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4-DIMENSIONAL DIGITAL UNIVERSE PROJECT
KOKUBO EUCHIRO,HAYASHI MITSURU,KATO TSUNEHIKO,TAKEDA TAKAAKI,KAIFU NORIO,MIYAMA SHOKEN,MIURA HITOSHI,TAKAHEI TOSHIYUKI The Korean Astronomical Society 2005 Journal of The Korean Astronomical Society Vol.38 No.2
We have developed the four-dimensional digital universe theater at which we can visualize the observational data and theoretical models of astronomical objects stereoscopically. The astronomical objects cover all scales of the universe from the solar system to the large-scale structure of the universe. We have also produced the three-dimensional movies of various astronomical processes based on the results of computer simulations. We plan to distribute all the products of this project through the internet.
The Effect of L-Ornithine on the Phosphorylation of mTORC1 Downstream Targets in Rat Liver
Kokubo, Takeshi,Maeda, Shyuichi,Tazumi, Kyoko,Nozawa, Hajime,Miura, Yutaka,Kirisako, Takayoshi The Korean Society of Food Science and Nutrition 2015 Preventive Nutrition and Food Science Vol.20 No.4
A non-protein amino acid, L-ornithine (Orn), has been shown to stimulate the urea cycle and tissue protein synthesis in the liver. The purpose of the current study was to assess whether Orn affects the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) pathway, which is involved in protein synthesis. Primary cultured cells isolated from Wistar rat liver were incubated in an amino acid-free medium, followed by addition of Orn for 3 h. The cell lysate was subjected to immunoblotting to evaluate the phosphorylation of downstream targets of mTORC1, including p70S6K, S6, and 4EBP1. To assess the involvement of mTORC1 for the effect of Orn, the cells were pretreated with the mTOR inhibitor rapamycin before the addition of Orn and the cell lysate was subjected to immunoblotting. We next examined whether the effects of Orn were exerted in vivo. Orn was orally administered to 18 h food-deprived rats, the blood and the livers were collected at 1 and 3 h after administration for immunoblotting. Orn treatment for primary cultured cells for 3 h enhanced the phosphorylation of p70S6K, S6, and 4EBP1. In addition, rapamycin blocked the effects of Orn completely (p70S6K and S6) or partially (4EBP1). The oral administration of Orn to the rat also augmented the phosphorylation of mTORC1 downstream targets notably in S6 at 1 h. Our findings demonstrate that Orn has the potential to induce the phosphorylation of downstream targets of mTORC1 in the rat liver. This may be mediated by the augmentation of mTORC1 activity.
Kokubo, Tadashi,Uenoyama, Mayo,Kim, Hyun-Min,Minoda, Masahiko,Miyamoto, Takeaki,Nakamura, Takashi The Korean Ceramic Society 1999 The Korean journal of ceramics Vol.5 No.3
Polyethylene was modified with silanol groups on its surface by photografting of vinyltrimethoxysilane in vapor phase by using benzophenon as a polymerization initiator and by hydrolyzing the methoxysilane groups into the silanol groups with HCI solution. The modified polyethylene formed a dense and homogeneous apatite layer on its surface in a solution with ion concentrations 1.5 times those of human blood plasma within 21 days. This kind of biomimetic process could provide techniques for fabricating apatite-polymer composites with three dimensional structure analogous to the natural bone.
