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RISS 인기검색어
- 검색키워드
- 저자 : Kim Dongha (검색결과 248 건)
- 무료
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- 유료
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Copper-Catalyzed Selective Arylations of Benzoxazoles with Aryl Iodides
Kim, Donghae,Yoo, Kwangho,Kim, Se Eun,Cho, Hee Jin,Lee, Junseong,Kim, Youngjo,Kim, Min American Chemical Society 2015 Journal of organic chemistry Vol.80 No.7
<P>A copper-catalyzed direct ring-opening double N-arylation of benzoxazoles with aryl iodides has been developed. The present system exhibits high selectivity despite competition from C-arylation. The selectivity between ring-opening N-arylation and C-arylation was controlled by the choice of reaction vessel. The nitrile bound bis(triphenylphosphine)copper cyanide was identified as the active catalytic species for both reactions, and when combined with a nitrile-containing solvent, enhanced the reaction efficiency.</P>
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Kim, Hyunkyung,Kim, Dongha,Choi, Seon Ah,Kim, Chang Rok,Oh, Se Kyu,Pyo, Ki Eun,Kim, Joomyung,Lee, Seung-Hoon,Yoon, Jong-Bok,Zhang, Yi,Baek, Sung Hee National Academy of Sciences 2018 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.115 No.46
<P><B>Significance</B></P><P>An aberrant covalent histone modification which drives dysregulation of transcriptional program is related to human diseases such as cancer. Thus, identifying signaling pathways modulating transcription factors and epigenetic enzymes are coming into view as attractive therapeutic targets. In this study, we provide evidence that KDM3A is tyrosine-phosphorylated by JAK2, and tyrosine-phosphorylated KDM3A acts as a coactivator for STAT3, thereby exerting increased cancer cell growth and motility. We propose that JAK2-dependent tyrosine phosphorylation of KDM3A could be a potential therapeutic target for epigenetic control of oncogenic effect governed by JAK2−STAT3 signaling pathway.</P><P>Janus tyrosine kinase 2 (JAK2)−signal transducer and activator of transcription 3 (STAT3) signaling pathway is essential for modulating cellular development, differentiation, and homeostasis. Thus, dysregulation of JAK2−STAT3 signaling pathway is frequently associated with human malignancies. Here, we provide evidence that lysine-specific demethylase 3A (KDM3A) functions as an essential epigenetic enzyme for the activation of JAK2−STAT3 signaling pathway. KDM3A is tyrosine-phosphorylated by JAK2 in the nucleus and functions as a STAT3-dependent transcriptional coactivator. JAK2−KDM3A signaling cascade induced by IL-6 leads to alteration of histone H3K9 methylation as a predominant epigenetic event, thereby providing the functional and mechanistic link between activation of JAK2−STAT3 signaling pathway and its epigenetic control. Together, our findings demonstrate that inhibition of KDM3A phosphorylation could be a potent therapeutic strategy to control oncogenic effect of JAK2−STAT3 signaling pathway.</P>
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Kim Jin-Ju,Park Jae-Hyun,Kim Hyeok,Sim Woo-Sup,Hong Seokbeom,Choi Yeon-Jik,Kim Hyo-Jin,Lee Soon Min,Kim Dongha,Kang Sun-woong,Ban Kiwon,Park Hun-Jun 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Despite recent progress in medical and endovascular therapy, the prognosis for patients with critical limb ischemia (CLI) remains poor. In response, various stem cells and growth factors have been assessed for use in therapeutic neovascularization and limb salvage in CLI patients. However, the clinical outcomes of cell-based therapeutic angiogenesis have not provided the promised benefits, reinforcing the need for novel cell-based therapeutic angiogenic strategies to cure untreatable CLI. In the present study, we investigated genetically engineered mesenchymal stem cells (MSCs) derived from human bone marrow that continuously secrete stromal-derived factor-1α (SDF1α-eMSCs) and demonstrated that intramuscular injection of SDF1α-eMSCs can provide long-term paracrine effects in limb ischemia and effectively contribute to vascular regeneration as well as skeletal muscle repair through increased phosphorylation of ERK and Akt within the SDF1α/CXCR4 axis. These results provide compelling evidence that genetically engineered MSCs with SDF-1α can be an effective strategy for successful limb salvage in limb ischemia.
