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가와사끼 병 환아에서 이상뇌파와 신경학적 합병증 발현과의 연관성에 대한 고찰
박준수,공도연,박경배,민용식,김영창,정순이,이혜경 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2
목적 : 가와사끼 병의 뇌파 소견 및 다른 임상인자들과의 연관성을 알아보고자 하였다. 방법 : 1994년 1월부터 1995년 12월 사이에 순천향대학 천안병원 소아과에 입원한 23명의 신경학적으로 정상인 가와사끼 병 환아에게 뇌파검사를 실시하여 이를 검사시기, 성별, 연령, 혈소판, 간기능 검사치, 그리고 동맥류 유무등의 임상인자들과 비교하였다. 결과 : 이상뇌파가 23명중 52.2%인 12명에게서 관찰되었으며, 이상뇌파로는 예파 및 극파, 극·서파 복합 양상과 전반적인 배경파의 서파양상이 나타났다. 뇌파의 검사시기가 진단부터 1주 이내인 경우에 이상뇌파의 빈도가 그 후보다 의미있게 높았으나, 그 밖의 다른 임상인자와의 연관성은 별 의미가 없었다. 결론 : 가와사끼 병 초기에 이상뇌파가 나타나는 것은 비록 신경적 증상은 없지만 중추 신경계가 영향을 받는다는 간접적인 증거로 생각할 수 있어 향후 신경적 합병증 발생 여부에 대한 면밀한 관찰이 필요하다고 생각된다. Purpose : This study is to find out if there is any association between EEG abnormalities in Kawasaki disease with other clinical factors. Methods : We performed EEG in 23 Kawasaki disease patients without any neurologic sign who admitted in Soonchunhyang Chunan Hospital from 1994. 1. to 1995. 12. and compared it with sex, age, platelet count, liver function test and presence of coronary artery aneurysm. Results : Abnormal EEG findings were observed in 12 of 23 patients(52.2%) and as for abnormal EEG findings, sharp, spike, spike & slow wave complex, and generalized slow background activity were noted. When EEG was performed within a week after the diagnosis, the incidence of abnormalities of EEG increased significantly but there was no correlation with other clinical factors. Conclusion : EEG abnormalities in the early stage of Kawasaki disease indicate that although there is no abnormal neurologic signs clinically, central nervous system might be affected and there should be a close observation for the developement of neurologic complication.
Kim, Hyun-Jung,Tahk, Young-Wook,Jun, Hyunwoo,Kong, Eui-Hyun,Oh, Jae-Yong,Yim, Jeong-Sik Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.3
In this paper, the design stress intensity values for the plate-type fuel assembly for research reactor are presented. Through a tensile test, the material properties of the cladding (aluminum alloy 6061) and structural material (aluminum alloy 6061-T6), in this case the yield and ultimate tensile strengths, Young's modulus and the elongation, are measured with the temperatures. The empirical equations of the material properties with respect to the temperature are presented. The cladding undergoes several heat treatments and hardening processes during the fabrication process. Cladding strengths are reduced compared to those of the raw material during annealing. Up to a temperature of 150 ℃, the strengths of the cladding do not significantly decrease due to the dislocations generated from the cold work. However, over 150 ℃, the mechanical strengths begin to decrease, mainly due to recrystallization, dislocation recovery and precipitate growth. Taking into account the uncertainty of the 95% probability and 95% confidence level, the design stress intensities of the cladding and structural materials are established. The presented design stress intensity values become the basis of the stress design criteria for a safety analysis of plate-type fuels.
류봉조,임경빈,이규섭,송영봉,공용식,오부진 한밭대학교 생산기반기술연구소 2002 생산기반기술연구소 논문집 Vol.2 No.1
The paper deals with stress and deflection analyses for newly developed PP-pipe structures of LG-Caltex company. In order to calculate the values of stress and deflection, the elements of pipes and its hanger supports are discretized. Through the numerical simulations using commercial FEM code, stresses and deflections of pipes with two or more hanger supports are obtained, and the stability of pipes are checked. Finally, optimal numbers of hanger supports satisfying allowable bending stress is proposed.