마을기업에서 혁신적 지역리더의 역할: 일본 이로도리 주식회사의 사례를 중심으로
國保祥子 ( Kokubo Akiko ),배득종 ( Bae Deuk J ) 한국지방행정연구원 2018 地方行政硏究 Vol.32 No.1
본 연구는 일본 가미카쓰(上勝) 지역의 마을기업인 이로도리(彩)를 선정하여, 한국의 노령화된 농산어촌에 필요한 Best Practice를 제시한다. 주식회사 이로도리에서 노인들은 요리장식용 나뭇잎을 생산하는 개인사업자로서 상당 금액의 소득을 올리고, 신체적으로도 건강한 생활을 하고 있다. 그 결과, 이 마을에는 젊은이들이 U턴 또는 I턴해서 돌아오고 있다. 이런 성공사례 뒤에는 요코이시 토모지(橫石知二)라는 혁신적인 지역리더가 있다. 본 연구는 그의 리더십을 40여년에 걸친 마을기업 성장단계별로 나누어서 기술한다. 각 단계별로 그가 발휘한 리더십은 제각기 달라지는데, 그것은 단계별 도전과 응전의 성격에 따른 것이다. 그러나 장기적으로 보면, 그는 혁신적 지역리더의 5가지 특성(협동, 사명감, 꾸준함, 포용, 자기성찰)을 모두 발휘한다. 그 중에서도 가장 귀감이 되는 것은 꾸준함이다. The study is to present Irodori Company, Kamikatsu, Japan, as a best practice for Korea's aging farming and fishing villages. Irodori has turned the aged into active businessmen earning good amount of income and living physically healthy lives. As a result, young people comes back to the region, making a U-turn or an I-turn. Behind this success case is an innovative local leader, Yokoishi Tomoji. This study describes the dynamics of his leadership upon the four development stages of Irodori. It is revealed that the most important characteristics of his leadership is persistence, which might be a precious lesson for Korean leader or leader-to-be in community business.
Takeshi Kokubo,Shimpei Wakai,Daisuke Fujiwara,Osamu Kanauchi,Kenta Jounai,Hisahiro Ichikawa,Mihoko Takuma,Yoshihisa Kanaya,Ryohei Shiraoka 한국식품영양과학회 2020 Preventive Nutrition and Food Science Vol.25 No.2
Maintaining employees’ presenteeism is a major issue in the workplace. Simple and convenient methods to improve presenteeism are required. We investigated whether administering the lactic acid bacteria Lactococcus lactis strain Plasma (LC-Plasma) can improve the performance and physical condition of office workers. Subjects were randomly assigned to one of two groups: 1) an intake period (consumption of LC-Plasma-containing yogurt beverage) followed by a non-intake period, or 2) a non-intake period followed by an intake period. Each period lasted 4 weeks and there was a 4-week washout period between each. Assessment was conducted using the World Health Organization Health and Work Performance Questionnaire (HPQ), the Profile of Mood States (POMS) questionnaire and physical condition questionnaires. A total of 153 subjects were analyzed. Absolute presenteeism (as assessed by the HPQ) and vigor (as assessed by POMS) were significantly higher in the intake period than the non-intake period. The subject’s physical health (as assessed by typical common cold symptoms, physical condition, sneezing or runny noses, coughing or sore throats, and lassitude) was also superior during the LC-Plasma intake period. Our results suggest that intake of LC-Plasma for 4 weeks improves work performance through reducing the risk of infection.
The Effect of L-Ornithine on the Phosphorylation of mTORC1 Downstream Targets in Rat Liver
Takeshi Kokubo,Shyuichi Maeda,Kyoko Tazumi,Hajime Nozawa,Yutaka Miura,Takayoshi Kirisako 한국식품영양과학회 2015 Preventive Nutrition and Food Science Vol.20 No.4
A non-protein amino acid, L-ornithine (Orn), has been shown to stimulate the urea cycle and tissue protein synthesis in the liver. The purpose of the current study was to assess whether Orn affects the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) pathway, which is involved in protein synthesis. Primary cultured cells isolated from Wistar rat liver were incubated in an amino acid-free medium, followed by addition of Orn for 3 h. The cell lysate was subjected to immunoblotting to evaluate the phosphorylation of downstream targets of mTORC1, including p70S6K, S6, and 4EBP1. To assess the involvement of mTORC1 for the effect of Orn, the cells were pretreated with the mTOR inhibitor rapamycin before the addition of Orn and the cell lysate was subjected to immunoblotting. We next examined whether the effects of Orn were exerted in vivo. Orn was orally administered to 18 h food-deprived rats, the blood and the livers were collected at 1 and 3 h after administration for immunoblotting. Orn treatment for primary cultured cells for 3 h enhanced the phosphorylation of p70S6K, S6, and 4EBP1. In addition, rapamycin blocked the effects of Orn completely (p70S6K and S6) or partially (4EBP1). The oral administration of Orn to the rat also augmented the phosphorylation of mTORC1 downstream targets notably in S6 at 1 h. Our findings demonstrate that Orn has the potential to induce the phosphorylation of downstream targets of mTORC1 in the rat liver. This may be mediated by the augmentation of mTORC1 activity.