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( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3
Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)
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金德原(Kim, Deok-Won) 백산학회 2002 白山學報 Vol.- No.63
There has been little substantial progress in the study of King Jin Ji (眞智王). This is due to a shortage of records regarding his reign that resulted from the political turmoil leading up to his dethronement four years after taking the throne. Negative impressions implanted in the process of evaluating and recording his administrative achievements in comparison to King Jin Pyeong(眞平王) are another reason for this dearth of records. The background information that made it possible for him to become King, however, highlights both his personal ability and internal and external circumstances unique to the era of his accession. In terms of ability, his age was considered an important fact qualifying him to be King, as was his renown as a wise statesman with a keen and accurate sense of judgment. Taking into account the internal and external circumstances both before and after he became king, one must consider the Shilla Kingdom (新羅) suffering frequent attacks mounted by the Paekje Kindgom(百濟) externally given the inroads that King Jin Heung(眞興王) made into the Hang River(漢江) basin. The ideology of Cakravartirajan(轉輪聖王) late emerged as an internal factor, in terms of how it was closely connected to the Buddhist politics of King Jin Heung(眞興王). It was Geo Chil-bu(居柒夫) who played a pivotal role in bringing Jin Ji to the throne. He had been characterized as a symbolic figure that made great contributions to the expansion of Shilla Kingdom(新羅) territory by becoming a member of inner Buddhist circles somewhat earlier than others. In this context he was able to assist Jin Ji's accession to the throne in the following ways: Safeguarding the Shilla Kingdom territory from external threats was always an imminent proposition, while the internal politics of the Kingdom involved a pursuit of inheriting the Buddhist policies of King Jin Heung(眞興王). In addition to the Geo Chil-bu's(居柒夫) loyalty played in the coronation of King Jin Ji(眞智王), the role Kim Mu-ryeok(金武力) played is also worthy of attention. It has been inferred from what few records are available, that the military stronghold Kim Mu-ryeok had in cooperation with Geo Chil-bu(居柒夫) was a major factor in Jin Ji's accession to the throne. The relationship between King Jin Ji(眞智王) and Kim Mu-ryeok(金武力) also played had a significant influence on their kinsfolk. It has, therefore, been suggested that as a result King Yong-chun(金龍春) was nudged toward ties with Kim Seo-hyeon(金舒玄), and Kim Chun-chu(金春秋) affiliated himself with Kim Yu-sin(金庾信). It was perhaps these Saryun(舍輪系) and Kaya(加耶系) clique relationships, upon which a new aristocracy that has come to be known as the spread of ‘the middle ages(中代)’ was based.
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24/7 Elderly Guard Robot: Emergency Detecting, Reacting, and Reporting
Deok-won Lee,Ahmed Elsharkawy,Kooksung Jun,Yun-dong Lee,SeungJun Kim,Mun Sang Kim 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
As the number of elderly persons increases, greater attention must be given to how they or their caregivers deal with emergency situations. This paper describes an automated tracking, fall detection, and emergency recovery system for elderly persons, and shows that efficient a Socially Assistive Robot (SAR) can resolve emergency situations and abnormal behaviors for at-risk populations. Our assistant robot uses position data provided by Ultra-WideBand (UWB) wireless network and motion sensor information to detect potentially dangerous situations for elderly persons. In this context, a deep neural network–based double-check method has been developed to detect and confirm fall situation with high accuracy using in-house developed sensory hardware. We then simulated four typical emergency scenarios using SILBOT-3 robot. Interaction scenarios were demonstrated to 28 caregivers, who were then invited to complete a short questionnaire regarding benefits and improvements for our system. Caregivers responded positively to our system’s performance and stated that they would accept an assistant robot that could notify them quickly about a dangerous situation or possibly resolve the situation autonomously.
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Kim Ye Seul,Yoon Jung Won,Kim Dasol,Choi Seunghak,Kim Hyoung Kyu,Youm Jae Boum,Han Jin,Heo Soon Chul,Hyun Sung-Ae,Seo Jung-Wook,Kim Deok-Ho,Kim Jae Ho 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) have been reported to exhibit immature embryonic or fetal cardiomyocyte-like phenotypes. To enhance the maturation of hESC-CMs, we identified a natural steroidal alkaloid, tomatidine, as a new substance that stimulates the maturation of hESC-CMs. Treatment of human embryonic stem cells with tomatidine during cardiomyocyte differentiation stimulated the expression of several cardiomyocyte-specific markers and increased the density of T-tubules. Furthermore, tomatidine treatment augmented the number and size of mitochondria and enhanced the formation of mitochondrial lamellar cristae. Tomatidine treatment stimulated mitochondrial functions, including mitochondrial membrane potential, oxidative phosphorylation, and ATP production, in hESC-CMs. Tomatidine-treated hESC-CMs were more sensitive to doxorubicin-induced cardiotoxicity than the control cells. In conclusion, the present study suggests that tomatidine promotes the differentiation of stem cells to adult cardiomyocytes by accelerating mitochondrial biogenesis and maturation and that tomatidine-treated mature hESC-CMs can be used for cardiotoxicity screening and cardiac disease modeling.
