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김경아,남혜윤,문제혁,정진숙,임영,정치경 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4
목적 : Rat2 섬유모세포에서 α-quartz에 의해 유도된 NOS의 조절기전을 알아보기 위하여 본 연구가시도 되었다. 방법 : Rat2 세포에 있어서 α-quartz 자극에 의한 NO와 H₂O₂의 분비 및 iNOS의 발현을 관찰하였고, iNOS 억제제인 L-NIL과 H₂O₂ 억제제인Catalase를 전처리하고 마찬가지로 NO와 H₂O₂분비 그리고 iNOS의 단백발현 정도를 western blot-ting을 이용하여 관찰하였다. 결과 : o-quartz는 Rat2 세포에서 iNOS에 의한NO와 H₂O₂의 분비를 유도하였다. L-NIL은 R3t2세포에서 D-quartz에 의한 H₂O₂의 분비와 iNOS발현을 완전히 억제하였다. Catalase로 전처리 하였을 때 o-quartz로 유도된 iNOS에 의하여 생산증가된 H2Oa가 iNOS를 억제하는 autoinhibitorypathway가 차단되어 결과적으로 H₂O₂의 분비와 iNOS의 발현이 증가하였다. 결론 : Rat2 세포에서 α-quartz에 의하여 유도된iNOS는 H₂O₂의 분비를 촉진하고 이 H₂O₂는 iNOS기능을 조절하는 자가조절기전에 중요한 역할을 하는 것으로 생각된다. Objectives : This study was performed in order to investigate the molecular mechanism regulating nitric oxide synthase (NOS) induced by α-quartz in Rat2 fibroblast. Methods : α-quartz-induced nitric Oxide (NO) anti H₂O₂ formation anti α-quarts-induced iNOS protein expression in Rat2 fibroblast were monitored. With iNOS inhibitor (L-N6- (1-iminoethyl) lysine hydrochloride, L-NIL) or antioxidant (catalase), we observed NO and H₂O₂ formation and iNOS protein expression in Rat2 fibroblast stimulated with α-quartz. Results : α-quartz stimulated iNOS-induced NO and H₂O₂ formation in Rat2 fibroblast. L-NIL inhibited H₂O₂ formation and iNOS protein expression by α-quartz in Rat2 fibroblast. Pretreatment with catalase blocked the autoinhibitory pathway of iNOS by iNOS-induced H₂O₂ therefore H₂O₂ and NO production and iNOS protein expression were increased in Rat2 fibrobalst stimulated with α-quartz Conclusion : α-quartz-induced iNOS Stimulated H₂O₂ formation in Rat2 fibroblast. INOS-induced H₂O₂ by α-quartz plays an important role in the autoinhibition pathway for regulating the iNOS function in Rat2 fibroblast
Induction of Antioxidant Enzymes in Phloroglucinol Treated Cells
Kyoung Ah Kang,Kyoung Hwa Lee,Sungwook Chae,Rui Zhang,Myung Sun Jung,Young Min Ham,Jong Seok Baik,Nam Ho Lee,Jin Won Hyun 한국환경성돌연변이발암원학회 2005 한국환경성돌연변이·발암원학회지 Vol.25 No.4
We investigated the cytoprotective effect of phloroglucinol, which was isolated from Ecklonia cava (brown seaweed), against oxidative stress induced cell damage in Chinese hamster lung fibroblast (V79-4) cells. Phloroglucinol was found to scavenge intracellular reactive oxygen species (ROS) generated by γ-ray radiation. In addition, phloroglucinol inhibited cell damage induced by radiation through scavenging ROS. Phloroglucinol increased the superoxide dismutase and glutathione peroxidase activity. Taken together, the results suggest that phloroglucinol protects V79-4 cells against oxidative damage by enhancing the cellular antioxidant enzymes activity.
KANG, Kyoung Ah,ZHANG, Rui,LEE, Kyoung Hwa,CHAE, Sungwook,KIM, Bum Joon,KWAK, Young Sook,PARK, Jae Woo,LEE, Nam Ho,HYUN, Jin Won JAPAN RADIATION RESEACH SOCIETY 2006 JOURNAL OF RADIATION RESEARCH Vol.47 No.1
<P>We studied the cytoprotective effect of triphlorethol-A against γ-ray radiation- induced oxidative stress. In this study, hydrogen peroxide, which is a reactive oxygen species (ROS), was detected using 2',7'-dichlorodihydrofluorescein diacetate (DCF-DA) assay. Triphlorethol-A reduced intracellular hydrogen peroxide generated by γ-ray radiation. This compound provided protection against radiation-induced membrane lipid peroxidation and cellular DNA damage which are the main targets of radiation-induced damage. Triphlorethol-A protected the cell viability damaged by the radiation through inhibition of apoptosis. Triphlorethol-A reduced the expression of bax and activated caspase 3 induced by radiation, but recovered the expression of bcl-2 decreased by radiation. Taken together, the results suggest that triphlorethol-A protects cells against oxidative damage induced by radiation through reducing ROS.</P>
그레이브스병과 동반된 자가면역성 갑상선 질환 관련 뇌병증 1예
박경선 ( Kyoung Sun Park ),이신희 ( Shin Hee Lee ),조남열 ( Nam Yeol Cho ),최유아 ( Yu Ah Choi ),고윤명 ( Yun Myoung Ko ),남선우 ( Seon Woo Nam ),남수민 ( Soo Min Nam ) 대한내과학회 2016 대한내과학회지 Vol.91 No.2
A patient with encephalopathy associated with autoimmune thyroid disease (EAATD), which is one of the most important differential diagnoses of treatable dementia, presents with various neurological symptoms, such as repetitive epileptic seizures, altered mental status, and cognitive dysfunction. Steroid treatment is effective for EAATD. The incidence of EAATD increases considerably with age, particularly in female patients. Most patients with EAATD have normal thyroid function test results or mild hypothyroidism. Patients with EAATD with Graves’ disease are very rarely reported. Here, we report a case of a 63-year-old woman who complained of declining cognitive ability and ataxia. She was diagnosed with EAATD accompanied by Graves’ disease. Her neurological symptoms improved after intravenous steroid administration. (Korean J Med 2016;91:197-201)
