생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

Proteomic Approach to Analyzing Flooding Stress in Soybean (Glycine max(L.) Merr.)

Kim,Tae-Seon,Cho,Seong-Woo,Lee,Jae-Eun,Kim,Yook-Han,Cho,Kun,Choi,Jong-Soon,Chung,Keun-Yook,Song,Beom-Heon,Jong,Seung-Keun,Kim,Hong-Sig,Woo,Sun-Hee 한국작물학회 2005 한국작물학회 학술발표대회 논문집 Vol.2005 No.-

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구

민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.

WLL 증폭기 불요방사 성능분석

김성철,송인근 우송대학교 1999 우송대학교 논문집 Vol.4 No.-

In this paper the system perfomance degradation resulting from nonlinear transmitter power amplifier which is essential to increase the efficiency is analyzed in a WLL-CDMA system. The power amplifier is modeled by its AM-AM, AM-PM characteristics. Through the investigation of the power spectrum density of the transmitted signal , spectral regrowth or sideband regrowth which is result from amplitude distortion can be seen. All these characteristics result in BER performance degradation due to other user interferences and intersymbol interference. The analysis technique described here applies not only to power amplifier but also to any other nonlinear components such as mixers and switches. Also the effects of adjacent channel interference and supurious emission can be analyzed between different systems.

류마티스성 승모판 협착증의 치료를 위한 경피적 승모판 성형술의 치료성적

김성은,조흥근,박성훈,박시훈 梨花女子大學校 醫科大學 醫科學硏究所 1999 EMJ (Ewha medical journal) Vol.22 No.4

연구목적 : 류마티스성 승모판 협착증에 대한 유용한 치료법인 경피적 승모판 성형술의 본원의 단기 치료 성적을 알아보고자 하였다. 방법: 1993년 10월에서 1999년 4월까지의 이대목동병원에 내원한 류마티스성 승모판 협착증 환자 21명에서 투시조명 하에 경피적 승모판 성형술을 시행하였다. 시술전에 경흥부심초음파와 경식도초음파가 시행되었고, 시술후에는 경흉부초음파를 사용하여 혈역학적, 임상학적 변화를 비교하였다. 연구대상의 거의 모두가 NYHA class Ⅱ에 속했고, 5명이 심방세동을 가지고 있었으며, 모두 심초음파점수가 8이하였다. 좌심방에 혈전이 있는 경우로 혈전을 용해시킨 후 시술한 경우가 2예였다. 결과 : 경피적 승모판 성형술 이후의 평균 승모판구면적은 시술전의 1.16±0.36㎠에서 2.06±0.33㎠로 증가되었다. 경승모판 이완기 평균 압력차는 시술전 11.60±5.54mmHg에서 시술 후 4.93±2.53mmHg(p<0.001). 좌심방 크기는 46.41±14.66mm에서 42.03±15.01mm로(p=0.042), 그리고 심박출량은 4.21±1.25L/min에서 6.88±9.57L/min로(p<0.0001) 의미있는 호전을 보였다. 3도 이상의 심한 승모관폐쇄부전이나 심각한 시술후 합병증은 없었다. 결론 : 본원에서 약 6년간 시행된 경피적 승모판 성형술는 그 사례가 적고 시술전 예상되는 난이도 면에서 특이한 것은 없었지만, 시술후 합병증이 거의 발견되지 않았으며 혈역학적 측정상에서도 성공적인 시술을 보여주었다. 승모판구면적에 따른 시술후 단기내 호전의 정도는 거의 예측할 수 없었으나, 심초음파점수는 모두가 8점이하로 높은 성공율의 조건을 제공하였다. Objective : Percutaneous mitral valvuloplasty(PMV) became a treatment modality or mitral stenosis because of its low morbidity, short hospital stay, and low cost. We reviewed clinical and hemodynamic results after PMV for the patients with mitral stenosis in Ewha Womans University Mokdong hospital. Methods : We compared the results of echocardiographic, hemodynamic, and clinical parameters before and after PMV. PMV was performed under fluoroscopic guidance in 21 patients(M:4, F:17, mean age 43±12 years) with mitral stenosis from October 1993 to April 1999. Transesophageal echocardiography(TEE) and Transthoracic echocardiography(TTE) were performed for the evaluation of mitral valve, chamber size, and the presence of left atrial thrombus before procedures. TIE was also used for follow-up evaluation. On presentation, all patients showed at least NYHA class Ⅱ. Five patients had atrial fibrillation. Two patients with thrombus in the left atrium were included to study group after thrombolytic treatment with coumadin. Echo-score of our patients was not greater than 8. Results : Mean mitral valve area(MVA) by 2 dimensional or Doppler echocardiography was increased from 1.16±0.36㎠ before PMV to 2.06±0.33㎠ after PMV. There were marked improvements in transmitral gradients(11.60±5.54mmHg before PMV vs 4.93±2.53mmHg after PMV, p<0.001), left atrial dimension(46.41±14.66mm vs 42.03±15.01mm, p=0.042), and cardiac output(4.21±1.25L/min vs 6.88±9.57L/min, p<0.0001) following PMV, Severe(≥GⅢ) mitral insufficiency or severe postprocedural complications were not noted. This suggested that all procedure was successful. Conclusion : The Procedural success rate of PMV in Ewha Womans University Mokdong hospital was 100%. Low echo score of our patients might explain this high procedural success rate. Long-term-follow-up is warranted in the near future.