Kong, Kyoung Hye,Kim, Hyun Kyu,Song, Kwan Sung,Woo, Young Sik,Choi, Won Suk,Park, Hee Ra,Park, Mikyung,Kim, Mi Eun,Kim, Min-Sun,Ryu, Jeong Sim,Kim, Hyung Sik,Lee, Jaewon Taylor Francis 2010 Journal of toxicology and environmental health. Pa Vol.73 No.21
<P>Capsaicin (N-vanillyl-8-methyl-1-nonenamide) is a major pungent ingredient in hot peppers and induces apoptosis in malignant carcinoma cell lines. However, the adverse effects of capsaicin on neuronal development have not been fully explored. The aim of this study was to determine whether capsaicin affected murine-derived cerebellar multi-potent neural progenitor cells (NPC) or adult hippocampal neurogenesis in vivo. Capsaicin dose-dependently suppressed NPC proliferation, and higher concentrations were cytotoxic. Capsaicin decreased the activation of extracellular signal-regulated kinases (ERK) without markedly affecting p38 kinases. Capsaicin reduced the number of newly generated cells in the dentate gyrus of the hippocampus but did not significantly alter learning and memory performance in young adult mice. Interestingly, capsaicin decreased ERK activation in the hippocampus, suggesting that reduced ERK signaling may be involved in the capsaicin-mediated regulation of hippocampal neurogenesis.</P>
Hyung-Sik Kong,Kang-Sook Lee,Eun-shil Yim,Seon-Young Lee,Hyun-Young Cho,Bin Na Lee,Jee Young Park 대한직업환경의학회 2013 대한직업환경의학회지 Vol.25 No.-
Objectives: The purpose of this study was to identify the risk factors of metabolic syndrome (MS) and to analyze the relationship between the risk factors of MS and medical cost of major diseases related to MS in Korean workers, according to the scale of the enterprise. Methods: Data was obtained from annual physical examinations, health insurance qualification and premiums, and health insurance benefits of 4,094,217 male and female workers who underwent medical examinations provided by the National Health Insurance Corporation in 2009. Logistic regression analyses were used to the identify risk factors of MS and multiple regression was used to find factors associated with medical expenditures due to major diseases related to MS. Result: The study found that low-income workers were more likely to work in small-scale enterprises. The prevalence rate of MS in males and females, respectively, was 17.2% and 9.4% in small-scale enterprises, 15.9% and 8.9% in medium-scale enterprises, and 15.9% and 5.5% in large-scale enterprises. The risks of MS increased with age, lower income status, and smoking in small-scale enterprise workers. The medical costs increased in workers with old age and past smoking history. There was also a gender difference in the pattern of medical expenditures related to MS. Conclusions: Health promotion programs to manage metabolic syndrome should be developed to focus on workers who smoke, drink, and do little exercise in small scale enterprises.
황영남(Young Nam Whang),최규식(Kyu Sik Choi),김영자(Young Ja Kim),양윤모(Yoon Mo Yang),조승운(Seung Woon Cho),나정호(Jung Ho La),윤세옥(Sei Ok Yoon),이성공(Sung Kong Lee),윤영준(Young Joon Yoon),김희숙(Hee Sook Kim) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.3
Carcinoid tumors are slowly growing rare neoplasms that arise from argentaffin cells. In general, gastric carcinoids are very rare, constituting only 0.7-2.5% of all gastrointestinal carcinoids and approximately 0.3% of all gastric tumors. Gastric carcinod tumor commonly presents as a single polypoid mass and the most frequent site is the antral cavity. Clinical diagnosis is often difficult because the typical carcinoid syndrome is uncommon and nonspecific gastrointestinal symptoms are the more frequent clinical feature of this disease. Preoperative diagnosis is possible by large and deep endoscopic biopsies of the gastric wall. This paper presents a case of malignant gastric carcinoid tumor and a brief review of pertinent literature. A 52 year old female visited our medical hospital with the symptom of epigastric pain and indigestion for several months. Upper G-I series and gastrofiberscope showed malignat ulcerative lesion in the lesser curvature of the antral cavity. She had been operated under the diagnosis of gastric adenocarcinoma, but pathological findings demonstrated argyrophilic granules in tumor cell.
Hepatocellular Carcinoma in Korea: an Analysis of the 2015 Korean Na-tionwide Cancer Registry
( Jun Sik Yoon ),( Han Ah Lee ),( Hwi Young Kim ),( Dong Hyun Sinn ),( Dong Ho Lee ),( Suk Kyun Hong ),( Ju-yeon Cho ),( Jonggi Choi ),( Young Chang ),( Hyun-joo Kong ),( Eunyang Kim ),( Young-joo Won 대한간암학회 2021 대한간암학회지 Vol.21 No.1
Background/Aims: Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading cause of cancer-related death in Korea. This study evaluated the characteristics of Korean patients newly diagnosed with HCC in 2015. Methods: Data from the Korean Primary Liver Cancer Registry (KPLCR), a representative sample of patients newly diagnosed with HCC in Korea, were analyzed. A total of 1,558 patients with HCC registered in the KPLCR in 2015 were investigated. Results: The median age was 61.0 years (interquartile range, 54.0-70.0 years), and men accounted for 79.7% of the subjects. Hepatitis B virus infection was the most common underlying liver disease (58.1%). According to the Barcelona Clinic Liver Cancer (BCLC) staging system, stage 0, A, B, C, and D HCCs accounted for 14.2%, 26.3%, 12.7%, 39.0%, and 7.8% of patients, respectively. Transarterial therapy (29.5%) was the most commonly performed initial treatment, followed by surgical resection (25.1%), best supportive care (20.2%), and local ablation therapy (10.5%). Overall, 42.4% of patients were treated in accordance with the BCLC guidelines: 61.7% in stage 0/A, 39.0% in stage B, 18.1% in stage C, and 71.6% in stage D. The 1-, 3-, and 5-year OS rates were 66.5%, 49.0%, and 17.0%, respectively. Conclusions: In 2015, approximately 40% of Korean HCC cases were diagnosed at a very early or early stage, and 35% of patients underwent potentially curative initial treatment. BCLC guidance was followed in 42.4% of patients; in patients with stage B or C disease, there was relatively low adherence. (J Liver Cancer 2021;21:58-68)