates the aesthetic quality of the street, and reflects the culture and identity of the region. Outdoor advertizement improvement carried out in Korea emphasized only on the aesthetic quality, which resulted in the problem that unique place identity could not be reflected in the outdoor advertizement. The purpose of this research is to suggest the useful information on the outdoor advertizement improvement for place identity by investigating the effect of the Namhansansung Area Outdoor Improvement that was implemented in order to reflect the place identity. Specifically, this research adopted interview and questionnaire survey on the visitors and store owners in the study site. For an interview, 15 visitors and 5 store owners participated and 108 visitors and 48 store owners participated in the questionnaire survey. Research results showed that the satisfaction for the Improvement and effect of the street enhancement was rated high by both visitors and store owners. However, it was found that all the participants thought that outdoor advertizement did not harmonize with the street and that unique place identity was not reflected in the outdoor advertizement. Also, it was revealed that store owners` satisfactions for the Improvement and for the communication function of the advertizement were higher than those of visitors. Based on the results, three suggestions were made. First, diverse opinions should be collected from both visitors and store owners. Second, the harmony between outdoor advertizement and the whole street should be considered as important factors of advertizement design. Lastly, unique place identity should be reflected in outdoor advertizement by using of such design elements as wording, color, a style of penmanship, arrangement of design elements.

불국사 상업지역 간판 현황 분석

이서율(Seo Yul Lee),이영경(Young Kyoung Yi) 한국디자인문화학회 2011 한국디자인문화학회지 Vol.17 No.3

도시환경에서 간판은 시민들에게 정보를 제공하고, 도시의 아름다움을 증가시키며, 지역의 문화와 정체성을 형성하는 역할을 한다. 그러나 우리나라의 간판은 과도한 크기와 색상 등으로 인하여 시각적 환경에 큰 문제를 야기시키고 있다. 이러한 간판은 사람들에게 불쾌감을 유발하며 도시환경의 질을 떨어뜨리는 요인이 되고 있다. 우리나라에서 실시된 간판개선사업은 심미적 아름다움만을 강조할 뿐 간판의 정보전달기능이 아직 개선되지 않고 지역의 정체성이 반영되지 않는 문제점이 발견되고 있다. 이러한 문제는 가로경관에 대한 만족도를 저하시키며 획일적인 경험을 유발하기 때문에 독특한 매력과 이미지를 창출하지 못하는 결과를 초래한다. 바람직한 간판개선이 이루어지기 위해서는 개선대상지역의 간판현황과 가로현황을 면밀히 조사하여 정보 전달 기능을 향상하고 정체성을 확보하는데 필요한 정보를 도출하는 것이 필수적이다. 특히 역사문화지역의 간판계획에서는 다른 지역보다 더 면밀한 현황조사가 요구된다. 본 연구에서는 간판을 업종, 유형, 배치 및 구성요소에 따라 현황분석을 하고, 이를 바탕으로 정보전달에 효과적이면서도지역의 정체성을 확보할 수 있는데 필요한 요건을 제시하였다. 이를 위하여 우리나라의 대표적인 역사문화 지역인 경주 불국사 지역의 상업지역을 대상지로 설정하고, 상업거리에서 빈도가 높은 가로형간판, 세로형간판, 돌출형 간판, 창문이용간판, 지주이용간판을 연구대상 간판으로 선정하였다. 또한 상업주 5명과 방문자 10명을 대상으로 현재 대상지의 간판 및 개선의 필요성, 대상지에 대한 일반적인 사항에 대한 의식조사를 실시하였다. 연구결과 대상지의 간판은 지역, 부착된 건축물, 이웃한 간판과 모두 조화를 이루지 못하고 있다. 구체적으로 업종이 밀집해 있는 경우는 경쟁으로 인하여 간판의 크기와 수가 많고 자극적인 색상이 사용되고 있다. 이러한 간판의 과도한 사용은 정보전달에도 매우 부정적 영향을 미치고 있다. 상업주와 방문자와의 인터뷰결과를 보면 지역의 정체성을 보여주고 간판의 정보전달기능을 높이기 위한 간판개선이 필요하다는 공감대를 발견할 수 있다. 간판에 지역정체성을 반영하고 간판의 정보전달 기능향상을 위한 간판개선을 위해서는 현재 간판현황에 대한 정밀한 조사가 필수적임을 알 수 있다. 구체적으로 지역의 사회물리적 특성에 대한 조사와 함께 상업주와 방문자의 인식조사가 필요하다. 이를 바탕으로 조사대상지역의 지역성을 나타내는 다양한 요소(이미지, 색상, 형태, 글씨체 등)를 디자인하고 간판 개선에 활용되어야 한다. Outdoor advertizing sign in urban environment provides citizen with information, increases the beauty of the city, and formulates the city culture and identity. But Outdoor advertizing sign in our country are becoming one of the major visual problems due to the excessive sizes and colors. These Outdoor advertizing signs induce unpleasant feelings and destory the amenity. The advertizement improvement project performed recently in Korea only emphasized the visual quality but failed to enhance the communication function and regional identity. Therefore, visitors and store owners were not satisfied with the improved street and the streetscape does not show unique image and attraction. In order to improve the advertizement of the street, it is essential to analyze the present condition of the street so that useful information can be gained for the enhanced communication function and regional identity. Especially, the planning of advertizement for the historic area needs more thorough analysis of the present condition. In this study, a sign of business, type, placement, and depending on the components, and usage analysis, based on this information to deliver effective and which areas need to obtain the identity of the proposed requirements. To this end, Korea`s leading historical and cultural areas of the commercial target area Gyeongju Bulguksa set destination, and commercial signs in the streets with high frequency horizontal and vertical-type signs, raised signs, window signs available, holding up a sign used to study signs were selected. In addition, 10 visitors and 5 store owners participated in survey. Current designation of the signs and need for improvement, for general information on designation survey was conducted. Outdoor advertizing signs in the study area is not harmonized with the buildings, adjacent signs, and the unique characteristics of the area. Where diverse stores are found, singscape gets worse due to the strong colors, overused and oversized sings. Overused signs also have negative influence on the communication function. Interview with the visitors and store owners revealed that the outdoor advertizing signs of the area should be improved in order to display regional identity and to enhance communication function. Through analysis of the present condition of the outdoor advertizing signs are essential in the sign improvement for enhanced communication function and regional identity. Specifically, investigation should focused on the socio-physical characteristics of the site and the analysis of the awareness of visitors and store owners. Based on the results of the investigation, diverse factors related to regional identity should be designed and applied to sign improvement.