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RISS 인기검색어
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- 저자 : Kim Keong-Yo (검색결과 2 건)
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흰쥐에서 척수 편 절제가 보행운동에 미치는 영향의 분석
김상수,조경석,심대무,김태요,김종환 대한척추외과학회 1996 대한척추외과학회지 Vol.3 No.2
Spinal cords possess a remarkable capacity for locomotory recovery in the rat. For example, adult rate with dorsally hemisected thoracic(T7) spinal cord recover hindlimb locomotor function within a few weeks. The objective of this study was, therefore, to investigate recovery of locomotion after unilateral spinal cord hemisection in the fat. Especially, we were interested in comparing the locomotion of the limbs between the hemisected side and the intact sids. Adult Sprague-Dawley rate(290-310grams) were used. Unilateral hemisection on right spinal cord at T7 was performed on 10 rats under sterile condition. Foot trajectories of treadmill walking animals were video-taped and analyzed using a computerized motion analysis system. The foot trajectories, stride length, vertical displacement, peak velocities, duration of swing phase, and limb coordination were calculated and plotted. Following the right hemisection, all these kinematic varibles were initially disrupted but returned to prelesion values within three to six weeks, Even though the lesion was unilateral, disruption of locomotor behavior appeared bilaterally. Amplitude(1.44+0.26㎝) and velocities(19.24±3.6㎝/sec) of vertical movement of the hindfoot in the hemisected side was significantly(P<0.01) lower than those of the prelesion values(amplitude 1.96±0.21㎝; velocity 30.60±2.75㎝/sec) and these values did not recover to prelesion levels. The difference in locomotory behavior between the limbs of the injured and uninjured side could not be easily detectable without using kinematic analysis of the limb trajectories. In conclusion, asymmetry of the limb kinematics was found in the vertical movement of the hindlimb of the unilateral hemisection model.
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강활유풍탕(羌活愈風湯)이 뇌허혈(腦虛血)로 유도된 대뇌신경세포손상(大腦神經細胞損傷)에 미치는 영향
문병순,황충연,김경요,이건목,성강경,이대용,이성근,Mun Beong-Sun,Hwang Chung-Yeon,Kim Keong-Yo,Lee Geon-Mok,Sung Kang-Keong,Lee Dae-Yong,Lee Seoung-Geun 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.1
Objective : Experimental studies have been done to elucidate the effect of kangwhalyupung-tang(KWYPT) on neuronal cell damage induced by brain ischemia. Method : The cytotoxic effect of ischemia was measured in the MTS assay cultures. MTS assay, INT assay, neurofilament(NF) enzymeimmuno assay(EIA). And the KWYPT on ischemia-induced neurotoxicity were examined by in vitro assays. Results : 1. The KWYPT protected effectively neuronal cell-death resulted from brain ischemia induced by the treatment of $95%N_2/5%CO_2$ for 10 min in those dependent fashion. 2. The KWYPT effectively increased the amount of NF resulting from brain ischemia, induced by the treatment of $95%N_2/5%CO_2$ for 15 min in those dependent fashions. Conclusions : KWYPT protects the brain ischemia-induced neurotoxicity through the increase of cell viability and of neurofilament in dose-dependent manner.
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