급성기 주요우울장애 환자에서 Natural Killer T 세포

박이진,이제훈,이권행,한상익,전양환 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.3

Objectives : To evaluate an association between depression and altered immunity, we examined peripheral T lymphocyte or natural killer (NK) cell measures plasma ACTH and cortisol using the flow cytometry in acute and unmedicated patients with major depressive disorder (MDD). Methods : Forty-two patients with MDD from the outpatient clinic and forty normal controls from the hospital staff were recruited. We applied Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) for depressed subjects. Peripheral T lymphocyte or NK cell measures (CD3, CD4, CD8, or CD56) and plasma hormones (ACTH and cortisol) were obtained from all subjects. Results : There were no statistical differences in CD3, CD4, CD8, or CD56 between the two subjects. The number of CD56 cells negatively correlated with HAM-D scores (r= -0.42, P<0.01), but did not correlate with HAM-A scores in patients with MDD. The number of CD56 cells showed strong negative correlation with CD4/CD8 (r= -0.47, P<0.01) in the control group, but not in the depressed group. Patients with MDD had higher cortisol level than controls within the normal range. Conclusion : The trait of immunological imbalance and HPA axis abnormality were shown in patients with MDD. Especially, the severity of depression, but not the anxiety, could be reflected as decreased number of CD56 (NK T) cells in acute and Unmedicated state.

뇌졸중 환자에 동반된 환측 요신경총병증 1예

김권영,강정훈,박진우 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

The majority of stroke patients present that upper extremity of hemiplegic limb is weaker than lower extremity. So rehabilitation of hemiplegic upper extremity shows multiple problems. Peripheral nerve injuries included brachial plexopathy in hemiplegic upper extremity is more common reported than lower problem. Moreover, lumbar plexopathy in hemiplegic lower extremity is rarely reported. A 56-year old woman of acute hemiplegic stroke presented with back pain and proximal weakness of the hemiplegic leg. Neurologic examination and electrophysiologic studies show upper lumbar plexopathy. We report a stroke patient with lumbar plexopathy which leads to proximal weaknesss on hemiplegic leg.