VITAMIN E劑가 全身持久力 向上에 미치는 影響

金敎成,曺根鍾 漢陽大學校 體育科學硏究所 1986 體育科學 Vol.6 No.6

The purpose of this study was to investigate effect of Vitamin E on improvement of cardiovascular endurance. Selected subiects-12 soccer players and 12 general high school boys were divided into 4 groups as follows. A; Soccer players who were trained after taking Vitamin E, (6 persons) B; Soccer players who were trained only, not dosage. (6 persons) C: General students who were trained after dosed Vitamin E, (6 persons) D; General students who were not trained, but taking Vitamin E. (6 persons) Each group was trained for 5 weeks by training program. (17 mins/day, 3 days/ week), after training measured and analysised heart-rate, vital-capacity, 1000m race-record, heart-rate after 1000m race in every 5 weeks. The conclusions are as follows: 1. Resting heart-rate lowed 4. 0 beats/min in A, C group (P<0.05) after training but control group was not lowed. 2. Vital-capacity increased in C group(287cc, P<0.001) and A group (149cc, P<0.05). 3. 1000m race record improved in order of C-A-B group so, each group was shortened 17 sec (P<0.05) , 12 sec (P<0.05) 11 sec (P<0.05) 4. Heart-rate after 1000m race improved in order of C-A-K group so, each group was lowed 6.6 beats/min, 6.0 beats/min, 5.6 beats/min(P<0.05). Synthetically cardiovascular endurance improved both players and general group but general group rather than players. The result indicated that Vitamin E was effected to improvement of cardiovascular endurance. But there was no improvement of cardiovascular endurance in K group except 1000m race record. It was that the result was not dosage effect but training effect.

수면무호흡증의 다원수면기록 소견

김용조,이선우,왕성근 대한생물치료정신의학회 1996 생물치료정신의학 Vol.2 No.2

To identify the clinical characteristics of sleep apnea syndrome in Korean, author analyzed 24 cases of polysomnographic findings statistically, diagnosed as sleep apnea syndrome during May, 1995 to July,1996. The results were summarized as follows: 1. The mean age of subjects was 35.7 years, the distribution of age was 12 to 64 years, and male to female sex ratio was 5:1. 2. As for mean values of sleep parameters, total bed time was 429.8 minutes, waking after sleep onset was 93.4 minutes, total sleep time was 336.1 minutes and sleep efficiency was 77.7%. 3. The proportions of sleep stage 1, stage2,slow wave sleep, REM sleep, and movement time to total sleep time were 13.1%, 39.4%, 24.4%, 20.8%, and 2.2% respectively. 4. Mean AI(apnea index) was 28.7 and RD(respiration disturbance index ) was 34.3. 5. Waking after sleep onset correlated with total sleep time and sleep efficiency negatively, and with sleep stage 1 positively. Sleep efficiency correlated with sleep stage 1 negatively, and sleep stage 1 correlated with slow wave sleep negatively.