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김동하(Dongha Kim),김민정(Minjeong Kim),김희수(Heesu Kim),양동준(Dongjoon Yang),임승록(Seungrok Lim),김효선(Hyosun Kim) 한국HCI학회 2013 한국HCI학회 학술대회 Vol.2013 No.1
태블릿 PC에서 활용되는 "필기노트" 어플리케이션의 사용성을 향상시키고자 인터뷰와 설문을 실시하였다. 인터뷰와 설문을 통해서 필기노트 어플리케이션의 필기모드에서 사람들이 선호하는 기능 제공 방식과 그 이유들을 분석 하였다. 본 연구의 결과는 필기노트 어플리케이션 제작 시 고려해야할 사항을 발견할 수 있다는 것에 의의가 있으며, 향후 해당 어플리케이션의 사용성 발전에 도움이 될 것이다. In this paper, the result of survey and interview provides suggestions to improve usability for "Writing application" using tablet PC. Through this interview and survey, we found out the preferable method of providing different functions when using writing application. Through this analysis, what to be considered before designing writing application is presented in details and it can be considered when improving usability.
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Choi, Hee June;Lee, Ji Min;Kim, Hyunkyung;Nam, Hye Jin;Shin, Hi-Jai R.;Kim, Dongha;Ko, Enyoung;Noh, Dong-Young;Kim, Keun II;Kim, Jung Hwa;Baek, Sung Hee Sookmyung Women's University Research Institute of 2011 여성과 건강 Vol.6 No.2
B-cell lymphoma 3 (Bc13) is a proto-oncogene upregulated in a wide range of cancers, including breast cancer. Although Bc13 is known to promote cell proliferation and inhibit apoptosis, the molecular mech¬anisms underlying the proto-oncogenic function of Bc13 have not been completely elucidated. To gain insight into the oncogenic role of Bc13, we applied a proteomic approach, which led to the identification of C-terminal binding protein 1 (CtBP1) as a binding partner of Bc13. A PXDLS/R motif embedded in Bc13 was found to mediate the interaction between Bc13 and CtBP1, which caused the stabilization of CtBP1 by blocking proteasome-dependent degradation. Apoptotic stimuli-induced degradation of CtBP1 was sig¬nificantly abolished by the upregulation of Bc13, leading to the sustained repression of pro-apoptotic gene expression and subsequent inhibition of apoptosis. Intriguingly, a strong positive correlation between the protein levels of Bc13 and CtBP1 was detected in breast cancer patient samples. Our study reveals a novel combinatorial role for Bc13 and CtBP1, providing an explanation for the acquisition of resistance to apop¬tosis in cancer cells, which is a major requirement for cancer development.
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Kim, Dongha,Lee, Daehee,Kim, Joosun,Moon, Jooho American Chemical Society 2012 ACS APPLIED MATERIALS & INTERFACES Vol.4 No.10
<P>The SnO<SUB>2</SUB> anode is a promising anode for next-generation Li ion batteries because of its high theoretical capacity. However, it exhibits inherent capacity fading because of the large volume change and pulverization that occur during the charge/discharge cycles. The buffer matrix, such as electrospun carbon nanofibers (CNFs), can alleviate this problem to some extent, but SnO<SUB>2</SUB> particles are thermodynamically incompatible with the carbon matrix such that large Sn agglomerates form after carbonization upon melting of the Sn. Herein, we introduce well-dispersed nanosized SnO<SUB>2</SUB> attached to CNFs for high-performance anodes developed by Ni presence. The addition of Ni increases the stability of the SnO<SUB>2</SUB> such that the morphologies of the dispersed SnO<SUB>2</SUB> phase are modified as a function of the Ni composition. The optimal adding composition is determined to be Ni:Sn = 10:90 wt % in terms of the crystallite size and the distribution uniformity. A high capacity retention of 447.6 mA h g<SUP>–1</SUP> after 100 cycles can be obtained for 10 wt % Ni-added SnO<SUB>2</SUB>–CNFs, whereas Ni-free Sn/SnO<SUB>2</SUB>–CNFs have a capacity retention of 304.6 mA h g<SUP>–1</SUP>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2012/aamick.2012.4.issue-10/am301328u/production/images/medium/am-2012-01328u_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am301328u'>ACS Electronic Supporting Info</A></P>
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