백서에서 치아이동 후 보정기간 동안 교합이 치주조직섬유의 재형성에 미치는 영향

정권희,박영준,이기헌,황현식 대한치과교정학회 2003 대한치과교정학회지 Vol.33 No.2

본 연구는 실험적 치아이동 후 보정기간 동안 교합이 치주조직섬유의 물리적 강도에 미치는 영향을 알아보고자 시행되었다. 체중 200g 내외의 Sprague-Dawley계 백서 수컷에서 상악 양측 제1대구치와 2대구치 사이에 교정용 고무줄을 삽입하여 4일 동안 치아를 이동시킨 다음, 각 실험동물의 하악 좌측 베1, 2, 3대구치를 발치하여 우측은 대합치가 있는 교합측으로, 좌측은 비교합측으로 구분하였다. 상악 제1대구치와 2대구치 사이의 인접면에 유지구를 형성하고 광중합형 레진으로 채워 보정을 시행한 후 시작 0일, 4일, 8일, 12일, 16일 또는 20일 경과한 후 백서를 희생시킨 다음, 만능물성 시험기를 이용하여 상악 제1대구치를 발치할 때 필요한 최대인장강도를 측정 좌우간 비교 분석하여 다음과 같은 결과를 얻었다. 1. 교합측은 비보정군에서 보정 4일, 8일, 12일, 16일, 20일군으로 갈수록 최대인장강도사 증가하였고, 보정 12일군 이후부터 통계적으로 유의한 차이를 보였다(p<0.05). 2. 비교합측은 비보정군에서 4일, 8일, 12일, 16일, 20일군으로 갈수록 최대인장강도가 증가하는 경향을 보였으나 통계적으로 유의한 차이를 보이지 않았다(p<0.05) 3. 교합측과 비교합측의 최대인장강도를 비교한 결과 보정 8일군까지 통계적으로 유의한 차이를 보이지 않았으나 (p>0.05), 보정 12일군 이후 보정 20일군까지 통계적으로 유의한 차이를 보였다(p<0.05). 이상의 결과는 실험적 치아이동 후 보정기간 동안 교합이 치주조직 섬유의 재형성에 영향을 미침으로 보정장치의 선택, 기간설정 등 보정계획서 교합에 대한 고려가 필요함을 시사하였다. The purpose of this study was to valuate the effect of occlusion on the mechanical strength of periodontal fibers during retention periods after experimental tooth movement. In the Sprague-Dawley male rats weighing 200g or more, the intraoral elastics were inserted into the both right and left interproximal space between upper first and second molars for tooth movement. After 4 days later, the left lower first, second, and third molars were extracted for differentiating the non-occlusal side from the occlusal side in the same mouth. At the same time the elastics were removes and than light cured resin was placed in the space between upper first and second molard following undercut was made for retention bilaterally. From the beginning of retention, 7 rats were sacrificed at 0, 4, 8, 12, 16, 20 days respectively. For evaluating of magnitude on the mechanical strength of periodontal tissue, the maximal shear load of the upper first molars were measured bilaterally during extraction using Instron Universal Testing Machine. The results of this study were obtained as follows : 1. In the occlusal side, the maximal shear load was increased from no retention to retention 20 days group as time was going and statistically difference was shown from retention 12 days group (p<0.05). 2. In the non-occlusal side, the maximal shear load was increased slightly from no retention 20 days group as time was going but there was no statistically difference (p>0.05) 3. The result compared with the maximal shear load between occlusal and nonocclusal side showed no statistically difference until retention 8 day group (p>0.05), but showed statistically difference from retention 12 day to 20 day group (p<0.05). These results show that occlusion had an effect on mechanical strength of the periodontal fibers during retention periods after experimental tooth movement; therefore, it is suggested that occlusion should be considered while the retainer types and retention period are planned.

자질구조와 단일화 규칙을 이용한 한국어 구문 및 의미분석기

崔宰赫,朴相圭,金權洋 新羅大學校 1991 論文集 Vol.31 No.1

This paper describes an analyzer for Korean which is partially free word order language. The analyzer uses unordered set as a subcategorization feature in order to solve the free order problems. The analyzer consists of morphological analysis, semantic analysis, semantic structure construction, lexicon and chart modules. The knowledge representation for syntactic and semantic features and unification rule was described.

위암의 근치절제술 후 생존율과 예후인자

차윤정,박진영,장정환,김성환,김권천,조현진,민영돈 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

Background and Objectives: Gastric cancer is still the leading cause of cancer death in Korea, and surgery remains the only method of treatment that offers the potential for a cure. Purpose: The aims of this study are to examine the outcome of the patients with gastric adenocarcinoma who underwent curative resection and to identify the prognostic factors leading to improved survival rates in these patients. Materials and Methods: The medical records of 278 patients with gastric adenocarcinoma, treated curatively at the Chosun University Hospital between January 1990 and December 1994, were reviewed retrospectively from January 2000 to March 2000. Follow-up was obtained for 250 patients(89.9%). The survival rates were calculated by the Kaplan-Meier method, and the significance of differences between patient factors(age and sex), tumor factors(location, size, gross type, tumor depth, lymph node metastasis, and stage) and treatment factors(operation method and reconstruction type) were evaluated statistically by the log-rank test. Results: The overall five-year survival probability was 59.6%. There was no survival difference according to age and sex. The 5-year survival rates according to the tumor depth were 97.0% for Tl, 74.5% for T2, 39.6% for T3, and 23.1% for T4(p=0.0000); to the lymph node metastasis were 81,4% for N0, 51.9% for N1, and 21.2% for N2(p=0.0000); to the TNM stage were 96.7% for stage I a, 79.5% for stage I b, 68.8% for stage II, 52.9% for stage III a, 25.9% for stage III b, and 7.5% for stage IV(p=0.0000). Other statistically significant differences were shown in tumor location, size, gross type, operation method, and reconstruction type after subtotal gastrectomy. Conclusion: The most definitive prognostic factors affecting the survival rate of gastric adenocarcinoma were tumor depth, lymph node metastasis, and tumor stage. The keys to successful outcome includes early diagnosis and curative resection with radical lymph node dissection at early stage as possible.