Kang, Kyoung Ah,Lee, Kyoung Hwa,Chae, Sungwook,Zhang, Rui,Jung, Myung Sun,Lee, Youngki,Kim, So Young,Kim, Hee Sun,Joo, Hong Gu,Park, Jae Woo,Ham, Young Min,Lee, Nam Ho,Hyun, Jin Won Elsevier 2005 FEBS letters Vol.579 No.28
<P><B>Abstract</B></P><P>We have investigated the cytoprotective effect of eckol, which was isolated from <I>Ecklonia cava</I>, against oxidative stress induced cell damage in Chinese hamster lung fibroblast (V79-4) cells. Eckol was found to scavenge 1,1-diphenyl-2-picrylhydrazyl radical, hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>), hydroxy radical, intracellular reactive oxygen species (ROS), and thus prevented lipid peroxidation. As a result, eckol reduced H<SUB>2</SUB>O<SUB>2</SUB> induced cell death in V79-4 cells. In addition, eckol inhibited cell damage induced by serum starvation and radiation by scavenging ROS. Eckol was found to increase the activity of catalase and its protein expression. Further, molecular mechanistic study revealed that eckol increased phosphorylation of extracellular signal-regulated kinase and activity of nuclear factor κ B. Taken together, the results suggest that eckol protects V79-4 cells against oxidative damage by enhancing the cellular antioxidant activity and modulating cellular signal pathway.</P>
Induction of Antioxidant Enzymes in Phloroglucinol Treated Cells
Kang Kyoung Ah,Lee Kyoung Hwa,Chae Sungwook,Ahzang Rui,Jung Myung Sun,Ham Young Min,Baik Jong Seok,Lee Nam Ho,Hyun Jin Won Korean Environmental Mutagen Society 2005 한국환경성돌연변이·발암원학회지 Vol.25 No.4
We investigated the cytoprotective effect of phloroglucinol, which was isolated from Ecklonia cava (brown seaweed), against oxidative stress induced cell damage in Chinese hamster lung fibroblast(V79-4) cells. Phloroglucinol was found to scavenge intracellular reactive oxygen species (ROS) generated by $\gamma-ray$ radiation. In addition, Phloroglucinol inhibited cell damage induced by radiation through scavenging ROS. Phloroglucinol increased the superoxide dismutase and glutathione peroxidase activity, Taken together, the results suggest that phloroglucinol protectes V79-4 cells against oxidative damage by enhancing the cellular antioxidant enzymes activity.
Kang, Kyoung Ah,Lee, Kyoung Hwa,Chae, Sungwook,Zhang, Rui,Jung, Myung Sun,Ham, Young Min,Baik, Jong Seok,Lee, Nam Ho,Hyun, Jin Won Wiley Subscription Services, Inc., A Wiley Company 2006 Journal of cellular biochemistry Vol.97 No.3
<P>We investigated the cytoprotective effect of phloroglucinol, which was isolated from Ecklonia cava (brown alga), against oxidative stress induced cell damage in Chinese hamster lung fibroblast (V79-4) cells. Phloroglucinol was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>), hydroxy radical, intracellular reactive oxygen species (ROS), and thus prevented lipid peroxidation. As a result, phloroglucinol reduced H<SUB>2</SUB>O<SUB>2</SUB> induced apoptotic cells formation in V79-4 cells. In addition, phloroglucinol inhibited cell damage induced by serum starvation and radiation through scavenging ROS. Phloroglucinol increased the catalase activity and its protein expression. In addition, catalase inhibitor abolished the protective effect of phloroglucinol from H<SUB>2</SUB>O<SUB>2</SUB> induced cell damage. Furthermore, phloroglucinol increased phosphorylation of extracellular signal regulated kinase (ERK). Taken together, the results suggest that phloroglucinol protects V79-4 cells against oxidative damage by enhancing the cellular catalase activity and modulating ERK signal pathway. © 2005 Wiley-Liss, Inc.</P>
Cytotoxic Phenylpropanoids from the Rhizomes of Alpinia galanga
Nam, Joo-Won,Kim, Sun-Jack,Han, Ah-Reum,Lee, Sang-Kook,Seo, Eun-Kyoung 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.15
A bioassay-guided fractionation of the n-hexane and chloroform extracts of the rhizomes of Alpinia galanga led to the isolation of two active compounds, l'S-l-acetoxychavicol acetate (1) and p-coumaryl alcohol τ-O-methyl ehter (2). 1'S'-1-acetoxychavicol acetate (1) exhibited significant cytotoxicity against all human cancer cell lines tested (A549; 8.14, SNU638; 1.27, HCT16; 1.77, HT1080; 1.2, HL60; IC50 2.39 μg/ml), whereas p-coumaryl alcohol τ-O0methyl ether (2) showed selective cytotoxicity against the SNU638 cell (IC_(50) value of 1.62μg/ml).