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Kidney Toxicity Induced by 13 Weeks Exposure to the Fruiting Body of Paecilomyces sinclairii in Rats
Jeong, Mi-Hye,Kim, Young-Won,Min, Jeong-Ran,Kwon, Min,Han, Beom-Suk,Kim, Jeong-Gyu,Jeong, Sang-Hee Korean Society of ToxicologyKorea Environmental Mu 2012 Toxicological Research Vol.28 No.3
Paecilomyces sinclairiis (PS) is known as a functional food or human health supplement. However concerns have been raised about its kidney toxicity. This study was performed to investigate the kidney toxicity of PS by 13 week-oral administration to rats. Blood urea nitrogen (BUN), serum creatinine, and kidney damage biomarkers including beta-2-microglobulin (${\beta}2m$), glutathione S-transferase alpha (GST-${\alpha}$), kidney injury molecule 1 (KIM-1), tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), vascular endothelial growth factor (VEGF), calbindin, clusterin, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL) and osteopontin were measured during or after the treatment of PS. BUN, creatinine and kidney damage biomarkers in serum were not changed by PS. However, kidney cell karyomegaly and tubular hypertrophy were observed dose-dependently with higher severity in males. KIM-1, TIMP-1 and osteopontin in kidney and urine were increased dose dependently in male or at the highest dose in female rats. Increased urinary osteopontin by PS was not recovered at 2 weeks of post-exposure in both genders. Cystatin C in kidney was decreased at all treatment groups but inversely increased in urine. The changes in kidney damage biomarkers were more remarkable in male than female rats. These data indicate that the PS may provoke renal cell damage and glomerular filtration dysfunction in rats with histopathological lesions and change of kidney damage biomarkers in kidney or urine. Kidney and urinary KIM-1 and cystatin C were the most marked indicators, while kidney weight, BUN and creatinine and kidney damage biomarkers in serum were not influenced.
THE ACTUAL WEARING CONDITION OF MEN’S OUTDOOR JACKET FOR ACTIVE SENIOR
Kwon Jeong Ho,Lee Jeong Ran 글로벌지식마케팅경영학회 2015 Global Fashion Management Conference Vol.2015 No.06
Introduction 5 working days a week and wellness trends, that allows more consumers to actively enjoy outdoor activities, has led to a rapid growth in the outdoor clothing market. Buyers of outdoor clothing perceive them as causal and functional clothes that they can wear comfortably in daily life as well as for outdoor activities such as hiking and fishing (Park et al., 2002). There is an increased interest in outdoor activities by seniors who engage in various hobbies for health. Active seniors are energetic retirees who actively enjoy their retirement. They have emerged as a new consumer group in the inactive culture market (such as travel and the performing arts) due to their enjoyment of activities (such as language study, computer education, cosmetic/beauty treatments and sports) that is different from previous generations of older people (Korean Economic glossary, 2014). The most striking characteristic of active seniors is their generous investment in self-development based on secure assets and retirement income. Many studies have been done on senior citizens based on age that have examined body types (Ahn, 2003; Kim, 1995; Lee & Kim, 2007) and original clothing forms (Lee, 2003; Nam & Choi, 2002; Moon, 2008). However, these studies did not fully reflect the needs of active seniors interested in clothing. Additionally, most studies were conducted on female seniors with few studies on male seniors. It is necessary to accept and understand changes in the body types and physical functions of seniors body types and physical functions that accompany age and changing aesthetic sense with styles that are differentiated from existing elderly groups in regards to clothing for active seniors. A study on older men's body classification (Kim & Lee, 2003) indicated that the characteristics of older men's body types were not fully considered because a clothing sizing system was not separately established for older people. Most outdoor clothing companies produced patterns for a young generation. This study was conducted on the outdoor jacket wearing pattern of active male seniors. The results of this study can be used to design outdoor jackets that are produced at a reasonable price with a wearable function useful for outdoor activities and daily life.
Mitigation of Rayleigh crosstalk using noise suppression technique in 10-Gb/s REAM-SOA.