산·학·관 전략적 제휴를 통한 석재 신제품의 사업화 전략 : 학술적 기업가의 역할을 중심으로

김재명,박성익,이권표 강원대학교 부설 석재복합신소재 제품연구센터 2000 석재연 논문집 Vol.5 No.-

본 연구는 학술적 기업가의 역할을 중심으로 산ㆍ학ㆍ관 전략적 제휴모델을 제시하고, 고성능 폴리머 복합관 신제품 사업화 사례를 분석하였다. 벤처기업 창업 인프라 제공 주체는 정부, 대학, 벤처캐피탈기관 등이 대표적이며, 그 가운데 대학, 특히 학술적 기업가들의 역할이 가장 중요하다. 따라서 학술적 기업가의 창업동기와 창업지원 주체별 역할을 근거로 학술적 기업가 창업활동 지원모델을 제시하였다. 또한 산ㆍ학ㆍ관 협력사업인 폴리머 복합관 창업과정을 대상으로 사례연구를 통해 학술적 기업가의 창업추진인자로서 창업의 성패를 좌우함을 확인하였다. 이외에도 체계적 지원시스템은 물론 기술이전 과정에서 발생하는 갈등을 조정할 수 있는 제도적 장치가 필요한 것으로 나타났다. The major entity supplying the supporting infrastructure of the venture creation is the venture capitalists, university(and research center), and government. Especially, the role of the university and academic entrepreneurs is the key factor in the process of the technology transfer. This article suggests the supporting model for the venture creation of the R&D new products through the strategic alliance composed of the industry, university, and government based on both of the entities's role and the motives of academic entepreneurs. The capacity (or role) of the academic entrepreneurs to craft a vision, and then to lead, inspire, and persuade key members makes an enormous difference between success and failure according to the case study about the process of high-performance polymer-composite pipe business incubation. And the model of academic enterpreneurial venture creation requires that the systematic supporting system as well as the institutional framework for handling the among the members of a committed venture team.

위암 환자에서 절제된 림프절 수의 차이와 관련이 있는 인자

정귀애,박정희,변익건,김경종,장정환,김권천,민영돈 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Purpose: By the definition of UICC TNM classification (fifth edition), the nodal stage of gastric cancer is based on the number of metastatic lymph nodes, which is influenced by the number of resected lymph nodes. And individual differences in the number of resected lymph nodes had been observed in patients with gastric cancer. The aim of this study is to verify the factors which are associated with the difference in the number of resected lymph nodes in patients with gastric cancer. Methods: We reviewed 613 patients with gastric cancer who underwent curative resection and D2 lymph node dissection with 15 or more resected lymph nodes. The number of resected lymph nodes was analyzed according to the characteristics of patients, the types of operation and prognostic factors of gastric cancer. Results: The mean number of resected lymph nodes per patient was 33.0 (median: 31.0, range: 15-88). The number of resected lymph nodes was significantly associated with the types of operation, the location and size of tumor, macroscopic types, depth of tumor invasion and the number of metastatic lymph nodes. Patient's age, gender and the histopathological finding's had no relationship with the number of resected lymph nodes. Conclusions: The number of resected lymph nodes from gastric cancer was different in each patient despite of same D2 lymph node dissection and it was associated with several prognostic factors of gastric cancer.