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A Comparative Study on Power System Harmonics for Offshore Plants
Deok-Ki Kim,Won-Ju Lee,Jong-Su Kim 해양환경안전학회 2016 海洋環境安全學會誌 Vol.22 No.7
해양구조물에 전기 안전사고가 급증하면서 전력시스템 고조파 분야가 최근 많은 관심 받고 있다. 이것은 주로 비선형 (또는 고조파 생성) 부하가 일반적인 산업플랜트 전력시스템에서 계속 증가되고 있기 때문이다. 해양플랜트에서는 전력시스템의 안전설계로 인하여 고조파 문제의 발생률은 낮지만, 고조파 문제에 대한 인식은 전력시스템 설계의 신뢰성을 향상시키는데 여전히 도움이 될 수 있다. 전력시스템에 고조파 문제가 드물게 발생되는 경우, 이는 생성된 고조파의 크기 혹은 전력시스템의 공진 때문이다. 이 고조파 비교분석에 관한 연구는 전력부하를 고려한 부유식 액화천연가스 생산·저장·하역 (FLNG) 설비의 하역 운전 시나리오에 대한 전기적인 구성으로 비교분석하였다. 전기적인 네트워크 구성은 전기적인 네트워크 부하 흐름에서 볼 수 있다. 본 연구는 해양플랜트 전력시스템의 안전을 보장하기 위해 전기 모터 시스템의 고조파 효율에 초점을 맞추어 전력시스템 성능을 시뮬레이션을 통해 검증하였다. 또한, 본 연구의 설계분야에서도 운전 및 유지·보수의 향상시키기 위해 FLNG 설비의 전력시스템을 분석하였다. The field of power system harmonics has been receiving a great deal of attention recently. This is primarily due to the fact that non-linear (or harmonic-producing) loads comprise an ever-increasing portion of what is handled at a typical industrial plant. The incidence rate of harmonic-related problems is low, but awareness of harmonic issues can still help increase offshore power plant system reliability. On the rare occasion that harmonics become a problem, this is either due to the magnitude of harmonics produced or power system resonance. This harmonic study used an electrical configuration for the offloading scenario of a Floating LNG (FLNG) unit, considering power load. This electrical network configuration is visible in the electrical network load flow study part of the project. This study has been carried out to evaluate the performance of an electric power system, focusing on the harmonic efficiency of an electrically driven motor system to ensure offshore plant safety. In addition, the design part of this study analyzed the electric power system of an FLNG unit to improve the safety of operation and maintenance.
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Response of Odontoblast to the Bio-Calcium Phosphate Cement
Kim, Jin-Woo,Kim, Sung-Won,Kim, Gyoo-Cheon,Kim, Yong-Deok,Kim, Cheol-Hun,Kim, Bok-Joo,Kim, Uk-Kyu Korean Association of Maxillofacial Plastic and Re 2011 Maxillofacial Plastic Reconstructive Surgery Vol.33 No.4
Purpose: If the tooth structure is damaged, then it is impossible to regenerate the tooth. The materials used to restore the tooth structure are not related to the composition of the tooth. The materials used to restore the structure can't replace the natural tooth because they just fill the defective structure. Calcium phosphate cement remineralizes the dentin and almost replaces the natural tooth, but there are some disadvantages. We conducted basic tests with Biomimetic CPC (Bio-CPC) to make sure of the possibility of the biomaterial to remineralize the defective tooth structure. Methods: In this study, the bioactivity and biocompatibility of Bio-CPC were evaluated for its potential value as the bio-material for regeneration of damaged tooth structure by conducting a cell toxicity assay (WST-1 assay), a cytokinesis-block micronucleus assay, a chromosomal aberration test, total RNA extraction and RT-PCR on MDPC-23 mouse odontoblast-like cells. Results: The in vitro cytotoxicity test showed that the Bio-CPC was fairly cytocompatible for the MDPC-23 mouse odontoblast-like cells. Conclusion: Bio-CPC has a possibility to be a new biomaterial and further study of Bio-CPC is needed.
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Korean Youth with Comorbid Allergic Disease and Obesity Show Heightened Psychological Distress
Kim, Soo Yeon,Choi, Sun Ha,Kim, Jong Deok,Sol, In Suk,Kim, Min Jung,Kim, Yoon Hee,Jung, Young-Chul,Sohn, Myung Hyun,Kim, Kyung Won Elsevier 2019 The Journal of pediatrics Vol.206 No.-
<P><B>Objective</B></P> <P>To explore psychological distress in Korean adolescents having allergic disease comorbid with obesity.</P> <P><B>Study design</B></P> <P>A total of 703 869 adolescents who completed the Korean Youth Risk Behavior Web-based Survey between 2007 and 2016 were analyzed. Participants were divided into 4 groups—healthy control, allergic disease only, obesity only, and comorbidity of allergic disease and obesity—and compared them to determine whether they showed differences in mental health.</P> <P><B>Results</B></P> <P>Adolescents with both atopic dermatitis and obesity had significantly greater odds of experiencing unhappiness (OR, 1.17), stress (OR, 1.32), and suicidal ideation (OR, 1.25) than those without both conditions. The same was true of adolescents with obesity and allergic rhinitis (OR, 1.21, 1.37, and 1.27, respectively) or bronchial asthma (OR, 1.37, 1.39, and 1.37). The comorbidity groups also showed significantly greater odds of stress and suicidal ideation than the allergic disease-only (atopic dermatitis with obesity, 1.21 and 1.15, respectively; allergic rhinitis with obesity, 1.11 and 1.09; bronchial asthma with obesity, 1.17 and 1.14) and obesity-only groups (atopic dermatitis with obesity, 1.13 and 1.09; allergic rhinitis with obesity, 1.18 and 1.10; bronchial asthma with obesity, 1.18 and 1.21).</P> <P><B>Conclusions</B></P> <P>Allergic disease and obesity negatively and additively influence mental health in adolescents.</P>
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