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Arima, N.,Kim, S.,Kojima, M. Springer Science + Business Media 2016 Journal of optimization theory and applications Vol.168 No.3
<P>We propose the moment cone relaxation for a class of polynomial optimization problems to extend the results on the completely positive cone programming relaxation for the quadratic optimization model by Arima, Kim and Kojima. The moment cone relaxation is constructed to take advantage of sparsity of the polynomial optimization problems, so that efficient numerical methods can be developed in the future. We establish the equivalence between the optimal value of the polynomial optimization problem and that of the moment cone relaxation under conditions similar to the ones assumed in the quadratic optimization model.</P>
Microscale Determination of Aqueous Two Phase System Binodals by Droplet Dehydration in Oil
Kojima, Taisuke,Takayama, Shuichi American Chemical Society 2013 ANALYTICAL CHEMISTRY - Vol.85 No.10
<P>This paper analyzes the use of a dehydrating oil system to determine binodal curves of an aqueous two phase system (ATPS). Aqueous droplets containing phase-forming polymers are dehydrated at the interface between two immiscible oils. The droplets shrink due to diffusion of water into the oil phase while constantly maintaining a spherical shape. Upon sufficient dehydration, dilute one-phase solutions of phase-forming polymers separate into two phases. Comparison of the droplet diameter at this phase separation point and at the beginning allows facile calculation of the concentration of polymers that determine the binodal curve. The miniaturized droplet dehydration-based binodals obtained in this manner matched the binodals determined by the conventional diluting method but using several orders of magnitude less sample volume (150 nL droplets versus 10 mL vials).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2013/ancham.2013.85.issue-10/ac400628b/production/images/medium/ac-2013-00628b_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac400628b'>ACS Electronic Supporting Info</A></P>
Kojima Tsukasa,Yamasaki Yuzo,Kamitani Takeshi,Yabuuchi Hidetake,Shirasaka Takashi,Shimomiya Yamato,Kondo Masatoshi,Hamasaki Hiroshi,Kato Toyoyuki,Nagao Michinobu,Honda Hiroshi 아시아심장혈관영상의학회 2019 Cardiovascular Imaging Asia Vol.3 No.1
Objective: The smallest diagnostically sufficient amount of contrast media (CM) should be used for coronary computed tomography angiography (CCTA) to minimize the risk of contrast- induced nephrotoxicity in elderly patients with coronary artery disease. The purpose of this study was to propose dynamic-CCTA using a low dose of CM and temporal maximum intensity projection (TMIP) and to investigate its image quality compared to standard-CCTA. Materials and Methods: Participants comprised 30 patients with coronary artery disease who underwent dynamic-CCTA and standard-CCTA using 320-row CT. Dynamic-CCTA was continuously performed at mid-diastole throughout 15–25 cardiac cycles after bolus injection of CM [103 mg iodine/kg body weight (mgI/kg)]. TMIP-CCTA was reconstructed from three-phase dynamic-CCTA data, including a phase with peak enhancement of the ascending aorta. Standard-CCTA was performed using a standard CM dose (259 mgI/kg). Image quality of both TMIP-CCTA and standard-CCTA was analyzed. Results: The amount of CM used in TMIP-CCTA and standard-CCTA was 16.2±2.6 mL and 40.1±7.3 mL, respectively. The mean effective radiation dose was not significantly different between the two methods. Mean coronary attenuation was significantly lower for TMIP-CCTA than standard-CCTA [346.9±82.8 Hounsfield units (HU) vs. 455.4±75.3 HU, p<0.05]. Image noise was significantly lower for TMIP-CCTA than standard-CCTA (20.0±3.2 HU vs. 28.1± 3.6 HU, p<0.05). There were no differences in signal-to-noise ratio and visual assessment scores between the two methods. Conclusion: TMIP-CCTA can be performed using more than 50% less CM with the same image quality as standard-CCTA.
AGING IN JAPAN : POPULATION POLICY IMPLICATIONS
KOJIMA, HIROSHI Institute for Social Development and Policy Resear 1995 Korea Journal of Population and Development Vol.24 No.2
This paper describes the trends in population aging in Japan and its demographic determinants and consequences. It discusses the sociocultural contexts of aging with special reference to the family. Then, it presents the results of multinomial logit analysis of data from the National Opinion Survey on Population Issues conducted by the Institute of Population Problems in 1990 to explore the possible acceptance of alternative population policies to slow populating aging.
Kojima, Satoshi,Kao, Mimi H.,Doupe, Allison J.,Brainard, Michael S. Society for Neuroscience 2018 The Journal of neuroscience Vol.38 No.45
<P>The basal ganglia (BG) participate in aspects of reinforcement learning that require evaluation and selection of motor programs associated with improved performance. However, whether the BG additionally contribute to behavioral variation (“motor exploration”) that forms the substrate for such learning remains unclear. In songbirds, a tractable system for studying BG-dependent skill learning, a role for the BG in generating exploratory variability, has been challenged by the finding that lesions of Area X, the song-specific component of the BG, have no lasting effects on several forms of vocal variability that have been studied. Here we demonstrate that lesions of Area X in adult male zebra finches (<I>Taeniopygia gutatta</I>) permanently eliminate rapid within-syllable variation in fundamental frequency (FF), which can act as motor exploration to enable reinforcement-driven song learning. In addition, we found that this within-syllable variation is elevated in juveniles and in adults singing alone, conditions that have been linked to enhanced song plasticity and elevated neural variability in Area X. Consistent with a model that variability is relayed from Area X, via its cortical target, the lateral magnocellular nucleus of the anterior nidopallium (LMAN), to influence song motor circuitry, we found that lesions of LMAN also eliminate within-syllable variability. Moreover, we found that electrical perturbation of LMAN can drive fluctuations in FF that mimic naturally occurring within-syllable variability. Together, these results demonstrate that the BG are a central source of rapid behavioral variation that can serve as motor exploration for vocal learning.</P><P><B>SIGNIFICANCE STATEMENT</B> Many complex motor skills, such as speech, are not innately programmed but are learned gradually through trial and error. Learning involves generating exploratory variability in action (“motor exploration”) and evaluating subsequent performance to acquire motor programs that lead to improved performance. Although it is well established that the basal ganglia (BG) process signals relating to action evaluation and selection, whether and how the BG promote exploratory motor variability remain unclear. We investigated this question in songbirds, which learn to produce complex vocalizations through trial and error. In contrast with previous studies that did not find effects of BG lesions on vocal motor variability, we demonstrate that the BG are an essential source of rapid behavioral variation linked to vocal learning.</P>
Kojima, Takahiko,Inui, Yuji,Miyazaki, Soushi,Shiro, Motoo,Fukuzumi, Shunichi Royal Society of Chemistry 2009 Chemical communications Vol.2009 No.43
<P>A novel tetranuclear Ir(<SMALL>III</SMALL>) complex involving unprecedented coordination modes of alloxazine formed a closed π-space by intermolecular hydrogen bonding and the counter anions encapsulated in the space could be exchanged <I>via</I> self-assembly.</P> <P>Graphic Abstract</P><P>A novel tetranuclear Ir(<SMALL>III</SMALL>) complex involving unprecedented coordination modes of alloxazine formed a closed π-space by intermolecular hydrogen bonding; counter anions encapsulated in the space could be exchanged <I>via</I> self-assembly. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b911033j'> </P>