Jeong, Jong Sool,Kim, Hyun-Soo,Choi, Byung-Seok,Kim, Dong Churl,Kim, Ki-Soo,Park, Mi-Ran,Kwon, O-Kyun Optical Society of America 2012 Optics express Vol.20 No.24
<P>We demonstrate a mitigation of Rayleigh back-scattering (RBS) impact in 10-Gb/s reflective electroabsorption modulator monolithically integrated with semiconductor optical amplifier (REAM-SOA). The technique is based on the intensity-noise suppression of the centralized incoherent seed-light, which enables smooth evolution of deployed DWDM applications. We exhibit the power penalty of less than 1 dB at the large RBS crosstalk value of about 8 dB when the optical power of seed-light is lowered about -10 dBm.</P>
Kwon, Hyun-Jung,Kim, Tae-Myoung,Ryu, Jae-Myun,Son, Seung-Hwan,Hong, Jin-Tae,Jeong, Heon-Sang,Kang, Jin-Seok,Ahn, Ji-Yun,Kim, Sung-Ran,Ha, Tae-Youl,Kim, Dae-Joong The Korean Society of Food Science and Nutrition 2008 Preventive Nutrition and Food Science Vol.13 No.3
Cancer-preventive effects of ethanol extract of elm tree root (EEE) were investigated. In the in vitro cytotoxicity assay, colon cancer cells were incubated with a chloroform fraction of EEE (CF-EEE). CF-EEE significantly inhibited the proliferation of cells and induced apoptotic cell death in a dose-dependent manner. For the assessment of chemopreventive efficacy in vivo, male F344 rats were fed with EEE (0.5 or 1%) in diet for 8 weeks, and were subcutaneously injected with 1,2-dimethylhydrazine (DMH) to induce colonic aberrant crypt foci (ACF). EEE (0.5 and 1%) significantly decreased both the numbers of AC (1191.1/colon) and ACF (529.3/colon) induced by DMH. In addition, in the Western blot analysis on the colonic mucosa, administration of EEE triggered expression of caspase-3, a key factor of an apoptotic cascade. These results suggest that extract of elm tree root may have potential chemopreventive principles that lead to apoptosis of cancer cells, and thereby suppress colorectal carcinogenesis during the initiation stage.
ermK Leader Peptide : Amino Acid Sequence Critical for Induction by Erythromycin
Kwon, Ae-Ran,Min, Yu-Hong,Yoon, Eun-Jeong,Kim, Jung-A,Shim, Mi-Ja,Choi, Eung-Chil The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.12
The ermK gene from Bacillus lichenformis encodes an inducible rRNA methylase that confers resistance to the macrolide-lincosamide-streptogramin B antibiotics. The ermK mRNA leader sequence has a total length of 357 nucleotides and encodes a 14-amino acid leader peptide together with its ribosome binding site. The secondary structure of ermK leader mRNA and a leader peptide sequence have been reported as the elements that control expression. In this study, the contribution of specific leader peptide amino acid residues to induction of ermK was studied using the PCR-based megaprimer mutation method. ermK methylases with altered leader peptide codons were translationally fused to E. coli ${\beta}-galactosidase$ reporter gene. The deletion of the codons for Thr-2 through Ser-4 reduced inducibility by erythromycin, whereas that for Thr-2 and His-3 was not. The replacement of the individual codons for Ser-4, Met-5 and Arg-6 with termination codon led to loss of inducibility, but stop mutation of codon Phe-9 restored inducibility by erythromycin. Collectively, these findings suggest that the codons for residue 4, 5 and 6 comprise the critical region for induction. The stop mutation at Leu-7 expressed constitutively ermK gene. Thus, ribosome stalling at codon 7 appears to be important for ermK induction.
Kwon, Ae-Ran,Yoon, Eun-Jeong,Yoon, Jong-Min,Kim, Hyun-Jee,Shim, Mi-Ja,Choi, Eung-Chil 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
The antibacterial activities of clindamycin, synercid, telithromycin, linezolid and mupirocin were evaluated against erythromycin-resistant Gram-positive coccal clinical isolates collected in Korean hospitals. In Staphylococcus aureus, synercid, linezolid and mupirocin were the most active agents. Against coagulase-negative staphylococci (CNS), synercid, linezolid and mupirocin were also active. Telithromycin and synercid resistance was common against enterococci, only linezolid and mupirocin were active. The reason of low activity of telithromycin against staphylococci and enterococci is because most of the isolates were constitutively resistant to erythromycin. Synercid, telithromycin, linezolid and mupirocin were active against streptococci.
Jeong, Ji-Seon,Kwon, Ha-Jeong,Lee, Yong-Moon,Yoon, Hye-Ran,Hong, Seon-Pyo Elsevier 2007 Journal of Chromatography A Vol.1164 No.1-2
<P><B>Abstract</B></P><P>We have developed an improved analytical method for the determination of sugar phosphates using sodium carbonate (Na<SUB>2</SUB>CO<SUB>3</SUB>) for high-performance anion-exchange chromatography–pulsed amperometric detection. The target analytes were separated completely within 10min using eluent containing 20mM NaOH and 35mM Na<SUB>2</SUB>CO<SUB>3</SUB>. The limit of detection (S/N=3) and quantitation (S/N=10) for analytes were 10–30ng/mL and 35–100ng/mL, respectively. Linear dynamic range was 1–30μg/mL (<I>r</I><SUP>2</SUP>≥0.9998). The RSDs for intra- and inter-day assays were found to be of satisfactory results (0.23–3.09%), and the recoveries from blood spots were 97.62–99.69%.</P>