조기위암의 형태학적인 분류에 따른 임파절 전이 양상

최은서,강길,박정희,장정환,김권천,김경종,민영돈 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Currently, in the limited cases of early gastric cancer (EGC), endoscopic mucosal resection (EMR) is used for curative treatment. However, its completeness is still controversial. The purpose of this study was to review the suggested indications of EMR. We retrospectively analyzed 234 patients with EGC who underwent curative (RO) gastrectomy. The enrolled cases were further classified into mucosal and submucosal types, and mucosal EGC were further classified according to the size, gross type and histologic pattern. 133 patients had mucosal cancers and 101 patients submucosal. The overall incidence of positive lymph node was 14.1% (33/234), the incidence of mucosal cancer was 8. 3% (11/133), which was significantly lower than that of submucosal, 22% (22/101). Of 133 patients with mucosal EGC, 90 were smaller than 2㎝ in size and the incidence of lymph node metastasis was 5.6% (5/90), compared to 43 of larger than 2㎝ with the incidence of 14% (6/43). According to the gross type classification of mucosal cancer, incidence of lymph node metastasis in protruded type (EGC type Ⅰ, Ⅱa, Ⅰ+Ⅱa) was 15.4% (4/26), nat type(EGC type Ⅱb) 2. 9% (1/35), depressed type (EGC type Ⅱc, Ⅲ) 8.3% (6/72). Lymph node metastasis in differentiated type of mucosal cancer was 6.9% (5/72) and undifferentiatcd type 9.8% (6/61). In this study, there was no single indication free from lymph node metastasis, It is thought that the selection of EMR for the curative treatment of EGC should be considered carefully and more clinical studies with long-term follow up are necessary for EMR to be generally acceptable.

Trends in food and nutrient intake over 20 years: findings from the 1998-2018 Korea National Health and Nutrition Examination Survey

Sanghui Kweon,Jin Young Park,Myungsook Park,Yangha Kim,So Yeong Yeon,Leena Yoon,Sungha Yun,Suyeon Park,Ji Eun Yang,Youngtaek Kim,Ok Park,Kyungwon Oh 한국역학회 2021 Epidemiology and Health Vol.43 No.-

OBJECTIVES: We aimed to examine the current status and trends of food and nutrient intake in the Korean population over the past 20 years using the data from the Korea National Health and Nutrition Examination Survey (KNHANES). METHODS: We conducted a survey of 116,284 subjects over the age of one year in Korea, who participated in the KNHANES between 1998 and 2018. We collected data on the subjects’ intake for the day before using the 24-hour recall method. The annual percent change (APC) in the food groups and nutrient intake were calculated using SAS and Joinpoint software. RESULTS: The intake of grains (APC=-0.4, p<0.05) and vegetables (APC=-0.8, p<0.05) was observed to decrease. In contrast, the intake of beverages, meat, dairy, and eggs increased. In particular, beverage intake increased by more than four times (APC=9.2, p<0.05). There was no significant change in energy intake. However, the proportion of energy intake from carbohydrates decreased by approximately 5%p (APC=-0.3, p<0.05), whereas that from fat increased by approximately 5%p (APC=1.1, p<0.05). Additionally, there were decreases in the proportion of energy intake from breakfast and homemade meals and increases in the energy intake from snacks, dining out, and convenience food. The intake of vitamin C (APC=-3.2, p<0.05) and sodium (APC=-2.3, p<0.05) significantly decreased. CONCLUSIONS: Over the past 20 years, there has been decreases in the intake of grains, vegetables, carbohydrates, sodium, and vitamin C and increases in the intake of beverages, dairy, meat, eggs, and fat. Since nutritional status is an important factor in the prevention and management of chronic diseases, it should be continuously monitored.

Prediction Model for Screening Patients at Risk of Malnutrition after Gastric Cancer Surgery

Ji-Hyeon Park,Eunjung Kim,Eun-Mi Seol,Seong-Ho Kong,Do-Joong Park,Han-Kwang Yang,Jong-Ho Choi,Shin-Hoo Park,Hwi-Nyeong Choe,Meera Kweon,Jiwon Park,Yunhee Choi,Hyuk-Joon Lee 대한외과학회 2020 대한외과학회 학술대회 초록집 Vol.2020 No.11