6차 교육 과정에 따른 고등학교 공통 과학 (화학 부분) 교과서의 탐구 활동 분석

김윤희,정경규,문경근,문성배 부산대학교 사범대학 과학교육연구소 1998 科學敎育硏究報 Vol.25 No.-

In order to obtain the fundamental data for developing an ideal chemistry curriculum in the common science, four kind of common science textbooks were analyzed. Particularly, inquiry activities part was analyzed by the three dimension framework which consists of inquiry content dimension, inquiry process dimension and inquiry context dimension. The average volume of chemistry part in the common science text books was 13% (56 page). In the analysis of the inquiry content dimension of inquiry activities, the total number of themes in four kinds of textbook had similar inquiry activities. For the analysis of inquiry process dimension, 'interpreting data and formulating generalizations' category(39.1%) was most emphasized and the categories of 'observation and measuring'(30.8%), and 'building, testing and revising the theoretical model'(16.5%), 'seeing a problem and seeking ways to solve it'(13.5%) follow in order. As for the analysis of the inquiry context dimension, the scientific context was 82%, the individual context 1.8%, the social context 7.8% and the technical context 7.8%. It showed that the proportion of STS related contents in inquiry activities was 18%. For the purpose of common science text book in the 6th curriculum, it is expected to increase the proportion of the high level inquiry process and the proportion of STS related contents.

24시간 수면 박탈의 정신생리적 변화와 카페인의 효과

김준호,왕성근,김정란 대한생물치료정신의학회 2004 생물치료정신의학 Vol.10 No.1

Objectives : The purpose of this study is to evaluate the effects of 24 hours sleep deprivation on the psychophysiologic functions(daytime sleepiness, fatigue, mood, vigilance, attention and short-term memory) and then to examine whether caffeine ingestion improves the effects induced by sleep deprivation in healthy korean population. Methods : 16 healthy korean university students who didn't have psychiatric disorder or sleep disorder and complain sleep-wake cycle disturbance, carried out ESS(Epworth Sleepiness Scale), VAS(Visual Analogue Scale), MSLT, and Computerized Neurocognitive Function Test under following conditions : after normal usual sleep(Baseline), after 24 hours sleep deprivation, and after 24 hours sleep deprivation followed by 150mg of caffeine ingestion. Results : After 24 hours sleep deprivation, the subjective and objective daytime sleepiness, fatigue and dysphoria were increased as compared to baseline, attention and vigilance were decreased compared to baseline and short-term memory wasn't significantly changed. When the subjects ingested 150mg of caffeine after 24 hours sleep deprivation, an increment of subjective and objective daytime sleepiness, fatigue and dysphoria and a decrement of attention and vigilance induced in sleep deprivation was improved, 150mg of caffeine given after 24 hours sleep deprivation improved significantly the objective daytime sleepiness, attention, and vigilance to the baseline level, and also improved significantly the subjective daytime sleepiness, fatigue and dysphoria but didn't reach the baseline level. Conclusions: 24 hours sleep deprivation in the normal young adult increased the subjective and objective daytime sleepiness, fatigue and dysphoria and decreased attention and vigilance, whereas didn't develop short-term memory disturbance. Following caffeine ingestion improves an increased objective daytime sleepiness, a decreased attention, and a decreased vigilance induced in sleep deprivation to almost same degree of baseline, but doesn't improve an increased objective daytime sleepiness, fatigue and dysphoria induced sleep deprivation to same degree of baseline.